• Advances in Energy Research
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• 제6권1호
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• pp.75-90
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• 2019

Anthropogenic greenhouse gas emissions are rising rapidly despite efforts to curb release of such gases. One long term potential solution to offset these destructive emissions is the capture and storage of carbon dioxide. Partially depleted hydrocarbon reservoirs are attractive targets for permanent carbon dioxide disposal due to proven storage capacity and seal integrity, existing infrastructure. Optimum well completion design in depleted reservoirs requires understanding of prominent geomechanics issues with regard to rock-fluid interaction effects. Geomechanics plays a crucial role in the selection, design and operation of a storage facility and can improve the engineering performance, maintain safety and minimize environmental impact. In this paper, an integrated geomechanics workflow to evaluate reservoir caprock integrity is presented. This method integrates a reservoir simulation that typically computes variation in the reservoir pressure and temperature with geomechanical simulation which calculates variation in stresses. Coupling between these simulation modules is performed iteratively which in each simulation cycle, time dependent reservoir pressure and temperature obtained from three dimensional compositional reservoir models in ECLIPSE were transferred into finite element reservoir geomechanical models in ABAQUS and new porosity and permeability are obtained using volumetric strains for the next analysis step. Finally, efficiency of this approach is demonstrated through a case study of oil production and subsequent carbon storage in an oil reservoir. The methodology and overall workflow presented in this paper are expected to assist engineers with geomechanical assessments for reservoir optimum production and gas injection design for both natural gas and carbon dioxide storage in depleted reservoirs.

• 한국농촌건축학회논문집
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• 제21권2호
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• pp.27-34
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• 2019

This study explores the emergence of a modern form of Cheongju-eup townscape in the late 1930s by re-examining the 1960s restoration model of Seongan-dong and Jungang-dong in Cheongju, one of the historic cities in South Korea. According to the acquired data from the restoration model, it is found that the construction of a new urban area during the late 1930 was resulted from the following events: the development of a railroad station located outside of the north gate of Cheongju-eup since 1921, the completion of Musimcheon embankment outside the south gate in 1932, and the construction of Chungcheongbuk provincial office outside the eastern gate in 1937. In this period of development, which the author named 'Cheongju-eup period', the streets in the old castle, consisting only of two-story financial buildings, had been expanded from the existing area at the Seongan-gil intersection to the outside the east gate of Cheongju-eup. In addition, public government buildings, which were mainly located in both Seongan-gil and Yulgok-ro in the east-west direction, were newly constructed during the late 1930s in Seokgyo-dong, a new area in which a large number of commercial buildings including department stores, clothing stores, shoes shops, and watch stores were also built along the streets. Moreover, the modern form of Cheongju-eup was to be formed by several construction projects in the area of Jungang-ro in the late 1930s. Until the 1920s, the townscape outside the northern gate of Cheongju-eup, were composed of primary, agricultural, and female schools built on a largest site of Gyoseo-ro and Daeseong-ro as well as a transportation warehouse and a railway office near the Cheongju station. Then, entering the 1930s, new school buildings and domestic industrial shops and factories were built around the area of Jungang-ro ranging from the railway outside the northern gate to Bangadari. As a result, the expansion of townscape with newly constructed buildings in the late 1930s marked the emergence of a modern form of Cheongju-eup.

• 한국음향학회지
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• 제38권3호
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• pp.266-274
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• 2019

국내 문화예술공간에 대한 통계조사에서 나타나듯이, 국내의 많은 공연시설들은 노후화에 따른 크고 작은 규모의 개보수가 필요한 상태이다. 그러나 이와 같은 기존공간의 음향개보수과정에서 참고가 될만한 사례연구가 많지 않은 실정이다. 본 연구는 문화재로써 많은 제약조건을 갖는 SH고등학교 강당을 대상으로 초기 음향검토에서부터 사용자의 요구조건 및 문제점들을 고려한 대안의 수립 그리고 대안들의 적용에 따른 음향성능평가과정 및 그 결과를 분석함으로써 음향리노베이션 설계의 참고자료를 제공하고자 하였다. 개선방안들의 적용결과, 실의 잔향특성이 개선되었으며 언어명료도 및 음악명료도가 개선되었음을 확인하였다. 그러나 라우드니스는 목표한 수준에 미치지 못하였으며 이는 천장에 적용된 슬랫형 구조가 강한 반사음을 제공하지 못하기 때문인 것으로 분석되었다.

• Tuberculosis and Respiratory Diseases
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• 제82권1호
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• pp.15-26
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• 2019

The pathogen Mycobacterium avium complex (MAC) is the most common cause of nontuberculous mycobacterial pulmonary disease worldwide. The decision to initiate long-term antibiotic treatment is difficult for the physician due to inconsistent disease progression and adverse effects associated with the antibiotic treatment. The prognostic factors for the progression of MAC pulmonary disease are low body mass index, poor nutritional status, presence of cavitary lesion(s), extensive disease, and a positive acid-fast bacilli smear. A regimen consisting of macrolides (clarithromycin or azithromycin) with rifampin and ethambutol has been recommended; this regimen significantly improves the treatment of MAC pulmonary disease and should be maintained for at least 12 months after negative sputum culture conversion. However, the rates of default and disease recurrence after treatment completion are still high. Moreover, treatment failure or macrolide resistance can occur, although in some refractory cases, surgical lung resection can improve treatment outcomes. However, surgical resection should be carefully performed in a well-equipped center and be based on a rigorous risk-benefit analysis in a multidisciplinary setting. New therapies, including clofazimine, inhaled amikacin, and bedaquiline, have shown promising results for the treatment of MAC pulmonary disease, especially in patients with treatment failure or macrolide-resistant MAC pulmonary disease. However, further evidence of the efficacy and safety of these new treatment regimens is needed. Also, a new consensus is needed for treatment outcome definitions as widespread use of these definitions could increase the quality of evidence for the treatment of MAC pulmonary disease.

• 대한의용생체공학회:의공학회지
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• 제43권3호
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• pp.161-169
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• 2022

Engagement is an important factor in the field of rehabilitation as it is a known factor that have a positive influence on functional gaining in people who receive rehabilitation therapy. Although a number of measurements for engagement have been recently developed, investigation of possible factors that may have influence on engagement is not well established. Currently available evidence suggests that engagement is affected by mood and it is hypothesized that a personal factor may contribute to engagement. Therefore, this study aims to test the hypothetical relationship between mood and engagement while performing a manual dexterity task through an experiment in healthy participants prior to investigation on people with medical condition who requires rehabilitation therapy. After inducing target mood (positive or negative mood) for study participants by asking them to recall autobiographical memories, change in muscle activity, which was operationalized as an indicator of engagement, was investigated. Electromyogram (EMG) was recorded from four muscle areas in non-dominant hand side to quantify muscle activity. The results show that the target moods were appropriately induced with the method. Although there were subtle differences in the level of engagement between different moods, certain variables derived from muscle activity were significantly different; mean amplitude for wrist extensor EMG showed significant difference between different moods (Z = -2.023, p < .05) indicating that muscle activities in the wrist extensor are greater for positive mood than negative mood region during manual dexterity task. Meanwhile, performance outcomes of Minnesota Manual Dexterity Test (MMDT), such as mean completion time and number of errors, between moods showed no significant difference in two different moods, resulting in MMDT administration may not be useful task in distinguishing the level of rehabilitation engagement.

• Journal of Periodontal and Implant Science
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• 제52권5호
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• pp.352-369
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• 2022

The aim of this systematic review was to evaluate clinical and microbiological outcomes with the use of azithromycin as an adjunct to non-surgical subgingival professional mechanical plaque removal (PMPR) in the treatment of grade C periodontitis. Online database searches using high-level MeSH terms in a PICO structure were conducted along with hand-searching of relevant periodontal journals. Titles and abstracts of identified studies were independently reviewed by both authors and the full texts of studies meeting the inclusion criteria were independently reviewed. In total, 122 studies were identified through searches, of which 6 were included in the qualitative analysis and 4 in the meta-analysis. Three studies included in the meta-analysis were deemed at low risk of bias and 1 at serious risk. There were conflicting results on whether azithromycin reduced the number of subgingival pathogens or detectable subgingival Aggregatibacter actinomycetemcomitans between the included studies. The meta-analysis revealed a statistically significant probing depth reduction difference in favour of azithromycin compared to the control at 3 months (weighted mean difference [WMD]=-0.39 mm; 95% confidence interval [CI], -0.66 to -0.13 mm; I²=0%) and 12 months (WMD=-1.32 mm; 95% CI, -1.71 to -0.93 mm; I²=0%). The clinical attachment level change was also statistically significant in favour of azithromycin compared to the control at 3 months (WMD=-0.61 mm; 95% CI, -1.13 to -0.10 mm; I²=71%) and 12 months (WMD=-0.88 mm; 95% CI, -1.32 to -0.44 mm; I²=0%). Based upon these results, azithromycin offers additional improvements in some clinical parameters when used in conjunction with subgingival PMPR in patients with aggressive periodontitis over control groups. These improvements appear to be maintained for up to 12 months after treatment completion. However, due to a lack of well-designed studies, the conclusions that can be drawn from the available evidence are limited.

• 운동영양학회지
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• 제25권3호
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• pp.16-22
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• 2021

[Purpose] Exercise-associated hyponatremia (EAH) is a well-known condition among endurance athletes at low altitudes. The incidence of EAH during ultramarathons at high altitudes warrants further investigation. This prospective observational study was conducted on the participants of the Leadville Trail 100 run, a 161-km race held at a high altitude (2,800 m-3,840 m). [Methods] Venous blood samples were collected before and immediately after the race. The participants completed an electronic survey after the race. Our main outcome measure was the post-race serum sodium ([Na⁺]) level. [Results] Of the 672 athletes who started the race, 351 (52%) successfully completed the event within the 30-hour cut-off. Post-race blood samples were collected from 84 runners (66 finishers). Both pre- and post-race blood samples were collected from 37 participants. Twenty percent of the post-race participants had EAH. Only one post-race participant had a [Na⁺] level of <130 mmol/L. All participants with EAH were asymptomatic. One participant had an abnormal pre-race [Na⁺] level (134 mmol/L). Female participants had a significantly higher rate of EAH than male participants (40% vs. 16%; p=0.039). Age, body mass index, weight changes, race completion status, nonsteroidal anti-inflammatory drug use, and urine specific gravity were not associated with the development of EAH. Lower postrace [Na⁺] levels were associated with higher serum creatine kinase values (R²=0.1, p<0.005). [Conclusion] High altitude (3,840 m peak) does not appear to enhance the incidence of EAH after an ultramarathon footrace. This suggests that ambient temperature (low temperatures reduce risk), sex (female predilection), endurance running, and overhydration are more prominent risk factors for EAH than high altitude.

• 한국임상약학회지
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• 제33권3호
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• pp.202-209
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• 2023

Background: With the emergent transition of online learning during the COVID-19 pandemic, the need for online/offline blended learning that can effectively be utilized in a team-based learning (TBL) course has emerged. Methods: We used the online metaverse platforms, Gather and Zoom, along with face-to-face teaching methods in a team-based Introductory Pharmacy Practice Experience (IPPE) course and examined students' learning satisfaction and achievement, as well as their preferences to the learning platforms. A survey questionnaire was distributed to the students after the IPPE course completion. All data were analyzed using Excel and SPSS. Results: Students had high levels of course satisfaction (4.61±0.57 out of 5) and achievement of course learning objectives (4.49±0.70 out of 5), and these were positively correlated with self-directed learning ability. While students believed that the face-to-face platform was the most effective method for many of the class activities, they responded that Gather was the most effective platform for team presentations. The majority of students (64.3%) indicated that blended learning was the most preferred method for a TBL course. Conclusion: Students in a blended TBL IPPE course had high satisfaction and achievements with the use of various online/offline platforms, and indicated that blended learning was the most preferred learning method. In the post-COVID-19 era, it is important to utilize the blended learning approach in a TBL setting that effectively applies online/offline platforms according to the learning contents and activities to maximize students' learning satisfaction and achievement.

• 대한토목학회논문집
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• 제28권1B호
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• pp.79-93
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• 2008

방조제 공사 이후 제한된 배수갑문을 통한 해수유통으로 물리 환경이 크게 변화된 새만금호 내부의 수질특성을 이해하기 위해 EFDC 모델을 이용한 수치모의를 실시하였다. 수동역학 모델링 결과는 새만금 외해역의 순환양상 및 호 내부의 superelevation을 재현하는 등 관측결과와 부합된다. 방조제 공사 이전의 관측 자료를 이용한 수질 모델링의 보정 및 검증을 실시하였다. 만경 및 동진강 유량과 조간대가 수질에 미치는 영향을 검토하기 위한 민감도 분석도 실시되었다. 여름철 만경 동진강 입구역의 수심 평균된 DO 농도는 방조제 완공 이후 배수갑문을 통한 외해측과의 해수교환 영향력의 감소로 오염물질 배제 기능이 상실되고 상시 침수 조간대의 확대로 인한 SOD 소비의 영향으로 인해 2 mg/L 정도 까지 떨어진다. 그러나 호 중앙부는 개방된 배구갑문을 통해 소통되는 해수의 영향으로 인해 DO의 저하가 크게 심화되지 않는다. 새만금 방조제 완공 후, 만경 동진강 입구역 부근의 저층에서 급격한 산소소비로 여름철 연직방향의 DO 분포는 표저층간 6~7 mg/L의 큰 격차를 보이는 등 새만금호의 상류부 저층에서는 상당한 수질저하 현상이 나타나는 것으로 예측되었다.

• Journal of Trauma and Injury
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• 제36권4호
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• pp.421-424
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• 2023

This case report presents the case of a 49-year-old man who presented to our level I trauma center after sustaining injuries in an altercation with local law enforcement in which he was shot with a less lethal bean bag and tased. In a primary survey, a penetrating left supraclavicular wound was noted in addition to a taser dart lodged in his flank. No other traumatic findings were noted in a secondary survey. Given hemodynamic stability, completion imaging was obtained, revealing a foreign body in the left lung, a left open clavicle fracture, a C5 tubercle fracture, a possible grade I left vertebral injury, and a left first rib fracture. Soft tissue gas was seen around the left subclavian and axillary arteries, although no definitive arterial injury was identified. The bean bag projectile was embedded in the parenchyma of the left lung on cross-sectional imaging. The patient underwent thoracotomy for removal of the projectile and hemostasis. A thoracotomy was chosen as the operative approach due to concerns about significant bleeding upon foreign body removal. A chest tube was placed and subsequently removed on postoperative day 5. The patient was discharged on postoperative day 7. At a 2-week outpatient follow-up visit, the patient was doing well. This case report is the first to describe this outcome for a drag-stabilized bean bag. Although law enforcement officers utilize bean bag projectiles as a "less lethal" means of crowd control and protection, these ballistics pose significant risk and can result in serious injury.