Saccharomyces cerevisiae를 이용한 재조합 인간 훼리틴 발현 연구

  • 강환구 (한남대학교 화학공학과) ;
  • 이충열 (한남대학교 화학공학과) ;
  • 김원철 (한남대학교 화학공학과) ;
  • 윤지선 (한남대학교 화학공학과) ;
  • 박형수 (한남대학교 화학공학과) ;
  • 이지원 (생명공학연구원 생물공정연구실) ;
  • 정봉현 (바이오프로젠)
  • Published : 2001.11.07

Abstract

Ferritin an iron-storage protein. is found in bacteria and some animal tissues such as liver, spleen and bone marrow. It is more effective and causes less side reactions than traditional ferrous sulfate, which has been used primarily to treat iron deficiency in pregnancy anemia. Currently, the ferritin extracted from bovine and equine spleens are sold as a commercial product. Its markets are several hundreds of million US dollars. However, because of recent warnings against the viral diseases of animal origins such as mad cow disease, a safer ferritin is sought after. In this study, a production process for human ferritin was successfully developed. The amount of its produced in yeast is high enough to be economically viable.

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