• Structural Engineering and Mechanics
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• v.66 no.3
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• pp.353-368
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• 2018

In this work, a high order hyperbolic shear deformation theory with four variables is presented to study the vibratory behavior of functionally graduated plates. The field of displacement of the theory used in this work is introduced indeterminate integral variables. In addition, the effect of porosity is studied. It is assumed that the material characteristics of the porous FGM plate, varies continuously in the direction of thickness as a function of the power law model in terms of volume fractions of constituents taken into account the homogeneous distribution of porosity. The equations of motion are obtained using the principle of virtual work. An analytical solution of the Navier type for free vibration analysis is obtained for a FGM plate for simply supported boundary conditions. A comparison of the results obtained with those of the literature is made to verify the accuracy and efficiency of the present theory. It can be concluded from his results that the current theory is not only accurate but also simple for the presentation of the response of free vibration and the effect of porosity on the latter.

• YAKHAK HOEJI
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• v.39 no.6
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• pp.636-644
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• 1995

Comparison of bioavailabflity (BA) of three brands of ranitidine (RT) tablets has been studied m rats. The purpose of this study was to characterize the pharniacolunetics of RT tablets in the rat and to coinpare phannacolunetic parameters of three brands of RT tablets. In addition, it was investigated whether plasma RT concentrations m humans can be predicted from pharmacokinetic parameters obtained in rats. RT was administered intravenously in dose of RT.HCI 10mg/kg and orally in dose of RT.HCI 50mg/kg as solution or crushed sample of thablets. Plasma RT concentrations were determned by HPLC. Plasma RT concentrations as a function of time were fitted to two compartment model. Plasma RT concentrations declined with a terminal half life ($t_{{1}/2{\betha}}$) of 40.9 min. The plasma RT concentration-time curve showed two peak plasma concentrations following an oral administration of solution or crushed sample in rats like humans. No significant difference among pharmacokinetic parameters was observed except $T_{max2}$ (p<0.05). The BA for crushed sample A, B and C were found to be 54.6 40.7 and 40.0%, respectively. Equivalence of $C_{max1}$ and $T_{max2}$ were guaranteed in this study. However, it was concluded that three brands of RT tablets are bioequivalent, taking the following characteristics of RT into consideration;(1) rapid onset of the effect is not required, (2) $C_{max1}$ and $T_{max2}$ do not seem to influence the effectiveness of the drug during a long-term treatment by the usual administration of twice a day. Results from this study were combined with plarmacokinetic data for RT in dogs and humans to develop a basis for interspecies scale-up of the disposition characteristics of the drug. there were similarities in the general disposition of the drug. Allometric relationships were sought between pharmacokinetic parameters nd species body weight. Significant interspecies correlations were found for total body clearance($Cl_{t}$) and steady state volume of distribution ($Bd_{ss}$). Thus, plasma RT concentrations in humans can be predicted from pharmacokinetic parameters obtained in rats.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.379-384
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• 2006

Since the monolithic ceramic substrate was introduced for automotive catalytic converters, the durability of the substrate has been a continuing requirement to reduce the emission gas of vehicle. The substrate can occupy a volume as small as 82 $cm^3$ and as large as 8200 $cm^3$ to provide the required substrate for catalytic activity. The long-term durability varies with the size of the substrate from manufacture's point of view. Therefore This study presents that the response surface model using central composite design can explain size effect on the modulus of rupture in a cordierite ceramic monolithic substrate.

• Imaging Science in Dentistry
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• v.52 no.3
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• pp.283-288
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• 2022

Purpose: This study was conducted to measure the radiation exposure and image quality of various cone-beam computed tomography (CBCT) machines under common clinical conditions and to analyze the correlation between them. Materials and Methods: Seven CBCT machines used frequently in clinical practice were selected. Because each machine has various sizes of fields of view (FOVs), 1 large FOV and 1 small FOV were selected for each machine. Radiation exposure was measured using a dose-area product (DAP) meter. The quality of the CBCT images was analyzed using 8 image quality parameters obtained using a dental volume tomography phantom. For statistical analysis, regression analysis using a generalized linear model was used. Results: Polymethyl-methacrylate (PMMA) noise and modulation transfer function (MTF) 10% showed statistically significant correlations with DAP values, presenting positive and negative correlations, respectively (P<0.05). Image quality parameters other than PMMA noise and MTF 10% did not demonstrate statistically significant correlations with DAP values. Conclusion: As radiation exposure and image quality are not proportionally related in clinically used equipment, it is necessary to evaluate and monitor radiation exposure and image quality separately.

• Structural Engineering and Mechanics
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• v.85 no.5
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• pp.593-605
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• 2023

This work presents a comparison between analytical and finite element analysis for bending of porous sandwich functionally graded material (FGM) plates. The plate is rectangular and simply supported under static sinusoidal loading. Material properties of FGM are assumed to vary continuously across the face sheets thickness according to a power-law function in terms of the volume fractions of the constituents while the core is homogeneous. Four types of porosity are considered. A refined higher-order shear with normal deformation theory is used. The number of unknowns in this theory is five, as against six or more in other shear and normal deformation theories. This theory assumes the nonlinear variation of transverse shear stresses and satisfies its nullity in the top and bottom surfaces of the plate without the use of a shear correction factor. The governing equations of equilibrium are derived from the virtual work principle. The Navier approach is used to solve equilibrium equations. The constitutive law of the porous FGM sandwich plate is implemented for a 3D finite element through a subroutine in FORTRAN (UMAT) in Abaqus software. Results show good agreement between the finite element model and the analytical method for some results, but the analytical method keeps giving symmetric results even with the thickness stretching effect and load applied to the top surface of the sandwich.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.578-589
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• 2003

The fuzzy rat that expresses hypersecretion of sebum and hyperplastic sebaceous glands is a genetic mutant for the study of many pharmacological aspects especially human acne. Through this model, we examined the effects of several phospholipids on the secretion of sebum after topical application. The phospholipid derivatives were phosphatidylcholine (PC), hydrogenated phosphatidylcholine (HPC), phosphati dylserine (PS) and hydrogenated phosphatidylserine(HPS). All agents were dissolved into the vehicle (1, 3-Butanediol, ethanol and water) at 0.5％ weight volume and applied on the dorsal area of the fuzzy rat. To observe histological changes, the skin biopsies were stained with Oil Red O and the size and morphology of sebaceous gland was observed under microscope. Topical treatment with PC and/or HPC showed a marked decrease in sebum excretion. Especially hydrogenated PC (HPC) appeared to have more predominant sebosuppressive function than any other treatment. The other agents such as PS and HPS showed a marginal effect on sebum secretion. With the sebosuppressive activity, HPC and PC seem to have a good potential application on acne treatment. In order to obtain more insights into possible mechanisms behind the above observations, effects of each phospholipid on the expression of peroxisome proliferator-activated receptor (PPAR) genes were investigated. Recently, it has been demonstrated that expression and activation of PPAR subtypes appear to modulate the accumulation of cytoplasmic fat droplets that characterizes the sebocyte differentiation(1). It was also previously suggested that PPAR${\gamma}$ antagonist would seem possible to interfere sebum production without side effects (2). In this study we examined the diverse effects of the tested phospholipids on the expression of several PPAR genes based on reverse transcription-polymerase chain reaction (RT-PCR) from the topically treated skin of fuzzy rats. The results and possible implications are discussed.

• Advances in nano research
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• v.12 no.3
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• pp.301-317
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• 2022

Many studies have shown that Mg-Nd-Zn-Zr (abbreviated as JDBM) alloy has good biocompatibility and biodegradability as well as promotion of cell adhesion, proliferation and differentiation, and Wnt/β-catenin signaling pathway may play a unique role in joint tissue by controlling the function of chondrocytes, osteoblasts and synoviocytes. However, it is not clear whether the JDBM alloy induces osteochondral repair through Wnt/β-catenin signaling pathway. This study aims to verify that JDBM alloy can repair osteochondral defects in rats, which is realized by Wnt/β-catenin signaling pathway. In this study, the osteochondral defect model of the right femoral condyle non-weight-bearing area in rats was established and randomly divided into three groups: Control group, JDBM alloy implantation group and JDBM alloy implantation combined with signaling pathway inhibitor drug ICRT3 injection. It was found that after JDBM alloy implantation, the bone volume fraction (BVF) became larger, the bone trabeculae were increased, the relative expression of osteogenesis gene Runx2, Bmp2, Opn, Ocn and chondrogenesis gene Collagen II, Aggrecan were increased, and the tissue repair was obvious by HE and Masson staining, which could be inhibited by ICRT3.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.15 no.3
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• pp.124-132
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• 2010

In spite of the global importance of primary production of phytoplankton, some primary production data in Korean coastal waters still need to be better processed. The daily rates of water column primary production is generally estimated by integrating the primary production per unit volume over time and depth, but efforts for time integration algorithm have been conducted insufficiently. In this study a mathematical equation evaluating daily primary production integrated over time of a day is proposed and the effectiveness of the model is tested on Saemangeum Lake. The daily primary productions computed with the proposed equation were nearly the same with the results numerically integrated by substituting solar irradiance data. It was suggested that better estimation of primary production would be obtained by using monthly or weekly means of solar irradiance rather than more variable daily data. Because of the vertically heterogenous distribution of phytoplankton, it's hard to integrate the equation over depth to give the daily rates of primary production per unit area of water surface. However, the problem would be solved if, after the vertical distribution of phytoplankton was classified into several patterns and reduced to mathematical formula, every composite function of time integrated equation and chlorophyll distribution equation was integrated successfully.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.1
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• pp.9-18
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• 2015

In this paper, we verify the optimal topology design for heat conduction problems in steady stated which is obtained numerically using the adjoint design sensitivity analysis(DSA) method. In adjoint variable method(AVM), the already factorized system matrix is utilized to obtain the adjoint solution so that its computation cost is trivial for the sensitivity. For the topology optimization, the design variables are parameterized into normalized bulk material densities. The objective function and constraint are the thermal compliance of the structure and the allowable volume, respectively. For the experimental validation of the optimal topology design, we compare the results with those that have identical volume but designed intuitively using a thermal imaging camera. To manufacture the optimal design, we apply a simple numerical method to convert it into point cloud data and perform CAD modeling using commercial reverse engineering software. Based on the CAD model, we manufacture the optimal topology design by CNC.

• International Journal of Highway Engineering
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• v.13 no.4
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• pp.167-175
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• 2011

Evaluation of fuel consumption for the various road condition and vehicle type is necessary to perform the economic analysis of road construction which is important for the efficient design and management of road. Economic analysis of road should consider the social cost which can be divided into agency cost including initial construction expense, maintenance cost, and so on, and user cost consisting of vehicle operating cost, congestion cost, etc. Since vehicle operating cost depends on the traffic volume, fuel consumption that is a major part of vehicle operating cost will change by traffic volume as well. Fuel consumption is significantly affected by vehicle speed and road condition, especially the roughness. Thus, fuel consumption should be evaluated in terms of road condition, which is not currently considered. In this study, the estimation model of fuel consumption for the passenger cars in Korea has been developed by considering the road condition. First, the relationship between vehicle speed and fuel consumption that is used to calculate the vehicle operating cost for investment evaluation of transportation facility and the initial feasibility study of road construction was investigated. Second, with the consideration of road roughness, fuel consumption of the passenger car was measured. From the measurement, it was found that fuel consumption increased by $80m{\ell}$ per 100km driving as the roughness increased by 1m/km. Therefore, it is recommended that for the economic analysis of road design and management, the fuel consumption should be a function of road roughness.