Yesat 균주를 이용한 비만 억제 재조합 CMP(caseinomacropeptide) 발현 연구

CMP(caseinomacropeptide) is known to be a peptide which controls the gain of body weight and eventually will be used as a new candidate to control obesity problem. In this study, CMP gene was obtained using RT-PCR and ligated to secretion vectors having different kinds of promoters and P.pastoris and S.cerevisiae were transformed with these vectors. Colonies showing high titre of CMP cxpressecl were chosen and fed-batch fermentation is being carried out with these transformant to test economic feasibility