• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8197-8201
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• 2016

Background: To investigate the expression of the fragile histidine triad (FHIT) gene in acute lymphoblastic leukemia and its clinical significance. Materials and Methods: The level of expressed FHIT mRNA in peripheral blood from 50 patients with acute lymphoblastic leukemia (ALL) and in 50 peripheral blood samples from healthy volunteers was measured via RT-PCR. Correlation analyses between FHIT gene expression and clinical characteristics (gender, age, white blood count, immunophenotype of acute lymphoblastic leukemia and percentage of blast cells) of the patients were performed. Results: The FHIT gene was expressed at $2.49{\pm}7.37$ of ALL patients against $14.4{\pm}17.9$ in the healthy volunteers. The difference in the expression levels between ALL patients and healthy volunteers was statistically significant. The rate of gene expression did not significantly vary with immunophenotype subtypes. Gene expression was also found to be correlated with increase of total leukocyte and decrease in platelets, but not with age, gender, immunophenotyping or percentage of blast cells. Conclusions: FHIT gene expression is low in acute lymphoblastic leukemia and could be a useful marker to monitor minimal residual disease. This gene is also a candidate target for the immunotherapy of acute lymphoblastic leukemia.

• 한국융합학회논문지
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• 제8권10호
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• pp.311-321
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• 2017

최근 소통과 배려를 통하여 타인과 행복한 삶을 영위하기 위한 방법으로 재능기부에 대한 인식이 높아지고 있다. 본 연구는 재능기부에 참여하고 있는 미용전공자들을 중심으로 참여난관요인, 참여기간, 봉사대상, 참여분야, 참여방식, 참여동기 등의 특성을 분석하자 하였다. 설문응답은 701명의 미용재능기부자들을 대상으로 하였다. 참여난관으로는 능력 및 기술부족, 사회적 인식부족과 여유시간 부족 등으로 나타났다. 참여특성은 성별, 연령, 학력, 직업, 월소득 등에 따라 상이한 차이가 존재하였다. 이러한 연구결과를 토대로 미용재능기부를 위한 활성화 방안과 제언을 제시하였다.

• 한국환경성돌연변이발암원학회지
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• 제22권2호
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• pp.83-89
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• 2002

The single cell gel electrophoresis (comet) assay is one of the useful tools for the study of genetic damage in humans exposed to environmental mutagens and carcinogens. This study was undertaken to evaluate the status of DNA damage in peripheral lymphocytes depending on their sex, age, smoking habits, and other factors in normal healthy Korean population. The 99 volunteers included in the study and out of these, 36 volunteers were smoker and 63 volunteers were non-smoker aged between 20-59 years. All individual answered a questionnaire that assessed their general information including smoking habits and the extent of the environmental tobacco smoke (ETS) exposure, and blood samples were obtained. There was a statistically significant difference in the extent of DNA damage between smoker and non-smoker (p<0.001). A significant difference was also observed between male and female (p<0.001) and amongst the different group of age (p<0.005), however, correlation analysis showed that only smoking habit was a significant factor for DNA damage. No significant effect of smoking duration, number of cigarettes smoking a day, SPY (smoke pack years) in smokers and environmental tobacco smoke exposure in non-smokers on the status of DNA damage was observed.

• 동의생리병리학회지
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• 제26권4호
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• pp.566-571
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• 2012

The purpose of this study was to assess the effects of herbs aroma on relaxation in highly stressed volunteers with heart rate variability(HRV) and SACL(stress arousal check list). 28 highly stressed volunteers participated in this study. The volunteers were examined with heart rate variability(HRV) and SACL(stress arousal check list) before and after smell herbs aroma. After smelling powder incense composed with oriental medicine herbs, mean RR, SDNN, LF, HF, TP were incresed and mean HRV, LF/HF ratio were decreased, but it was not significant. And VLF, norm HF were incresed and norm LF was decreased significantly. This results show that the powder incense composed with oriental medicine herbs effects on decresing sympathetic nervous activity and increasing parasympathetic activity and rebalancing autonomic nervous system who were under stress.

• 동의신경정신과학회지
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• 제19권2호
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• pp.15-39
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• 2008

Objective : The objective of this study was to investigate the effects of breath meditation with neurofeedback on memory, concentration of healthy adult volunteers Method 25 healthy adult volunteers were divided into two groups. One group was treated with breath meditation and real neurofeedback, but the other group was administered with breath meditation and sham neurofeedback three times a week for 10 sessions, Before and after 10 sessions neurofeedback, all subjects were measured by cognitive functions assessment, heart rate variability, BDI, STAI, K-WAIS, HRSD, VAS about amnesia. Results : 1. Breath Meditation decreased error rate and increased concentration, cognition strength, and success rate of Cognitive Functions Assessment. Also, Breath Medication elevated IQ score of K-WAIS short form. 2. Sham : neurofeedback increased concentration, cognition strength compared to Real neurofeedback. Conclusion : The results suggest that breath meditation might effect cognitive function of healthy adult positively, but neurofeedback is not clear. In order to prove whether neurofeedback is effective or not, it should be studied more.

• 한국한의학연구원논문집
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• 제7권1호
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• pp.85-103
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• 2001

Objectives : Assuming that the characteristic of meridian system has been similar to this of electric potentials in human body and that measurements of electric potential at well(井穴) and sea(合穴) points in branches of the twelves meridians will be representative of measurements of the twelve meridians, to measure the electric potentials in twenty aged(TAG) and fifty aged(FAG) healthy volunteers groups when they were sleeping or awakening respectively, to do significance test for electric potential of meridian system among circadian rhythms(CR) and Sasang constitutions(SC). Methods : We selected who thirty healthy volunteers were diagnosed by a blood test, urine examination and differentiation of syndromes by five viscera among volunteers. When they were sleeping, their electric potentials of well and sea points in branches of the twelve meridians were simultaneously measured by physiograph. After a minute we measured them again, totally 5 times. And then when they were awakening, their electric potentials were measured 5 times by the above method. Results : Measurements were analyzed by statistical ANOVA test, we obtained that some of the electric potentials of TAG at sleeping significantly varied with CR, SC, and at awakening some of the electric potentials of FAG also significantly did with CR, SC.

• Archives of Pharmacal Research
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• 제26권5호
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• pp.416-420
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• 2003

The analytical method of antispasmodic agent tiropramide {$(\pm)\alpha$-(benzoylamino)-4-[2-(diethylamino)ethoxy]-N,N-dipropylbenzenepropanamide hydrochloride} was developed by gas chromatography/nitrogen-phosphorus detector (GC/NPD) in human plasma. Two kinds of tiropramide tablets were orally administered to volunteers by Latin square crossover design, and blood was withdrawn as designed schedule. The plasma of 1 mL was loaded on Sep-pak $C_{18}$ cartridge and eluted with methanol after washing with 30% methanol. The residue dissolved in 100 $\mu$L of methanol after evaporation was analyzed by GC/NPD. Precision (CV%) of intra-day was located within 2.6% and accuracy was less than 9.7%. Inter-day precision was below 8.7% and accuracy was relatively good as less than 14%. Plasma samples obtained from human volunteers were analyzed for the determination of tiropramide concentration by using this method. The method was sensitive, rapid and suitable enough to be applied for pharmacokinetic and bioequivalence studies of tiropramide in human volunteers.

• 보건교육건강증진학회지
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• 제25권4호
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• pp.83-92
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• 2008

Objectives: This study was to develop and evaluate a web-based multimedia content for the education of hospice volunteers. Methods: The multimedia content was developed based on Baik's teaching and learning structure plan model. The developed program was evaluated by 24 hospice volunteer university students. Results: On main page, there were 4 menu bars that consisted of a lecture guide, cyber lecture, pause and quiz. In the operation of the web based multimedia content, HTML, Java Script, Photoshop and multimedia technology were utilized. There were significant differences in the test scores, before and after using this web-based learning program. After using a web-based learning program, scores of students were much higher. Conclusion: The developed web based program is based on systematic structure and it can provide hospice volunteers with the educational flexibilities and will be help for them to perform the more efficient hospice care.

• 지역사회간호학회지
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• 제11권2호
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• pp.373-388
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• 2000

The purpose of this study was to investigate the activities of woman volunteers. The sample consisted of 626 woman volunteers working in 18 districts in Kangwon province. The questionnaires consists of three parts: The first part of the questionnaire addresses demographic information. The second part of the questionnaire asks the feelings of subjects concerning volunteer activities (15 items). The third part of the questionnaire was to explore their perspectives of volunteer activities. An SAS was used for frequency. F-test, and a Pearson Correlation. The results of this study were as follows: 1. Most of the subjects were in their 40's(37.7%) and 10.7% were under age 20. About two thirds(69.8%) were housewives, the Buddhists were the highest religious groups (34.9%). Most of the subjects(36.7%) worked at Red-Cross. 2. Most of the subjects(56.8%) have nuclear families. 3. The subjects worked most frequently was at the Social Welfare Center, followed by homes, and welfare centers. 4. The most frequently used direct service was conversation(38.2%) followed by assistance with the eating process. 5. About thirty-nine percent of the subjects had less than one year of experience, and the majority of subjects had volunteer service once per week. 6. There was a significant relationship among age, number of family, duration of volunteer service, and experience. Integrated service will be needed to connect home health nursing with welfare service.

• 대한예방한의학회지
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• 제13권2호
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• pp.27-38
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• 2009

Objective : This study was to examine a relationship among subjective psychological stress, physical stress response and oxidative stress. Methods : The subjects were consisted of 87 healthy volunteers. To assess subjective psychological stress, SRI(stress response inventory) was completed. To assess psychological and physical stress response, HRV(Heart Rate Variability) were tested. To assess oxidative stress, d-roms(Derivatives of reactive oxygen metabolites test) test was conducted. Subjects were divided into 3 groups depending on SRI(Stress Response Inventory) score, low stress response(LSR: lower than 30 percentile), Medium(MSR: 30-70 percentile) and high stress response(HSR: higher than 70 percentile). The Relationship between Stress Response and Oxidative Stress was estimated by correlation and One-way ANOVA analysis. Results : There were no significant differences of demographic data among 3 groups. There was a significant difference of oxidative stress among 3 groups. Conclusion : Our results suggest that there is a weak positive correlation between subjective psychological stress and oxidative stress. There is a significant difference of oxidative stress between HSR group and LSR group.