Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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The Role of PLC $\beta1$ in Desensitization of Acetycholine Activated $K^+$ Currents in Mouse Atrial Myocytes

  • Hana Cho (Department of Physiology, Seoul National University College of Medicine) ;
  • Ho, Won-Kyung (Department of Physiology, Seoul National University College of Medicin) ;
  • Earm, Yung-E (Department of Physiology, Seoul National University College of Medicine)
  • Published : 1999.06.01
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Abstract

The negative chronotropic effect of ACh on heart fades in the continuous presence of ACh, which is known as a phenomenon called "vagal escape". The underlying mechanism of vagal escape is not entirely clear, but desensitization of acetylcholine-activated $K^{＋}$ currents ($K_{ACh}$) was suggested, at least in part, to be responsible.(omitted)d)

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