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Association between Diabetes Mellitus and Fatty Liver Based on Ultrasonography Screening in the World's Highest Cholangiocarcinoma Incidence Region, Northeast Thailand

  • Thinkhamrop, Kavin;Khuntikeo, Narong;Phonjitt, Pichai;Chamadol, Nittaya;Thinkhamrop, Bandit;Moore, Malcolm Anthony;Promthet, Supannee
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.9
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    • pp.3931-3936
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    • 2015
  • Fatty liver disease (FLD) can be a precondition for other liver pathology including cholangiocarcinoma (CCA). Diabetes mellitus (DM) has been suggested in some studies to be a risk factor for FLD as well as cancers, including cholangiocellular carcinoma; however, there are currently very few studies on FLD in DM subjects, although the rate of FLD continues to increase annually. To determine the association between DM and FLD ultrasonographic data were analyzed from the Cholangiocarcinoma Screening and Care Program (CASCAP), in northeast Thailand. DM was reported by the subjects based on the CASCAP health questionnaire. Factors that were associated with FLD were determined by prevalence, odds ratio (ORs) and its 95% confidence intervals (CIs) using multiple logistic regression. There were 45,263 subjects with a mean age of 53.46 (${\pm}9.25$) years. FLD was found in 36.3% of DM subjects but only in 20.7% of non-DM subjects. The association between DM and FLD was adjusted for all other factors including gender, age, education level, relatives diagnosed with CCA, smoking, alcohol consumption, and hepatitis B and C. The risk of DM in subjects having FLD was highly significant compared with the non-DM subjects (OR 2.13; 95%CI: 1.92 to 2.35; p-value < 0.001). Thus DM is significantly associated with FLD which in turn may facilitate the development of several diseases including CCA. DM should be taken into consideration in future ultrasonic investigations of FLD and CCA.

A Study on Foods for the Ancestral Rites (祭需에 관한 문헌고찰)

  • Lee, Kil-Pyo;Kim, In-Ok
    • Journal of the Korean Home Economics Association
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    • v.37 no.1
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    • pp.133-143
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    • 1999
  • Originally, ancestral rites is a ceremony to pay filial piety to ancestors continuously even though they died, and this is a startingpoint based on the thought of paying respect to ancestors and 'root consciousness' which Korean people have. In the earliest days, Korean people worshipped nature and the sacrificial rituals were performed mainly for the fods of the skies and the earth. After the end-Koryeo Era introduced [Juja-Garye]ancestrial rites of forefather in home generalized. By the way, the foods for ancestrial rites on the original literature centering the [Sa-Rye-Pyon-Ram]are as follows: raw meat(saeng: 牲), rice and broth(ban, gaeng: 飯羹), fruits(果), slice meats(po: 脯), salted dry fish(jaban(佐飯), rice punch(sikhye: 食醯), soup(tang: 湯), fish and meat, roasts beef (jeok: 炙), roast vegetable(sookchae: 熟菜), rice cake(pyon: 餠), noodles(麵), soy(醬), Kimchi(沈菜), drink(酒), green tea(cha: 茶) etc. Today, ancestral rites, basically with this conception, has a function to bind the family and relatives as one. But as double income family are increasing, most housewives have heavy burden mentally and financially to prepare the food for the ancestral. The foods for ancestral rites can be said a way to express the internal true heart, and a basic medium to practice the filial piety. Many documents let us know that a few days before the ancestral rites, we should prepare the food for it with careful and pious attitude. And, they stress that our sincere attitude in preparing food is important rather than its quantity. In this industrial society, we have lots of difficulty preparing and observing the same service as it in the traditional socity. But I think that housewives can be freed from the burden they have to some degree when they realize what the true meaning of ancestral rites is and that the food for it plays a role an external expression.

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Evaluation of Optimum Genetic Contribution Theory to Control Inbreeding While Maximizing Genetic Response

  • Oh, S.H.
    • Asian-Australasian Journal of Animal Sciences
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    • v.25 no.3
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    • pp.299-303
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    • 2012
  • Inbreeding is the mating of relatives that produce progeny having more homozygous alleles than non-inbred animals. Inbreeding increases numbers of recessive alleles, which is often associated with decreased performance known as inbreeding depression. The magnitude of inbreeding depression depends on the level of inbreeding in the animal. Level of inbreeding is expressed by the inbreeding coefficient. One breeding goal in livestock is uniform productivity while maintaining acceptable inbreeding levels, especially keeping inbreeding less than 20%. However, in closed herds without the introduction of new genetic sources high levels of inbreeding over time are unavoidable. One method that increases selection response and minimizes inbreeding is selection of individuals by weighting estimated breeding values with average relationships among individuals. Optimum genetic contribution theory (OGC) uses relationships among individuals as weighting factors. The algorithm is as follows: i) Identify the individual having the best EBV; ii) Calculate average relationships ($\bar{r_j}$) between selected and candidates; iii) Select the individual having the best EBV adjusted for average relationships using the weighting factor k, $EBV^*=EBV_j(1-k\bar{{r}_j})$ Repeat process until the number of individuals selected equals number required. The objective of this study was to compare simulated results based on OGC selection under different conditions over 30 generations. Individuals (n = 110) were generated for the base population with pseudo random numbers of N~ (0, 3), ten were assumed male, and the remainder female. Each male was mated to ten females, and every female was assumed to have 5 progeny resulting in 500 individuals in the following generation. Results showed the OGC algorithm effectively controlled inbreeding and maintained consistent increases in selection response. Difference in breeding values between selection with OGC algorithm and by EBV only was 8%, however, rate of inbreeding was controlled by 47% after 20 generation. These results indicate that the OGC algorithm can be used effectively in long-term selection programs.

Characteristics of Woman's Jogori through the costumes excavated from ChangRyung Jo's family(1721~1742) grave and preserved in Yeoju Museum Gyeounggi Province, Korea (여주박물관 소장 창녕조씨(1721~1742)묘 복식을 통해 본 여자저고리의 조형적 특성)

  • Song, Mi-Kyung
    • Journal of the Korean Society of Costume
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    • v.62 no.6
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    • pp.218-230
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    • 2012
  • The 25 pieces of women's jogori worn by ChangRyung Jo's family(1721~1742) that are preserved in Yeoju Museum, Gyeounggi Province, Korea were examined in this study. The aim of this study is to analyze women's jogori that were excavated from the grave of Changryung Jo's family, and to characterize women's costumes around the middle $18^{th}$ Century. The size of the jogori was divided into two groups. The garment length of the first group ranged from 31cm to 34cm and the bigger size ranged from 36.5cm to 40cm. The number of jogori in the group with the smaller size was twenty-five pieces and five pieces for the group with the bigger size. Changryung Jo's jogori was composed of two pieces of padded jogori, four pieces of quilted jogori and nineteen pieces of double layer jogori. Even though the direction of the margin located on back seemed point toward the right hand side, the gorum, the string for the tie, and the Sup, the outer gore of the jogori located on the other side of the margin had no pattern of direction. The line of jogori from the armhole gets narrower toward the edge of sleeves which could be recognized as a typical pattern of the middle $18^{th}$ Century jugori. The bigger group of jogori seemed to be worn by people other than ChangRyung Jo's relatives and used to be a gifts to aid in funerals. Major characteristics of jogori is could be categorized into the Dangko Mokpan collar jogori and Samhaejang jogori. The results of this study helps set the relative dating for the women's jogori of middle $18^{th}$ Century where not much excavations have been made.

Genomic DNA Extracted from Ancient Antarctic Glacier Ice for Molecular Analyses on the Indigenous Microbial Communities

  • Lee, Sang-Hoon;Bidle, Kay;Falkowski, Paul;Marchant, David
    • Ocean and Polar Research
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    • v.27 no.2
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    • pp.205-214
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    • 2005
  • From ancient Antarctic glacier ice, we extracted total genomic DNA that was suitable for prokaryotic 16S rDNA gene cloning and sequencing, and bacterial artificial chromosome (BAC) library and end-sequencing. The ice samples were from the Dry Valley region. Age dating by $^{40}Ar/^{39}Ar$ analysis on the volcanic ashes deposited in situ indicated the ice samples are minimum 100,000-300,000 yr (sample DLE) and 8 million years (sample EME) old. Further assay proved the ice survived freeze-thaw cycles or other re-working processes. EME, which was from a small lobe of the basal Taylor glacier, is the oldest known ice on Earth. Microorganisms, preserved frozen in glacier ice and isolated from the rest of the world over a geological time scale, can provide valuable data or insight for the diversity, distribution, survival strategy, and evolutionary relationships to the extant relatives. From the 16S gene cloning study, we detected no PCR amplicons with Archaea-specific primers, however we found many phylotypes belonging to Bacteria divisions, such as Actinobacteria, Acidobacteria, Proteobacteria $({\alpha},\;{\beta},\;and\;{\gamma})$, Firmicutes, and Cytophaga-Flavobacterium-Bacteroid$. BAC cloning and sequencing revealed protein codings highly identical to phenylacetic acid degradation protein paaA, chromosome segregation ATPases, or cold shock protein B of present day bacteria. Throughput sequencing of the BAC clones is underway. Viable and culturable cells were recovered from the DLE sample, and characterized by their 16S rDNA sequences. Further investigation on the survivorship and functional genes from the past should help unveil the evolution of life on Earth, or elsewhere, if any.

The SAFE Management System Model Based on Context Automatic Awareness

  • Han, Kook-Hee;Liu, Yiwen;Kwon, Young-Jik;Kang, Byeong-Do
    • Proceedings of the Korea Society for Industrial Systems Conference
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    • 2007.02a
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    • pp.87-96
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    • 2007
  • Ubiquitous is a Latin-derived word meaning "to exist at any time and place" like water or air. In computing, the word "ubiquitous" indicates an environment in which users have access to networks without any limitation regarding computer networks or places. Important issues in building Ubiquitous Korea (U-Korea) are the social problems appearing with a rapid increase in the old age population. Nowadays, with the rise of the nuclear family, the increase in the number of elderly people living alone, and the change in the status of women, both wives and husbands are employed outside the home, and the relatives who would be responsible for supporting the elderly sometimes are on long or short business trips, and it happens that old people can't be looked after. Therefore the government developed a wireless paging system for the sick, disabled, old and weak so that when an emergency happens, by just simply dialing 119, an emergency aid center could take prompt action. However, the present wireless paging systems composing the under-layer of the emergency aid information system have some problems, such as, a lack of reliability, problems among terminals, mobile transmitters and receiving terminals, the users' refusal to admit the need for the system and poor operational skills, administrators' perfunctory management and checks, etc. On account of these problems, the system efficiency has degraded and therefore a system upgrade is necessary. In this paper, we attempt to evaluate the newly implemented SAFE119 system, a new wireless paging system seeking to correct the problems of the current system.

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Significance of Unreduced ( 2n ) Gametes in Plant Breeding (식물육종에 있어서 비환원 ( 2n ) 배우자의 중요성)

  • Rim, Yong-Woo
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.17 no.1
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    • pp.1-10
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    • 1997
  • Unreduced (2n) gametes are meiotic products (pollen or egg) having a sporophytic (somatic) chromosome number, resulting from abnormalities during either microsporogenesis or megasporogenesis. They occur naturally at a low frequency in many plant species. Unreduced (2n) gametes in plants can be identified for four possible ways as follow i) pollen size and/or shape differences between haploid (n) and diploid (2n) pollen, ii) ploidy analysis (chromosome number) of progeny or meiotic analysis (presence of dyads andlor triads at the microspore stage), iii) progeny performance and fertility and iv) dosage of isozyme and DNA markers. Unreduced (2n) gametes can be an effective breeding tool in synthesizing new cultivars, providing a unique method to maximizing heterozygosity, i.e., transferring a large proportion of the non-additive genetic effects (intra- and inter- locus interactions) h m parent to offspring and can also be used to overcome infertility of interploidy crosses. Sexual polyploidization through 2n gametes has been a major route to the formation of naturally occurring polyploids. The three mechanisms of 2n pollen formation in potato have been discovered as follow: i) parallel spindles (ps) or tripolar spindles (ts), ii) premature cytokinesis (pc-I, pc-2) and iii) synaptic mutants (sy-2, sy-3, sy-4). Genetic analysis indicated that the mechanisms of 2n gamete formation were controlled by single recessive gene in potato, alfalfa, red clover, etc., and by two recessive genes in wheat. The use of 2n gametes which can efficiently transfer germplasm fiom wild relatives to cultivated species, especially fiom diploid to tetraploid could make a contribution to the improvement of germplasm base in breeding programs.

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Study on Economic Valuation of Manufacturing Technology of Platycodon grandiflorum Using Contingent Valuation Method - Focusing on the Virtual Market of Platycodon grandiflorum's Health Functions Food - (조건부가치측정법(CVM)을 이용한 도라지 제조기술의 경제적 가치 추정 연구 -도라지 건강기능식품 가상시장을 중심으로-)

  • Lee, Hyun Ji;Chang, Insu;Jo, Haeun;Kim, Brian H.S
    • Journal of Korean Society of Rural Planning
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    • v.26 no.1
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    • pp.137-147
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    • 2020
  • Rural Development Administration (RDA) has developed a manufacturing technology which can increase the amount of platycodin D in Platycodon grandiflorum. A study is needed to estimate the value of this new technology and predict the market demand for a new product. This study estimates additional amount of willingness to pay (WTP) using contingent valuation method (CVM) for a new product with the technology that RDA has developed. The survey was created under virtual health functional foods market of Platycodon grandiflorums. It was conducted with 1,000 adult males and females aged between 19 and 59 years old in 17 major cities and provinces nationwide from December 4 to December 7, 2018. The amount of WTP for the health functional Platycodon grandiflorum was drawn using maxinum likelihood estimation method. The estimated average and median WTP values are 21,933.85 won per person and 10,000 won per person, respectively. The independent factors, including the ratio of monthly average health function food consumption to income, the average monthly income level of a household, and existence of family members or relatives engaged in food and nutrition-related professions in a household, have been shown to have a statistically significant influence on the WTP. This study presents the potential magnitude of health functional food market and the value of the new technology based on health functional food market.

RADIOPACITY OF DENTAL GLASS POLYALKENOATE CEMENTS (치과용 Glass Polyalkenoate cement의 방사선 불투과성에 관한 비교 연구)

  • Rim, Young-Il;Um, Chung-Moon;Lee, Chung-Sik;Kwon, Hyuk-Choon
    • Restorative Dentistry and Endodontics
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    • v.22 no.1
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    • pp.464-469
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    • 1997
  • The radiopacity of glass ionomer cements is quite variable. The use of a poorly radiopaque material as a base under other restorative materials can mislead the dentist to a diagnosis of recurrent decay. This study investigates the radiopacity of these materials and proposes a minimal radiopacity under which a material should not be used as a base or liner. It is important to determine the radiopacity of glass ionomer dental materials so that the clinician can appreciate the type of restorative materials used when radiographically evaluation the possibility of recurrent dental caries. In this study, radiopacity of Vitrement and Chemfil was compared with that of Cavalite, Miracle mix and polycarboxylate cement. Tooth model of artificial cavity preparation for diagnosis of recurrent caries was omitted. Radiopacity of each material was measured using relatives between thickness and radiopacity of Aluminium step wedge. The results were as follows : 1. Radiopacity of Vitrement was some higher than enamel. 2. Chemfil, restorative glass ionomer, was less radiopaque than enamel. 3. In order of higher radiopacity than enamel, Miracle mix was highest and was followed by polycarboxylate cement, Cavalite and Vitremer. 4. Vitremer, the Glass Ionomer Cement, is useful to detection of recurrent caries, because it is slightly higher radiopaque than enamel. So, it is suitable for restorative material and luting cement.

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A study on vertical distribution observation of giant jellyfish (Nemopilema nomurai) using acoustical and optical methods (음향 및 광학기법을 이용한 노무라입깃해파리 (Nemopilema nomurai)의 수층별 분포 관찰에 관한 연구)

  • Lee, Kyoung-Hoon;Kim, In-Ok;Yoon, Won-Duk;Shin, Jong-Keun;An, Heui-Chun
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.43 no.4
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    • pp.355-361
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    • 2007
  • A giant jellyfish (Nemopilema nomurai), which is presumed developing in the East China Sea, is recently one of major issues in the Northeast Asia region due to its fatal damage to the fishery. The biomass estimates have generally been conducted by trawl sampling and sighting survey methods. The biological research is also needed to clarify such environmental origin or diurnal migration patterns. While trawl sampling or sighting survey methods are effective to investigate its density estimates in its distributed community of near bottom or surface, they have a problem in investigation on the vertical distribution of jellyfishes. In this case, an echo sounding detection would have an advantage to survey it more extensively and effectively. This trial was conducted to observe the vertical distribution of giant jellyfish, where thermocline strongly formed, during mooring at each station of the East China Sea and southern coastal area using acoustical and optical methods. By the results, they were observed to exit and move at the water column under the thermocline using the optical camera and echo sounder system, and the information was analyzed to find out the acoustical sound scattering characteristics relatives to 120kHz frequency. These results can be utilized effectively to estimate the vertical distribution and biomass of Giant jellyfish with comparing results from trawl sampling and sighting survey methods, hereafter.