• 한국조경학회지
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• 제30권3호
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• pp.57-63
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• 2002

This landscape design was proposed for the Buchon Special School Competition, held by the Kyonggi Province Office of Education. The authors collaborated on this design and won first prize in November of 2001. In the design proposal, on the basis of the knowledge of; mentally retarded children the children's activities, nature and health, and the healing gardens, the special school outdoor spaces were designed to meet the particular needs of the users. The school outdoor spaces are design for various types of users-children, adolescents, parents, siblings, staff, volunteers and visitors. The following are some of the basis concerns in the design of the school outdoor spaces : garden site planning, garden location, security, microclimate, entering and exiting, accessibility, usability, user group territories, supervision, attracting trained volunteers, a range of high-quality social settings, accommodation of different student types, accommodation of needs for both challenge and rest, child nature interaction, diversity of natural settings, hands-on activity, integrating the arts, and maintenance. The following are some of the major features in the design of school outdoor spaces : pleasant and inviting entry areas, sports grounds with different levels of challenge, gardens with plants having strong fragrances and/or tactile qualities, resting places with many types and forms of seating and weather-mitigating features, play grounds for all student types, roof gardens for users to experience nature in man-made environments, and walkways and winding paths with various trees, shrubs and flowers. In the special school outdoor spaces, people would perceive a unique sense of place through the various types of spaces and features described above. An example of the true meaning of a playing and resting place and a restorative and therapeutic environment is provided in the school outdoor spaces.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권3호
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• pp.143-157
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• 2015

Successful integration of cementless femoral stems using porous surfaces relies on effective periimplant bone healing to secure the bone-implant interface. The initial stages of the healing process involve protein adsorption, fibrin clot formation and cell osteoconduction onto the implant surface. Modelling this process in vitro, the current work considered the effect of fibrin deposition on the responses of human mesenchymal stromal cells cultured on ferritic fibre networks intended for magneto-mechanical actuation of in-growing bone tissue. The underlying hypothesis for the study was that fibrin deposition would support early stromal cell attachment and physiological functions within the optimal regions for strain transmission to the cells in the fibre networks. Highly porous fibre networks composed of 444 ferritic stainless steel were selected due to their ability to support human osteoblasts and mesenchymal stromal cells without inducing untoward inflammatory responses in vitro. Cell attachment, proliferation, metabolic activity, differentiation and penetration into the ferritic fibre networks were examined for one week. For all fibrin-containing samples, cells were observed on and between the metal fibres, supported by the deposited fibrin, while cells on fibrin-free fibre networks (control surface) attached only onto fibre surfaces and junctions. Initial cell attachment, measured by analysis of deoxyribonucleic acid, increased significantly with increasing fibrinogen concentration within the physiological range. Despite higher cell numbers on fibrin-containing samples, similar metabolic activities to control surfaces were observed, which significantly increased for all samples over the duration of the study. It is concluded that fibrin deposition can support the early attachment of viable mesenchymal stromal cells within the inter-fibre spaces of fibre networks intended for magneto-mechanical strain transduction to in-growing cells.

• Annals of Surgical Treatment and Research
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• 제95권6호
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• pp.312-318
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• 2018

Purpose: Acute normovolemic hemodilution (ANH) is an autologous transfusion method, using blood collected during surgery, to reduce the need for allogeneic blood transfusion. ANH is controversial because it may lead to various complications. Among the possible complications, anastomotic leakage is one that would have a significant effect on the operation outcome. However, the relationship between ANH and anastomotic site healing requires additional research. Therefore, we conducted this prospective study of ANH, comparing it with standard intraoperative management, undergoing gastric anastomosis in rats. Methods: Sixteen Sprague-Dawley rats were randomly assigned to three groups: group A, surgery with ANH; group N, surgery with standard intraoperative management; and group C, sham surgery with standard intraoperative management. ANH was performed in group A animals by, removing 5.8-6.6 mL of blood and replacing it with 3 times as much crystalloid. All rats were enthanized on postoperative day 6, and histopathologic analyses were performed. Results: The mean hematocrit values, after hemodilution were 22.0% (range, 18.0%-29.0%), group A; 33.0% (29.0%-35.0%), group N; and 32.5% (29.0%-34.0%), group C. There were significant differences between groups A and N (P = 0.019, P = 0.009, P = 0.004, P = 0.039, and P = 0.027), and between groups N and C (P = 0.006, P = 0.027, P = 0.04, P = 0.008, and P = 0.009) with respect to inflammatory cell numbers, neovascularization, fibroblast numbers, edema and necrosis, respectively; there were no differences between groups A and N. Conclusion: In rat model, anastomotic complications did not increase in the ANH group, compared with the standard intraoperative management group.

• Journal of Veterinary Science
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• 제24권3호
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• pp.35.1-35.10
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• 2023

Background: Titanium is the most widely used metal for bone integration, especially for cancer patients receiving ionizing radiation. This study aimed to investigate the amifostine administration that would reduce the effects of radiation on bone healing and osseointegration in rat models. Objectives: It is aimed that the application of amifostine in rats receiving radiotherapy treatment will reduce the negative effects of ionizing radiation on the bone. Methods: Thirty-five adult male Wistar rats were randomly divided into one healthy and four experimental groups. In three consecutive days, two experimental groups of rats (AMF-RT-IMP and RT-IMP) were exposed to radiation (15 Gy/3 fractions of 5 Gy each). Then the titanium implants were inserted into the left tibia. Before the radiotherapy process, a 200 mg/kg dose of amifostine (AMF) was administered to the rats in the AMF-IMP and AMF-RT-IMP groups. Twenty-eight days after the screw implant, all rats were sacrificed, and their blood samples and tibia bones were collected for analysis. Results: The results indicated an accelerated bone formation and a more rapid healing process in the screw implants in the AMF-IMP, AMF-RT-IMP, and AMF-RT groups than in the RT-IMP group. Also, bone-implant contact area measurement and inflammation decreased with amifostine treatment in the implants subjected to irradiation (p < 0.05). Conclusions: The results obtained in the present study suggested that amifostine prevents the losses of bone minerals, bone integrity, and implant position from ionizing-radiation when given before exposure.

• Journal of Periodontal and Implant Science
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• 제39권sup2호
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• pp.213-222
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• 2009

Purpose: Recently, interest in chitosan has increased due to its excellent biological properties such as biocompatibility, antibacterial effect, and rapid healing capacity. On the other hand, hydroxyapatite is used as a bone substitute in the fields of orthopedics and dentistry. The hydroxyapatite-chitosan (HA-CS) complex containing hydroxyapatite nanoparticles was developed for synergy of both biomaterials. The objective of this study was to evaluate the effect of hydroxyapatite (HA)-chitosan (CS) membrane on bone regeneration in the rat calvarial defect. Methods: Eight-millimeter critical-sized calvarial defects were created in 70 male Sprague-Dawley rats. The animals were divided into 7 groups of 10 animals and received either 1) chitosan (CS) 100% membrane, 2) hydroxyapatite (HA) 30%/CS 70% membrane, 3) HA 30%/CS 70%, pressed membrane, 4) HA 40%/CS 60% membrane, 5) HA 50%/CS 50% membrane, 6) HA 50%/CS 50%, pressed membrane, or 7) a sham . surgery control. The amount of newly formed bone from the surface of the rat calvarial defects was measured using histomorphometry, following 2- or 8- week healing intervals. Results: Surgical implantation of the HA - CS membrane resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. The HA - CS membrane would be significantly more effective than the chitosan membrane in early bone formation. Conclusions: Concerning the advantages of biomaterials, the HA-CS membrane would be an effective biomaterial for regeneration of periodontal bone. Further studies will be required to improve the mechanical properties to develop a more rigid scaffold for the HA-CS membrane.

• 대한소아치과학회지
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• 제34권3호
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• pp.438-446
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• 2007

치주인대섬유모세포들은 완전탈구 된 치아의 성공적인 재식을 위한 중요한 요소이다. 따라서, 외상으로 인해 완전탈구된 치아의 보존을 위한 보관액을 선택하는 것이 중요하다. 성장인자들과 호르몬들은 치주인대섬유모세포들의 생존을 위한 치료적 제제로 고려되고 있다. Epidermal growth factor(EGF)는 다른 조직에서 재생과 상처 치유 과정의 중요한 역할인자로 대두되고 있다. 따라서, 완전탈구 된 치아를 위한 치료적 적용을 위해 EGF의 세포 증식에 미치는 영향을 평가하였다. 또한 EGF와 tri-iodothyronine(T3)의 혼합액, EGF와 Heparin-binding epidermal growth factor-like growth factor(HB-EGF)의 혼합액이 세포 증식에 미치는 상승 효과를 평가하였다. 치주인대섬유모세포의 세포증식은 EGF 농도가 증가함에 따라 증가하였고, 10 ng/ml 농도에서 최대 세포증식을 보였다. EGF는 상처치유분석에서 상처 치유촉진과 이동성을 보여주었다. EGF에 T3와 HB-EGF를 첨가한 혼합액에서 배양한 세포는 EGF만 처리한 경우보다 세포 증식이 상승되었다. EGF와 T3 혼합액의 상승효과 기전을 유추하기 위해서 RT-PCR로 EGF 수용기의 발현을 확인하였고, T3가 EGF 수용기 발현을 증가시켰음을 확인하였다. 따라서 EGF와, EGF와 T3, EGF와 HB-EGF의 혼합액은 완전탈구된 치아의 치료에 있어 유용한 선택이 될 것이다.

• 한국가정과교육학회지
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• 제25권3호
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• pp.93-104
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• 2013

본 연구에서는 청소년의 음식선택동기와 전통발효음식에 대한 태도 및 섭취행동과의 관련성을 분석하여 섭취행동에 영향을 미치는 요인들을 알아보았다. 서울시에 거주하는 고등학생 319명을 대상으로 음식선택동기, 전통발효음식에 대한 태도, 섭취행동에 관한 설문을 실시하여 분석하였으며 그 결과는 다음과 같다. 첫째, 음식선택동기는 건전성, 힐링, 편의성, 체중조절, 친숙성, 가격, 건강의 7개 요인으로 추출되었으며, 전통발효음식에 대한 태도와 섭취행동은 각각 하나의 요인으로 추출되었다. 둘째, 전통발효음식 만들기 체험을 하였던 집단의 건전성, 체중조절, 건강, 태도, 섭취행동 평균이 유의하게 높았다. 셋째, 음식선택동기는 전통발효음식에 대한 태도에 유의한 영향을 미쳤다. 전통발효음식에 대한 태도에 영향을 미치는 변수들의 상대적인 영향력은 가격(${\beta}$=.235)이 가장 컸으며, 그 다음은 힐링(${\beta}$=.190), 건강(${\beta}$=.175), 편의성(${\beta}$=.126)의 순이었다. 넷째, 전통발효음식에 대한 태도는 전통발효음식의 섭취행동에 유의한 영향을 미쳤다(${\beta}$=.549). 다섯째, 체중조절은 섭취행동에 직접적으로 영향을 미쳤다. 가격, 힐링, 건강, 편의성은 섭취행동에 직접적으로 영향을 미치지는 않았지만 태도를 통해 간접적으로 영향을 미쳤다. 결론적으로, 전통발효음식의 섭취행동을 높이기 위해서는 전통발효음식에 대한 긍정적인 태도의 형성이 중요하며 태도 형성에 영향을 미치는 음식선택동기에 대한 관심과 분석이 요구된다.

• 대한소아치과학회지
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• 제32권3호
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• pp.395-402
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• 2005

손상 받은 치주 조직의 치유과정은 치주인대 섬유 모세포의 세포 활성도에 영향을 받는다. 또한 치유과정 중 치주인대 섬유 모세포간의 재부착이 이루어져야 한다. 본 연구의 목적은 표피성장인자가 치주인대 세포의 증식과 부착에 미치는 영향을 알아보는 것으로 이를 바탕으로 향후 완전 탈구된 치아의 보관용액이나 재식전 처리제로서의 표피성장인자의 효용성을 고찰해 보기 위함이다. 발치된 사람의 제 1소구치에서 치주인대 섬유모세포를 채취 및 배양한 후, 세포독성을 및 세포의 최고 활성도를 평가 하기 위해 MTT assay를 시행하였다. 표피성장인자가 첨가된 실험군과 대조군의 세포증식의 차이를 비교하였고, western blot을 통해서 세포 부착에 관여하는 섬유결합소의 발현을 실험군과 대조군을 통해 비교하여 다음의 결과를 얻었다. 표피성장인자는 치주인대 섬유모세포에 대하여 세포독성을 보이지 않으며, 최고의 활성도를 보이는 농도는 10ng/ml였다. 또한 치주인대 섬유모세포의 배지내 증식정도는 10ng/ml의 실험군에서 대조군에 비해 유의하게 높았다. 세포간 부착에 관여하는 섬유결합소의 발현율이 실험군에서 대조군에 비해 유의하게 증가하였다. 본 연구를 통해 표피성장인자는 치주인대 섬유모세포의 재생을 촉진하며 따라서 완전 탈구된 치아의 보관용액이나 재식전 처리제로 사용될 수 있음을 시사한다.

• 한국환경생태학회지
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• 제30권1호
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• pp.118-129
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• 2016

본 연구의 목적은 산림치유 프로그램 개발을 위한 기초자료를 제공하는데 있다. 본 연구는 탐색적 연구로 산림치유 잠재수요자의 산림치유 프로그램 선호도가 무엇인지 파악하게 함으로써, 산림치유 프로그램을 개발하고 운영하는데 중요한 기초자료가 될 것이라고 생각된다. 일반 성인 남 여 620명을 대상으로 산림치유 프로그램의 선호도에 관한 설문조사를 실시하였다. 자료분석은 SPSS 21.0 프로그램을 사용하여 빈도분석(Frequency analysis), T검정(T-test), 일원분산분석(One-way ANOVA)을 통해 성별, 연령, 직업에 따른 산림치유 프로그램 선호도의 차이를 살펴보았다. 산림치유 프로그램 선호도가 성별, 연령, 직업 등에 따라 다양하다는 것을 알 수 있었다. 첫째, 성별에 따라, 남성은 여성에 비해 숲속 운동회, 캠핑을 선호하고, 여성은 남성에 비해 전반적인 프로그램에서 선호도가 높은 것으로 나타났다. 둘째, 연령에 따라서 다른 연령과 비교해서 20대는 스트레스 평가와 진단, 음식 만들기, 숲속 사진치료 등, 30대는 자유롭게 숲속 걷기, 상담, 강의 듣기(스트레스, 대인관계 관련), 비전 세우기 등, 40대는 명상, 경관보기, 삼림욕, 풍욕, 일광욕, 맨발로 숲속 걷기 등, 50대는 호흡법 호흡체조, 요가, 등산, 묵언 산행, 자연음식 먹기 등의 프로그램을 각각 특히 선호하는 것으로 나타났다. 셋째, 직업에 따른 산림치유 프로그램 선호도를 살펴보면 다음과 같다. 다른 직업과 비교해서 학생은 스트레스 평가와 진단, 음식 만들기 등을, 교사는 자유롭게 숲속걷기, 등산, 숲속 독서, 경관보기, 삼림욕 풍욕 일광욕, 캠핑 등을, 주부는 요가, 물 흐르는 소리 듣기, 허브차 마시기, 자연음식 먹기 등을, 전문 연구직은 호흡법 호흡체조, 묵언산행, 명상, 숲속 잠자기 등을 각각 선호하는 것으로 나타났다. 본 연구의 분석 결과가 성인을 대상으로 하는 산림치유 프로그램 개발을 위한 기초자료로 활용되기를 기대한다.

• 기본간호학회지
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• 제6권2호
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• pp.320-330
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• 1999

Nursing, a behavior of caring, means a connection of patients and clients has done through the caring of clients. Nurses are always with patients. In fact, caring is very important and the core of nursing, the true meaning of caring was embedded in our custom and consciousness before the approach of academic research. As a result, the existence of caring has not seen and revealed. Therefore, there is a need to study and confirm that caring has been placed in nursing and, nurses are doing caring in practice. The purpose of this study is to present the basis of nursing theory and practice through careful analysis of presence being, an aspect of caring. The presence of nurse shows a personal and healing relationship between nurses and patients on the basis of the respect for the humanity, Also, the role of nurses is to help a patient to integrate one's physical, mental and spritual aspects. Thanks to role of nurse, the pratical nursing has the characteristic of art and becomes more aesthetic and artistic. As we have seen above, we define 'presence' as 'being there' and 'being with' a patient for the purpose of meeting the health care needs. The attributes for which presence would be most appropriate would include the following : (1) being with and being together (2) take attention (3) mutual openness (4) experience an empathy (5) have an intention (6) therapeutic interaction process A caring situation as a necessary condition must be presupposed and the factors in that situation are the nurse's intense attention to the patient and a humanistic philosophy of the institutions of the patient. In any nursing intervention skill, there is listening, touching, giving hope, reassurancing, comforting and so on ; as a result, some positive effects can be expected between nurse and patient.