• 제목/요약/키워드: withdrawal period

검색결과 141건 처리시간 0.023초

유우에 oxytetracycline 및 sulfadimethoxine sodium 투여 후 혈청내 잔류함량 변화추이 (Changes of residual concentration in serum of the dairy cattle after administration of oxytetracycline and sulfadimethoxine sodium)

  • 도재철
    • 한국동물위생학회지
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    • 제25권2호
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    • pp.141-151
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    • 2002
  • In order to know the depletive changes of sulfadimethoxine and oxytetracycline residues in se겨m of dairy cattle intramusculally administered with sulfadimethoxine sodium(SDS) and oxytetracycline(OTC), the concentration of sulfadimethoxine and oxyteracycline was measured in serum of dairy cattle with using high performance liquid chromatography(HPLC). SDS and OTC was intramuscularlly administrated to dairy cattle at the rate of 10mg/kg(SDS) and 10mg/kg(OTC) body weight(recommended therapeutic dose) once to four dairy cattle. There were investigated the depletive changes of the sulfadimethoxine and oxytetracycline in serum of dairy cattle at the time 2, 4, 8 hours, 1st, 2nd, 3rd, 4th and 5th day after administration SMS and OTC, respectively. The results obtained were summarized as follows; 1. After intramuscularlly administration of the SMS, the mean concentrations of sulfamethazine in serum according to the time lapsed were showed 33.964 $\pm$ 4.435ppm at the 4 hours after withdrawal of medicated sulfadimethoxine sodium. And gradually according to the time lapsed, the concentrations of sulfadimethoxine residues in serum were significantly (p<.05) decreased 6.596 $\pm$ 3.402 ppm at 1st day, 0.217 $\pm$ 0.119 ppm at 3rd day and 0.057 $\pm$ 0.032 ppm at 4th day, respectively. 2. The mean residual concentration of OTC in serum according to the time lapsed after intramuscularly administration OTC were showed 0.743 $\pm$ 0.368ppm at the 8 hours. And gradually according to the time lapsed, the mean concentrations of OTC residues in serum of dairy cattle were significantly(p<.05) decreased such as 0.057 $\pm$ 0.047ppm at 3rd day and 0.039 $\pm$ 0.016ppm at the 5th day, respectively. In conclusion, this study could be suggested the relationship between administrated period, sulfonamides and tetracycline residual aspects in serum, and the importance of observing ceasing period of antibiotic drugs before forwarding livestocks to slaughter, Thus, this results would be able to be used the basic index for prevention of sulfonamides and tetracycline residues in dairy breedings.

중온 혐기성 연속회분식 공정에 의한 도시하수슬러지의 소화가능성 평가 (Application of Anaerobic Sequencing Batch Reactor to Mesophilic Digestion of Municipal Sewage Sludge)

  • 허준무;장덕;정태학;손부순;박종안
    • 한국환경보건학회지
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    • 제24권2호
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    • pp.9-19
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    • 1998
  • Laboratory experiments were carried out to investigate the performance of anaerobic sequencing batch reactor(ASBR) for digestion of a municipal sludge. Each cycle of the ASBR comprised feeding, two-or three-day reaction, one-day thickening, and withdrawal. The reactors were operated at an HRT of 10days and 5days with an equivalent organic loading rate of 0.8-1.54 gVS/l/d, 1.81-3.56 gVS/l/d at 35$\circ$C, respectively. Solids accumulation was remarkable in the ASBR during start-up period, and directly affected by settleable solids in the feed sludge. Floatation thickening occured in the ASBRs, and Solids profiles at the end of thickening step dramatically changed at solid-liquid interface. Slight difference in solids concentrations was observed within thickened sludge bed. Efficiencies through floatation thickening were comparable to that of additional thickening of the completely mixed control reactor. Average solids concentrations in the ASBRs were 2.2-2.6 times higher than that in the control throughout the total operation period. The dehydrogenase activity had a strong correlation with the solids concentration. Organics removals based on clarified effluent of the ASBRs were consistently above 86%. Remarkable increase in equivalent gas production of 27-52% was observed at the ASBRs compared with the control though the control and ASBRs showed similiar effluent quality. Thus, digestion of a municipal sludge was possible using the ASBR in spite of high concentration of solids in the sludge.

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Participation and Influencing Factors in the Decision-Making of Life-Sustaining Treatment: A Focus on Deceased Patients with Hematologic Neoplasms

  • Jae Eun Jang;Jeong Moon Ryu;Min Hee Heo;Do Eun Kwon;Ji Yeon Seo;Dong Yeon Kim
    • Journal of Hospice and Palliative Care
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    • 제26권2호
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    • pp.69-79
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    • 2023
  • Purpose: This study aimed to investigate the involvement of patients who died from hematologic neoplasms in the decision-making process surrounding the withdrawal of life-sustaining treatment (LST). Methods: A total of 255 patients diagnosed with hematologic neoplasms who ultimately died following decisions related to LST during their end-of-life period at a university hospital were included in the study. Data were retrospectively obtained from electronic medical records and analyzed utilizing the chi-square test, independent t-test, and logistic regression. Results: In total, 42.0% of patients participated in the decision-making process regarding LST for their hematologic neoplasms, while 58.0% of decisions were made with family involvement. Among these patients, 65.1% died in general wards and 34.9% in intensive care units (ICUs) as a result of decisions such as the suspension of LST. The period from the LST decision to death was longer when the decision was made by the patient (average, 27.15 days) than when it was made by the family (average, 7.48 days). Most decisions were made by doctors and family members in the ICU, where only 20.6% of patients exercised their right to make decisions regarding LST, a rate considerably lower than 79.4% observed in general wards. Decisions to withhold or withdraw LST were more commonly made by patients themselves than by their families. Conclusion: The key to discussing the decision to suspend hospice care and LST is respecting the patient's self-determination. If a patient is lucid prior to admission to the ICU, considerations about suspending LST should involve the patient input.

탈레반의 실체와 한국에 대한 테러위협 분석 (Analysis of True Nature of Taliban and Terror Threat to Korea)

  • 최기남
    • 융합보안논문지
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    • 제12권1호
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    • pp.97-107
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    • 2012
  • 올해 말로 파병기간이 마무리되는 우리나라는 3월 핵안보정상회담, 5월 EXPO개막 및 총선, 대선의 선거철을 맞이하게 된다. 따라서 탈레반의 테러를 통한 철군여론조성전략에 우리나라가 선택될 가능성이 높다. 이는 탈레반 테러홍보전략과 부합하며 과거 사례에 따른 학습효과이다. 이에 따른 탈레반 테러위협의 가능성을 요약한다면 위협의 시기는 우리나라에서 핵안보정상회담과 EXPO가 개막되는 상반기에 집중 고조될 것이며, 대상과 방법은 국내 정부기관이나 미국시설물 등에 대한 자살폭탄, 폭탄적재차량의 추돌 테러 가능성과 국외 관광객, 선교사 등 우리 국민에 대한 납치행위가 자행될 가능성이 높다. 범행에 가담할 테러 조직으로는 국내에 이미 거점을 확보한 이슬람 불법체류자들 이용하거나 알카에다와 연결된 전문 테러리스트의 입국 공작이 우려된다. 이러한 테러의 명분은 아프가니스탄 주둔 우리군 및 서방 동맹군의 철수일 것이다. 따라서 올 전반기 세계핵안보정상회담, 여수EXPO 등 국제행사의 안전대책과 해외 체류 내국인에 대한 탈레반의 홍보성 테러에 철저하게 대비하여야 하며, 국내 불법체류외국인의 동향 파악과 탈레반 관련 국제테러리스트의 국내 잠입의 차단책을 강구하여야 한다. 또한 아프가니스탄 주둔 우리 군에 대한 정부의 정책적 의지를 조기 표명할 필요가 있다.

전자상거래에서의 소비자보호에 관한 법.제도적 연구 (A Legal and Systematic Study On Consumer Protection In Electronic Commerce)

  • 권상로
    • 한국콘텐츠학회논문지
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    • 제9권12호
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    • pp.787-796
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    • 2009
  • 전자상거래는 1990년대 후반 이후부터 폭발적인 성장을 거듭해 가고 있다. 그러나 전자상거래의 비대면성과 익명성, 국제성, 일방성, 현혹가능성 등과 같은 특성으로 인하여 소비자의 피해가 증가하고 있다. 따라서 본 논문에서는 소비자보호를 위한 법 제도적 개선점을 다음과 같이 종합적으로 도출해 보았다. 첫째, 전자상거래소비자보호법상 청약철회권 행사기간을 연장할 필요가 있다. 둘째, 전자상거래는 비대면적으로 이루어지기 때문에 소비자가 착오를 일으킬 가능성이 높으며, 소비자가 자신의 착오를 입증하기가 용이하지 않으므로 사전에 착오가 발생하지 않도록 정확한 정보가 제공되도록 해야 한다. 셋째, 전자약관에 대한 인증마크 제도를 도입하여야 한다. 넷째, 소비자의 안전한 개인정보관리를 통한 개인정보유출과 이용에 대한 불안감이 없도록 법적, 제도적 그리고 기술적 대책이 강구되어야 한다. 다섯째, 인터넷 신뢰마크에 대한 엄격한 감독이 요구된다. 마지막으로 온라인 조정에 있어서 절차상 전송된 메시지나 문서에 대한 해킹 등을 통하여 제3자의 개입과 간섭이 있을 수 있으므로 당사자간의 명확한 인증을 통하여 시스템상에서의 보안성을 높일 필요가 있다.

혐기성 연속 회분식 공정에 의한 도시하수슬러지 소화시 고액분리 특성에 따른 처리효율평가 (Performances of Anaerobic Sequencing Batch Reactor for Digestion of Municipal Sludge at the Conditions of Critical Solid-liquid Separation)

  • Hur, Joon-Moo;Park, Jong-An
    • 한국환경보건학회지
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    • 제28권5호
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    • pp.77-85
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    • 2002
  • 중온과 고온의 혐기성 연속회분식 공정(anaerobic sequencing batch reactor ; ASBR)에서 소화슬러지의 고액분리특성이 처리효율에 미치는 영향을 규명하고자 하였다. 연구결과 침전가능 고형물농도가 높은 도시하수슬러지 처리시 고액분리특성 및 고액분리형태가 전체처리의 안정성 및 처리효율에 상당한 영향을 미쳤다. 중온ASBR에서는 부상농축현상이 일어났으나, 고온ASBR에서는 중력농축에 의한 고액분리가 일어났으며, 상대적으로 고온 ASBR의 처리효율이 우수하였다. 그리고 수리학적 체류시간, cycle period 및 고액분리형태는 소화슬러지의 농축 특성과 임계 고형물농축을 지배하는 중요한 인자였다. 중온ASBR에서 고액분리 후 농축슬러지베드용적(thickened sludge bed volume)은 매우 중요한 운전 요소이며, 소화슬러지의 중력농축특성은 배출시 농축고형물의 유실현상과 침전시 계속적으로 발생하는 소화가스에 의한 슬러지계면의 파괴현상 및 슬러지베드의 불안전성을 야기시켜 처리효율을 감소시켰다. 중력농축의 경우 소화가스와 슬러지농축용적간의 상호작용(cyclic mutual effect)이 주기적으로 일어났으나, 부상농축에서는 이러한 현상이 일어나지 않았다.

암 환아 부모의 경험에 대한 질적 연구 (The Experience of Parents Whose Child is Dying with Cancer)

  • 조영숙;김수지
    • 대한간호학회지
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    • 제22권4호
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    • pp.491-505
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    • 1992
  • The purpose of this research was to understand the structure of the lived experience of parents of a child terminally ill with cancer The research question was “What is the structure of the experience of parents of a child terminally ill with cancer\ulcorner” The sample consisted of 17 parents of children admitted to the cancer units of two university hospitals in Seoul. The unstructured interviews were carried out from October 10, 1991 through January 10, 1992. They were audio-recorded and analysed using Van Kaam's method. Parents ascribed the cause of the cancer to the mother's emotional imbalance during pregnancy, the mother's stress, failure to observe religious rites, food, the parent's sin, misfortune and pollution. The theme clusters were tension, fear and depression experienced during pregnancy, stress that children suffer from abusive parents, failure to observe religious activites, bad luck, and sins committed during a previous life. When the child suffered a recurrence of cancer, the parents experienced negative emotions, nervousness, sorrow. depression and death. The theme clusters were feelings of despair, helplessness, regret, guilt, insecurity, emptyness and apathy. The long struggle with cancer resulted in the loss of economic security, loss of psychological and physical well being, and social withdrawal. The theme clusters were the economic burden of medical cost, giving up treatment, debt, limited medical insurance coverage and blood transfusion. The loss of psychological well being included stress, lack of support systems, inability to carry out responsibilities, lack of trust of the medical ten family breakdown, inappropriate expression of emotion and not disclosing the diagnosis to the child. Physically the parents suffered fatigue, insomnia, loss of appetite, loss of weight, dizzness, headache, psychosomatic symptoms, and increased consumption of liquor and cigarettes. Social withdrawal was manifested by taking time off from work to look after the child, decrease of outside social activities and feelings of isolation. Influences on family life were spousal conflicts, negative response of siblings, separation of the family members and economic hardship. The theme clusters were blaming a spouse for the cause of the illness and disagreements, maladjustment, lonliness, hostility and depression of siblings. The high price of medical care over the long period was a major factor influencing the life of the family. Positive experiences during the child's long illness were the strengthening of support systems and religious beliefs and financial help from social organizations. The support of one's spouse primarily helped to overcome the stress of the long illness. In addition, support was received from parents of other children with cancer and from nurses and religious leaders. The nurse, by providing empathetic support, should be a person with whom parents can express their feelings and share their experiences.

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양식 넙치(Paralichthys olivaceus)에 경구투여한 Ampicillin 및 Amoxicillin의 어류체내 잔류량의 변화 (Residues of Ampicillin and Amoxicillin in Olive Flounder Paralichthys olivaceus Following Oral Administration)

  • 손광태;조미라;오은경;목종수;권지영;이태식;송기철;김풍호;이희정
    • 한국수산과학회지
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    • 제44권5호
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    • pp.464-469
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    • 2011
  • Residues of ampicillin and amoxicillin in the muscles of olive flounder Paralichthys olivaceus were investigated after oral doses of 20 mg/kg body weight/day of ampicillin and 40 mg/kg body weight/day of amoxicillin in a first examination and 40 mg/kg body weight/day of ampicillin and 80 mg/kg body weight/day of amoxicillin in a second examination for 5-6 days. The ranges of seawater temperatures in the $1^{st}$ and $2^{nd}$ examinations were $13.4-15.6^{\circ}C$ and $16.8-21.4^{\circ}C$, respectively. Ampicillin and amoxicillin concentrations were analyzed by high performance liquid chromatography (HPLC). The average recovery rates of ampicillin and amoxicillin in fish samples ranged from 84.8-95.2% and 100.8-103.8%, respectively. Residual concentrations in the olive flounder peaked on the $5^{th}$ day, with average concentrations of 0.075 mg/kg and 0.311 mg/kg in the $1^{st}$ examination, and 0.098 mg/kg and 0.630 mg/kg in the $2^{nd}$ examination for ampicillin and amoxicillin, respectively, with maximum concentrations in muscle. In the $1^{st}$ examination, ampicillin concentrations in olive flounder after withdrawals of 1 and 3 days were 0.041 mg/kg and 0.023 mg/kg, respectively, and amoxicillin concentrations after withdrawals of 1 day and 10 days were 0.172 mg/kg and 0.023 mg/kg, respectively. In the $2^{nd}$ examination, the ampicillin concentrations in olive flounder after withdrawals of 1 and 3 days were 0.041 mg/kg and 0.023 mg/kg, respectively, and amoxicillin concentration after withdrawals of 1 day and 10 days were 0.172 mg/kg and 0.023 mg/kg, respectively. We suggest that the recommended withdrawal periods should be 3 days for ampicillin and 10 days for amoxicillin in the olive flounder.

전자담배흡연이 심장자율신경조절에 미치는 반응: 궐련담배와의 비교 검증 (Influence of Electronic-cigarette Smoke on Cardiac Autonomic Nerve Responses in Comparison with Conventional-cigarette Smoke)

  • 김춘섭;김맹규
    • 생명과학회지
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    • 제28권5호
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    • pp.587-596
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    • 2018
  • 전 세계적으로 담배흡연자의 심혈관 위험 감소와 금연을 위한 대안으로 전자담배 이용이 급속하게 확산되고 있지만 니코틴을 포함한 잠재적 유해화합물을 함유한 전자담배의 심혈관 효과는 불분명하다. 본 연구는 전자담배 사용에 따른 심장자율신경조절 변화를 관찰하고 급성적인 교감신경흥분효과 및 부교감신경활동 저하 반응을 궐련담배 흡연과 직접 비교하려는 목적으로 수행되었다. 41명의 젊고 건강한 흡연남성들을 대상으로 자료 분석을 수행하였으며, 무작위 교차 설계에 의해 1주의 wash-out period를 적용하여 전자담배와 궐련담배 세션이 각각 실시되었다. 전자담배는 흡연 시를 포함한 흡연 후 5분까지, 궐련담배의 경우 흡연 시 및 흡연 후 최대 30분까지 교감신경활성화 및 부교감신경 감소가 관찰되었다. 두 제품 간 비교에서, 흡연 시를 포함한 흡연 후 30분 동안의 HRV 분석에서 전자담배는 궐련담배에 비해 비교적 교감신경흥분효과 및 부교감신경저하에서 적은 변화수준 및 단시간 변화를 제공하는 것으로 나타났다. 이상의 결과들은 비록 전자담배가 궐련담배에 비해 심장자율신경조절에서 상대적으로 완화된 효과를 제공한다고 할지라도 전자담배 내 니코틴 및 잠재적 위험요인들을 고려해 볼 때 급성적인 교감신경흥분작용 및 부교감신경의 저하를 야기함으로 과도한 사용에 주의가 요구된다.

Effects of Low and High Molecular Weight Hyaluronic Acids on Peridural Fibrosis and Inflammation in Lumbar Laminectomized Rats

  • Lee, Jun-Geol;Lee, Sang-Chul;Kim, Yong-Chul;Lim, Young-Jin;Shin, Jae-Hyuck;Kim, Jae-Hun;Park, Sang-Hyun;Choi, Yun-Ra;Sim, Woo-Seog
    • The Korean Journal of Pain
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    • 제24권4호
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    • pp.191-198
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    • 2011
  • Background: Postlaminectomy peridural fibrosis is inevitable. Some studies have compared and identified the effects of high molecular weight hyaluronic acids (HMWHA) and low molecular weight hyaluronic acids (LMWHA) on peridural fibrosis in postlaminectomy animal models. However, no studies have been found that compare pain behaviors between hyaluronic acids or among hyaluronic acids and other solid materials. The purpose of this study was to examine the correlation between pain-related behaviors and histopathologic changes in laminectomized rats using various peridurally administered materials. Methods: Forty male Sprague-Dawley rats, laminectomized at the L5 and L6 levels, were divided into four groups: group C, laminectomy only; group L, laminectomy and LMWHA application; group H, laminectomy and HMWHA application; group F, laminectomy and fat interposition. Pain behaviors were checked before, 3 days, 1 week, and 3 weeks after surgery. Histopathological changes were checked at the L5 level 3 weeks after the surgery. Results: The 50% withdrawal thresholds in groups L and H were higher than that in groups C and F three days after laminectomy (P < 0.05). The paw withdrawal time did not change among the groups and in each group during the study period. Peridural fibrosis in group F was significantly lower than in the other groups (P < 0.05). Conclusions: Hyaluronic acids significantly reduced mechanical allodynia but not thermal hyperalgesia. Peridural fibrosis did not show any correlation with pain behaviors. There have been limited studies on the correlation between peridural fibrosis and pain behavioral change, which should be verified by further studies.