Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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PEROXYNITRITE SCAVENGING BY NO MODULATORY ACTIVITIES OF HYDROQUINONE FROM COFFEE

  • Kim, Ae-Ra (College of Pharmacy, Pusan National University) ;
  • Park, Jae-Sue (Science and Biotechnology, Pukyong National University) ;
  • Chung, Hae-Young (College of Pharmacy, Pusan National University)
  • Published : 2001.10.01
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Abstract

Peroxynitrite (ONOO), a potent cytotoxic oxidant formed by the reaction of nitric oxide (ㆍNO) and superoxide radical (ㆍO$_2$), reacts rapidly to cause of oxidization and nitration process. The importance of the regulation of ONOO$^{-}$ has been recently recognized because of the lack of specific endogenous enzymes against ONOO$^{-}$. Coffee that is a complex mixture containing a variety of components has been reported to have both beneficial and hazardous effects.

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