Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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PEROXYNITRITE SCAVENGING ACTIVITY OF HERB EXTRACTS

  • Kim, Ae-Ra (College of Pharmacy, Pusan National University) ;
  • Zou, Ya-Ni (College of Pharmacy, Pusan National University) ;
  • Park, Tae-Hyun (College of Pharmacy, Pusan National University) ;
  • Park, Jae-Sue (Faculty of Food Science and Biotechnology, Pukyong National University) ;
  • Chung, Hae-Young (College of Pharmacy, Pusan National University)
  • Published : 2001.10.01
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Abstract

Peroxynitrite (ONOO$^{-}$) is one of cytotoxic species produced by the reaction between superoxide(ㆍ $O_2$$^{-}$) and nitric oxide (NO). The aim of this study was to characterize ONOO$^{-}$ scavenging constituents from herbs. Methanolic extract derived from one hundred fifty nine herbs were screened out for their ONOO$^{-}$ scavenging activities. It was investigated that about 33 herbs was excellent scavengers of ONOO$^{-}$. The extracts exhibited dose-dependent ONOO$^{-}$ scavenging activities.

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