• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2489-2493
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• 2015

Background: Loss of heterozygosity (LOH) on chromosomal regions is crucial in tumor progression and this study aimed to identify genome-wide LOH in pancreatic cancer. Materials and Methods: Single-nucleotide polymorphism (SNP) profiling data GSE32682 of human pancreatic samples snap-frozen during surgery were downloaded from Gene Expression Omnibus database. Genotype console software was used to perform data processing. Candidate genes with LOH were screened based on the genotype calls, SNP loci of LOH and dbSNP database. Gene annotation was performed to identify the functions of candidate genes using NCBI (the National Center for Biotechnology Information) database, followed by Gene Ontology, INTERPRO, PFAM and SMART annotation and UCSC Genome Browser track to the unannotated genes using DAVID (the Database for Annotation, Visualization and Integration Discovery). Results: The candidate genes with LOH identified in this study were MCU, MICU1 and OIT3 on chromosome 10. MCU was found to encode a calcium transporter and MICU1 could encode an essential regulator of mitochondrial $Ca^{2+}$ uptake. OIT3 possibly correlated with calcium binding revealed by the annotation analyses and was regulated by a large number of transcription factors including STAT, SOX9, CREB, NF-kB, PPARG and p53. Conclusions: Global genomic analysis of SNPs identified MICU1, MCU and OIT3 with LOH on chromosome 10, implying involvement of these genes in progression of pancreatic cancer.

• 한국정보과학회논문지:시스템및이론
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• 제33권4호
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• pp.216-222
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• 2006

벡터 필드는 공간상에 눈으로 보이지 않거나 표현하기 어려운 데이타의 진행을 이해 하기 쉽게 표현하는데 많이 사용되고 있다. 예를 들면, 바람이나 물의 진행 방향 및 세기, 온도의 전도, 전자기파 등의 과학적인 데이타의 시각화에 사용되고 있다. 본 연구에서는 3차원 모델상에 존재하는 벡터 필드에 대해 시각적인 정보와 더불어 촉각을 통한 직관적인 인식을 제공하기 위한 햅틱 렌더링 기술을 개발하였다. 이를 구현하기 위해 벡터 필드를 햅틱 인터페이스에 적합하게 모델링 하는 기법과 시뮬레이션 기술을 개발하였다. 이를 바탕으로 일상생활에 사용되는 지도에서 사용자가 원하는 목적지로 햅틱 인터페이스를 통해 안내해 주는 햅틱 맵과 해류의 흐름을 보여주는 시각적인 벡터 필드를 사용자가 촉각을 통해 직관적으로 느낄 수 있도록 해주는 시스템에 적용하였다. 앞으로 교육, 훈련, 그리고 오락 등 다양한 분야에서 이러한 햅틱 벡터 필드 기술이 사용될 수 있을 것으로 기대된다.

• Imaging Science in Dentistry
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• 제46권3호
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• pp.159-165
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• 2016

Purpose: The purpose of this study was to detect the anterior loop of the mental nerve and the mandibular incisive canal in panoramic radiographs (PAN) and cone-beam computed tomography (CBCT) images, as well as to determine the anterior/mesial extension of these structures in panoramic and cross-sectional reconstructions using PAN and CBCT images. Materials and Methods: Images (both PAN and CBCT) from 90 patients were evaluated by 2 independent observers. Detection of the anterior loop and the incisive canal were compared between PAN and CBCT. The anterior/mesial extension of these structures was compared between PAN and both cross-sectional and panoramic CBCT reconstructions. Results: In CBCT, the anterior loop and the incisive canal were observed in 7.7% and 24.4% of the hemimandibles, respectively. In PAN, the anterior loop and the incisive canal were detected in 15% and 5.5% of cases, respectively. PAN presented more difficulties in the visualization of structures. The anterior/mesial extensions ranged from 0.0 mm to 19.0 mm on CBCT. PAN underestimated the measurements by approximately 2.0 mm. Conclusion: CBCT appears to be a more reliable imaging modality than PAN for preoperative workups of the anterior mandible. Individual variations in the anterior/mesial extensions of the anterior loop of the mental nerve and the mandibular incisive canal mean that is not prudent to rely on a general safe zone for implant placement or bone surgery in the interforaminal region.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.787-792
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• 2015

Background: Non-Hodgkins lymphoma (NHL) is a heterogeneous group of malignancies, originating in the lymphatic organs, whose incidence is increasing in developed as well as developing countries. Epidemiological evidence suggests that aspirin may reduce the incidence and mortality of several cancers. The main objective of this study was to evaluate the potential relationship between using aspirin and development of NHL with a meta-analysis. Materials and Methods: A total of 7 studies were included. Outcome was calculated and reported as odds ratios (ORs). Heterogeneity was assessed with Cochrane Q and $I^2$ statistics. Dissemination bias was evaluated by funnel plot visualization and trim-and-fill analysis. Results: Our analysis showed OR of developing NHL overall of 1(95% CI: 0.87-1.16, p=0.9), and in females this was 0.81 (95%CI: 0.72-.92, p=0.001) and in males 1.01 (95%CI: 0.82-1.26, p=0.86). The odds ratio (OR) of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) was 0.85 (95%CI: 0.75-0.97, p=0.02), The ORs of follicular lymphoma (FL) and large B-cell lymphoma (DLBCL) in individuals exposed to aspirin were 1.12 (95%CI: 0.86-1.45, p=0.37) and 1.03 (95%CI: 0.9-1.19, p=0.6) respectively. Conclusions: In conclusion, individuals taking aspirin do not demonstrate any change in risk of Non-Hodgkins lymphoma.

• International Journal of Reliability and Applications
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• 제7권1호
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• pp.27-39
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• 2006

Many real world cases in material failure analysis do not follow perfectly the normal distribution. Forcing of the normality assumption may lead to inaccurate predictions and poor product quality. We examine the failure process of the internal bond (IB or tensile strength) of medium density fiberboard (MDF). We propose a forced censoring technique that closer fits the lower tails of strength distributions and better estimates extremely smaller percentiles, which may be valuable to continuous quality improvement initiatives. Further analyses are performed to build an accelerated common-shaped Weibull model for different product types using the $JMP^{(R)}$ Survival and Reliability platform. In this paper, a forced censoring technique is implemented for the first time as a software module, using $JMP^{(R)}$ Scripting Language (JSL) to expedite data processing, which is crucial for real-time manufacturing settings. Also, we use JSL to automate the task of fitting an accelerated Weibull model and testing model homogeneity in the shape parameter. Finally, a package script is written to readily provide field engineers customized reporting for model visualization, parameter estimation, and percentile forecasting. Our approach may be more accurate for product conformance evaluation, plus help reduce the cost of destructive testing and data management due to reduced frequency of testing. It may also be valuable for preventing field failure and improved product safety even when destructive testing is not reduced by yielding higher precision intervals at the same confidence level.

• Imaging Science in Dentistry
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• 제39권1호
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• pp.41-49
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• 2009

Purpose: To detect the progression of experimentally induced periapical lesions on periapical radiograph and cone beam computed tomograph (CBCT) by quantitative analysis. Materials and Methods: After the removal of coronal pulps from premolars of two Beagle dogs, the root canals of premolars were exposed to oral environment during one week and then sealed for 70 days. Digital periapical radiographs and CBCTs were taken at baseline and every 7 days for 77 days after pulp exposure. We examined occurrence and areas of periapical bone resorption. Three comparative groups of CBCT radiographs were prepared by average projection of thin slabs with different bucco-lingual thicknesses (0.1, 3.0, and 8.0 mm) using a 3D visualization software. Radiographic densities were compensated by image normalization. Digital images were processed with mathematical morphology operations. The radiographic density and morphological features of periapical lesions were compared among three groups of CBCT in different time points. Results: In the CBCT group with 0.1 mm thickness, radiographic density (p<0.05) and trabecular bone area (p<0.01) were significantly decreased at the fifth week. However, in the CBCT groups with 3 mm and 8 mm thickness and periapical radiographs, none of densitometric and morphological features showed any significant differences in different time points. Radiographic density of periapical lesion showed increasing tendency at the eleventh week after pulp exposure. Conclusion: Radiographic detection of periapical lesions was possible at the fifth week after pulp contamination by quantitative method and was affected by buccolingual bone thickness.

• 대한기계학회논문집B
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• 제35권2호
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• pp.153-160
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• 2011

레이저가공에서 가공부위의 용융물질을 제거하는 보조가스의 역할을 살펴보기 위하여, 절단경사면에 충돌하는 초음속 동축/탈축노즐 유동의 특성이 실험적으로 관찰되었다. 보조가스의 압력, 노즐과 절단면과의 사이거리, 절단폭, 그리고 탈축노즐의 위치 등 다양한 관계변수의 변화에 대하여, 수백 개의 고해상도의 쉴러린 영상이 획득되었다. 그 결과, 단순한 보조가스의 증가가 절단면 하부에서 발생하는 유동박리를 제거하는데 효율적이지 않음이 관찰되었고, 절단폭의 증가와 탈축노즐의 운용으로 절단면에서의 박리현상을 경감시킬 수 있음이 확인되었다. 또한 음속노즐에 비하여 초음속노즐의 경우는 노즐출구와 가공면 사이의 사이거리가 절단면에서의 박리현상에 큰 영향을 미치지 않음이 관찰되었다.

• Composites Research
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• 제29권5호
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• pp.288-292
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• 2016

본 연구에서는 전영역 초음파전파영상화 시스템이라 불리는 새로운 초음파전파영상화 장치를 소개한다. 본 시스템은 비파괴적으로 구조를 2 축 선형 이동 스테이지 기반으로 검사한다. 일치된 초음파 센싱과 가진 레이저 빔이 구조를 스캔하며 동시에 펄스-에코 모드 레이저 초음파를 수집한다. 이 과정은 스캔영역만큼 큰 두께 방향의 전영역 초음파를 생성하는 것을 가능하도록 한다. 본 시스템을 사용하여 실제로 운용 중인 알루미늄 허니콤 구조 기반의 CN-235의 도색된 샌드위치 조종면를 검사 및 평가하고 구조 검사 결과로써 전영역 초음파전파 영상을 소개하였으며 기존 초음파 탐상 기법의 결과와 비교하여 성능 및 민감도를 검증하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7507-7512
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• 2015

Background: In the low incoming country Bangladesh, breast cancer is second most common neoplasm and is increasing at an alarming rate among females. Lack of awareness and illiteracy are contributory factors for late presentation and therefore mortality. Purpose: To examine associations of different factors with breast cancer mortality and to raise awareness among the women of society in Bangladesh. Materials and Methods: This descriptive case-control study was conducted on 160 participants from April 2011 till July 2014. Through a valid questionnaire covering personal and family history, data were collected by face to face interview. For analyzing correlations among factors with breast cancer data, binary logistic regression, Pearson's ${\chi}^2$-value, odd ratios and p-value tests were conducted with SPSS version 20. Results: The mean age of the patients was 43.0 ($SD={\pm}11.12$). In ascending order the leading significant factors were hormone therapy (p<0.0000, OR=4.897), abortion (p<0.0001, OR=3.452), early start menarche (p<0.0002, OR=3.500), family history (p<0.0022, OR=3.235), and late menopause (p<0.0093, OR=3.674) with both ${\chi}^2$ test and logistic regression analyses. Non-significant factors were cancer experience, fatty food habits, marital status and taking alcohol. Conclusions: Regarding the investigation of this study, significant and insignificant factor's correlation visualization with breast cancer will be helpful to increase awareness among Bangladeshi women as well as all over the world.

• Advances in Computational Design
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• 제5권2호
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• pp.127-146
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• 2020

Building Information Modeling (BIM) is increasingly used throughout the facility's life cycle for various applications, such as design, construction, facility management, and maintenance. For existing buildings, the geometry of as-built BIM is often constructed using dense, three dimensional (3D) point clouds data obtained with laser scanners. Traditionally, as-built BIM systems do not contain the material and textural information of the buildings' elements. This paper presents a semi-automatic method for generation of material and texture rich as-built BIM. The method captures and integrates material and textural information of building elements into as-built BIM using thermal infrared sensing (TIS). The proposed method uses TIS to capture thermal images of the interior walls of an existing building. These images are then processed to extract the interior walls using a segmentation algorithm. The digital numbers in the resulted images are then transformed into radiance values that represent the emitted thermal infrared radiation. Machine learning techniques are then applied to build a correlation between the radiance values and the material type in each image. The radiance values were used to extract textural information from the images. The extracted textural and material information are then robustly integrated into the as-built BIM providing the data needed for the assessment of building conditions in general including energy efficiency, among others.