• Journal of Pharmaceutical Investigation
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• 제34권4호
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• pp.269-274
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• 2004

To enhance the solubility and stability of lansoprazole (LAN), new proton pump inhibitor, we were prepared various molar ratio of inclusion complex with $2-hydroxypropyl-{\beta}-cyclodextrin$ (HPCD) and organic alkali agent, meglumine (MEG). Inclusion complex formation of LAN with HPCD was investigated by Differential Scanning Calorimetry and X-ray diffractometry. The aqueous solubilities of inclusion complexes, and the stabilities of 1:4 and 1:5 inclusion complexes in aqueous solutions containing different concentrations of MEG were examined. The stability of 1:5 LAN-HPCD inclusion complex containing MEG, which was equaled to amount of LAN, was performed in 0.9% NaCl and 5% dextrose solution. The formation of inclusion complex of LAN with HPCD was $A_L$ type and the molar ratio of complex was 1:1. The stability constant was $41.557\;M^{-1}$. As molar ratio of LAN to HPCD was increased, solubility of inclusion complex was increased. 1:5 LAN-HPCD inclusion complex was more stable than 1:4 LAN-HPCD inclusion complex. And as contained MEG amount in LAN solution was increased, stability of 1:4 and 1:5 LAN-HPCD inclusion complexes was improved. Also stability of 1:5 LAN-HPCD-MEG inclusion complex in 0.9% NaCl solution and 5% dextrose solution was similar to it in water at room temperature, but it was unstable at $40^{\circ}C$.

• 조명전기설비학회논문지
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• 제23권12호
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• pp.224-232
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• 2009

화력발전소를 기동하기 위해서는 수많은 기기조작들이 수동 및 자동으로 또한 순차적 및 병렬로 정확하게 진행되어야 한다. 따라서 발전소의 기동 중 긴박하게 이루어지는 수많은 기기 조작들이 모두 제대로 진행되고 있는지의 여부를 실시간으로 감시하는 일은 매우 복잡하고 긴장을 요하는 임무(task)이다. 본 논문에서는 화력 발전소의 기동시퀀스의 정상 진행 여부를 효과적으로 감시하기 위하여 Event Sequence Monitoring Graph(ESMG)라는 자료구조(Data Structure)를 제안하고 그 구현 기법에 대하여 논하고자 한다. 제안하된 ESMG는 용량 500MW 급의 국내 전형적인 표준형 화력발전소의 주 급수펌프 시스템의 기동 시퀀스의 진행 감시에 적용하기 위한 예를 들었으며 향후 유용하게 활용될 수 있는 가능성을 보였다.

• 자원리싸이클링
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• 제9권3호
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• pp.13-21
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• 2000

본 연구는 폐용제를 가열, 증발 및 음축과정을 거쳐 용제를 회수하는 시스템의 열교환기 해석에 관한 것으로, 고온 열매체유로 가열되는 이중관형 열교환기를 사용하여 용제 증발과정의 열전달 특성을 분석하고 용제유량과 가열온도에 따라 물, 벤젠 및 알칼벤젠의 증발을 위해 요구되는 전열면적을 분석하였다. 폐용제 회수장치는 용제 공급펌프 이중관형 열교환기, 진공 스프레이 챕버 및 응축기동으로 구성되며, 이중관형 열교환기는 용제액을 열적 포화온도를 가열시키는 구간과 포화된 용제액을 증발시키는 구간으로 구성된다. 관 내 용제의 증발을 위한 전열면적을 열평형 모델링에 의해 예측하였고, 이중관형 열교화기의 관 내 온도분포 측정을 통해 이론값과 비교 분석하였다. 용제유량 0.1~0.51l/mm 및 가열온도 130~$260^{\circ}C$의 범위에서 용제유향 증가 및 가열온도 감속에 따라 단위전열면적당 열전달양이 감소하기 때문에 용제 증발을 위한 전열면적은 증가하였다. 관 내 용제 증발을 위한 전열면적의 이론적 분석결과는 측정값과 일치하였으며, 이중관형 열교환기를 사용한 폐용제의 증발과정을 통해 용제를 회수하는 기술에 적용이 가능하다.

• Safety and Health at Work
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• 제9권1호
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• pp.42-52
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• 2018

Background: Maintenance operations on-board ships are highly demanding. Maintenance operations are intensive activities requiring high man-machine interactions in challenging and evolving conditions. The evolving conditions are weather conditions, workplace temperature, ship motion, noise and vibration, and workload and stress. For example, extreme weather condition affects seafarers' performance, increasing the chances of error, and, consequently, can cause injuries or fatalities to personnel. An effective human error probability model is required to better manage maintenance on-board ships. The developed model would assist in developing and maintaining effective risk management protocols. Thus, the objective of this study is to develop a human error probability model considering various internal and external factors affecting seafarers' performance. Methods: The human error probability model is developed using probability theory applied to Bayesian network. The model is tested using the data received through the developed questionnaire survey of >200 experienced seafarers with >5 years of experience. The model developed in this study is used to find out the reliability of human performance on particular maintenance activities. Results: The developed methodology is tested on the maintenance of marine engine's cooling water pump for engine department and anchor windlass for deck department. In the considered case studies, human error probabilities are estimated in various scenarios and the results are compared between the scenarios and the different seafarer categories. The results of the case studies for both departments are also compared. Conclusion: The developed model is effective in assessing human error probabilities. These probabilities would get dynamically updated as and when new information is available on changes in either internal (i.e., training, experience, and fatigue) or external (i.e., environmental and operational conditions such as weather conditions, workplace temperature, ship motion, noise and vibration, and workload and stress) factors.

• Nuclear Engineering and Technology
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• 제51권7호
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• pp.1738-1748
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• 2019

Previous research has shown that the inclined condition has an impact on the natural circulation (natural circulation) mode operation of Floating Nuclear Power Plant (FNPP) mounted on the movable marine platform. Due to its compact structure, small volume, strong maneuverability, the Integral Pressurized Water Reactor (IPWR) is adopted as marine reactor in general. The OTSGs of IPWR are symmetrically arranged in the annular region between the reactor vessel and core support barrel in this paper. Therefore, many parallel natural circulation loops are built between the core and the OTSGs primary side when the main pump is stopped. and the inclined condition would lead to discrepancies of the natural circulation drive head among the OTSGs in different locations. In addition, the flow rate and temperature nonuniform distribution of the core caused by inclined condition are coupled with the thermal hydraulics parameters maldistribution caused by OTSG group operating mode on low power operation. By means of the RELAP5 codes were modified by adding module calculating the effect of inclined, heaving and rolling condition, the simulation model of IPWR in inclined condition was built. Using the models developed, the influences on natural circulation operation by inclined angle and OTSG position, the transitions between forced circulation (forced circulation) and natural circulation and the effect on natural circulation operation by different OTSG grouping situations in inclined condition were analyzed. It was observed that a larger inclined angle results the temperature of the core outlet is too high and the OTSG superheat steam is insufficient in natural circulation mode operation. In general, the inclined angle is smaller unless the hull is destroyed seriously or the platform overturn in the ocean. In consequence, the results indicated that the IPWR in the movable marine platform in natural circulation mode operation is safety. Selecting an appropriate average temperature setting value or operating the uplifted OTSG group individually is able to reduce the influence on natural circulation flow of IPWR by inclined condition.

• 대한건축학회논문집:구조계
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• 제35권3호
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• pp.43-48
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• 2019

Since the revision of the Rationalization of Energy Use Law, the spread of new and renewable energy in buildings has been promoted. In addition, the production of electric power and thermal energy is an important issue in the change of energy paradigm centered on the use of distributed energy. Among them, geothermal energy is attracting attention as a high-performance energy-saving technology capable of coping with heating / cooling and hot water load by utilizing the constant temperature zone of the earth. However, there is a disadvantage that the initial investment cost is high as a method of calculating the capacity of a geothermal facility by calculating the maximum load. The disadvantages of these disadvantages are that the geothermal energy supply is getting stagnant and the design of the geothermal system needs to be supplemented. In this study, optimization design of geothermal system was carried out using optimization tool. As a result of the optimization, the ground heat exchanger decreased by 30.8%, the capacity of the heat pump decreased by 7.7%, and the capacity of the heat storage tank decreased by about 40%. The simulation was performed by applying the optimized value to the program and confirmed that it corresponds to the load of the building. We also confirmed that all of the constraints used in the optimization design were satisfied. The initial investment cost of the optimized geothermal system is about 18.6% lower than the initial investment cost.

• 한국해양학회지:바다
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• 제12권3호
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• pp.239-243
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• 2007

울릉분지의 일부 저층수에서 아질산염의 존재가 확인된 것은 용존산소가 매우 풍부한 환경에서 예상되지 않던 결과로서 괄목할만한 사실이었지만 과학적으로 설명되지 않았다. 오캄의 제안에 따르면 가능한 몇 가지 설명 가운데 대륙사면 표층 퇴적물 안에서 일어나는 탈질산화의 중간산물로써 해수로 유출되는 것이 제반 여건과 가장 잘 부합된다. 그런데 울릉분지에서는 이런 탈질산화에 따른 무기질소의 손실을 보상하는 특별한 방법이 존재하지 않은 것으로 보이며 이는 현재 심해수의 낮은 질소: 인의 비와 일맥상통한다. 여기에 열염순환을 약화시키는 온난화의 효과가 가중될 경우 현재의 생물펌프가 위축될지 또는 현재 식물플랑크톤 군집을 대체하는 새로운 군집으로 바뀌게 될지도 모른다. 그 경우 이는 동해 생태계가 직면하게 될 심각한 도전이 될 것이다. 한편으로는 수중에 산화제가 풍부함에도 불구하고 표층 퇴적물의 유기탄소함량이 아주 높게 나타나서 울릉분지에서 질소(유기물)의 순환에 대해 풀리지 않는 문제가 여전히 남아있다.

• 멤브레인
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• 제34권2호
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• pp.114-123
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• 2024

수소 동위 원소는 중성자 수에 따라 경수소, 중수소, 삼중수소로 분류될 수 있으며, 각 원소는 특정 분야에서 사용되고 있다. 구체적으로, 중수소는 전자 산업, 원자력에너지 산업, 분석기술 산업, 의약품 산업, 그리고 통신 산업에서 관심을 받고 있다. 냉각 증류, 열 주기 흡수 공정, Girdler sulfide 공정, 그리고 수전해와 같은 기존의 방법들은 각각의 장단점을 가지고 있지만, 공통적으로 막대한 에너지를 필요로 하는 공정에 기반한다는 문제점을 가지고 있다. 높은 에너지 효율을 보이는 기술을 기반으로 분리하는 공정의 개발이 요구되는 실정이다. 이런 맥락에서 막을 사용한 수소 동위 원소 분리 기술이 에너지 소비를 줄이는 유망한 해결책 중 하나라 볼 수 있다. 이 총설에서는 분리막을 활용한 수소 동위원소 분리에 관한 선행 연구와 그들의 작동 원리를 소개하고자 한다. 특히 최근 제시되고 있는, 그래핀 기반 전기적 펌핑을 통한 수소 동위원소 분리기술에 대하여 다루고자 한다. 분리막을 활용한 수소 동위원소 분리에 대한 기술은 이제 개념이 제안되기 시작한 단계이며, 많은 부분에서 해결해야 할 난제가 있다. 그러나 이를 달성할 경우 경제적인 효과가 상당할 것으로 판단된다. 이를 위한 향후 연구 방향에 대해서 논하고자 한다.

• 원예과학기술지
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• 제33권4호
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• pp.605-617
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• 2015

본 연구의 최종 목표는 실내의 공간과 식물바이오필터의 규모에 따라 실내공기 오염물질을 정화할 수 있는 식물 녹화와 자동관수 그리고 생물학적 여과 기능을 통합한 식물바이오필터 시스템의 개발이다. 본 연구는 가습 주기에 따른 벽면형(수직형) 식물바이오필터내 공기 흐름의 특성에 대한 안정성과 미세먼지 제거율을 비교하고, 이 식물바이오필터에 의한 휘발성 유기화합물의 제거율을 조사하기 위해 수행하였다. 본 실험에 사용된 식물바이오필터는 실내 공간 활용에 적합하도록 물펌프, 물탱크, 송풍기, 가습장치, 그리고 다층구조의 식물 식재 공간을 일체형으로 설계하였다. 실험 결과, 물펌프에 의해 작동하는 세 가지 다른 가습 주기 처리에 관계없이 식물바이오필터의 상대습도, 온도, 그리고 토양 수분 함량은 안정된 값을 나타내었다. 토양 수분 함량은 모든 가습 주기 처리에서 27.1-29.7%의 범위에서 안정적으로 유지하였으며, 특히 15분 작동 45분 작동 중지의 가습 주기를 120시간 동안 처리하여 $29.0{\pm}0.2%$의 평균 토양 수분 함량을 유지하면서 가장 수평적인 일차회귀식(y = 0.0008x + 29.09)을 보여주었다. 가습 주기에 따라 식물바이오필터를 통과한 미세먼지(PM10)와 초미세먼지(PM2.5) 입자 수에 대한 제거율(RE)은 각각 82.7-89.7%와 65.4-73.0% 범위에 있었고, PM10의 무게에 대한 RE는 58.1-78.9%의 범위에 있었다. 식물바이오필터를 통과한 자일렌, 에틸벤젠, 총 휘발성 유기화합물, 톨루엔의 RE는 71.3-75.5%의 범위에 있었으나, 벤젠과 포름알데히드의 RE는 각각 39.7%와 44.9%로 나타났다. 따라서 실내식물을 식재할 수 있는 본 벽면형 식물바이오필터는 실내 공기 정화에 매우 효과가 있는 것으로 확인하였다.

• 설비공학논문집
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• 제21권12호
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• pp.715-732
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• 2009

This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2008. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. Conclusions are as follows. (1) Research trends in thermal and fluid engineering have been surveyed in the categories of general fluid flow, fluid machinery and piping, new and renewable energy, and fire. Well-developed CFD technologies were widely applied in developing facilities and their systems. New research topics include fire, fuel cell, and solar energy. Research was mainly focused on flow distribution and optimization in the fields of fluid machinery and piping. Topics related to the development of fans and compressors had been popular, but were no longer investigated widely. Research papers on micro heat exchangers using nanofluids and micro pumps were also not presented during this period. There were some studies on thermal reliability and performance in the fields of new and renewable energy. Numerical simulations of smoke ventilation and the spread of fire were the main topics in the field of fire. (2) Research works on heat transfer presented in 2008 have been reviewed in the categories of heat transfer characteristics, industrial heat exchangers, and ground heat exchangers. Research on heat transfer characteristics included thermal transport in cryogenic vessels, dish solar collectors, radiative thermal reflectors, variable conductance heat pipes, and flow condensation and evaporation of refrigerants. In the area of industrial heat exchangers, examined are research on micro-channel plate heat exchangers, liquid cooled cold plates, fin-tube heat exchangers, and frost behavior of heat exchanger fins. Measurements on ground thermal conductivity and on the thermal diffusion characteristics of ground heat exchangers were reported. (3) In the field of refrigeration, many studies were presented on simultaneous heating and cooling heat pump systems. Switching between various operation modes and optimizing the refrigerant charge were considered in this research. Studies of heat pump systems using unutilized energy sources such as sewage water and river water were reported. Evaporative cooling was studied both theoretically and experimentally as a potential alternative to the conventional methods. (4) Research papers on building facilities have been reviewed and divided into studies on heat and cold sources, air conditioning and air cleaning, ventilation, automatic control of heat sources with piping systems, and sound reduction in hydraulic turbine dynamo rooms. In particular, considered were efficient and effective uses of energy resulting in reduced environmental pollution and operating costs. (5) In the field of building environments, many studies focused on health and comfort. Ventilation. system performance was considered to be important in improving indoor air conditions. Due to high oil prices, various tests were planned to examine building energy consumption and to cut life cycle costs.