Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.196-196
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- 2001
STEREOSELECTIVE METABOLISM AND INHIBITION OF LANSOPRAZOLE ENANTIOMERS ON HUMAN LIVER CYPs.
- Kim, Kyung-Ah (Department of Pharmacology, Inje University College of Medicine) ;
- Yoon, Young-Ran (Department of Pharmacology, Inje University College of Medicin) ;
- Shin, Jae-Gook (Department of Pharmacology, Inje University College of Medicine)
- Published : 2001.10.01
Abstract
Stereoselective metabolism and inhibitory potential of lansoprazole enantiomers were evaluated from the incubational studies of human liver microsomes and eDNA-expressed CYP isoforms in vitro. The formation of lansoprazole sulfone from both enantiomers appeared to be catalyzed by single and low affinity enzyme. Lansoprazole 5-hydroxylation, however, appeared to be mediated by two kinetically distinct CYP enzymes.(omitted)
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