Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.123-124
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- 2001
MUTAGENIC POTENTIAL OF FREE RADICALS GENERATED FROM INFLAMMATORY LEUKOCYTES AND INHIBITION OF THE MUTAGENICITY BY FOOD FACTORS
- Kim, Ha-Won (Graduate School of Agriculture, Kyoto University) ;
- Akira Murakami (Faculty of Biology-Oriented Science and Technology, Kinki University) ;
- Yoshimasa Nakamura (Graduate School of Bioagricultural Sciences, Nagoya University) ;
- Hajime Ohigashi (Graduate School of Agriculture, Kyoto University)
- Published : 2001.10.01
Abstract
DNA mutations undoubtedly contribute to the onset of some life style-related diseases including cancer. Rapid and reliable methods to detect DNA mutations and to isolate mutants should have a great impact on this field. Activated inflammatory leukocytes are considered to play some important roles in carcinogenesis by generating reactive oxygen species (ROS). The purpose of the present study is to examine the relationship between leukocyte activation by TPA and mutagenesis.(omitted)
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