• Proceedings of the PSK Conference
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• 2002.04a
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• pp.217.1-217.1
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• 2002

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.295.1-295.1
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• 2001

• Bulletin of the Korean Chemical Society
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• v.31 no.1
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• pp.27-30
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• 2010

A series of thioureas were synthesized as inhibitors of NO production in lipopolysaccharide-activated macrophages. We investigated the effect of lipophilic moiety and N-substituents of the thioureas on the activity. Phenoxazine and carbazole-containing derivatives revealed higher activity than indole-containing thioureas. The appropriate spacer between lipophilic tail and thiourea head and methyl substituent at N3 position of thiourea brought beneficial effect on the inhibition of NO production. Among prepared compounds, phenoxazine-containing derivative 2a was the most potent with $2.32 {\mu}M$ of $IC_{50}$ value. RT-PCR analysis suggested that the prepared thioureas inhibited NO production through the suppression of iNOS mRNA expression.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.171-171
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• 2002

This study was carried out by an Korean GLP laboratory to assess the combined repeated dose, reproduction and developmental toxicity of benzoyl peroxide for OECD SIDS(Screening Information Data Set) program. Male and female Sprague Dawley rats were exposed to benzoyl peroxide at levels of 0, 250, 500 and 1,000 mg/kg/day for 29 days for male and for 41-51 days for female.(omitted)

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.10a
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• pp.144-144
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• 2003

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.10a
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• pp.142-142
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• 2003

• Korean Journal of Pharmacognosy
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• v.9 no.2
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• pp.89-91
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• 1978

Free amino acids and mineral substance in radix of Polygonum cuspidatum, Polygonum elliptica, and Polygonum sachalinense were analyzed by amino acid autoanalyzer and atomic absorption spectrophotometer. Gross contents of free amino acids in root of P. cuspidatum and P. elliptica are 12.99mg/g and 9.58mg/g respectively. The analysis of inorganic constituents of Polygonum sp. showed that it generally contains copper, iron, manganese, zinc, potassium and potassium salt.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.241.2-241.2
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• 2003

We report the synthesis of key intermediates for the development novel flavonoid derivatives with potential antiinflammatory activity and propose a mechanism of the one-pot reaction. The various amines (1) for this work were commercially available. Secondary amines (2) were formed by nucleophilic attraction using ethyl benzoylacetate. The C-N bond formation proceeded at refluxing in toluene with catalytic amount of p-toluenesulfonic acid and a removal of water was important in this reaction. (omitted)

• Journal of Korean Academy of Nursing
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• v.29 no.5
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• pp.1021-1029
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• 1999

Koreans rarely complain of depression or other psychological problems because mental illness is viewed as a stigmatizing and threatening experience. This study examined the relationships among stressful life events, close relationships, self-esteem. and depression in 400 college women aged 18 to 30 years. Depression was positively related to stressful life events (r＝.21, p＝＜.01). Depression and stressful life events were negatively associated with self-esteem (r＝-.67; r＝-.11, p＜.01; p＜.05 respectively). Close relationships with women and men friends were each negatively associated with depression (r＝-.24; r＝-.16, p＜.01; p＜.05). Close relationships with women and men friends were positively associated with self-esteem (r＝.23; r＝.20, p＜.01). Forty nine percent of variance in depression rates in this sample was explained. After adjustment for degrees of freedom, a total of 49% of the variance in depression was explained by self-esteem and stressful life events. This investigation into the relationships among the variables influencing depression for college women is a critical issue as health professionals need to be aware that college women are at considerable risk for depression. Effective psychosocial interventions are those designed for specific populations to meet unique care needs and since young Korean women may be at considerable risk for depression.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.407.3-408
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• 2002

A portable near infrared (NIR) system which was newly integrated by our lab has been used to develop a non-invasive blood glucose monitoring. The portable NIR system includes a tungsten halogen lamp, a photo diode array type-InGaAs detector, and specialized reflectance fiber optic probes. The shape of probes is composed of two parts. one for illumination into sample and the other for receiving the radiation from sample. Three kinds of probes with different distance between illumination and receiving part. such as 0.03. 0.1. and 0.5mm, were investigated for optimization. (omitted)