• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.3
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• pp.201-210
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• 2017

Objectives : To report the patient suspected chronic arsenic intoxication after Korean medicine treatment. Methods : One patient with highly suspected chronic arsenic intoxication was selected. He was suspected to be chronic arsenic intoxication because symptoms and hair heavy metals test. Acupuncture was applied for twice a day and herbal medicine(Pyeonghyeol-eum) was administered in 28 days. Evaluation method applied to xeroderma, pruritus, psoriasis were overall dry skin score(ODS), visual analogue scale(VAS), pruritus grading system(PGS). Results : Pyeonghyeol-eum, acupuncture and the other Korean medicine treatments improved xeroderma, pruritis, psoriasis after 28 days of treatment. ODS decreased from 3 to 2. VAS of Pruritus decreased from 8 to 1. PGS decreased from 15 to 4. Adverse effects were not reported. Conclusions : This study shows that the Korean medicine treatment was effective in impoving symptoms of chronic arsenic intoxication. But the additional study will be conducted for revealing dermatitis caused by chronic arsenic intoxication.

• The Korean Journal of Mycology
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• v.22 no.3
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• pp.216-221
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• 1994

As a part of studies on the fungal flora of Korea, authors have collected over 60 higher fungi specimens during summer season in 1993 in Mt. Hungjung which was located in eastern part of Korea. Among them two genera are new to Korea: Neobulgaria Petrak and Melastiza Boudier. Following five species are recorded for the first time in Korea: Psilocybe xeroderma Huijsm, Galerina vittaeformis (Fr.) Singer var. vittaeformis f. vittaeformis (Fr.) Singer, Gyromitra infula (Schaeffer ex Fries) Quelet, Neobulgaria pura (Fries) Petrak and Melastiza chateri (W. G. Smith) Boudier, for which Korean common names are designated in this present paper. All color names and terms within quotation marks are taken from Kornerup and Wanscher 1983, Methuen handbook of colour. The specimens are all deposited in the RDAGB's herbarium.

• Journal of Photoscience
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• v.9 no.2
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• pp.186-189
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• 2002

Many of the adverse effects of solar UV exposure appear to be directly attributable to damage to epidermal DNA. In particular, cyclobutane pyrimidine dimers (CPD) may initiate mutagenic changes as well as induce signal transduction responses that lead to a loss of skin immune surveillance and micro-destruction of skin structure. Our approach is to reverse the DNA damage using prokaryotic DNA repair enzymes delivered into skin using specially engineered liposomes. T4 endonuclease V encapsulated in liposomes (T4N5 liposome lotion) enhanced DNA repair by shifting repair of CPD from the nucleotide excision to the base excision repair pathway. Following topical application to humans, increased repair limited UV-induction of cytokines, many of which are immunosuppressive. In a recent clinical study, topical treatment of UV-irradiated human skin with T4N5 liposome lotion reduced the suppression of the nickel sulfate contact hypersensitivity response. Similarly, the photoreactivating enzyme enhances repair by directly reversing CPDs after absorbing activating light. Here also treatment of UV-irradiated human skin with photoreactivating enzyme in liposomes and photoreactivating light restored the response to the contact allergen nickel sulfate. These findings confirm in humans the observation in mice that UV induced suppression of contact hypersensitivity is caused in part by CPDs. We have tested the ability of T4N5 liposome lotion to prevent UV-induced skin cancer in patients with xeroderma pigmentosum (XP), who have an elevated incidence of skin cancer resulting from a genetic defect in DNA repair. Daily use of the lotion for one year in a group of 20 XP patients reduced the average number of actinic keratoses by 68% and basal cell cancers by 30% compared to 9 patients in the placebo control group. Delivery of DNA repair enzymes to skin is a promising new approach to photoprotection.

• The Journal of Pediatrics of Korean Medicine
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• v.22 no.3
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• pp.63-73
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• 2008

Objectives : The purpose of this study is to analyze the baby moisturizers and give information about basis of herbal moisturizer. Methods : We selected 243 goods by searching with keywords as "baby moisturizer" at 6 major web search engines, 12 web shopping malls in Korea. 10 items were evaluated under three evaluation criteria such as type of product, ingredient and function of goods. Results : Study resulted that the most type of moisturizers were lotion type. 80% of the products contained medical agents. Ingredients of medical agents were herbal medicine, aroma oil, vitamin and extract. The moisturizer for atopic dermatitis contained ceramide about half. The ingredient of herbal medicine existed usually as excipients, not as active ingredient. Conclusion : It is necessary to study and develop new products contained herbal medicine as active ingredient based on the oriental medical theory.

• BMB Reports
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• v.34 no.6
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• pp.489-495
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• 2001

DNA damage by UV and environmental agents are the major cause of genomic instability that needs to be repaired, otherwise it give rise to cancer. Accordingly, mammalian cells operate several DNA repair pathways that are not only responsible for identifying various types of DNA damage but also involved in removing DNA damage. In mammals, nucleotide excision repair (NER) machinery is responsible for most, if not all, of the bulky adducts caused by UV and chemical agents. Although most of the proteins involved in NER pathway have been identified, only recently have we begun to gain some insight into the mechanism by which proteins recognize damaged DNA. Binding of Xeroderma pigmentosum group C protein (XPC)-hHR23B complex to damaged DNA is the initial damage recognition step in NER, which leads to the recruitment of XPA and RPA to form a damage recognition complex. Formation of damage recognition complex not only stabilizes low affinity binding of XPA to the damaged DNA, but also induces structural distortion, both of which are likely necessary for the recruitment of TFIIH and two structure-specific endonucleases for dual incision.

• Korean Journal of Clinical Laboratory Science
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• v.39 no.2
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• pp.63-67
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• 2007

A ring, monosomy and marker chromosome 13 was found in a 14 months old male with multiple congenital anomalies which suggested the deletion 13 syndrome. He presented development retardation, mental retardation, syndactyly of thumbs, xeroderma, dyspnea, dyslogia and face deformity diagnosed by chromosomal analysis using synchronized G-banding technique which revealed of 46,XY,r(13)(p13q34)[48]/45,XY,-13[28]/46,XY,-13,+mar[13]. We report this case with a brief review of the correlation between clinical features and the observed 13 polymorphism chromosome.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.137-137
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• 1993

방사선, 자외선, 화학물질 등 여러 변이원에 의해 생긴 DNA 손상의 대부분은 생체내에 존재하는 효소들에 의해 수복(repair)되어 DNA는 안정하게 유지된다. T$_4$ phage 유래의 T$_4$ endonuclease V는 자외선에 의해 DNA에 pyrimidine dimer가 생겼을때 이것을 특이적으로 절제 수복하는 효소이다. 인간의 질환인 색소성 걸피증(Xeroderma pigmentosum)은 태양광선, 특히 자외선에 의해 고빈도로 피부암을 발생한다. 이 질환은 유전적으로 DNA 수복기구에 장애가 있기 때문에 일어난다. 색소성 건피증의 배양세포에 T$_4$ endonuclease V를 도입하면 세포의 DNA 수복능력이 회복되기 때문에 인간과 phage라는 서로 멀리 떨어진 생물종에 공통의 DNA 수복기구가 존재하고 있다는 것을 알 수 있다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.26 no.1
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• pp.104-117
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• 2013

Objective : The aim of this review is to development of clinical trial protocol for against cosmetics as a treatment of dry skin condition. Methods : We searched the literature from 2002 through April 2012 using 5 databases. We included randomized controlled trials(RCTs) in which human participants with dry skin condition as chief complaint were treated with cosmetics. The methodological quality of all RCTs was using the Jadad score. Results : Nine RCTs met the inclusion criteria. Cosmetic types included cream (7 trials), lotion (1 trial), oil (1 trial) and body wash (1 trial). The methodological quality of the trials was generally low (Jadad score: mean 1.78; range, 1 to 3). Conclusions : The evidence for cosmetics as an effective treatment for dry skin condition(xerosis) is currently scarce and of poor quality, and is therefore inconclusive. More rigorous studies are warranted.

• Journal of Sasang Constitutional Medicine
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• v.27 no.3
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• pp.346-355
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• 2015

Objectives The aim of this study was to report significant improvement of paresthesia and weakness in the limbs of unknown cause after treatment with Mangeummoonmu-tang and Cheongeummoonmu-tang in a Taeeumin patient. Methods The patient was diagnosed as Taeeumin Dry-Heat (Joyeol) pattern and treated with Mangeummoonmu-tang, Cheongeummoonmu-tang and acupuncture. The patient's subjective symptoms of paresthesia and weakness were observed using Global Assessment Scale (GAS) during the treatment period. Results and Conclusion The symptoms of paresthesia and weakness decreased from GAS 100 to GAS 0 for two weeks. Furthermore, the patient's symptoms of fatigue and xeroderma were reported to be improved after treatment. In conclusion, this study shows that Sasang constitutional medicine can be effective treatment for Taeeumin patient with paresthesia and weakness in the limbs of unknown cause.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.145-148
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• 2013

Aim: Individual differences in chemosensitivity and clinical outcome of non-small-cell lung cancer (NSCLC) patients may be induced by host inherited factors. We investigated the impact of XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp and XPD Lys751Gln gene polymorphisms on the efficacy of platinum-based chemotherapy in NSCLC patients. Methods: A total of 496 were consecutively selected from the Affiliated Hospital of Nantong University between Jan. 2003 and Nov. 2006, and all patients were followed-up until Nov. 2011. The genotyping of XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp and XPD Lys751Gln was conducted by duplex polymerase-chain-reaction with the confronting-two-pair primer methods. Results: Individuals with XPD 312 C/T+T/T and XPD 711 C/T+T/T exhibited poor responses to chemotherapy when compared with the wild-type genotype, with adjusted ORs(95% CI) of 0.67(0.38-0.97) and 0.54(0.35-0.96), respectively. Cox regression showed the median PFS and OS of patients of XPD 312 C/T+T/T genotype and XPD 711 C/T+T/T genotype to be significantly lower than those with wild-type homozygous genotype. Conclusion: We found polymorphisms in XPD to be associated with response to platinum-based chemotherapy in NSCLC, and our findings provide information for therapeutic decisions for individualized therapy.