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Integrated Bioinformatics Approach Reveals Crosstalk Between Tumor Stroma and Peripheral Blood Mononuclear Cells in Breast Cancer

  • He, Lang;Wang, Dan;Wei, Na;Guo, Zheng
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.3
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    • pp.1003-1008
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    • 2016
  • Breast cancer is now the leading cause of cancer death in women worldwide. Cancer progression is driven not only by cancer cell intrinsic alterations and interactions with tumor microenvironment, but also by systemic effects. Integration of multiple profiling data may provide insights into the underlying molecular mechanisms of complex systemic processes. We performed a bioinformatic analysis of two public available microarray datasets for breast tumor stroma and peripheral blood mononuclear cells, featuring integrated transcriptomics data, protein-protein interactions (PPIs) and protein subcellular localization, to identify genes and biological pathways that contribute to dialogue between tumor stroma and the peripheral circulation. Genes of the integrin family as well as CXCR4 proved to be hub nodes of the crosstalk network and may play an important role in response to stroma-derived chemoattractants. This study pointed to potential for development of therapeutic strategies that target systemic signals travelling through the circulation and interdict tumor cell recruitment.

A study on the knowledge and utilization of Korea traditional basic side dishes I -Jangachies- (전통 밑반찬의 인지도와 이용실태에 관한 조사연구 I - 장아찌류-)

  • Yoon, Gye-Soon
    • Journal of the Korean Society of Food Culture
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    • v.10 no.5
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    • pp.457-463
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    • 1995
  • This study was undertaken to investigate the knowledge and the use of Korea traditional basic side dishes, Jangachies, by housewives. Among the 58 kinds Jangachies, the most well-known Jangachies (above 80% of subjects) turned out to be Perilla leaf, Red pepper leaf, Garlic, Young stem of garlic, Green red leaf, Cucumber and dried Radish Jangachi in the order. In cooking experience of Jangachi, 40% of subjects in Perilla leaf, 28.0% in Green red pepper, 24.8% in Garlic and 24.1% in Red pepper leaf Jangachi have cooked frequently. The proportion of subjests who has bought the marketed Jangachi products were 51.6%. Major problem of that products was pointed out for a sanitary condition, high price and poor taste. If marketed Jangachies were improved over the aspects, the proportion of subjects who would buy the products was 76.2%. The frequency of Jangachi intake was very low on a average due to too salty taste and the difficulty in preparation. The older in age, the more in interest level for Jangachi (p<0.05). 39.6% of subject have had preparation ability of Jangachies. With increasing age (p<0.01), decreasing education level (p<0.01) and those who live in rural area (p<0.05), preparation ability of Jangachi tended to be higher.

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Subjective Evaluation of Soundscape on the Street of Art in Gwangju (광주 예술의 거리 사운드스케이프의 주관적 평가)

  • 전지현;장길수;김선우
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2004.05a
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    • pp.1014-1017
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    • 2004
  • The Street of Arts Is a famous site for artists as well as tourists in Gwangju, as it harbors clusters of galleries, antique shops, and dealers of materials for fainting and calligraphy, studded with ateliers and traditional tea huts. It is the mecca of arts which Gwangju-ites, who boast of themselves being in the 'Land of Arts', take great pride in, and it has been deemed as symbolizing the cultural excellence of Gwangju and the Honam area. Recently, however, it has been repeatedly pointed out that its glory has been somewhat tamished, and there have been numerous efforts made to restore its declining image. As a way to restore and enhance the image of the Street of Arts, it was decided to apply a soundscape to the area. As on initial step for designing the soundscape, the following questions were researched: How many kinds of sounds generated in the street were perceived by residents and passers-by\ulcorner How did people feel about the sounds\ulcorner The results were analyzed to determine which sounds would be most suitable for enhancing the image of the 'Street of Arts'.treet of Arts'.pos;.

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The Change in the Housing Affordability of Japanese Tenants and the Policy Implication (일본 임차가구의 주거비부담능력 변화와 정책적 함의)

  • Nam, Won-Seok
    • Journal of the Korean housing association
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    • v.22 no.4
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    • pp.23-32
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    • 2011
  • The change in the Japanese rental housing policy since the 1990s appeared as a reduction in the role of central government, an expansion in the local government's discretion, and an increase in the dependence on the housing market. As a result, the supply of new public rental housing decreased drastically and the rent regulation was eased. This study is designed to evaluate the validity of the policy change through an analysis of the change in housing affordability of tenants during the period of 1983~2008. The analysis showed that the housing affordability and the accessibility to the housing market by tenants had been improved, confirming that if the public rental housing stock was properly used, the housing needs of the low-income tenants would be met without new supply. Therefore, it appeared that the change in the Japanese rental housing policy may have a certain amount of validity. However, the study pointed out that the validity of the policy change must be limited as the future risk factors such as the possibility of residualisation of public rental housing and the increase of poor households according to job insecurity were not well considered. Accordingly, in conclusion this study suggests that new policy instruments should be developed at central government-level, such as offering incentives for local governments and establishing a housing allowance etc.

A Study on the Environment Innovation of University Library by the Post Occupancy Evaluation (거주후 평가를 통한 대학도서관의 환경개선에 관한 연구)

  • 김성기
    • Korean Institute of Interior Design Journal
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    • no.23
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    • pp.116-123
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    • 2000
  • The importance of evaluation in design activity has been increased. Specially, it is necessary to take into consideration of user's needs as design criteria nowadays. Through these evaluations, the comprehensive quality of architectural design could be substantially improved and play the part of recycling at least in cases of theme similar structures. By a viewpoint of library patrons, there have increased many problems In library environment because more library patrons use the reference room for their study since reform of university education was carried out In 1981. Therefore, after post occupancy evaluation and spatial-planning matters of architecture are taken into consideration in this study, the problems of the plan-composition on the existing structure is pointed out and introduced the concept of post occupancy evaluation to grope the solution. With the question about users's needs and the state of use in the K-University Library, this study aims to investigate the actual use circumstance of space and maintenance of facilities as well as giving the most relevant alternatives instead of already existing one. This also intends to propose the essential date to meet the users' sociopsychological needs and environment innovation when planning the university library.

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AHP 기법을 이용한 안티바이러스 소프트웨어 평가 요인 분석

  • Kim, Jong-Ki;Hwang, Suk-Yeon;Lee, Dong-Ho
    • The Journal of Information Systems
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    • v.14 no.1
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    • pp.19-40
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    • 2005
  • The history of computer virus comes along with that of computer. Computer virus han surfaced as a serious problem in information age. The advent of open network and widespread use of Internet made the problem even more urgent. As a method of defense for computer virus most companies use anti-virus software. Selecting appropriate anti-virus software involves various criteria and thus it is a multiple-attribute decision making problem. The purpose of this study is to prioritize anti-virus software evaluation factors. To do that, first of all, important evaluation factors are selected based on previous research on anti-virus software as well as general software evaluation models. Then, a questionnaire survey was conducted on end-users, system administrators and anti-virus software developers. The survey result was analyzed with ExpertChoice 2000 which is based on Analytic hierarchy Process technique. This study found that there are clear differences among three survey groups regarding the relative importance of overall evaluation factors. End-user group ranked "cost" first, but it was the least important factor to developer group. Developers pointed out "operational support" ad the most important factor. There were also obvious differences in the relative importance of detail evaluation items. Both end-users and system administrators shared 7 common items among top 10 most important items. Moreover, neither of the two groups ranked any of the items in the "operational support" factor in top 10, whereas all 4 items in the factor were included in top 10 by developer group.

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Computational Study of the Axisymmetric, Supersonic Ejector-Diffuser Systems

  • Kim, Heuy-Dong;Lee, Young-Ki;Seo, Tae-Won;Raghunathan, Srinivasan
    • Proceedings of the KSME Conference
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    • 2000.04b
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    • pp.520-524
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    • 2000
  • A ejector system is one of the fluid machinery, which has been mainly used as an exhaust pump or a vacuum pump. The ejector system has often been pointed out to have only a limited efficiency because it is driven by pure shear action and the mixing action between primary and secondary streams. In the present work, numerical simulations were conducted to investigate the effects of the geometry and the mass flow ratio of supersonic ejector-diffuser systems on their mixing performance. A fully implicit finite volume scheme was applied to solve the axisymmetric Navier-Stokes equations, and the standard ${\kappa}-{\varepsilon}$ turbulence model was used to close the governing equations. The flow fields of the supersonic ejector-diffuser systems were investigated by changing the ejector throat area ratio and the mass flow ratio. The existence of the second throat strongly affected the shock wave structure inside the mixing tube as well as the spreading of the under-expanded jet discharging from the primary nozzle, and served to enhance the mixing performance.

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The Development of the Standards of Performance Assessment for an Affective Domain of Mathematics in High School (고등학교 수학의 정의적 영역에 대한 수행평가 기준 개발)

  • 이종연
    • School Mathematics
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    • v.4 no.2
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    • pp.193-204
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    • 2002
  • Performance assessment has been introduced to school education as an alternative measure of the former educational assessment which put much emphasis on the result rather than the process of learning, memorization than pursuit of knowledge, and passive than active study. As for the subject of mathematics, the change of the assessment came to replace multiple choice tests with descriptive- and statement-type tests. This means animprovement on the testing system, focusing on the process of finding out the answer. The main focus, however, is still on the intellectual domain without paying due attention to the emotional domain of mathematics education. The previous studies on the assessment of emotional domain In mathematics have shown that there are stumbling blocks in the application of the assessment, such as the disputes on the reliability, objectivity, and fairness as well as the complicated procedure of applying the results to school records. The lack of the development and supply of the appropriate assessment tools have also been pointed out. Therefore, this study has been carried out with the intention of establishing an applicable standard of assessment on the emotional domain of high school matematics. As a result, detailed standards of performance assessment, which adopt oral examination, discussion, observation, and report have been developed. The problems which are likely to emerge In the course of the application of the newly developed assessment are under study as a continuing research project.

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Numerical Analysis on Feedback Mechanism of Supersonic Impinging Jet using LES (LES를 이용한 초음속 충돌제트의 피드백 메커니즘에 대한 수치해석 연구)

  • Oh, Se-Hong;Choi, Dae Kyung;Kim, Won Tae;Chang, Yoon-Suk;Choi, Choengryul
    • Transactions of the Korean Society of Pressure Vessels and Piping
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    • v.13 no.2
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    • pp.51-59
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    • 2017
  • Steam jets ejected from a rupture zone of high energy pipes may cause damage to adjacent structures. This event could lead to more serious accidents in nuclear power plants. Therefore, to prevent serious accidents, high energy pipes of nuclear power plants are designed according to the ANSI / ANS 58.2 technical standard. However, the US Nuclear Regulatory Commission (USNRC) has recently pointed out non-conservatism in existing high energy pipe fracture evaluation methods, and required the assessment of the unsteady load of the jet caused by a potential feedback mechanism as well as the impact range of steam jet, the jet impact loads and the blast wave effects at the initial breakage stage. The potential feedback mechanism refers to a phenomenon in which a vortex formed by impingement jets amplifies vortex itself and induces jet vibration in a shear layer. In this study, CFD methodology using the LES turbulence model is established and numerical analysis is carried out to evaluate the dynamic behavior of impingement jets and the potential feedback mechanism during jet impingement. Obtained results have been compared with an empirical correlation and experiment.

Consumer's Apparel Brand Preference and Fit of Ready-to-wear for Women (소비자(消費者)의 여성정장(女性正裝) 브랜드 선호(選好)와 기성복(旣成服) 치수(値數)의 맞음새)

  • Oh, Seol-Young;Chun, Jong-Suk
    • Journal of Fashion Business
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    • v.6 no.1
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    • pp.128-136
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    • 2002
  • This study was initiated to study suitability of the apparel sizing systems that utilized in women's ready-to-wear market. To achieve this, the researchers surveyed 383 women from the ages of 18 through 59. The result of this study are followed. 1) The targeted age of the apparel brand does not always correspond with the purchaser's age. The subjects tend to prefer the brands targeting younger women than their age. The women who prefer the brand targeting younger women than their age were less satisfied with the jacket size available in Korean apparel market. They also took into consideration their body size. 2) The subjects who prefer the brands aimed for younger women were dissatisfied with fit at waist and hips. 3) The result of this study also shows that the more sizes are needed for short and tall women. The subjects pointed out that hips of the pants gave worst fit. 4) KS standard size designation system which listed body measurements bust-hips stature was not well known to the consumers.