• Title/Summary/Keyword: z-domain

Search Result 249, Processing Time 0.023 seconds

Continual Learning with Mimicking Human Memory System For Multi-domain Response Generator (다중 도메인 답변 생성 모델을 위한 인간의 기억 시스템을 모방하는 지속 학습 기법)

  • Lee, Jun-Beom;Park, Hyeong-Jun;Song, Hyun-Je;Park, Seong-Bae
    • Annual Conference on Human and Language Technology
    • /
    • 2021.10a
    • /
    • pp.215-220
    • /
    • 2021
  • 다중 도메인에 대해 답변 생성 모델이 동작 가능하도록 하는 가장 쉬운 방법은 모든 도메인의 데이터를 순서와 상관없이 한번에 학습하는 것이다. 하지만 이경우, 발화에 상관 없이 지나치게 일반적인 답변을 생성하는 문제가 발생한다. 이에 반해, 도메인을 분리하여 도메인을 순차적으로 학습할 경우 일반적인 답변 생성 문제를 해결할 수 있다. 하지만 이경우 새로운 도메인의 데이터를 학습할 때, 기존에 학습한 도메인에 대한 성능이 저하되는 파괴적 망각 현상이 발생한다. 파괴적 망각 현상을 해결하기 위하여 다양한 지속학습기법이 제안되었으며, 그 중 메모리 리플레이 방법은 새로운 도메인 학습시 기존 도메인의 데이터를 함께 학습하는 방법으로 파괴적 망각 현상을 해결하고자 하였다. 본 논문에서는, 사람의 기억 시스템에 대한 모형인 앳킨슨-쉬프린 기억 모형에서 착안하여 사람이 기억을 저장하는것과 유사한 방법으로 메모리 리플레이 방법의 메모리 관리방법을 제안하였고, 해당 메모리 관리법을 활용하는 메모리 리플레이 방법을 통해 답변 생성 모델의 파괴적 망각 현상을 줄이고자 하였다. 다중 도메인 답변 생성에 대한 데이터셋인 MultiWoZ-2.0를 사용하여 제안 모델을 학습 및 평가하였고, 제안 모델이 다중 도메인 답변 생성 모델의 파괴적 망각 현상을 감소시킴을 확인하였다.

  • PDF

A new viewpoint on stability theorem for engineering structural and geotechnical parameter

  • Timothy Chen;Ruei-Yuan Wang;Yahui Meng;Z.Y. Chen
    • Geomechanics and Engineering
    • /
    • v.36 no.5
    • /
    • pp.475-487
    • /
    • 2024
  • Many uncertainties affect the stability assessment of rock structures. Some of these factors significantly influence technology decisions. Some of these factors belong to the geological domain, and spatial uncertainty measurements are useful for structural stability analysis. This paper presents an integrated approach to study the stability of rock structures, including spatial factors. This study models two main components: discrete structures (fault zones) and well known geotechnical parameters (rock quality indicators). The geostatistical modeling criterion are used to quantify geographic uncertainty by producing simulated maps and RQD values for multiple equally likely error regions. Slope stability theorem would be demonstrated by modeling local failure zones and RQDs. The approach proided is validated and finally, the slope stability analysis method and fuzzy Laypunov criterion are applied to mining projects with limited measurement data. The goals of this paper are towards access to adequate, safe and affordable housing and basic services, promotion of inclusive and sustainable urbanization and participation, implementation of sustainable and disaster-resilient buildings, sustainable human settlement planning and manage. Simulation results of linear and nonlinear structures show that the proposed method is able to identify structural parameters and their changes due to damage and unknown excitations. Therefore, the goal is believed to achieved in the near future by the ongoing development of AI and fuzzy theory.

VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma

  • Jungwhoi Lee;Woogwang Sim;Jungsul Lee;Jae-Hoon Kim
    • BMB Reports
    • /
    • v.57 no.7
    • /
    • pp.324-329
    • /
    • 2024
  • The aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma cells through blockade of the intracellular signalling pathway. In silico analysis showed that VSTM2L affected the positive regulation of cell growth in cholangiocarcinoma. Liptak's z value revealed that the expression of VSTM2L worsened the prognosis of cholangiocarcinoma patients. In addition, soluble VSTM2L was significantly detected in the whole blood of cholangiocarcinoma patients compared with that of healthy donors. Our report reveals that VSTM2L might be the potential therapeutic target and a soluble prognostic biomarker against cholangiocarcinoma.

Longitudinal Study about Science Process Skills Item Forms Transition before and after Scholastic Ability Test for College (과학(科學) 탐구능력(探究能力) 평가(評價) 문항(問項) 유형(類型) 변화(變化)에 관(關)한 종단적(縱斷的) 연구(硏究))

  • Woo, Jong-Ok;Lee, Hang-Ro;Goo, Chang-Hyun
    • Journal of The Korean Association For Science Education
    • /
    • v.16 no.3
    • /
    • pp.314-328
    • /
    • 1996
  • This study investigated the literature about science process skills' evaluation to analyse transition of evaluation objectives before and after a Scholastic Ability Test for College Entrance. In the literature survey the researcher established a 3 dimensional science assessment framework with X axis as science concept, Y axis as science process skills and Z axis as problem context. In order to analysis and compare each items the researcher selected 210 items from the 1st to the 7th trials and 138 items from the 1st to 4th Scholastic Ability Test for College Entrance and sampled 2873 science achievement test items from 10 high schools. In accordance with this taxonomy the researcher analysed and compared science process skills item forms. The following results were drawn : The items were evenly distributed in all the four areas(Earth Science, Biology, Physics and Chemistry) of the science concept domain, but they were heavily concentrated on data analysis and drawing a conclusion in science process domain. In the domain of problem context school context was the majority. In spite of distribution like this the ratio on science process skills measurement items and science achievement test items was increased after the Scholastic Ability Test for College Entrance was given. Also the ratio on item expression type was increased. Item form was almost 5 options selection type in the national level test. Although there were 4 options selection type, 5 options selection type, short answer type, essay type in school level test, rising from 33.1% to 65.5% on 5 options selection type is exhibited. This study showed that the school level item form was better various than the nation level. This point like this is the evidence for the improvement toward the science process skills test and influenced by Scholastic Ability Test for College Entrance. The ratio on the item which joined with the 3 axes had a mean of 99.3% in nation level test and mean 44.9% in school achievement test level. But the ratio in the school achievement test level increased after the Scholastic Ability Test for College Entrance was given. In view of this study we must furthermore study the item types which can evaluate valjdately science process skill's five stage each and evaluation method by the high school students' problem solving patterns and features in scientific inquiry on all science process skills elements.

  • PDF

In Silico Analysis and Molecular Docking Comparison of Mosquito Oviposition Pheromone and Beta-asarone on the Mosquito Odorant Binding Protein-1 (In Silico 분자결합 분석방법을 활용한 MOP와 베타아사론의 열대집모기 후각단백질 활성 부위에 대한 결합 친화도 비교 분석)

  • Kim, Dong-Chan
    • Journal of Life Science
    • /
    • v.28 no.2
    • /
    • pp.195-200
    • /
    • 2018
  • Beta-asarone is the well-known active ingredient of Rhizoma acori graminei. In this study, we investigated and compared the binding affinity of mosquito oviposition pheromone (MOP; (5R,6S)-6-acetoxy-5-hexadecanolide) and beta-asarone on the A domain of the mosquito odorant binding protein 1 (CquiOBP1) by in silico computational docking studies. The three-dimensional crystallographic structure of CquiOBP1 was obtained from the PDB database (PDB ID: 3OGN). In silico computational auto-docking analysis was performed using PyRx, Autodock Vina, Discovery Studio Version 4.5, and the NX-QuickPharm option based on scoring functions. The beta-asarone showed optimum binding affinity (docking energy) with CquiOBP1 as -6.40 kcal/mol as compared to the MOP (-6.00 kcal/mol). Among the interacting amino acids (LEU76, LEU80, ALA88, MET89, HIS111, TRP114, and TYR122), tryptophan 114 in the CquiOBP1 active site significantly interacted with both MOP and beta-asarone. Amino acids substitution (mutation) from non-polar groups to the polar (or charged) groups of the CquiOBP1 dramatically changed the X, Y, Z grid position and binding affinity of both ligands. These results significantly indicated that beta-asarone could be a more potent ligand to the CquiOBP1 than MOP. Therefore, the extract of Rhizoma acori graminei or beta-asarone can be applied to the fields of insecticidal and repellant biomaterial development.

Similarity of Gene Expression Profiles in Primary Brain Tumors with the Toxic Mechanism by Environmental Contaminants

  • Kim, Yu-Ri;Kim, Ki-Nam;Park, Yoon-Hee;Ryu, Yeon-Mi;Sohn, Sung-Hwa;Seo, Sang-Hui;Lee, Seung-Ho;Kim, Hye-Won;Lee, Kweon-Haeng;Kim, Meyoung-Kon
    • Molecular & Cellular Toxicology
    • /
    • v.1 no.3
    • /
    • pp.209-215
    • /
    • 2005
  • Recently, a large number of clinical experiments have shown that exposure of organic pollutants lead to various cancers through the abnormal cell growth. Environmental pollutants, such as 2, 3, 7, 8-Tetrachloro dibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons (PAHs), are carcinogen and are known to cause the cognitive disability and motor dysfunction in the developing of brain. The effects of these pollutants on neurodevelopmental disorder is well established, but the underlying mechanism(s) and similarity of gene expression profiles in human brain tumors with organic pollutants still remain unclear. In this study, we first examined the gene expression profiles in glioblastomas compared with meningioma that are kinds of primary human brain tumor by using human cDNA microarray. The results of cDNA microarray analysis revealed that 26 genes were upregulated (Z-ratio>2.0) and 14 genes were downregulated (Z-ratio<-2.0) in glioblastoma compared with meningioma. From the altered gene patterns, mitogen-activated protein kinase (MAPK) signaling related genes, such as MAP2K3, MAP3K11 and jun activated domain binding protein, and transcription factors, such as UTF2 and TF12, were upregulated in glioblastoma. Also, we tried to investigate the relation between important genes up- and down-regulated in giloblastoma and various organic pollutants. Therefore, the identification of changes in the patterns of gene expression may provide a better understanding of the molecular mechanisms involved in human primary brain tumors and of the relation between gene expression profiles and organic pollutants in brain tissue.

Analysis of IR-UWB Tapered Slot Antenna Radiation Pattern using the Group delay and Fidelity (군 지연 및 충실도를 이용한 IR-UWB용 테이퍼 슬롯 안테나 방사패턴 분석)

  • Kim, Keun-Yong;Ko, Yong-Mok;Park, Kyoung-Jin;Kang, Een-Kyun;Lee, Dae-Woo;Park, Jong-Hyun;Ra, Keuk-Whan
    • Journal of the Institute of Electronics and Information Engineers
    • /
    • v.50 no.8
    • /
    • pp.308-315
    • /
    • 2013
  • In this paper, Tapered slot antenna of IR-UWB was Designed and fabricated using HFSS and we suggest the beam width of the broadband antenna using group-delay and fidelity. For this purpose, acquired data from the Network Analyzer was analyzed in the time domain by using the chirp-Z transform and Simulation was conducted and confirmed with the CST microwave studio. Analysis of the antenna radiation pattern is the antenna separation at intervals of 0.5 metres and then transmit antenna is fixed and the receiving antenna 360 degree intervals of 10 degree each, The results of the analysis are as follows, and analyzer of the fidelity of the antenna's performance. An analysis of more than 90 percent of the cases is less than ${\pm}40$ degrees in good fidelity, more than 90% less than ${\pm}40$ degrees and lowe fidelity. In conclusion, Analysis of Beam width of wideband antenna with more precise is possible through using these radiation pattern using fidelity.

Study on Expression and Characterization of HRD3 Gene Related DNA Repair from Eukaryotic Cells (진핵세포에서 DNA 회복에 관련된 HRD3 유전자의 분리, 발현 및 특성 연구)

  • Shin, Su-Hwa;Park, In-Soon
    • Journal of Life Science
    • /
    • v.14 no.2
    • /
    • pp.325-330
    • /
    • 2004
  • The RAD3 gene of Saccharomyces cerevisiae is required for excision repair and is essential for cell viability. RAD3 encoded protein possesses a single stranded DNA-dependent ATPase and DNA and DNA-RNA helicase activities. To examine the extent of conservation of structure and function of RAD3 during eukaryotic evolution, the RAD3 homolog gene was isolated by screening of genomic DNA library. The isolated gene was designated as HRD3 (Homologue of RAD3 gene). The over-expressed HRD3 protein was estimated to be a 75 kDa in size which is in good agreement with the estimated by the nucleotide sequence of the cloned gene. Two-dimensional gel electrophoresis showed that a number of other protein spots dramatically disappeared when the HRD3 protein was overexpressed. The overexpressed RAD3 protein showed a toxicity in E. coli host, suggesting that this protein may be involved in the inhibition of protein synthesis and/or degradation of host protein. To determine which part of HRD3 gene contributes to the toxicity in E. coli, various fusion plasmids containing a partial sequence of HRD3 and lac'Z gene were constructed. These results suggest that the C-terminal domain of HRD3 protein may be important for both toxic effect in E. coli and for its role in DNA repair in S. pombe.

Analysis of Tubulysin Biosynthetic Genes in Archangium gephyra (Archangium gephyra의 tubulysin 생합성 유전자 분석)

  • Choi, Juo;Park, Taejoon;Kang, Daun;Lee, Jeongju;Kim, Yungpil;Lee, Pilgoo;Chung, Gregory J.Y.;Cho, Kyungyun
    • Microbiology and Biotechnology Letters
    • /
    • v.49 no.3
    • /
    • pp.458-465
    • /
    • 2021
  • Tubulysins are a group of bioactive secondary metabolites from myxobacteria exhibiting strong anticancer activity against various cancer cell lines. In this study, we describe the identification of putative tubulysin biosynthetic gene clusters (tubA~tubF) in the genome sequences of two tubulysin-producing myxobacterial strains, Archangium gephyra MEHO_002 and MEHO_004. The inactivation of the putative tubulysin biosynthetic genes resulted in a tubulysin-production defect. The DNA sequences of the A. gephyra MEHO_002 and MEHO_004 tubulysin biosynthetic genes were 97% identical, and the amino acid sequences of the encoded proteins shared a similarity of 97-100%. The nucleotide sequences of the tubulysin biosynthetic gene clusters in MEHO_002 and MEHO_004 were 86% identical to that in Cystobacter sp. SBCb004 known as a tubulysin-producing myxobacterium, and the organization of the clusters was identical except for the lack of a tubZ gene in the clusters in MEHO_002 and MEHO_004. The amino acid sequences of the proteins encoded by each gene were 88-97% similar to those encoded by SBCb004, and the domain compositions of the proteins were also identical.

KNU Korean Sentiment Lexicon: Bi-LSTM-based Method for Building a Korean Sentiment Lexicon (Bi-LSTM 기반의 한국어 감성사전 구축 방안)

  • Park, Sang-Min;Na, Chul-Won;Choi, Min-Seong;Lee, Da-Hee;On, Byung-Won
    • Journal of Intelligence and Information Systems
    • /
    • v.24 no.4
    • /
    • pp.219-240
    • /
    • 2018
  • Sentiment analysis, which is one of the text mining techniques, is a method for extracting subjective content embedded in text documents. Recently, the sentiment analysis methods have been widely used in many fields. As good examples, data-driven surveys are based on analyzing the subjectivity of text data posted by users and market researches are conducted by analyzing users' review posts to quantify users' reputation on a target product. The basic method of sentiment analysis is to use sentiment dictionary (or lexicon), a list of sentiment vocabularies with positive, neutral, or negative semantics. In general, the meaning of many sentiment words is likely to be different across domains. For example, a sentiment word, 'sad' indicates negative meaning in many fields but a movie. In order to perform accurate sentiment analysis, we need to build the sentiment dictionary for a given domain. However, such a method of building the sentiment lexicon is time-consuming and various sentiment vocabularies are not included without the use of general-purpose sentiment lexicon. In order to address this problem, several studies have been carried out to construct the sentiment lexicon suitable for a specific domain based on 'OPEN HANGUL' and 'SentiWordNet', which are general-purpose sentiment lexicons. However, OPEN HANGUL is no longer being serviced and SentiWordNet does not work well because of language difference in the process of converting Korean word into English word. There are restrictions on the use of such general-purpose sentiment lexicons as seed data for building the sentiment lexicon for a specific domain. In this article, we construct 'KNU Korean Sentiment Lexicon (KNU-KSL)', a new general-purpose Korean sentiment dictionary that is more advanced than existing general-purpose lexicons. The proposed dictionary, which is a list of domain-independent sentiment words such as 'thank you', 'worthy', and 'impressed', is built to quickly construct the sentiment dictionary for a target domain. Especially, it constructs sentiment vocabularies by analyzing the glosses contained in Standard Korean Language Dictionary (SKLD) by the following procedures: First, we propose a sentiment classification model based on Bidirectional Long Short-Term Memory (Bi-LSTM). Second, the proposed deep learning model automatically classifies each of glosses to either positive or negative meaning. Third, positive words and phrases are extracted from the glosses classified as positive meaning, while negative words and phrases are extracted from the glosses classified as negative meaning. Our experimental results show that the average accuracy of the proposed sentiment classification model is up to 89.45%. In addition, the sentiment dictionary is more extended using various external sources including SentiWordNet, SenticNet, Emotional Verbs, and Sentiment Lexicon 0603. Furthermore, we add sentiment information about frequently used coined words and emoticons that are used mainly on the Web. The KNU-KSL contains a total of 14,843 sentiment vocabularies, each of which is one of 1-grams, 2-grams, phrases, and sentence patterns. Unlike existing sentiment dictionaries, it is composed of words that are not affected by particular domains. The recent trend on sentiment analysis is to use deep learning technique without sentiment dictionaries. The importance of developing sentiment dictionaries is declined gradually. However, one of recent studies shows that the words in the sentiment dictionary can be used as features of deep learning models, resulting in the sentiment analysis performed with higher accuracy (Teng, Z., 2016). This result indicates that the sentiment dictionary is used not only for sentiment analysis but also as features of deep learning models for improving accuracy. The proposed dictionary can be used as a basic data for constructing the sentiment lexicon of a particular domain and as features of deep learning models. It is also useful to automatically and quickly build large training sets for deep learning models.