ACTIVATION OF PI3K IS NOT SUFFICIENT, BUT REQUIRED FOR H-Ras-INDUCED INVASIVE PHENOTYPE IN MCFIOA CELLS

  • Shin, Il-Chung (College of Pharmacy, Duksung Womens University) ;
  • Aree Moon (College of Pharmacy, Duksung Womens University)
  • Published : 2001.10.01

Abstract

We have previously shown that H-ras, but N-ras, induces an invasiveness and cell motility in human breast epithelial cells (MCFl0A), while both H-ras and N-ras induce transformed phenotype. It has been recently shown that phosphatidylinositol 3-kinase (PI3K) plays an important role on cell migration. In the present study, we wished to investigate the functional role of PI3K in H-ras-induced invasive phenotype in MCF10A cells.(omitted)

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