ACTIVATION OF p38 MITOGEN-ACTIVATED PROTEIN KINASE IN H-Ras MCF10A CELLS: ROLE IN H-Ras-INDUCED CELL MOTILITY

  • Lee, Eun-Jung (College of Pharmacy, Duksung Womens University) ;
  • Kim, Mi-Sung (College of Pharmacy, Duksung Womens University) ;
  • Aree Moon (College of Pharmacy, Duksung Womens University)
  • Published : 2001.10.01

Abstract

One of the most frequent defects in human cancer is the uncontrolled activation of the ras-signaling pathways. We have previously shown that H-ras, but not N-ras, induces an invasiveness and motility in human breast epithelial cells (MCF10A), while both H-ras and N-ras induce transformed phenotype. Since migration plays a crucial role in invasive, we examined motility of MCF10A cells transformed with H-ras of N-ras.(omitted)

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