• The Korean Journal of Applied Statistics
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• v.25 no.6
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• pp.987-997
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• 2012

The sales volume of men's cosmetics has drastically increased in Korea. In recent years, men's needs for cosmetics have been diversified and the consumer demand for functional cosmetics has greatly risen. In particular, male consumers have become more interested in essence product that is a light and concentrated treatment to correct skin problems. This research analyzes consumer preferences for essence-for-men through the use of choice-based conjoint analysis. This approach is adopted since the task of respondents to choose the most preferred option from several alternatives closely mimics actual marketplace purchasing behavior by consumers. New technique for the construction of choice sets is suggested based on the balanced incomplete block design, to accommodate a larger number of product profiles. The proposed design for choice sets is balanced and provides a tool to filter the contradictory choices. Conjoint analyses are performed to assess the relative importance of attributes and identify the most preferred profile of essence-for-men with respect to attributes such as emphasized function, price, type of content, and design of container. Some differences are indicated in the analysis results between age brackets as well as between groups classified by the amount of fashion item expenditures.

• Journal of Korea Multimedia Society
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• v.17 no.5
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• pp.640-653
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• 2014

Recently medical consumers pursue high leveled quality of life through active promotion, prevention, management activity of health as the importance of health during home life is emerged to meet the aging society and chronic diseases. In addition, people are directed to the m-Health for managing yourself their health by using smartphone and various personal health devices, if necessary transmits health data to the physician himself. In the previous studies, m-Health Application were developed and applied in the real clinical environment by adopting the medical information standards was rarely conducted. Therefore, in this study, the m-Health application platform was developed. Developed application was communicate with IEEE 11073 standard protocol using the Bluetooth Health Device Profile in personal health device via smart phone to process blood pressure information, and it converted to HL7 V2.6 ORU_R01 message for send to remote medical server. In addition, we tested the interoperability and safety of the developed application for 23 inpatient and 17 outpatient at D University Hospital. As a result, the blood pressure information has been transmitted without error.

• Structural Engineering and Mechanics
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• v.51 no.4
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• pp.627-641
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• 2014

Functionally graded steels (FGSs) are a family of functionally graded materials (FGMs) consisting of ferrite (${\alpha}$), austenite (${\gamma}$), bainite (${\beta}$) and martensite (M) phases placed on each other in different configurations and produced via electroslag remelting (ESR). In this research, the flow stress of dual layer austenitic-martensitic functionally graded steels under hot deformation loading has been modeled considering the constitutive equations which describe the continuous effect of temperature and strain rate on the flow stress. The mechanism-based strain gradient plasticity theory is used here to determine the position of each layer considering the relationship between the hardness of the layer and the composite dislocation density profile. Then, the released energy of each layer under a specified loading condition (temperature and strain rate) is related to the dislocation density utilizing the mechanism-based strain gradient plasticity theory. The flow stress of the considered FGS is obtained by using the appropriate coefficients in the constitutive equations of each layer. Finally, the theoretical model is compared with the experimental results measured in the temperature range $1000-1200^{\circ}C$ and strain rate 0.01-1 s-1 and a sound agreement is found.

• Journal of The Korean Astronomical Society
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• v.51 no.6
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• pp.185-195
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• 2018

Galaxy clusters are known to host many active galaxies (AGNs) with radio jets, which could expand to form radio bubbles with relativistic electrons in the intracluster medium (ICM). It has been suggested that fossil relativistic electrons contained in remnant bubbles from extinct radio galaxies can be re-accelerated to radio-emitting energies by merger-driven shocks via diffusive shock acceleration (DSA), leading to the birth of radio relics detected in clusters. In this study we assume that such bubble consist primarily of thermal gas entrained from the surrounding medium and dynamically-insignificant amounts of relativistic electrons. We also consider several realistic models for magnetic fields in the cluster outskirts, including the ICM field that scales with the gas density as $B_{ICM}{\infty}n^{0.5}_{ICM}$. Then we perform time-dependent DSA simulations of a spherical shock that runs into a lower-density but higher-temperature bubble with the ratio $n_b/n_{ICM}{\approx}T_{ICM}/T_b{\approx}0.5$. We find that inside the bubble the shock speed increases by about 20 %, but the Mach number decreases by about 15% in the case under consideration. In this re-acceleration model, the observed properties of a radio relic such as radio flux, spectral index, and integrated spectrum would be governed mainly by the presence of seed relativistic electrons and the magnetic field profile as well as shock dynamics. Thus it is crucial to understand how fossil electrons are deposited by AGNs in the ICM and how the downstream magnetic field evolves behind the shock in detailed modeling of radio relics.

• Journal of Microbiology and Biotechnology
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• v.32 no.1
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• pp.126-140
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• 2022

Stem cells can be applied usefully in basic research and clinical field due to their differentiation and self-renewal capacity. The aim of this study was to establish an effective novel therapeutic cellular source and create its molecular expression profile map to elucidate the possible therapeutic mechanism and signaling pathway. We successfully obtained a mesenchymal stem cell population from human embryonic stem cells (hESCs) cultured on chemically defined feeder-free conditions and treated with connective tissue growth factor (CTGF) and performed the expressive proteomic approach to elucidate the molecular basis. We further selected 12 differentially expressed proteins in CTGF-induced hESC-derived mesenchymal stem cells (C-hESC-MSCs), which were found to be involved in the metabolic process, immune response, cell signaling, and cell proliferation, as compared to bone marrow derived-MSCs(BM-MSCs). Moreover, these up-regulated proteins were potentially related to the Wnt/β-catenin pathway. These results suggest that C-hESC-MSCs are a highly proliferative cell population, which can interact with the Wnt/β-catenin signaling pathway; thus, due to the upregulated cell survival ability or downregulated apoptosis effects of C-hESC-MSCs, these can be used as an unlimited cellular source in the cell therapy field for a higher therapeutic potential. Overall, the study provided valuable insights into the molecular functioning of hESC derivatives as a valuable cellular source.

• Journal of Ocean Engineering and Technology
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• v.36 no.2
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• pp.125-131
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• 2022

Structural design for shipbuilding is generally divided into three stages: the basic, detailed, and production designs, of which the production design is the most frequently revised among the three design stages. The revision involved in production design department was approximately 61% of the total 4,211 revision members and approximately 56% of the total 710 revision cases in the survey on the number of design revisions for nine ships. In this study, members and drawings with a high revision rate were investigated, and related design departments were identified. In addition, the work contents of the design department were analyzed to reduce the number of design revisions and three tasks are very frequently revised were selected. A survey was conducted with engineers engaged in the production design, after which, standards were proposed for the method of aggregating bills of materials, to employ macros to calculate the length of members and that of profile input data when reviewing drawings. Via the study, it was determined that the major causes of design revision are simple mistakes by engineers or lack of understanding on structural arrangement of basic members more than intricacies of prior design and high level specification. As a result of applying the proposed standards, it was confirmed that the design revision was reduced by approximately 40%.

• Steel and Composite Structures
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• v.43 no.5
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• pp.533-552
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• 2022

The current article deals with the dynamic stability, and structural improvement of vibrating electrically curved screen on the viscoelastic substrate. By considering optimum value for radius curvature of the electrically curved screen, the structure improvement of the system occurs. For modeling the electrically system, the Maxwell's' equation is developed. Hertz contact model in employed to obtain contact forces between impactor and structure. Moreover, variational methods and nonlinear von Kármán model are used to derive boundary conditions (BCs) and nonlinear governing equations of the vibrating electrically curved screen. Galerkin and Multiple scales solution approach are coupled to solve the nonlinear set of governing equations of the vibrating electrically curved screen. Along with the analytical solution, 3D finite element simulation via ABAQUS package is provided with the aid of a FE package for simulating the current system's response. The results are categorized in 3 different sections. First, effects of geometrical and material parameters on the vibrational performance and stability of the curves panel. Second, physical properties of the impactor are taken in to account and their effect on the absorbed energy and velocity profile of the impactor are presented. Finally, effect of the radius and initial velocity on the mode shapes of the current structure is demonstrated.

• The korean journal of orthodontics
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• v.52 no.5
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• pp.362-371
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• 2022

Orthognathic surgery is the primary treatment option for severe skeletal discrepancy. However, orthodontic camouflage should be considered as an alternative treatment option, considering the risks of surgery. A 19.5-yearold man presented with a severe prognathic mandible with a Class III molar relationship and an anterior crossbite. Orthognathic surgery could be considered because of his severe skeletal discrepancy and mandibular prognathism. However, the anesthetist for orthognathic surgery did not recommend surgery under general anesthesia because of risk factors associated with the patient's aplastic anemia, including bleeding and infections. Thus, a camouflage treatment to promote backward rotation of the mandible via orthodontic extrusion of the posterior teeth was planned. An anterior bite plate, intermaxillary elastics, and fixed orthodontic appliances were used to extrude the posterior teeth and to align the dentition. After 17 months of nonsurgical orthodontic treatment, normal occlusion was achieved, and the facial profile was dramatically improved. This case report describes the dentoskeletal and soft-tissue effects of mandibular rotation and its long-term stability.

• The Korean Journal of Applied Statistics
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• v.35 no.6
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• pp.755-764
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• 2022

This paper is concerned with power transformations in estimating GARCH volatility. To handle a semi-parametric case for which the exact likelihood is not known, quasi-likelihood (QL) rather than maximum-likelihood method is investigated to best estimate GARCH via maximizing the information criteria. A power transformation is introduced in the innovation generating QL estimating functions and then optimum power is selected by maximizing the profile information. A combination of two different power transformations is also studied in order to increase the parameter estimation efficiency. Nine domestic stock prices data are analyzed to order to illustrate the main idea of the paper. The data span includes Covid-19 pandemic period in which financial time series are really volatile.

• BMB Reports
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• v.56 no.7
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• pp.398-403
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• 2023

Natural killer (NK) cells are an essential part of the innate immune system that helps control infections and tumors. Recent studies have shown that Vorinostat, a histone deacetylase (HDAC) inhibitor, can cause significant changes in gene expression and signaling pathways in NK cells. Since gene expression in eukaryotic cells is closely linked to the complex three-dimensional (3D) chromatin architecture, an integrative analysis of the transcriptome, histone profiling, chromatin accessibility, and 3D genome organization is needed to gain a more comprehensive understanding of how Vorinostat impacts transcription regulation of NK cells from a chromatin-based perspective. The results demonstrate that Vorinostat treatment reprograms the enhancer landscapes of the human NK-92 NK cell line while overall 3D genome organization remains largely stable. Moreover, we identified that the Vorinostat-induced RUNX3 acetylation is linked to the increased enhancer activity, leading to elevated expression of immune response-related genes via long-range enhancer-promoter chromatin interactions. In summary, these findings have important implications in the development of new therapies for cancer and immune-related diseases by shedding light on the mechanisms underlying Vorinostat's impact on transcriptional regulation in NK cells within the context of 3D enhancer network.