• Korean Journal of Radiology
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• 제24권1호
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• pp.31-38
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• 2023

• Journal of Chest Surgery
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• 제21권3호
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• pp.531-534
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• 1988

Castleman`s disease is a rare disease entity of unknown etiology, with the characteristics of large, well marginated benign lymph node hyperplastic mass. This disease occurs predominantly in the mediastinum but also occurred in other areas of the body usually where lymph nodes are normally found. They have been divided into two histologic types: the hyaline vascular lesion which comprises over 90% of the cases; the plasma cell lesions, which was characterized by large follicle with plasma cell and systemic manifestation, such as fever, anemia elevated ESR, hypergammaglobulinemia, hypoalbuminemia. This disease have behaved in a benign fashion and complete surgical excision is the choice of treatment. We experienced a case of Castleman`s disease which was treated by surgical resection through the thoracotomy, and has good postoperative and follow up result. We report a case of the Castleman`s disease with its review.

• The Korean Journal of Pain
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• 제14권2호
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• pp.271-275
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• 2001

Buerger's disease is a nonatherosclerotic occlusive inflammatory disease of the small and medium arteries, and veins of the distal leg or arm. Percutaneous lumbar sympathectomy is used to lower extremity occlusive vascular disease as well as Buerger's disease. Lumbar sympathectomy improves blood flow and provides pain relief in the lower extremity. We report two cases of lumbar sympathectomy using radiofrequency thermocoagulation in patients with Buerger's disease. After no paresthesia and muscle contracture at 50 Hz, 1 volt and 2 Hz, 3 volts, respectively, radiofrequency lesioning was performed for 90 sec at $80^{\circ}C$. After the procedure, both patients showed skin temperature increases greater than $2^{\circ}C$ on the affected extremity. Both patients received relief from pain and symptoms without complications. We consider that lumbar sympathectomy using radiofrequency thermocoagulation is a safe and effective procedure that can relieve pain in patients with Buerger's disease.

• 한국방사선학회논문지
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• 제14권5호
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• pp.705-713
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• 2020

동맥경화는 혈관이 좁아지면서 탄력을 잃어 혈액 순환 장애가 발생하는 질병으로, 최근 증가하는 심혈관 및 뇌혈관 질환의 잠재적 원인이 된다. 경동맥초음파 검사는 동맥경화 정도를 평가하여 심혈관 및 뇌혈관 질환의 예측인자로 사용되고 있다. 이에 본 논문은 경동맥초음파 검사에서 내중막 두께 증가와 여러 임상변수들 간 상관성을 알아보고자 하였다. 경동맥초음파검사 소견을 가지고 있는 환자를 대상으로 경미한 내중막 두께 비후, 경화반, 유의한 협착 3단계로 분류하였다. 경동맥의 동맥경화 정도와 신체적 특성(성별, 연령, 신체질량지수법, 혈압), 혈액검사(총콜레스테롤, 중성지방, 고밀도지단백질, 저밀도지방단백질, 크레아틴포스포키나제, 공복혈당)와 동맥경화도 검사에서 계측된 CAVI(Carotid Ankle Vascular Index : 혈관연령) 데이터를 수집하였다. 경동맥 내중막 두께는 고혈압, 고지혈증, BMI 등의 변수와 상관관계가 있었으며, 또한 CAVI가 증가될수록 심혈관계 질환의 위험요인과 상관관계가 있음을 확인하였다.

• Journal of Ginseng Research
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• 제34권3호
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• pp.212-218
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• 2010

Korean red ginseng (KRG) has been shown to enhance endothelium-dependent vasorelaxation in experimental animals; however, little is known about its pharmacological effects on vascular stiffness in patients with coronary artery disease (CAD). This randomized, double-blind, placebo-controlled crossover trial was carried out to determine whether KRG has beneficial effects on arterial stiffness, cardiovascular risk factors such as plasma lipid profiles and blood pressure (BP), and Rho-associated kinase (ROCK) activity. Twenty patients (mean age, 62.5 years) with stable angina pectoris were given KRG (2.7 g/day) and a placebo alternatively for 10 weeks. Blood biochemical analysis and pulse wave velocity (PWV) recording were performed on day 0 and after the completion of each treatment. ROCK activity was assessed based on the level of phospho-$Thr^{853}$ in the myosin-binding subunit of myosin light chain phosphatase, determined by Western blot analysis of peripheral blood mononuclear cells. KRG significantly decreased the systolic BP, brachial ankle PWV, and heart femoral PWV in the patients (all p<0.05), but did not significantly alter the serum lipid profiles, including triglycerides and total, high-density lipoprotein, and low-density lipoprotein cholesterol levels. The ROCK activity tended to decrease (p=0.068) following KRG treatment. The placebo did not significantly alter any of the variables. In conclusion, KRG decreased systolic BP and arterial stiffness, probably via the inhibition of ROCK activity, in patients with CAD, but had a neutral effect on serum lipid profiles. Our data suggest that KRG has a therapeutic effect on CAD.

• IMMUNE NETWORK
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• 제11권6호
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• pp.368-375
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• 2011

Background: Recent clinical observation reported that there was a significant correlation between change in circulating vascular endothelial growth factor (VEGF) levels and the occurrence of severe acute graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the action mechanisms of VEGF in GVHD have not been demonstrated. Methods: This study investigated whether or not blockade of VEGF has an effect on acute GVHD in a lethally irradiated murine allo-HSCT model of $B6\;(H-2^b)\;{\rightarrow}B6D2F1\;(H-2^{b/d})$. Syngeneic or allogeneic recipient mice were injected subcutaneously with anti-VEGF peptides, dRK6 ($50{\mu}g/dose$) or control diluent every other day for 2 weeks (total 7 doses). Results: Administration of the dRK6 peptide after allo-HSCT significantly reduced survival with greaterclinical GVHD scores and body weight loss. Allogeneic recipients injected with the dRK6 peptide exhibited significantly increased circulating levels of VEGF and expansion of donor $CD3^+$ T cells on day +7 compared to control treated animals. The donor $CD4^+$ and $CD8^+$ T-cell subsets have differential expansion caused by the dRK6 injection. The circulating VEGF levels were reduced on day +14 regardless of blockade of VEGF. Conclusion: Together these findings demonstrate that the allo-reactive responses after allo-HSCT are exaggerated by the blockade of VEGF. VEGF seems to be consumed during the progression of acute GVHD in this murine allo-HSCT model.

• The Korean Journal of Physiology and Pharmacology
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• 제12권5호
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• pp.275-280
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• 2008

A brief ischemic insult induces significant protection against subsequent massive ischemic events. The molecular mechanisms known as preconditioning (PC)-induced ischemic tolerance are not completely understood. We investigated whether kinetic changes of cyclooxygenase (COX)-2 during reperfusion time-periods after PC were related to ischemic tolerance. Rats were given PC by occlusion of middle cerebral artery (MCAO) for 10 min and sacrificed after the indicated time-periods of reperfusion (1, 2, 4, 8, 12, 18 or 24 h). In PC-treated rats, focal ischemia was induced by occlusion of MCA for 24 h and brain infarct volume was then studied to determine whether different reperfusion time influenced the damage. We report that the most significant protection against focal ischemia was obtained in rats with 8 h reperfusion after PC. Administration of indomethacin (10 mg/kg, oral) or rofecoxib (5 mg/kg, oral) 48 h prior to PC counteracted the effect of PC. Immunohistochemical analysis showed that COX-2 and HO-l protein were induced in PC-treated rat brain, which was significantly inhibited by rofecoxib. Taken together, we concluded that the kinetic changes of COX-2 expression during the reperfusion period after PC might be partly responsible for ischemic tolerance.

• 한국산학기술학회논문지
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• 제12권11호
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• pp.5150-5155
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• 2011

인지증을 유발하는 원인은 알츠하이머병(Alzheimer's Disease: AD)과 혈관성 인지증(vascular Dementia: VD)이 가장 높은 비율을 차지한다. 본 논문에서는 측정된 라만 스펙트럼에서 AD, VD, 정상(NOR: normal)을 분류하기 위해 변별력 있는 영역을 조사하고, 특징 변환을 이용한 분류 실험 결과를 제시하였다. 혈소판으로부터 측정한 라만 스펙트럼은 먼저 smoothing을 적용한 다음 배경 잡음을 제거하고 스펙트럼의 기준 피크를 중심으로 그 위치를 정렬하였고 minmax 방법을 사용하여 정규화 하였다. 전처리를 거친 스펙트럼은 AD와 VD, NOR를 변별하기 가장 용이한 영역을 결정하기 위해 조사되었으며, 그 결과 725-777, 1504-1592, 1632-1700 $cm^{-1}$ 영역에서 스펙트럼이 많은 차이를 보임을 확인하였다. 분류 실험은 선택한 각 영역에 대하여 PCA(principal component analysis)와 NMF(nonnegative matrix factorization) 방법을 적용하여 얻은 특징을 이용하여 행하였다. 총 327개의 라만 스펙트럼에 대한 MAP(maximum a posteriori probability) 분류 실험 결과에 따르면, 본 연구에서 제안된 국부 영역 변환 특징을 사용했을 때 평균 92.8 %의 분류율을 보임을 알 수 있었다.

• Vascular Specialist International
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• 제34권4호
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• pp.83-87
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• 2018

Purpose: Thrombosis of the portal vein, known as pylephlebitis, is a rare and fatal complication caused by intraperitoneal infections. The disease progression of superior mesenteric venous thrombosis (SMVT) is not severe. This study aimed to determine the clinical features, etiology, and prognosis of SMVT. Materials and Methods: We retrospectively reviewed the medical records of 41 patients with SMVT from March 2000 to February 2017. We obtained a list of 305 patients through the International Classification of Disease-9 code system and selected 41 patients with SMVT with computed tomography. Data from the medical records included patient demographics, comorbidities, review of system, laboratory results, clinical courses, and treatment modalities. Results: The causes of SMVT were found to be intraperitoneal inflammation in 27 patients (65.9%), malignancy in 7 patients (17.1%), and unknown in 7 patients (17.1%). Among the patients with intraperitoneal inflammation, 14 presented with appendicitis (51.9%), 7 with diverticulitis (25.9%), and 2 with ileus (7.4%). When comparing patients with and without small bowel resection, the differences in symptom duration, bowel enhancement and blood culture were significant (P=0.010, P=0.039, and P=0.028, respectively). Conclusion: SMVT, caused by intraperitoneal inflammation, unlike portal vein thrombosis including pylephlebitis, shows mild prognosis. In addition, rapid symptom progression and positive blood culture can be the prognostic factors related to extensive bowel resection. Use of appropriate antibiotics and understanding of disease progression can help improve the outcomes of patients with SMVT.

• 한국융합학회논문지
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• 제11권12호
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• pp.383-390
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• 2020

본 연구는 알츠하이머와 혈관성 치매 환자를 대상으로 구어유창성과 이야기이해 과제 수행능력의 차이 및 작업기억 처리수준과의 상관 그리고 언어능력 관련 요인선별을 위해 시행되었다. 전반적인 인지능력에서 차이를 보이지 않는 각기 15명의 환자를 대상으로 구어유창성 내 음소유창성 및 이야기이해 그리고 작업기억 하위과제인 지연회상과 재인과제에서 두 그룹 간 유의한 수행능력의 차이를 보였다. 상관 및 회귀분석에서는 알츠하이머 그룹이 작업기억 내역행 숫자기억 과제와 이야기이해 과제에서만 유의한 상관을 보인 반면, 혈관성 치매 그룹은 추가적으로 재인 점수에서도 이야기이해 능력과의 유의한 상관이 나타났다. 한편, 회귀분석에서는 혈관성 치매 그룹에서만 언어적 작업기억 능력이 이야기이해 능력의 예측 요인임을 확인하였다. 결론적으로 두 유형의 치매를 구분하는 데 있어 음소유창성 과제 외에 이야기이해 및 작업기억 과제가 유의한 도구임이 확인되었는데, 이를 통해 두 유형의 치매에 대한 분류기준을 제고함은 물론 적절한 치료계획 및 효율적인 중재에 부가적인 기여를 할 것으로 보인다.