Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.241.3-242
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- 2002
Phosphatidylinositol 3-Kinase Regulates Nuclear Translocation of NF-E2-Related Factor 2 through Actin Rearrangement in Response to Oxidative Stress
- Kang, Keon-Wook (Seoul National University) ;
- Lee, Seung-Jin (Seoul National University) ;
- Park, Jeong-Weon (Seoul National University) ;
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Kim, Sang-Geon
(Seoul National University)
- Published : 2002.10.01
Abstract
Expression of phase II detoxifying genes is regulated by NF-E2-related factor 2 (Nrf2)-mediated antioxidant response element (ARE) activation. Phosphatidylinositol 3-kinase (PI3-kinase) plays an essential role in ARE-mediated rGSTA2 induction by oxidative stress and controls microfilaments and translocation of actin-associated proteins. This study was designed to investigate the P13-kinase-mediated nuclear translocation of Nrf2 and the interaction of Nrf2 with actin. (omitted)
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