Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Ionic Basis of Spike Afterdepolarization in Rat Hippocampal Dentate Granule Cell

  • Park, Won-Sun (Department of Physiology and National Research Laboratory for Cellular Signaling, Seoul National University College of Medicine) ;
  • Ho, Won-Kyung (Department of Physiology and National Research Laboratory for Cellular Signaling, Seoul National University College of Medicin) ;
  • Lee, Suk-Ho (Department of Physiology and National Research Laboratory for Cellular Signaling, Seoul National University College of Medicine)
  • Published : 2001.06.01
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Abstract

When repolarization of neuronal action potential does not decline monotonically but interrupted by additional depolarization, this prolonged depolarization phase is referred to afterdepolarization(ADP). ADP is considered to playa crucial role in the modulation of neuronal excitability, since it contributes to burst firing. We studied the ionic mechanisms underlying ADP in the soma of dentate granule cells, using rat hippocampal slice (300${\mu}{\textrm}{m}$ in thickness) prepared from 3- to 3-week-old SD rats.(omitted)

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