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Effect of Fructose-1,6-diphosphate[FDP] on Red Blood Cells after Extracorporeal Circulation (체외순환후 fructose-1,6-diphosphatate[FDP]가 적혈구에 미치는 영향)

  • 이정렬
    • Journal of Chest Surgery
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    • v.25 no.7
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    • pp.693-701
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    • 1992
  • Extracorporeal cardiopulmonary bypass[CPB] has been associated with a wide variety of hematologic derangements, including a transient deformation and hemolysis of red blood cells[RBCs], which is supposed to be due to mechanical trauma and/or metabolic alterations. Since membrane integrity is, in part, maintained by energy requiring process, inadequate function of erythrocyte glycolytic pathway, which is inevitalble during CPB, may cause depletion of high energy phosphate pool and result in hemolysis. The authors performed an investigation to assess whether administration of Fructose-l, 6-diphsphate [FDP], which has been known to enhance intracellular glycolytic activities, could counteract erythrocyte hemolytic events caused by CPB. Sixty pateints with cyanotic congenital heart diseases, who underwent open heart surgery under CPB longer than 60 minutes, were randomly divided into two groups depending on whether use of FDP[Group FDP] or not[Group Control]. The age, sex, CPB time, preoperative hemoglobin level, disease entities were all similar[Table 1], and membrane type oxygenators were used in all patients. In Group, FDP, a dose of 250mg/kg body weight of FDP was administered by intravenous dripping every 12 hours from the morning of the operation to postoperative 48 hours, To demonstrate the degree and pattern of hemolysis of erythrocyte, reticulocyte count, indirect /direct bilirubin, haptoglobin, plasma hemoglobin, lactate dehydrogenase were measured every 12 hours from the time of cessation of CPB to 48 hours and RBC morphologic study, osmotic fragility test were done every 24 hours. All parameters revealed less hemolytic in group FDP [Fig. 1~5], though the differences between two groups were not significant, except plasma hemoglobin, lactate dehydrogenase changes. A pattern of sequential changes of plasma hemoglobin, lactate deh-ydrogenase showed the highest level at the time of CPB stop and abrupt decrease in following 24 hours in both groups, and statistically significant differences were demonstrated in group FDP at least for the first 12 hours postoperatively[p<0.05]. The authors conclude that they can expect the benificial effect of FDP on the maintenance of membrane stability of RBC probably by energy enhancement during the shock status of CPB, but FDP could not completely prevent the damaging effect on RBC by cardiopulmonary bypass

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Open Heart Surgery During The First 12 Months Of Life (유아기의 개심술14례 보고)

  • Ahn, Kyuk;Suh, Kyung-Phill
    • Journal of Chest Surgery
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    • v.14 no.4
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    • pp.381-387
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    • 1981
  • Fourteen Infants with congenital cardiac anomalies underwent primary surgical Intervention within the first 12 months of life. There were eight patients with ventricular septal defect, two with total anomalous pulmonary venous return [TAPVR], and the remainders with tetralogy of Fallot, transposition of great arteries [d-TGA], Taussing-Bing malformation, and coronary A-V fistula. The age of the patients ranged from 5 to 12 months, with a mean age of 9.9 months. The mean weight was 6.7 Kg [3.8 to 9.5 KS]. Congestive heart failure persisting despite intensive medical treatment was present In 8 patients [56%], and was the most common indication for operation. Early operation was necessary in 5 of these patients [35%], because of failure to thrive and recurrent pulmonary infection. In one patient with TOF, frequent hypoxic spell prompted the necessity for early operation. In cases of VSD, TAP. VR, TOF, and coronary A-V fistula, Intracardiac repair was done with conventional cardiopulmonary bypass, chemical cold cardioplegia, and topical myocardial cooling. Deep hypothermic circulatory arrest with surface induced cooling, followed by core cooling and core rewarming, was employed .for better exposure in the cases of d-TGA and Taussing-Bing malformation. The results were however, not satisfactory. The overall mortality was 28 per cent. There were no deaths in the eight patients with VSD. The one with coronary A-V fistula survived. The other 5 cases all expired either on the table or immediately after operation. The non-fatal post-operative complications included low cardiac output, respiratory insufficiency, bleeding, and temporary A-V block. The causes of death were prolonged circulatory arrest time in d-TGA, complete A-V block and low cardiac output in TOF and Taussing-Bing malformation and prolonged bypass time and Inadequate correction in TAPVR.

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Open Heart Correction Of Ebstein`S Anomaly: A Report Of 8 Cases (Ebstein`s 심기형의 개심수술 8예)

  • 김삼현
    • Journal of Chest Surgery
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    • v.14 no.4
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    • pp.388-398
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    • 1981
  • Fourteen Infants with congenital cardiac anomalies underwent primary surgical Intervention within the first 12 months of life. There were eight patients with ventricular septal defect, two with total anomalous pulmonary venous return [TAPVR], and the remainders with tetralogy of Fallot, transposition of great arteries [d-TGA], Taussing-Bing malformation, and coronary A-V fistula. The age of the patients ranged from 5 to 12 months, with a mean age of 9.9 months. The mean weight was 6.7 Kg [3.8 to 9.5 KS]. Congestive heart failure persisting despite intensive medical treatment was present In 8 patients [56%], and was the most common indication for operation. Early operation was necessary in 5 of these patients [35%], because of failure to thrive and recurrent pulmonary infection. In one patient with TOF, frequent hypoxic spell prompted the necessity for early operation. In cases of VSD, TAP. VR, TOF, and coronary A-V fistula, Intracardiac repair was done with conventional cardiopulmonary bypass, chemical cold cardioplegia, and topical myocardial cooling. Deep hypothermic circulatory arrest with surface induced cooling, followed by core cooling and core rewarming, was employed .for better exposure in the cases of d-TGA and Taussing-Bing malformation. The results were however, not satisfactory. The overall mortality was 28 per cent. There were no deaths in the eight patients with VSD. The one with coronary A-V fistula survived. The other 5 cases all expired either on the table or immediately after operation. The non-fatal post-operative complications included low cardiac output, respiratory insufficiency, bleeding, and temporary A-V block. The causes of death were prolonged circulatory arrest time in d-TGA, complete A-V block and low cardiac output in TOF and Taussing-Bing malformation and prolonged bypass time and Inadequate correction in TAPVR.

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An Improvement of VLC Using Tree Splay Algorithm (트리 스플레이를 이용한 가변장 부호화기의 성능개선)

  • 김정우
    • Journal of Korea Multimedia Society
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    • v.7 no.5
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    • pp.640-647
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    • 2004
  • This paper presents a method that, by using a tree splay, dynamically modifies the fixed table of a VLC used in the standards and thus improves the performance of a video encoder. The previous standards, which drew up tables by using a limited number of images, were not able to accommodate the characteristics of new image input. The new method proposed in this paper employs the probabilistic characteristics of an image input, thus making encoding more effective. Furthermore, the present study also proposes a method to regulate the weight in order that the accumulated probabilities can make a dominant symbol emerge, while keeping the probability adequate and thus maximally accommodating the characteristics of the image input. The results from applying the proposed method to a variety of image sequences showed that, while various types of images yielded slightly different results, it improved the performance up to a maximum of 0.23㏈, compared to MPEG-4 standard.

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A Study on the Development of the Goals and Contents System of Healthy Dietary Education Program for After-School Care in Lower Grade in Elementary School (초등 저학년 돌봄 교실 건강식생활 교육프로그램의 목표 및 내용체계 개발 연구)

  • Kim, Jung-Hyun;Lee, Myoung Hee;Park, Okjin;Choi, Kyung Sook
    • Korean Journal of Community Nutrition
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    • v.24 no.1
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    • pp.24-37
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    • 2019
  • Objectives: The study purpose is to develop a content system for a healthy dietary education program for after-school care in lower grade in elementary school. Methods: The contents of healthy dietary education in the 2015 revised curriculum and textbooks and the major education programs related to dietary life that are currently used in elementary school education were analyzed. Focus group interviews were held with field experts related to lower grade in elementary care class. Accordingly, the structuring of the education area and the detailed education contents were systematized. Results: From the analysis results, the contents of curriculum, textbook, and administrative department were classified as hygiene safety, health, and culture. The goal of the educational content system was divided into three areas: nutritional dietary life, food hygiene and health, and food culture. The subjects consisted of dietary balance, healthy body weight, digestion and absorption, food hygiene, Korean agricultural products, traditional food, and table manners. The curriculum was composed of 12 content elements. Conclusions: In order to ensure that after-school care students can grow into healthy, growth-oriented and creative talents, the role of the caring guide is important, and associated guidelines are needed in the future.

Development of a Screw-Crane System for Pre-Lifting the Sternal Depression in Pectus Excavatum Repair: A Test of Mechanical Properties for the Feasibility of a New Concept

  • Park, Hyung Joo;Rim, Gongmin
    • Journal of Chest Surgery
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    • v.54 no.3
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    • pp.186-190
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    • 2021
  • Background: Pre-lifting of the sternum marked a major turning point in pectus excavatum repair. The author developed the crane technique in 2002 and successfully applied it to more than 2,000 cases using sternal wire stitching. However, blind sternal suturing limited the use of the wire-stitch crane. We propose a novel screw for sternal lifting as a new tool for the crane technique. Methods: We developed a screw system strong enough to withstand the pressure needed for sternum lifting. The screw was designed to have a broader thread to hold the bony tissue securely. The screw's sustaining power was tested using the torsion, driving torque, and axial pull-out tests in a polyurethane block and ex-vivo porcine sternum. Results: The screws were easily driven into the sternum, and the head of the screw was connectable to the table-mounted retractor. In the torsion test, the 2° offset torsional yield was 4.53 N·m (reference value, 1 N·m). In the polyurethane block driving torque test, the maximum torque was 0.98 N·m (reference value, 0.70 N·m). The axial pull-out test was 446 N (reference value, 100 N). The maximum pull-out resistance in the ex-vivo porcine sternum model was 1,516 N. Conclusion: The screw crane was strong enough to sustain the chest wall weight to be lifted. Thus, the screws could effectively replace the sternal wire stitching in crane pre-lifting of the sternum. We expect that application of the screw-crane will be easy and that it will improve the safety and success rate of pectus repair surgery.

Experimental Study on the Characteristics of Microbubbles Generated by an Effervescent Tablet in Water (수중 내 발포성 정제로부터 생성된 미세기포 특성에 관한 실험적 연구)

  • Myeong, Jaewon;Maeng, Juyoung;Kim, Young Jun;Cho, Kyungmin;Lee, Woonghee;Kim, Sungho;Park, Youngchul;Sohn, Youngku;Shin, Weon Gyu
    • Journal of the Korean Society of Visualization
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    • v.19 no.3
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    • pp.84-91
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    • 2021
  • Effervescent tablets generate gas bubbles when chemical reaction occurs between water and tablets. Most of previous studies have been focused on pharmaceutical characteristics of tablets. However, for their applications in disinfectants, cleaners, and pesticides, physical characteristics of bubbles released from the effervescent tablets when they are in water are important. In this study, we experimentally investigated the characteristics of microbubbles generated by an effervescent tablet made of sodium bicarbonate and tartaric acid using PDPA and high-speed camera. Microbubbles were generated using different weights of effervescent tablet as well as in different water temperature. The experimental study shows increase in reaction time, bubble concentration and rise velocity as the weight of effervescent tablet increases from 1 to 20 g. The decrease in average bubble diameter was observed when the temperature of water increased from 25 to 45 ℃. Further, reaction time varies inversely with increase in water temperature, while bubble rise velocity is directly proportional to increase in water temperature. Effervescent table continuously generates the bubble with approximately constant diameter (235 ㎛) in the water. However, bubble concentration and bubble rise velocity decreased over time.

An Experimental Study on Quality Properties of Living Concrete Using Loess-Magnesia Composites (황토-마그네시아 복합체 활용 Living Concrete의 품질특성에 관한 실험적 연구)

  • Yun-Wang, Choi;Young-Woo, Na;Yong-Woo, Kwon
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.10 no.4
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    • pp.498-505
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    • 2022
  • In this study, as a result of eva lua ting the quality properties of Living Concrete, the flow of the table showed a tendency to decrease as the mixing ratio of ocher increased. Compressive strength was found to decrease with increasing loess mixing ratio. Density properties were evaluated for weight reduction, As a result of comparison with the panel using cement as a comparison group, the density was measured to be a bout 20 % lower than that of the cement panel, and it is judged that it is less affected by the load and can be installed in the structure. As a result of evaluating the panel temperature reduction, there was a difference in the temperature reduction with time. It is judged that the panel planted with moss has a lower temperature than the panel without moss, so it is judged that it can be used in a vertical greening system.

Effects of Shoulder Abduction Angles on Rounded Shoulders During Lower Trapezius Strengthening Exercise (아래등세모근 강화운동 시 어깨관절의 벌림 각도에 따라 둥근 어깨에 미치는 영향)

  • Hyeon-Su Kim;Ji-Won Han;Keon-Cheol Lee
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.1
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    • pp.131-140
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    • 2023
  • Purpose : The purpose of this study is to find out which shoulder abduction angle among the three representative angles of lower trapezius strengthening exercises most effectively improves rounded shoulder posture. Methods : Thirty-one people with rounded shoulders, the subjects of this study, were selected. With the use of a random number table, group A was randomly assigned to a Y-type exercise, group B to a T-type exercise, and group C to an MPC exercise. In the prone position, both arms are abducted at the angles suggested for each group (145 °, 90 °, and 45 °, respectively), and the hands are holding dumbbells to assume a functional posture. With the start signal, the thumb raised the arm to the sky and the arm is raised to the level of the ear for 10 seconds and then returned to the original position. Each week, the strength required was increased by changing the resistance weight, number of times, and set, and the exercise was performed three times a week for a total of four weeks. Results : There was a significant difference in the change in shoulder height of each group after four weeks of exercise in comparison to the amount of change in height before and after exercise in all groups (p<.05). However, no significant difference was observed between all groups in the change in muscle activity of the lower trapezius muscle in each group following four weeks of exercise (p>.05). Conclusion : The results of this study showed that the three lower trapezius strengthening exercises have a positive effect on the improvement of rounded shoulders. In consideration of these results, it is therefore proposed that the various lower trapezius strengthening exercises be applied in parallel during physical therapy for patients with rounded shoulders in clinical practice.

Analysis of Latency and Computation Cost for AES-based Whitebox Cryptography Technique (AES 기반 화이트박스 암호 기법의 지연 시간과 연산량 분석)

  • Lee, Jin-min;Kim, So-yeon;Lee, Il-Gu
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2022.05a
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    • pp.115-117
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    • 2022
  • Whitebox encryption technique is a method of preventing exposure of encryption keys by mixing encryption key information with a software-based encryption algorithm. Whitebox encryption technique is attracting attention as a technology that replaces conventional hardware-based security encryption techniques by making it difficult to infer confidential data and keys by accessing memory with unauthorized reverse engineering analysis. However, in the encryption and decryption process, a large lookup table is used to hide computational results and encryption keys, resulting in a problem of slow encryption and increased memory size. In particular, it is difficult to apply whitebox cryptography to low-cost, low-power, and light-weight Internet of Things products due to limited memory space and battery capacity. In addition, in a network environment that requires real-time service support, the response delay time increases due to the encryption/decryption speed of the whitebox encryption, resulting in deterioration of communication efficiency. Therefore, in this paper, we analyze whether the AES-based whitebox(WBC-AES) proposed by S.Chow can satisfy the speed and memory requirements based on the experimental results.

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