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Full-scale testing and modeling of the mechanical behavior of shield TBM tunnel joints

  • Ding, Wen-Qi;Peng, Yi-Cheng;Yan, Zhi-Guo;Shen, Bi-Wei;Zhu, He-Hua;Wei, Xin-Xin
    • Structural Engineering and Mechanics
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    • v.45 no.3
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    • pp.337-354
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    • 2013
  • For shield TBM (Tunnel Boring Machine) tunnel lining, the segment joint is the most critical component for determining the mechanical response of the complete lining ring. To investigate the mechanical behavior of the segment joint in a water conveyance tunnel, which is different from the vehicle tunnel because of the external loads and the high internal water pressure during the tunnel's service life, full-scale joint tests were conducted. The main advantage of the joint tests over previous ones was the definiteness of the loads applied to the joints using a unique testing facility and the acquisition of the mechanical behavior of actual joints. Furthermore, based on the test results and the theoretical analysis, a mechanical model of segment joints has been proposed, which consists of all important influencing factors, including the elastic-plastic behavior of concrete, the pre-tightening force of the bolts and the deformations of all joint components, i.e., concrete blocks, bolts and cast iron panels. Finally, the proposed mechanical model of segment joints has been verified by the aforementioned full-scale joint tests.

Proteomic Profiling of Serum from Stage I Lung Squamous Cell Carcinoma Patients

  • Li, Xin-Ju;Wu, Qi-Fei;He, Da-Lin;Fu, Jun-Ke;Jin, Xin
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.4
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    • pp.2273-2276
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    • 2013
  • Objectives: This study employed proteomic profiling to identify specific tumor markers that might improve early diagnosis of lung squamous cell carcinoma. Methods: Serum samples were isolated from 30 patients with stage I lung squamous cell carcinoma and 30 age-and gender-matched healthy controls, and proteomic profiles were obtained by matrix-assisted laser desorption ionization time of flight mass spectrometry. Results: Three highly expressed potential tumor markers were identified in the sera of stage I lung squamous cell carcinoma patients, with molecular weights of 3261.69, 3192.07, and 2556.92 Da. One protein peak with molecular weight 3261.69 Da was chosen as the candidate biomarker and identified as a fibrinogen alpha chain through a search of the IPI, NCBI or SWISS-PROT protein databases. Conclusion: As a potential tumor biomarker, fibrinogen alpha chain may be applicable for the early diagnosis and prognosis of lung squamous cell carcinoma patients.

Infrared Target Recognition using Heterogeneous Features with Multi-kernel Transfer Learning

  • Wang, Xin;Zhang, Xin;Ning, Chen
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.14 no.9
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    • pp.3762-3781
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    • 2020
  • Infrared pedestrian target recognition is a vital problem of significant interest in computer vision. In this work, a novel infrared pedestrian target recognition method that uses heterogeneous features with multi-kernel transfer learning is proposed. Firstly, to exploit the characteristics of infrared pedestrian targets fully, a novel multi-scale monogenic filtering-based completed local binary pattern descriptor, referred to as MSMF-CLBP, is designed to extract the texture information, and then an improved histogram of oriented gradient-fisher vector descriptor, referred to as HOG-FV, is proposed to extract the shape information. Second, to enrich the semantic content of feature expression, these two heterogeneous features are integrated to get more complete representation for infrared pedestrian targets. Third, to overcome the defects, such as poor generalization, scarcity of tagged infrared samples, distributional and semantic deviations between the training and testing samples, of the state-of-the-art classifiers, an effective multi-kernel transfer learning classifier called MK-TrAdaBoost is designed. Experimental results show that the proposed method outperforms many state-of-the-art recognition approaches for infrared pedestrian targets.

An analysis of Clinical Studies on Banha-Sasim-Tang (반하사심탕에 대한 임상연구 분석)

  • Jeon, Su-Yeon;Kim, Won-Bae;Seok, Eun-Joo;Song, Si-Yeong;Jeong, Jong-Gil;Lee, Soong-In
    • Herbal Formula Science
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    • v.26 no.3
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    • pp.267-281
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    • 2018
  • Objective : This study's purpose was to review the clinical studies of Banha-Sasim-Tang. Method : We searched papers about Banha-Sasim-Tang using KISS, KTKP, PUBMED, Embase, Science Direct, and the key words 'Hangeshashinto', 'Ban Xia Xie Xin Tang', 'Pinellia Heart-Draining Decoction', 'Banhasasim tang' were used. Papers not matched with inclusion criteria were excluded. Results : Until today, there have been 65 studies on the Banha-Sasim-Tang. Of these, 12 studies were classified as clinical research papers. There were 4 cases of Functional Dyspepsia, 2 cases of Peptic Ulcer, 6 case of Oral mucositis induced by Anti-cancer Therapy. Conclusion : It can be seen that Banha-Sasim-Tang has established the basis for application to the purpose of functional dyspepsia, peptic ulcer and oral mucositis induced by anti-cancer therapy.

A research of Ruyi(儒醫), Li-Chan(李梴)'s viewpoint on Taoism (명대(明代) 유의(儒醫) 이천(李梴)의 도교(道敎)이해)

  • Sung, Ho-Jun
    • Journal of Korean Medical classics
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    • v.26 no.4
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    • pp.281-290
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    • 2013
  • Objective : The medicine originated from Taoist tradition which identifies itself with medicine, making a harmonic combination between taoist theory of life fostering(養生論) and confucianism was a everlasting task for Ru-Yi, Li-chan who attach great importance to Confucian-medicine. Differing from the ideological background of precedent medical theorists, made his own confucianism the main theory of medicine. I think we need a rational reflection over these issues and am trying to focus on it. I hereby analyse the Ru-Yi, Li-chan's viewpoint on Taoism since after Ming(明)-dynasty during which his theoretical ideology has bloomed in chinese medicine. Method : I analyze the sentences in Li-Chan's Yisuerumen(Medical beginner's book, 醫學入門) From the perspective of Confucianism and Taoism. Result & Conclusion : Li-Chan understood Taoism from the viewpoint of Confucian medicine. Thus, He accepted the life-fostering of Taoism from the point of Confucian-moral cultivation. He emphasized the role of the Xin(mind, 心) and he was rejected Taoist mysticism. He interpreted Medical classics-Huangdineijing(黃帝內經) from the perspective of the Confucian classics and understanding of each other was similar position. Because he was a Confucian scholar and medical scientists.

Changes in Median Ages at Death from Selected Cancer Types in Relation to HLA-DRB1/DQB1

  • An, Wan-Xin;Fan, Ya-Xin;Liang, Xiao-Hua;Liu, Hui
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.10
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    • pp.4125-4128
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    • 2014
  • The median ages at death from cancers between 1985 and 2005 were calculated to demonstrate that inherent anticancer mechanisms may be a common pathway for different cancers. Seventy-eight patients with gastric, liver and lung cancers, were recruited in the solid cancer group. The leukemia group consisted of 31 patients with three main types of leukemia. The controls were 100 healthy individuals. The samples were typed using an HLA-DR/DQ PCR-SSP typing kit. The results showed that the median ages at death from all causes were 64.7 years in 1985 and 70.1 years in 2005. The range of the median ages at death from all cancers was similar to the corresponding value for deaths attributed to all causes. The frequency of $DRB1^*03$ was 9.6% in the solid cancer group and 3.0% in the control group (p<0.05). The frequency of $DRB1^*04$ in the leukemia group were significantly lower than that of the control (p<0.05). $DRB1^*13$ and $DRB1^*06$ frequencies in the leukemia group were significantly higher than those of the controls (p<0.05). It is suggested that inherent anti-cancer mechanisms may be a common pathway for different cancers and are associated with the immune system and HLA.