• Structural Engineering and Mechanics
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• v.42 no.6
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• pp.883-897
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• 2012

Cold-formed channel sections are used in a variety of applications in which they are required to absorb deformation energy. This paper investigates the collapse behaviour and energy absorption capability of cold-formed steel channels with flange edge stiffeners under large deformation major-axis bending. The Yield Line Mechanism technique is applied using the energy method, and based upon measured spatial plastic collapse mechanisms from experiments. Analytical solutions for the collapse curve and in-plane rotation capacity are developed, and used to model the large deformation behaviour and energy absorption. The analytical results are shown to compare well with experimental values. Due to the complexities of the yield line model of the collapse mechanism, a simplified procedure to calculate the energy absorbed by channel sections under large bending deformation is developed and also shown to compare well with the experiments.

• Structural Engineering and Mechanics
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• v.6 no.4
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• pp.395-409
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• 1998

This paper concerns the development and implementation of an orthotropic, stress resultant elasto-plastic finite element model for the collapse load analysis of reinforced concrete plates. The model implements yield line plasticity theory for reinforced concrete. The behaviour of the yield functions are studied, and modifications introduced to ensure a robust finite element model of cases involving bending and twisting stress resultants ($M_x$, $M_y$, $M_{xy}$). Onset of plasticity is always governed by the general yield-line-model (YLM), but in some cases a switch to the stress resultant form of the von Mises function is used to ensure the proper evolution of plastic strains. Case studies are presented, involving isotropic and orthotropic plates, to assess the behaviour of the yield line approach. The YLM function is shown to perform extremely well, in predicting both the collapse loads and failure mechanisms.

• Computers and Concrete
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• v.12 no.6
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• pp.819-829
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• 2013

The objective of this study is to determine whether or not the yield line theory, an effective method widely used for slabs made of ordinary concrete, can be used also for the reinforced concrete slabs made of high-strength concrete. Flexural behavior of simply supported slabs in three different sizes were investigated under concentrated load at mid-span. Additionally, behavior of high strength reinforced concrete slabs with 50 mm and 150 mm reinforcement spacings also studied. Failure loads, deflections, experimental and theoretical failure mechanisms were evaluated. The difference between the moments based on yield line theory and experimental moments varied between 1% to 3%. Experimental and analysis results revealed that yield line analysis could conveniently be employed in the analysis of high strength reinforced concrete slabs.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.4 no.4
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• pp.37-48
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• 1984

The yield-line analysis is used for earring out the limit analysis of reinforced concrete slabs which are for example like those of vertical walls of tanks subjected to the loads of hydrostatical type. It is considered both isotropic and orthotropic reinforcement using the coefficient of orthotropy with different edge conditions. The yield-line analysis is carried out by using the vertical work method and four collapse mechanisms including the fan mechanisms which is more realistic than over diagonal mechanisms is considered. It is found that the fan mechanisms are more complicated than ever simple diagonal mechanisms which have used for the orthotropically reinforced concrete slabs subjected to hydrostatic pressures. Especially Horton's study is extended in this study, and they are formulated to the constrained multi-variables nonlinear optimization problems, which are solved by the Rosen-Brock Hillclimb Procedure Program and are more critical.

• Structural Engineering and Mechanics
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• v.29 no.6
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• pp.623-642
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• 2008

While spatial plastic mechanism analysis has been widely and successfully applied to thinwalled steel structures to analyse the post-failure behaviour of sections and connections, there remains some contention in the literature as to the basic capacity of an inclined yield line. The simple inclined hinge commonly forms as part of the more complex spatial mechanism, which may involve a number of hinges perpendicular or inclined to the direction of thrust. In this paper some of the existing theories are compared with single inclined yield lines that form in flange outstands, by comparing the theories with plate tests of plates simply supported on three sides with the remaining (longitudinal) edge free. The existing mechanism theories do not account for different in-plane displacement gradients of the loaded edge, nor the slenderness of the plates, and produce conservative results. A modified theory is presented whereby uniform and non-uniform in-plane displacements of the loaded edge of the flange, and the slenderness of the flange, are accounted for. The modified theory is shown to compare well with the plate test data, and its application to flanges that are components of sections in compression and/or bending is presented.

• The Journal of Internal Korean Medicine
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• v.32 no.4
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• pp.530-541
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• 2011

Objectives : Categorized as 'cheongyeol' herbs, Herba Prunellae, Flos Lonicerae and Radix Scutellaria have been proven to have effect on degenerative brain disease, cerebrovascular disease and brain tumor because of their anti inflammation, antioxidant, or anticancer effects. In this study, we studied activity against reactive oxygen species and anti inflammation effect of these three 'Cheongyeol' herbs. Methods : We measured each herb's yield of ethanol extracts, phenolic contents and activities against DPPH, hydroxyl radical and superoxide anion. Also through 6-hydroxydopamine (6-OHDA) induced oxidative damage in SH-SY5Y human neuroblastoma cell line, we measured antioxidant effect and NO activity of the three herbs. From the three herbs, we chose Prunella Herba, which showed the highest antioxidant effect, and studied its cell survival rate and anti inflammation effect through COX-2 and iNOS. Results : All three herbs showed significant results, and especially Prunella Herba showed significant effect on phenol contents, antioxidant effect on various active oxygen and antioxidant, and anti inflammation effect through cell line. Conclusions : Further study of the origin concept of 'cheongyeol' and research into specific mechanisms and role in treatment of cranial nerve disease, seems warranted.

• Journal of Korean Society for Atmospheric Environment
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• v.26 no.2
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• pp.219-233
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• 2010

Understanding the Nano size particles is of great interest due to their chemical and physical behaviors such as compositions, size distributions, and number concentrations. Therefore, accurate measurements of size distributions and number concentrations in ultrafine particles are getting required because expected losses such as diffusion for the instrument system from ambient inlet to detector are a significant challenge. In this study, the data using the computed settling losses, impaction losses, diffusion losses for the sampling lines (explored different sampling line diameters, horizontal length, number of bending, line angles, flow rates with and without a bypass), and diffusion losses for the Scanning Mobility Particle Sizers are examined. As expected, the settling losses and impaction losses are very minor under 100 nm, however, diffusion loss corrections for the sampling lines and the size instrument make a large difference for any measurement conditions with high numbers of particles smaller mobility size. Both with and without the loss corrections, which can affect to size distributions and number concentrations are described. First, 80% or more of the smallest particles (less than 10 nm) can be lost in the condition of a flow rate of 0.3 liter per minute and the length of sampling line of 1.0 m, second, total number concentrations of measurements are quite significantly affected, and the mode structure of the size distribution changes dramatically after the loss corrections applied. With compared to the different measurements, statistically diffusion loss corrections yield a required process of the ambient particle concentrations. Based on the current study, as an implication, a possibility of establishing direct revelation mechanisms is suggested.

• Steel and Composite Structures
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• v.25 no.3
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• pp.271-286
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• 2017

The use of Hollow Structural Sections (HSS) provides an alternative for steel buildings in seismic zones, with the advantage over WF columns that the HSS columns have similar resistance along both axes and enhanced performance under flexure, compression and torsion with respect to other columns sections. The HSS columns have shown satisfactory performance under seismic loads, such as observed in buildings with steel moment frames in the Honshu earthquake (2011). The purpose of this research is to propose a new moment connection, EP-HSS ("End-plate to Hollow Structural Section"), using a wide flange beam and HSS column where the end plate falls outside the range of prequalification established in the ANSI/AISC 358-10 Specification, as an alternative to the traditional configuration of steel moment frames established in current codes. The connection was researched through analytical, numerical (FEM), and experimental studies. The results showed that the EP-HSS allowed the development of inelastic action on the beam only, avoiding stress concentrations in the column and developing significant energy dissipation. The experiments followed the qualification protocols established in the ANSI/AISC 341-10 Specification satisfying the required performance for highly ductile connections in seismic zones, thereby ensuring satisfactory performance under seismic actions without brittle failure mechanisms.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.3
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• pp.287-292
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• 2017

Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of vitiligo, its intrinsic mechanisms have never been investigated in vitro. This research aimed to study the ability of pimecrolimus on stimulating melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression. Results showed that pimecrolimus at the dosages of 1, 10, $10^2$nM were neither mitogenic nor cytotoxic to melanocytes. The addition of pimecrolimus at 10, $10^2$ and $10^3nM$ significantly increased intracellular tyrosinase activity, which was consistent with the elevated content of melanin content at the same concentrations. The peak effect was seen at 72 h in response to $10^2$nM pimecrolimus. Results of the wound scratch assay and Transwell assays indicate that pimecrolimus is effective in facilitating melanocyte migration on a collagen IV-coated surface. In addition, MITF protein yield reached the highest by pimecrolimus at $10^2nM$. In brief, pimecrolimus enhances melanin synthesis as well as promotes migration of melanocytes directly, possibly via their effects on MITF protein expression.

• Journal of the Korea Concrete Institute
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• v.18 no.4 s.94
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• pp.469-477
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• 2006

Models to predict the ultimate strength of simply supported or continuous deep beams with web openings are proposed. The derived equations are based on upper-bound theorem. The concrete is assumed as a perfectly plastic material obeying the modified Coulomb failure criteria with zero tension cutoff. Reinforcing bar is considered as elastic-perfectly plastic material and its stress is calculated from the limiting principal compressive strain of concrete. The governing failure mechanisms based on test results are idealized as rigid moving blocks separated by a hyperbolic yield line. The effective compressive strength of concrete is calculated from the formula proposed by Vecchio and Collins. Comparisons with existing test results are performed, and they show good agreement.