• Journal of Nutrition and Health
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• 제29권9호
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• pp.943-949
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• 1996

Bone mineral density depends largely on the status of dietary minerals such as Ca, P, Mg, and F and proteins, physical activities, parathyroid hormone(PTH), calcitonin(CT), and vitamin D. The decrease of bone density often results in bone fractures and osteoporosis which is prevalent among postmenopausal women. This study was intended to examine the role of parathyroid hormone, calcitonin and cholecaliferol in bone density of mice that were fed different dual photon energy beams. We have measured three major parts of the bone : whole body, head and femur. The results are summarized as follows : 1) Bone mineral density (BMD) was more increased by feeding high Ca diet compared to that of the low Ca diet. 2) Both PTH and Vit D3 enhanced BMD in all of the different Ca levels. 3) When the dietary Ca was deequate CT showed a synergistic effect with PTH in boosting bone density, while CT+Vit D3 showed a negative effect. 4) CT tended to inhibit the effect of increasing bone density by PTH and Vit D3 in medium and low Ca groups. 5) The effect of increasing bone density by PTH in the head of mouse increased when dietary Ca was lower : The increment of bone density by PTH in high, medium, and low Ca was 3%, 8%, 19%, respectively. 6) Femur bone density was affected significantly by dietary Ca levels than hormones. The above observations indicate that bone mineral density can be improved by high dietary Ca and hormone injections including PTH, CT and cholecalciferol, and thus proper dietary and hormonal treatment may be used in preventing bone fractures and osteoporosis.

• Journal of Nutrition and Health
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• 제47권2호
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• pp.89-98
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• 2014

본 연구는 성장기 흰쥐에서 저 적정 고수준의 칼슘과 비타민 D의 첨가식이가 흰쥐의 지질대사에 어떠한 영향을 미치는지 검토하고자 하였다. 56마리의 5주령 된 수컷 흰쥐에게 대조군 (CON; 0.5% Ca, 1,000 IU VD)을 포함하여 식이중의 칼슘의 수준에 따라 저칼슘군 (LC; 0.25%), 고칼슘군 (HC; 1%)으로 설정하였다. 그리고 칼슘 수준에 따라 vitamin D를 저비타민 D군 (LD; 10 IU), 적정비타민 D군 (ND; 1,000 IU), 고비타민 D군 (HD; 5,000 IU)으로 나누어 실험식이를 5주간 급여하였다. 1) 체중 증가량은 HC군이 LC군 보다 유의하게 낮았으나 (p < 0.05), 비타민 D의 수준에 따라서는 유의한 차이가 없었다. 2) 체내 복부지방, 내장지방, 부고환지방의 무게와 렙틴의 농도는 HC군이 LC군보다 유의하게 낮았다 (p < 0.01). 3) 25(OH)D의 농도는 비타민 D의 섭취수준이 증가할수록 유의하게 높아졌다 (p < 0.01). 부갑상선호르몬 농도는 실험군간 비교에서 LCLD군에서 가장 높았다 (p < 0.05). 4) 혈중 TG, T-C, HDL-C, LDL-C 농도는 HC군이 LC군에 비해 유의하게 낮았으며 (p < 0.01), HDL-C 농도의 경우 LCHD군에서 유의하게 높았다 (p < 0.05). 5) 여러 가지 지표간의 상관성을 분석한 결과 칼슘의 섭취와 혈중 지질성분, 체내 복부, 내장, 부고환지방무게가 모두 유의한 음의 상관관계를 보였다 (p < 0.01). 또한 비타민 D 섭취와 혈중 HDL-C농도가 유의한 양의 상관관계를 보였다 (p < 0.05). 혈중 부갑상선호르몬 농도와 혈중 TG농도, 체내 부고환지방과는 유의한 양의 상관관계를 보였다 (p < 0.01, p < 0.05). 혈중 leptin 농도와 혈중 T-C, TG농도, 체내 복부, 내장, 부고환 지방 무게는 모두 양의 상관관계를 보였다 (p < 0.01). 이상과 같은 결과로 볼 때 성장기 흰 쥐의 지질대사에서 낮은 수준의 칼슘 섭취는 체중증가량의 폭을 높임과 동시에 혈중 지질의 증가에 영향을 미치며 뿐만 아니라 체내 지방축적을 증가시키는 것으로 나타났다. 또한 낮은 수준의 칼슘섭취 시 비타민 D 섭취에 의한 지질대사는 HDL-C 농도를 높이는 효과를 나타냈다. 그러므로 체내 지질 대사를 개선하기 위해서는 적정량의 칼슘의 섭취뿐만 아니라 비타민 D 섭취와의 관계를 반드시 고려하여야 할 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7749-7755
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• 2013

Nutritional status and dietary intake play a significant role in the prognosis of breast cancer and may modify the progression of disease. The aim of this study was to determine the influence of nutritional status on the quality of life of Iranian breast cancer survivors. Cross-sectional data were collected for 100 Iranian breast cancer survivors, aged 32 to 61 years, attending the oncology outpatient clinic at Golestan Hospital, Ahvaz, Iran. Nutritional status of subjects was assessed by anthropometric measurements, Patient-Generated Subjective Global Assessment (PG-SGA) and three non-consecutive 24-hour diet recalls. The European Organization of Research and Treatment of Cancer Quality of Life form (EORTC QLQ-C30) was used to assess quality of life. Ninety-four percent of the survivors were well-nourished, 6% were moderately malnourished or suspected of being malnourished while none were severely malnourished. Prevalence of overweight and obesity was 86%. Overall, participants had an inadequate intake of vitamin D, E, iron and magnesium according to dietary reference intake (DRI) recommendations. Survivors with better nutritional status had better functioning scales and experienced fewer clinical symptoms. It appears important to provide educational and nutritional screening programs to improve cancer survivor quality of life.

• 한국식품영양과학회지
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• 제39권1호
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• pp.78-84
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• 2010

본 연구는 부산시 해운대구 보건소에서 과체중 이상인 30세 이상 중년여성을 대상으로 스스로 평생 자기 건강관리를 할 수 있는 능력을 키울 수 있는 건강 체중조절 프로그램을 개발하여 운영하고, 효과적인 영양교육의 필요성과 체계적이고 지속적인 체중조절 프로그램의 운영방안을 마련하고자 하였다. 상반기, 하반기로 2차례에 걸쳐서 과체중 이상인 해운대구 거주 주민 여자 53명을 선착순 모집하여 프로그램을 운영하였다. 프로그램 시작 전후에 건강검진, 체력측정, 체성분측정, 설문조사를 하고, 건강상태와 비만도에 따른 결과를 개인상담으로 실시하였으며, 영양교육은 비만 특강(1시간)을 시작으로, 소그룹별로 4주간 매주 1회 실시한 결과는 다음과 같다. 영양교육과 운동프로그램 전후의 대상자의 체중, BMI는 유의적으로 감소(p<0.001)하였으며 체격 및 체력검사결과 허리둘레, 엉덩이둘레, 상완배부, 견갑하연부는 유의적으로 감소하였으며(p<0.001), 배근력(p<0.001), 악력(p<0.01)은 유의적으로 증가하였다. 또한 영양교육과 운동프로그램 실시 후에 공복 시 혈당(p<0.001), 중성지방(p<0.01)의 농도는 유의적으로 감소하였다(p<0.01). 건강 상태에 대한 평가 결과, 스스로의 건강상태에 대해 긍정적으로 변화되었고, 프로그램 실시 후에 건강관리를 위해서 운동을 중요시하는 양상을 보였다. 영양소 섭취 상태 조사 결과 비타민 D의 섭취량은 유의적으로 증가하였으며(p<0.05). 식습관 조사와 영양지식평가 결과, 평균점수가 유의적인 증가를 보였다(p<0.001). 4주간의 영양교육과 운동프로그램 실시 후 대상자의 식습관과 비만도, 혈액수치에 있어서 긍정적인 영향을 미쳤다고 사료되며, 교육효과를 더 증진시키기 위한 보다 체계적이고 지속적인 영양교육 프로그램의 개발이 필요하며 잘못된 식습관으로 인한 영양불균형이 성인병 등을 유발하지 않도록 평소 균형된 식생활이 이루어지도록 하여야 할 것이다.

• 한국치위생학회지
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• 제19권3호
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• pp.387-397
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• 2019

Objectives: This study was conducted to examine the subjects' oral health status and changes in the oral environment after mouthwash with effervescent Vitamin C and its intake and to understand the impact on changes in the number of bacteria causing periodontal diseases in the oral cavity based on the oral health status and oral environmental condition. Methods: After obtaining approval from the Institutional Review Board of D-University, 45 people (24 in an experimental group and 21 in a control group) who participated in the oral health program were selected, among visitors of the Clinical Dental Hygienics Laboratory of D. University in B. Results: Based on the subjects' periodontal health status, the number of bacteria causing periodontal diseases in the oral cavity decreased in both experimental and control groups before and after the experiment. However, in the experimental group, it was significant when the Bleeding on Probing(BOP) level was below average, and Calculus index(CAL) was above average, in Aggregatibacter actinomycetemcomitans and the red complex. It was also significant when CAL was above average in the orange complex in the control group. Regarding bacterial changes in periodontal diseases based on the subjects' oral environmental condition, there was a significant change in the Adenosine Tri Phosphate (ATP : intraoral contaminants test) test in the oral cavity in A. actinomycetemcomitans and the red complex in the experimental group and in the O'Leary index in the control group. Further, there was a significant change in the orange complex in the ATP test in the experimental group. Conclusions: A comprehensive analysis of the results revealed that the oral health care program for dental hygiene decreased the number of bacteria causing periodontal diseases in the oral cavity in both experimental and control groups.

• 한국식품영양과학회지
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• 제29권1호
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• pp.99-105
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• 2000

The purpose of this study was to evaluat the Zn, Cu, Mn and Ni status and correlation of their concentrations in serum, urine, hair and fingernail in female college students. As the results are follows; The mean age of subjects was 22.5 years and height, weight and BMI were 160.1 cm, 51.0 kg and 20.0 respectively. The daily intake of energy 1769.5 kcal and the ratio of carbohydrate, fat and protein for energy is 60 : 20 : 15. The daily intake of energy (88.5%), vitamin B2 (86.1%), Ca (75.4%), Fe (58.3%) and Zn (63.0%) of subjects did not reach to Korean Recommended Dietary Allowance (RDA). The daily mean intake of Zn, Cu, Mn and Ni were 7.56 mg, 2.30 mg, 3.81 mg and 0.18 mg respectively. The concentrations of Zn in serum, urine, hair and nail were 85.6$\mu\textrm{g}$/dL, 391.2$\mu\textrm{g}$/day, 174.6$\mu\textrm{g}$/g and 102.4$\mu\textrm{g}$/g respectively and those Cu were 84.2$\mu\textrm{g}$/dL, 56.6 $\mu\textrm{g}$/day, 20.3$\mu\textrm{g}$/g and 4.3$\mu\textrm{g}$/g respectively. The concentrations of Mn in serum, urine, hari and nail were 0.2$\mu\textrm{g}$/dL, 1.1$\mu\textrm{g}$/day, 1.8$\mu\textrm{g}$/g and 1.6$\mu\textrm{g}$/g respectively and those of Ni were 0.6$\mu\textrm{g}$/dL, 24.5$\mu\textrm{g}$/day, 3.5$\mu\textrm{g}$/g and 3.1$\mu\textrm{g}$/g respectively. The daily intake of Mn showed the positive correlations with concentration of Mn in hair (p<0.05) and the daily intake of Ni was positively correlated with urinary exretion (p<0.05) and hair contents (p<0.001) of Ni. The more detailed studies about these trace mineral status should be required.

• 동의생리병리학회지
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• 제20권1호
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• pp.31-36
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• 2006

The aim of this study was to elucidate the mechanism of anemia associated with Dangguibohyel-tang (DBT) in rats. Using cyclophosphamide-induced (30mg/kg BW) anemic rats, changes in weight gain, the levels of red blood cell (RBC), hematocrit (Hct), platelet and hemoglobin (Hgb), serum vitamin B12, ALT(GPT) levels and erythropoietin (EPO) gene expression were monitored, and compared with DBT (1,000mg/kg BW, 14d)-treated and EPO (1,000IU/kg BW, 14d, s.c.)-treated rats. Food efficiency ratio (FER) were 31.6%, in normal group, 28.1% in cyclophosphamide-induced control group, 31.7% in DBT-treated group and 25.1%, in EPO-treated group after 14 days. The levels of red blood cell (RBC), hematocrit (Hct), platelet and hemoglobin (Hgb) of DBT-treated group were significantly higher than those of control. And DBT extract administered group showed dominant effects on the recovery of Hgb level. Serum vitamin B12 and ALT(GPT) levels were significantly increased at DBT-treated groups. EPO gene expression was decreased 91,9% in control group, 79.6% in DBT-treated group and 53.9% in EPO-treated group, respectively. These results suggest that administration of DBT could prevent human patient from chemotherapy derived anemia by improving hematological value and EPO status.

• 대한지역사회영양학회지
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• 제2권2호
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• pp.141-150
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• 1997

This study was designed to investigate the obesity rate with anthropometric indices, nutritional status and serum lipid levels of 260 school children from 5th grade of elementry school residing in Puchon city. Obesity was defined as fat percentage that exceeds 25$\%$. The prevalence rate of obesity were 15.2$\%$ for male and 14.1$\%$ for female. Mean fat percentage, BMI and Rohrer indice of obese male were 30.3$\%$, 21.0 and 150.2 respectively and 28.0$\%$, 21.5 and 151.9 for obese female. Mean serum TG, apo-B of obese female was significantly lower than that of non-obese. Obese male did not show any difference in serum lipid levels. The proportion of students whose serum cholesterol levels exceed 170mg/dI, which is cutoff point of bordeline for coronary artery disease, was 12.0% for male and 15.6$\%$ for female. The major factors affecting nutritional status were the amount of living expense, existence of mother's job and the regularity of having breakfast. Children who's living expense more than 500 thousants Won showed lower intake of Iron, vitamin A, thiamin, niacin and ascorbic acid(p$\ll$0.05). Children who's mothers are having a job were observed with decreased height(p$\ll$0.05). Children having breakfast regularly showed increased BMI and Rohrer indice than those of children having breakfast often of never.

• 동아시아식생활학회지
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• 제16권2호
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• pp.145-155
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• 2006

This study investigated the correlation of the nutritional status of antioxidant vitamins and serum lipids and MDA levels in postmenopausal women. Data about general characteristics, dietary intakes and biochemical parameters, including serum lipids, MDA and antioxidant vitamins levels, were collected from 85 postmenopausal women. The subjects were classified into three groups according to their serum total cholesterol level: normocholesterolemia group (NC, < 200 mg/dL), moderate hypercholesterolemia group (MC, $200{\sim}239mg/dL$) and hypercholesterolemia group(HC, ${\geq}240mg/dL$). The results are as follows. 1) General characteristics and serum MDA levels were not significantly different among the three groups. 2) Daily nutrients intakes adjusted to energy intake were not significantly different among the three groups, and were compatible with dietary reference intakes (DRIs) for Koreans. 3) Dietary Vt. A, ${\beta}-carotene$, Vt. C and Vt. E intake were not significantly different among the groups, while Vt. E intake was positively related with serum TC (r=0.288, p<0.05) and triglyceride (r=0.341, p<0.001) levels. 4) Serum Vt. A level standardized by serum TC level was significantly low and serum Vt. E level was significantly high in the HC group. Serum Vt. E level was positively related with serum TC level (r=0.389, p<0.001). 5) Dietary Vt. E intake was negatively correlated to serum MDA level (r=-0.242 p<0.05). Serum Vt. C and Vt. E levels were also negatively correlated to serum MDA level (r=-0.312, p<0.001 and r=-0.299, p<0.05). When the correlation was analyzed only in the group with hypercholesterolemia, correlation coefficients between the antioxidant vitamin and serum MDA level were higher. We concluded that intakes of antioxidant vitamins can contribute to decreasing the risk of cardiovascular disease by decreasing the oxidative stress of body rather than by controlling serum lipid levels.

• Animal Bioscience
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• 제34권2호
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• pp.276-284
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• 2021

Objective: The objective of this study was to determine whether a dietary vitamin E (VE) supplement could alleviate any detrimental effects of aged corn on lipid metabolism and antioxidant status in laying hens. Methods: The experiment consisted of a 2×3 factorial design with two corn types (normal corn and aged corn (stored for 4 yr) and three concentrations of VE (0, 20, and 100 IU/kg). A total of 216 Lohmann laying hens (50 wk of age) were randomly allocated into six treatment diets for 12 wk. Each treatment had 6 replicates of 6 hens per replicate. Results: The results show that aged corn significantly decreased the content of low-density lipoprotein cholesterol (p<0.05), and reduced chemokine-like receptor 1 (CMKLR1) mRNA expression (p<0.05) in the liver compared to controls. Diet with VE did not alter the content of crude fat and cholesterol (p>0.05), or acetyl-CoA carboxylase, lipoprotein lipase, fatty acid synthase or CMKLR1 mRNA expression (p>0.05) in the liver among treatment groups. Aged corn significantly increased the content of malondialdehyde (MDA) (p<0.05) and decreased superoxide dismutase (SOD) activity (p<0.05) in the liver. The VE increased the content of MDA (p<0.05) but decreased glutathione peroxidase (GSH-Px) activity in serum (p<0.01) and in the ovaries (p<0.05). Adding VE at 20 and 100 IU/kg significantly increased GSH-Px activity (p<0.05) in liver and in serum (p<0.01), 100 IU/kg VE significantly increased SOD activity (p<0.05) in serum. Aged corn had no significant effects on GSH-Px mRNA or SOD mRNA expression (p<0.01) in the liver and ovaries. Addition of 100 IU/kg VE could significantly increase SOD mRNA expression (p<0.01) in the liver and ovary. Conclusion: Aged corn affected lipid metabolism and decreased the antioxidant function of laying hens. Dietary VE supplementation was unable to counteract the negative effects of aged corn on lipid metabolism. However, addition of 100 IU/kg VE prevented aged corninduced lipid peroxidation in the organs of laying hens.