• Title/Summary/Keyword: weight efficiency

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Ethyl acetate fraction of GGEx18 modulates feeding efficiency ratio and blood leptin level in high fat diet-fed obese mice (GGEx18의 ethyl acetate 분획물에 의한 고지방식이 비만 마우스의 식이효율과 혈중 leptin 농도에 미치는 영향)

  • Park, Ki-Jeong;Lee, Hee-Young;Lee, Hye-Rim;Yoon, Mi-Chung;Park, Sun-Dong;Lee, Yong-Tae;Shen, Zhi-Bin;Cui, Hong-Hua;Shin, Soon-Shik
    • Herbal Formula Science
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    • v.19 no.1
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    • pp.219-231
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    • 2011
  • Objectives : This study was designed to determine the effects of the GGEx18 ethyl acetate fraction(EF) on body weight gain, feeding efficiency ratio, and obesity-related factors in plasma as well as histology of liver and adipose tissues using high fat diet-fed male C57BL/6N obese mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, EF(1), EF(2) and EF(3). After mice were treated with EF for 9 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also analysed histology of liver and adipose tissues on high fat diet-fed male C57BL/6N obese mice. Results : Compared with control, EF-treated mice had significantly lower body weight gain and feeding efficiency ratio. Consistent with the effects on body weight gain, EF significantly decreased the adipose tissue weight compared with control. Consistent with the effects on feeding efficiency ratio, EF significantly decreased plasma leptin concentrations compared with control. EF reduced the size of adipocytes as well as hepatic lipid accumulation compared with control. EF seems to be safe since not only the plasma levels of ALT and AST are within the normal range, but also EF did not show any toxic effects on organs. EF(3) was most effective among EF(1), EF(2), and EF(3) at doses of 25, 50, and 100 mg/kg, respectively. Conclusions : These results demonstrate that EF effectively reduces body weight gain, feeding efficiency ratio in high fat diet-fed obese mice, leading to the modulation of obesity. In addition, EF decreases the size of adipocytes and improves plasma lipids and controls hepatic lipid accumulation, suggesting that EF may act as a therapeutic agent for obesity.

Transfection Property of a New Cholesterol-Based Cationic Lipid Containing Tri-2-Hydroxyethylamine as Gene Delivery Vehicle

  • Kim, Bieong-Kil;Doh, Kyung-Oh;Hwang, Guen-Bae;Seu, Young-Bae
    • Journal of Microbiology and Biotechnology
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    • v.22 no.6
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    • pp.866-871
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    • 2012
  • A novel cholesterol-based cationic lipid containing a tri-2-hydroxyethylamine head group and ether linker (Chol-THEA) was synthesized and examined as a potent gene delivery vehicle. In the preparation of cationic liposome, the addition of DOPE as helper lipid significantly increased the transfection efficiency. To find the optimum transfection efficiency, we screened various weight ratios of DOPE and liposome/DNA (N/P). The best transfection efficiency was found at the Chol-THEA:DOPE weight ratio of 1:1 and N/P weight ratio of 10~15. Most of the plasmid DNA was retarded by this liposome at the optimum N/P weight ratio of 10. The transfection efficiency of Chol-THEA liposome was compared with DOTAP, Lipofectamine, and DMRIE-C using the luciferase assay and GFP expression. Chol-THEA liposome with low toxicity had better or similar potency of gene delivery compared with commercial liposomes in COS-7, Huh-7, and MCF-7 cells. Therefore, Chol-THEA could be a useful non-viral vector for gene delivery.

Effect of Molecular Weight of Epoxidized Liquid Isoprene Rubber as a Processing aid on the Vulcanizate Structure of Silica Filled NR Compounds

  • Ryu, Gyeongchan;Kim, Donghyuk;Song, Sanghoon;Hwang, Kiwon;Kim, Wonho
    • Elastomers and Composites
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    • v.56 no.4
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    • pp.223-233
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    • 2021
  • In this study, epoxidized liquid isoprene rubber (E-LqIR) was used as a processing aid in a silica-filled natural rubber compound to improve the fuel efficiency, abrasion resistance, and oil migration problems of truck and bus radial tire tread. The wear resistance, fuel efficiency, and extraction resistance of the compound were evaluated according to the molecular weight of E-LqIR. Results of the evaluation showed that the E-LqIR compound had a lower chemical crosslink density than that of a treated distillate aromatic extract (TDAE) oil compound because of the sulfur consumption of E-LqIR. However, the filler-rubber interaction improved because of the reaction of E-LqIR with silica and crosslink with the base rubber by sulfur. As the molecular weight of E-LqIR increased, crosslink with sulfur was facilitated, and the filler-rubber interaction improved, resulting in improved abrasion resistance. The fuel efficiency performance of the E-LqIR compound was poorer than that of the TDAE oil compound because of the low chemical crosslink density and hysteresis loss at the free chain end of E-LqIR. However, the fuel efficiency performance improved as the molecular weight of E-LqIR increased.

Dietary Effect of Tangle-supplementation on the Albino Rats - Specially Nutritional Physiology of Various Levels of Tangle-addition Supplementation - (미역첨가식이(添加食餌)에 관한 영양생리학적(營養生理學的) 연구(硏究) - 특(特)히 미역농도별(濃度別) 첨가식이(添加食餌)가 백서생육(白鼠生育)에 미치는 영향(影響)에 관하여 -)

  • Yang, I.S.;Lee, K.Y.
    • Journal of Nutrition and Health
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    • v.8 no.2
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    • pp.7-13
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    • 1975
  • In the classic point of view, it has well known that the tangle is the mineral source, especially iodide. However, there are few reports that the tangle can be used the high-protein source. With the consideration whether the tangle can be used as a protein source as well as one of the foodstuff or not, this studies is done by animal experiment. The Albino rats to be examined were fed on the basal diet (Table 1) and the others including the polished tangle by weight 2%, 3%, 4% and 5%, as experimental diets, for 4 weeks, respectively. The weight gain(Fig. 1), total amount of diet intake (Fig. 2), total water intake(Fig. 3), feed efficiency ratio (Fig. 4) and protein efficiency ratio (Fig. 5) was measured by each week, respectively. In addition, organ weight (Fig. 6) and blood study (Fig. 7, Fig. 8) was also analyzed at the end of the experiment. As the results of this study, growth rate, that is, weight gain, feed efficiency ratio and protein efficiency ratio in all experimental groups increased more than those of the control group. Moreover, it was also found that weight gain, feed efficiency ratio, protein efficiency ratio by feeding on the 2 percent tangle group was higher than the corresponding values of all experimental groups. However, feed intake and total water gain were the most by feeding on the 5% tangle group. This result may be interpreted to show that the total content of sodium includes more than enough in the feed intakes. To obtain further information concerning the effect of the tangle-dietary conditions on the growth rate of Albino rats, it was measured the organ weight. In the adrenal and spleen, the total weight by feeding on the all experimental groups were decreased more than that in the case of the control group. In the other hand, in the liver the weight by feeding on the high concentration groups (4%, 5% tangle diets) were not higher than the control group, while in the case of the low concentration groups (2%, 3% tangle diets) were higher than that of the control group. When it was observed the blood components, total protein, hemoglobin, sodium, potassium, white blood cell and red blood cell of rats, the content of white blood cell by feeding on all experimental groups were lower than that by feeding on the control group, but it was also clear that in the other components except white blood cell in blood the contents by feeding on all experimental groups were similar to that in the case of the control groups. However, in the 5% tangle group, the content of sodium was the lowest of all experimental groups, where as the content of potassium was the highest of all experimental groups.

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Study on Effect of GyeongshinhaeGihwan 1 in Body Weight and Food Intake for High fat Diet Induced Obese Male Rats (고지방식이 수컷 비만백서에서 경신해지환(輕身解脂丸)이 체중 및 사료섭취량에 미치는 영향)

  • Jung Yang-Sam;Yoon Ki-Hyeon;Choi Seung-Bae;Shin Soon-Shik
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.5
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    • pp.1267-1271
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    • 2005
  • To investigate the effect of the frequently used anti-obese medicine GyeongshinhaeGihwan 1 (GGT1), in food intake, body weight and food efficiency ratio for high fat diet induced obese male rats. Also, to value the diffences between GyeogshinhaeGihwan 1 and FDA approved Sibutramine in anti-obesity effect. High fat diet induced obese male rats were classified into four groups - positive control group, negative control group, GyeongshinhaeGihwan 1 group and Sibutramine group - and their food intake and body weight were observed for eight weeks. Anti-obesity effect was estimated with food efficiency ratio which is calculated by weight inclose divided by food intake. The result shown in Fig. 2 suggests that the GyeongshinhaeGihwan 1 group is more effective on food intake control than the Sibutramine group. Average weight variation shows an increase in both positive/negative control group and medication group. Also, the result in Fig. 3 indicates that average food efficiency ratio decreases contrary to the average weight variation. In addition, repeatedly estimated variance analysis on average food efficiency ratio of the GyeonushinhaeGihwan 1 group shows (1) the result corollary to the time of observation of food efficiency ratio was effective under 0.05 variance (P-value 0.000). The differences between each groups were not shown under 0.05 variance. Compared to the control group, medication groups were visually more effective on food intake control. Although both groups had a tendency of weight increasing, food efficiency ratio considering food intake and weight variation rate showed a decrease. Especially, the medication group variated less than the control group corollary to the point of time, proving the individuals react less sensitive to the medicine. Moreover, there were no differences in the anti-obesity effect between GyeongshinhaeGihwan 1 group and Sibutramine group studied by repeatedly estimating variance analysis(P-value: 0.610). When considering Sibutramine as an anti-obesity medicine approved by FDA, the point of being classifed in the same group proves the effect of GyeongshinhaeGihwan 1 as an anti-obesity medicine.

Verification of Weight Effect Using Actual Flight Data of A350 Model (A350 모델의 비행실적을 이용한 중량 효과 검증)

  • Jang, Sungwoo;Yoo, Jae Leame;Yo, Kwang Eui
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.50 no.1
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    • pp.13-20
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    • 2022
  • Aircraft weight is an important factor affecting performance and fuel efficiency. In the conceptual design stage of the aircraft, the process of balancing cost and weight is performed using empirical formulas such as fuel consumption cost per weight in estimating element weight. In addition, when an airline operates an aircraft, it promotes fuel efficiency improvement, fuel saving and carbon reduction through weight management activities. The relationship between changes in aircraft weight and changes in fuel consumption is called the cost of weight, and the cost of weight is used to evaluate the effect of adding or reducing weight to an aircraft on fuel consumption. In this study, the problems of the existing cost of weight calculation method are identified, and a new cost of weight calculation method is introduced to solve the problem. Using Breguet's Range Formula and actual flight data of the A350-900 aircraft, two weight costs are calculated based on take-off weight and landing weight. In conclusion, it was suggested that it is reasonable to use the cost of weight based on the take-off weight and the landing weight for other purposes. In particular, the cost of weight based on the landing weight can be used as an empirical formula for estimating element weight and optimizing cost and weight in the conceptual design stage of similar aircraft.

Relative efficiency of monofilament and multifilament nylon gill net forMarbled sole (Pleuronectes yokohamae) in the western sea of Korea (그물실 종류에 따른 서해안 문치가자미 자망의 어획성능)

  • Kim, In-Ok;Park, Chang-Doo;Cho, Sam-Kwang;Kim, Hyun-Young;Cha, Bong-Jin
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.47 no.4
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    • pp.290-299
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    • 2011
  • Field tests were carried out with five different mesh sizes (86.6, 101.0, 121.2, 137.7, 151.5mm) to study the relative efficiency of monofilament and multifilament gill net for Marbled sole, Pleuronectes yokohamae, in the western sea of Korea, 2007-2009. The relative efficiency was analyzed by length distribution, catch in number, catch in weight and weight per individual for Marbled sole. Statistical T-test was done to verify the efficiency between two gears. In the field tests, the total body length range, catch in number and weight of Marbled sole was 15.8-48.2cm, 728 and 254,939g, respectively. During the field tests, Marbled sole less than 15cm length which is prohibition size of fishing was not caught, but the caught number of Marbled sole less than 19.5cm length which is first maturity length was 13 (1.8%) and the caught number of Marbled sole more than 19.5cm was 715 (98.2%). Catches of monofilament gill net was average 1.4 times more efficient than multifilament gill net. The weight per individual and total length by mesh sizes in the two gears tended to gradually increase according to mesh size increasing. But there was little difference of weight per individual and total length by mesh sizes between two gears.

Growth, Feed Conversion Efficiency and Carcass Characteristics of Malpura and Malpura × Awassi Crossbred Lambs in a Hot Semi Arid Environment

  • Karim, S.A.;Santra, A.;Verma, D.L.
    • Asian-Australasian Journal of Animal Sciences
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    • v.15 no.3
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    • pp.377-381
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    • 2002
  • The growth rate, feed conversion efficiency and carcass characteristics of nine native Malpura (M) and eight Awassi ${\times}$ Malpura half bred (AM) male lambs were compared under intensive feeding on 60:40 concentrate and roughage based composite feed. Weaning body weight was similar in the two genetic groups while finishing body weight, total body weight gain and average daily gain during the experiment were higher (p<0.01) in AM than M lambs. The feed conversion efficiency was lower in M than AM lambs with 15.7 and 19.8 per cent feed conversion efficiency, respectively, in the two genetic groups. The dressing yield in terms of preslaughter weight or empty live weight was however similar in the two genetic groups. The loin eye area was also greater (p<0.01) in AM than M lambs. The cutability was similar for the two groups amounting to 33.2, 13.3, 13.2, 23.3 and 16.6% of half carcass, respectively, for leg, loin, rack, neck and shoulder and breast and foreshank. On an average the separable lean, fat and KOH bone content of the half carcass were 48.3, 16.8 and 23.3% for native M and 54.1, 15.0 and 19.0% for AM lambs, respectively. It is concluded that growth rate and feed conversion efficiency were better in Awassi ${\times}$ Malpura half bred than native Malpura lambs while dressing yield and cutability of standard cuts were similar in the two genetic groups.

Relationship between Body Weight of Primiparous Sows during Late Gestation and Subsequent Reproductive Efficiency over Six Parities

  • Kim, Jin Soo;Yang, Xiaojian;Baidoo, Samuel Kofi
    • Asian-Australasian Journal of Animal Sciences
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    • v.29 no.6
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    • pp.768-774
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    • 2016
  • The present study investigated the impact of parity 1 gilt body weight during late gestation (d 109) on subsequent reproductive performance of sows and performance of suckling pigs. A total of 2,404 farrowing records over 6 parities were divided into six groups on the basis of body weight (190, 200, 210, 220, 230, and 240 kg) at d 109 of gestation of 585 gilts. Significant effects (p<0.05) of body weight on sow retention rate was noticed, with the 210 kg group having the lowest culling rate and highest total number of piglets born alive over the 6 parities. With increase of body weight, a linear increase (p<0.05) in losses of body weight and backfat during the lactation period of parity 1 and a linear decrease (p<0.05) in backfat loss for parities 4 and 6 were found. Compared with light sows, heavy sows had higher (p<0.05) litter weight at birth for parities 1 and 2 and at weaning in parity 1. Sow weaning-to-estrus interval of sows was not influenced (p>0.05) by body weight. In conclusion, maintaining optimal body weight during gestation would be beneficial to sows and suckling piglets.

New High Efficiency Zero-Voltage-Switching AC-DC Boost Converter Using Coupled Inductor and Energy Recovery Circuit (결합 인덕터 및 에너지 회생 회로를 사용한 새로운 고 효율 ZVS AC-DC 승압 컨버터)

  • Park, Gyeong-Su;Kim, Yun-Ho
    • The Transactions of the Korean Institute of Electrical Engineers B
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    • v.50 no.10
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    • pp.501-507
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    • 2001
  • In this paper, new high-efficiency zero voltage switching (ZVS) AC-DC boost converter is proposed to achieve power factor correction by simplifing energy recovery circuit. A lot of high power factor correction circuits have been proposed and applied to increase input power factor and efficiency. Most of these circuits may obtain unity power factor and achieve sinusoidal current waveform with zero voltage or/and zero current switching. However, it is difficult for them to obtain low cost, small size, low weight, and low noise. The topology proposed to improve these problems can compact the devices in circuit and can achieve high efficiency ZVS AC-DC boost converter. Simulation and experimental results show that this topology is capable of obtaining high power factor and increasing the efficiency of the system.

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