• Transactions of Materials Processing
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• v.19 no.7
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• pp.411-415
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• 2010

A sandwich panel which is comprised of truss cores faced with solid face sheets is lightweight and multi-functional. So it is widely used to not only structural material but also heat transfer media in transportation field such as airplane, train and vessel. There are various core topologies such as pyramidal and tetrahedral truss, square honeycombs and kagome truss. The study focused on analytical approach to optimize compression and shear quality of the unit cell of PCM with pyramidal configuration. With various unit cell models which have the same core weight per unit area but different truss member angle, analytical solution for effective stress ($\bar{\sigma},\bar{\tau}$), peak stress ($\bar{\sigma}_{peak},\bar{\tau}_{peak}$) by yielding and buckling, relative density ($\bar{\rho}_c$) and effective stiffness ($\bar{E},\bar{G}$) have been computed and compared each other. With this approach, the most optimal core configuration was predicted. The result has become the efficient guidelines for the design of PCM core structure.

• Special Issue of the Society of Naval Architects of Korea
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• 2007.09a
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• pp.99-106
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• 2007

The IACS Common Structural Rules are to be applied for double hull tanker of more than 150m length with contracted after 1 April 2006. The objectives of the rules are to make more robust, safer ship and to ensure transparency of the technical background. In compliance of CSR, we had carried out prescriptive rules scantling determination and 3-D hold FE analysis of AFRAMAX TANKER. Prescriptive rules scantling determines the minimum required scantling, hull-girder longitudinal bending and shear strength, hull girder ultimate strength, local strength of plate and stiffener, strength of primary supporting member and fatigue assessment of the longitudinal stiffener end connections to the transverse bulkhead. 3-D hold FE analysis assesses the structural adequacy of the vessel's primary hull structure and major supporting members using yielding and buckling failure modes. So we could verify the strength assessment of AFRAMAX TANKER applied CSR.

• Journal of the Korea Concrete Institute
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• v.28 no.6
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• pp.673-683
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• 2016

In recent years, frequent terror or military attack by explosion, impact, fire accidents have occurred. Particularly, World Trade Center collapse and US Department of Defense Pentagon attack on Sept. 11 of 2001. Also, nuclear power plant incident on Mar. 11 of 2011. These attacks and incidents were raised public concerns and anxiety of potential terrorist attacks on major infrastructures and structures. Therefore, the extreme loading researches were performed of prestressed concrete (PSC) member, which widely used for nuclear containment vessel and gas tank. In this paper, to evaluate the blast resistance capacity and its protective performance of bi-directional unbonded prestressed concrete member, blast tests were carried out on $1,400{\times}1,000{\times}300mm$ for reinforced concrete (RC), prestressed concrete without rebar (PSC), prestressed concrete with rebar (PSRC) specimens. The applied blast load was generated by the detonation of 55 lbs ANFO explosive charge at 1.0 m standoff distance. The data acquisitions not only included blast waves of incident pressure, reflected pressure, and impulse, but also included displacement, acceleration, and strains at steel, concrete, PS tendon. The results can be used as basic research references for related research areas, which include protective design and blast simulation under blast loading.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1589-1595
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• 2014

Objective: Forkhead box C2 (FOXC2) is a member of the winged helix/forkhead box (Fox) family of transcription factors. It has been suggested to regulate tumor vasculature, growth, invasion and metastasis, although it has not been studied in cervical cancer. Here, we analyzed FOXC2 expression in cervical tissues corresponding to different stages of cervical cancer development and examined its correlation with clinicopathological characteristics. In addition, we examined the effects of targeting FOXC2 on the biological behavior of human cervical cancer cells. Methods: The expression of FOXC2 in normal human cervix, CIN I-III and cervical cancer was examined by immunohistochemistry and compared among the three groups and between cervical cancers with different pathological subtypes. Endogenous expression of FOXC2 was transiently knocked down in human Hela and SiHa cervical cells by siRNA, and cell viability and migration were examined by scratch and CCK8 assays, respectively. Results: In normal cervical tissue the frequency of positive staining was 25% (10/40 cases), with a staining intensity (PI) of $0.297{\pm}0.520$, in CIN was 65% (26/40cases), with a PI of $3.00{\pm}3.29$, and in cancer was 91.8% (68/74 cases), with a PI of $5.568 {\pm}3.449$. The frequency was 100% in adenocarcinoma (5/5 cases) and 91.3% in SCCs (63/69 cases). The FOXC2 positive expression rate was 88.5% in patients with cervical SCC stage I and 100% in stage II, showing significant differences compared with normal cervix and CIN. With age, pathologic differentiation degree and tumor size, FOXC2 expression showed no significant variation. On transient transfection of Hela and SiHa cells, FOXC2-siRNA inhibition rates were 76.2% and 75.7%; CCK8 results showed reduced proliferation and relative migration (in Hela cells from $64.5{\pm}3.16$ to $49.5{\pm}9.24$ and in SiHa cells from $60.1{\pm}3.05$ to $44.3{\pm}3.98$) (P < 0.05). Conclusion: FOXC2 gene expression increases with malignancy, especially with blood vessel hyperplasia and invasion degree. Targeted silencing was associated with reduced cell proliferation as well as invasion potential.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.1
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• pp.71-82
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• 2008

Survivin is a member of the inhibitors of apoptosis (IAP) family that have been known to inhibit activated caspases in apoptosis. In contrast to most IAP family members, survivin mRNA is expressed during fetal development, is not found in normal adult tissues and is overexpressed again in the cancer. Though survivin expression has been documented in most human cancers, little is known about its expression in OSCC and its potential value as a predictor of cancer survival. The purpose of this study was to investigate survivin expression in OSCC and to evaluate its value as a prognostic marker. We evaluated survivin expressions in cancer lines and OSCC samples and investigated the relationships between survivin expressions and clini-co-pathological parameters including stage, differentiation, proliferation, lymph node metastasis, blood vessel density, and gelatinolytic activity. With immunohistochemistry, we analyzed survivin expression in 38 OSCCs. Patients' clinico-pathological parameters and their survival rate were analyzed to reveal their correlations with Survivin expressions. We cultured oral cancer cell lines and evaluated the correlation between gelatinolytic activities and survivin expressions of them. Survivin protein was observed both in nuclei and cytoplasm of tumor specimens while little or not observed in normal gingival mucosal tissues. Additionally, survivin expressions were correlated with lymph node metastasis, tumor proliferation and survival rate. Survivin expression was observed in 100% of 38 samples of OSCC and its expression levels are statistically associated with the proliferative activity of the tumors, lymph node metastasis and the survival of the patients. Based on these results, survivin is commonly expressed in OSCC and may thus provide valuable prognostic information related with lymph node metastasis, proliferation and survival rate as well as a potential therapeutic target in OSCC.

• Journal of Advanced Marine Engineering and Technology
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• v.23 no.2
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• pp.192-200
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• 1999

This paper describes experimental investigations of helium-air exchange flow through parti-tioned opening. Such exchange flow may occur following rupture accident of stand pipe in high temperature gas cooled reactor. A test vessel with a opening on top of test cylinder is used for experiments. An estimation method of mass increment is developed and applied to measure the exchange flow rate. A technique of flow visualization by Mach-Zehnder interferometer is provided to recognize the exchange flows. Flow measurements are made with partitioned opening for parti-tion rations $H_p/H_1$ in the range 0 to 1 where $H_p$ and $H_1$ are partition length and height of the open-ing respecticely. In the case of $H_p/H_1$ of 0 flow passages of upward flow of the helium and down-ward flow of the air within the opening are unseparated (bidirectional) and the two flows interact exchange flow rate is minimum through range of the partition ratios, Two flow zones i.e. separat-ed(unidirectional)flow zone and unseparated(bidirectional) flow zone exist with increasing the partition. length, The exchange flow rate increases with increasing the separated flow zone. It is found that a maximum exchange flow rate exists at $H_p/H_1$ of 1. As a result fo comparison of the exchange flow rates by changing the partition ration the fluids interaction in the unseparated zone is found to be an important factor on the helium-air exchange flow rate.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.39 no.3
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• pp.369-380
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• 2019

When a extreme loading such as blast is applied to prestressed concrete (PSC) structures and infrastructures for an instantaneous time, serious property damages and human casualties occur. However, a existing design procedure for PSC structures such as prestressed containment vessel (PCCV) and gas storage tank do not consider a protective design for extreme internal blast scenario. Particularly, an internal blast is much more dangerous than that of external blast. Therefore, verification of the internal blast loading is required. In this paper, the internal blast resistance capacity of PSC member is evaluated by performing internal blast tests on RC and bi-directional PSC scaled down specimens. The applied internal blast loads were 22.68, 27.22, and 31.75 kg (50, 60, and 70 lbs) ANFO explosive charge at 1,000 mm standoff distance. The data acquisitions include blast pressure, deflection, strain, crack patterns, and prestressing force. The test results showed that it is possible to predict the damage area to the structure when internal blast loading occurs in PCCV structures.

• Journal of the Korea Concrete Institute
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• v.24 no.6
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• pp.695-703
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• 2012

Recently, major infrastructure such as bridges, tunnels, PCCVs (Prestressed Concrete Containment Vessel), and gas tanks are Prestressed Concrete (PSC) structure types, which improve their safety by using confining effect from prestressing. Generally, concrete is known to be an outstanding fire resistant construction material. Because of this reason, researches related to extreme fire loaded PSC member behaviors are not often conducted even though PSC behavior under extreme fire loading is significantly different than that of ordinary reinforced concrete (RC) behavior. Therefore, in this study, RABT fire loading tests were performed on bi-directionally prestressed concrete panels with $1000{\times}1400{\times}300mm$ dimensions. The prestressed specimens were applied with 430 kN prestressing (PS) force using unbonded PS thread bars. Also, residual strength structural tests of fire tested PSC and ordinary RC structures were performed for comparison. The study results showed that PSC behavior under fire loading is significantly different than that of RC behavior.

• Journal of the Korea Concrete Institute
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• v.29 no.3
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• pp.237-248
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• 2017

Frequent terror or military attack by explosion, impact, fire accidents have occurred recently. These attacks and incidents raised public concerns and anxiety of potential terrorist attacks on important infrastructures. However, structural behavioral researches on prestressed concrete (PSC) infrastructures such as Prestressed Concrete Containment Vessel (PCCV) and Liquefied Natural Gas (LNG) storage tanks under extreme loading are significantly lacking at this time. Also, researches on possible secondary fire scenarios after terror and bomb explosion has not been performed yet. Therefore, a study on PSC structural behavior from an blast-induced fire scenario was undertaken. To evaluate the blast-fire combined resistance capacity and its protective performance of bi-directional unbonded PSC member, blast-fire tests were carried out on $1,400mm{\times}1,000mm{\times}300mm$ PSC specimens. Blast loading tests were performed by the detonation of 25 kg ANFO explosive charge at 1.0 m standoff distance. Also, fire and blast-fire combined loading were tested using RABT fire loading curve. The test results are discussed in detail in the paper. The results can be used as basic research references for related research areas, which include protective design simulation under blast-fire combined loading.

• Journal of Navigation and Port Research
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• v.44 no.6
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• pp.488-493
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• 2020

In this study, we sought to establish a vessel-discharge pollutant-treatment system recommended by IMO by first investigating advanced facilities overseas to help us understand and evaluate our domestic facility and needs. IMO recommends the installation and operation of port pollutant-storage facilities to adequately treat pollutants emitted by ships entering the port, and we reviewed the registration and operation of these facilities in IMO member countries, focusing on the IIII Code. Due to recent environmental regulations, additional facilities are required to treat the washing water discharged from equipment such as scrubbers mounted on the ship so pollutant-storage facilities must be established. Currently, Korea's ship-discharged wastes are being moved from ports to land waste-treatment plants, and their quantity and properties are not being monitored. Therefore, in this study, we improved monitoring of the discharged pollutants and investigated the proper arrangement of pollutant storage facilities as recommended by IMO. The system we established can help provide smooth service to incoming ships - and appropriate treatment of pollutants and will greatly benefit international maritime operations.