Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Inhibition of Acetylcholine-activated $K^+$ Current by Chelerythrine and Bisindolylmaleimide I in Atrial Myocytes from the Mice

  • Hana Cho (National Research Laboratory for Cellular Signalling and Department of Physiology ＆ Biophysics, Seoul National University College of Medicine) ;
  • Youm, Jae-Boum (Department of Physiology, Cheju National University College of Medicin) ;
  • Earm, Yung-E (National Research Laboratory for Cellular Signalling and Department of Physiology ＆ Biophysics, Seoul National University College of Medicin) ;
  • Ho, Won-Kyung (National Research Laboratory for Cellular Signalling and Department of Physiology ＆ Biophysics, Seoul National University College of Medicine)
  • Published : 2001.06.01
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Abstract

The effects of protein kinase C inhibitors, chelerythrine and bisindolylmaleimide I, on acetylcholine activated $K^{＋}$ currents ( $I_{KACh}$) were examined in atrial myocytes of mice using patch clamp technique. Chelerythrine and bisindolylmaleimide I inhibited $I_{KACh}$ in reversible and dose-dependent manners. Half maximal effective concentrations were 0.49 $\pm$ 0.01 $\mu$M for chelerythrine and 98.69 $\pm$ 12.68 nM for bisindolylmaleimide I.(omitted)

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