THE ALTERATION OF OXIDATIVE DAMAGE AND ACTMTIES OF METABOLIZING ENZYMES IN RATS TREATED WITH PEROXISOME PROLIFERATORS

  • Sea, Kyung-Won (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administration) ;
  • Kim, Kyu-Bong (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
  • Kim, Yun-Jung (College of Pharmacy, Kyunghee Univ.) ;
  • Suh, Soo-Kyung (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
  • Kim, Jong--Min (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
  • Park, Chang-Won (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
  • Kim, Jong-Won (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
  • Kim, Kwang-Jin (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
  • Choi, Ju-Young (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administration) ;
  • Kim, Joo-Il (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administration) ;
  • Lee, Kyung-Tae (College of Pharmacy, Kyunghee Univ.) ;
  • Lee, Sun-Hee (Pharmacology Dept., National Institute of Toxicological Research, Korea Food & Drug Administration)
  • Published : 2001.10.01

Abstract

The phthalates have been shown to produce hepatic peroxisome proliferation and certain peroxisome proliferators (PPs) are also known to increase the incidence of liver tumors in rodents. In this study we investigated the correlation between oxidative injury, changes in peroxisomal and microsomal enzymes and tumor formation in PP-treated rats.(omitted)

Keywords