Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.198-198
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- 2001
INVOLVEMENT OF CYP2C9 ON CHLORPROPAMIDE 2-HYDROXYLATION IN HUMAN: IN VITRO AND IN VIVO EVIDENCE.
- Shon, Ji-Hong (Dept. of Phannacol., Inje Univ., ColI. of Med. and Clin. Phannacol. Center, Pusan Paik Hosp.) ;
- Yoon, Young-Ran (Dept. of Phannacol., Inje Univ., ColI. of Med. and Clin. Phannacol. Center, Pusan Paik Hosp) ;
- Kim, Min-Jung (Dept. of Phannacol., Inje Univ., ColI. of Med. and Clin. Phannacol. Center, Pusan Paik Hosp) ;
- Cha, In-June (Dept. of Phannacol., Inje Univ., ColI. of Med. and Clin. Phannacol. Center, Pusan Paik Hosp) ;
- Shin, Jae-Gook (Dept. of Phannacol., Inje Univ., ColI. of Med. and Clin. Phannacol. Center, Pusan Paik Hosp.)
- Published : 2001.10.01
Abstract
No report has been addressed to the CYP isoforms catalyzing chlorpropamide, a structural analogue of tolbutamide. To evaluate enzyme(s) mediating formation of 2-hydroxycWorpropamide, a major metabolite and identified by LC/Mass and NMR, incubation studies using human liver microsomes and cDNA expressed CYP were performed on the presence or absence of selective inhibitors of each CYP isoform. (omitted)
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