Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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ENANTIOSELECTIVE DISPOSITION OF LANSOPRAZOLE IN EXTENSIVE AND POOR METABOLIZERS OF CYP2C19.

  • Kim, Kyung-Ah (Department of Pharmacology, Inje University College of Medicine) ;
  • Shon, Ji-Hong (Department of Pharmacology, Inje University College of Medicin) ;
  • Park, Ji-Young (Department of Pharmacology, Inje University College of Medicin) ;
  • Yun, Doo-Hee (Department of Pharmacology, Inje University College of Medicin) ;
  • Shin, Jae-Gook (Department of Pharmacology, Inje University College of Medicine)
  • Published : 2001.10.01
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Abstract

The effect of CYP2C19 genetic polymorphism on the disposition of lansoprazole enantiomers was determined in order to evaluate the contribution of CYP2Cl9 in the stereoselective metabolism of lansoprazole. After single oral dose of 30mg lansoprazole racemate in 6 subjects with CYP2C19 PM genotype and 6 with EM genotype, the plasma concentrations of R-enantimers were consistently higher than those of S-enantiomer in boty EM and PM subjects.(omitted)

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