• Analytical Science and Technology
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• v.19 no.6
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• pp.519-528
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• 2006

An analytical method for the determination of thyroid hormones in urine samples has been studied by using solid-phase extraction and high-performance liquid chromatography/diode array detector/electro-spray mass spectrometry. Seven thyroid hormones were successfully separated by gradient elution on the reverse phase Hypersil ODS column (4.6 mm I.D., 100 mm length, particle size $5{\mu}m$) with ammonium formate buffer and acetonitrile, and UV spectra and mass fragment could be confirmed. The extraction recoveries of thyroid hormones in the urine samples (pH 3) were in the range of 89.0-113.1% with solid-phase extraction by C18, followed by elution with 4 ml of methanol/ammonium hydroxide (9 : 1). The calibration curves showed good linearity with the correlation coefficients ($r^2$) varying from 0.992 to 0.998 and the detection limits of all analytes were obtained in the range of 2-4 ng/ml (3.8-13.0 pmol/ml).

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2B
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• pp.249-259
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• 2008

The present paper studies the effect of the slope gradient of a fully permeable submerged breakwater using a newly developed numerical model that is able to consider the flow through a porous midium with inertial, laminar and turbulent resistance terms, i.e. simulate directly WAve-Structure (submerged breakwater)-Sand seabed interaction and can determine the eddy viscosity with LES turbulence model in 2-Dimensional wave field (LES-WASS-2D). The developed model was validated through the comparison with an existing experimental data, and further used for various numerical experiments in oder to investigate the complicated hydrodynamics on the varying slope gradient of permeable submerged breakwater. We found an acceptable phenomenon, as we expect intuitively, that reflection and transmission coefficients decrease simultaneously as slope gradient decrease. In addition, the breaking point, the circulation flow and mean vorticity around a submerged breakwater are throughly discussed.

• Journal of Biomedical Engineering Research
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• v.44 no.5
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• pp.303-314
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• 2023

This study aimed to assess the practical feasibility of advanced deformable image registration (DIR) algorithms in radiotherapy by employing two distinct datasets. The first dataset included 14 4D lung CT scans and 31 head and neck CT scans. In the 4D lung CT dataset, we employed the DIR algorithm to register organs at risk and tumors based on respiratory phases. The second dataset comprised pre-, mid-, and post-treatment CT images of the head and neck region, along with organ at risk and tumor delineations. These images underwent registration using the DIR algorithm, and Dice similarity coefficients (DSCs) were compared. In the 4D lung CT dataset, registration accuracy was evaluated for the spinal cord, lung, lung nodules, esophagus, and tumors. The average DSCs for the non-learning-based SyN and NiftyReg algorithms were 0.92±0.07 and 0.88±0.09, respectively. Deep learning methods, namely Voxelmorph, Cyclemorph, and Transmorph, achieved average DSCs of 0.90±0.07, 0.91±0.04, and 0.89±0.05, respectively. For the head and neck CT dataset, the average DSCs for SyN and NiftyReg were 0.82±0.04 and 0.79±0.05, respectively, while Voxelmorph, Cyclemorph, and Transmorph showed average DSCs of 0.80±0.08, 0.78±0.11, and 0.78±0.09, respectively. Additionally, the deep learning DIR algorithms demonstrated faster transformation times compared to other models, including commercial and conventional mathematical algorithms (Voxelmorph: 0.36 sec/images, Cyclemorph: 0.3 sec/images, Transmorph: 5.1 sec/images, SyN: 140 sec/images, NiftyReg: 40.2 sec/images). In conclusion, this study highlights the varying clinical applicability of deep learning-based DIR methods in different anatomical regions. While challenges were encountered in head and neck CT registrations, 4D lung CT registrations exhibited favorable results, indicating the potential for clinical implementation. Further research and development in DIR algorithms tailored to specific anatomical regions are warranted to improve the overall clinical utility of these methods.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.5
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• pp.75-83
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• 2023

As part of a study to analyze the excessive camber occurring in prestressed concrete railway bridges, this paper presents a calculation method and analysis results for the creep coefficient which defines the increase in camber of a concrete structure over time. Using the creep coefficient formula of the design code, the coefficient is obtained by applying the climatic conditions (relative humidity and temperature) of 12 regions in Korea. The effects of differences in climatic conditions by region and starting time of load on the creep coefficient are analyzed. In order to properly calculate the creep, most of which occurs in the early stages of loading, a detailed analysis is performed by applying a time step analysis method to consider varying climate conditions through loaded period. The creep coefficient obtained by applying the average climate conditions of the region is similar to the average of the creep coefficients obtained by time step analysis. Through time step analysis, it is shown that the offset and overlap effects of relative humidity and temperature on the creep coefficient and the climate effect at the time of initial loading can be appropriately represented.

• The Journal of the Acoustical Society of Korea
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• v.29 no.4
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• pp.243-250
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• 2010

This paper proposes a spectral modeling of Korean traditional instrument, Haegeum, using cepstral analysis to naturally describe Haegeum sounds varying with time. To get a precise result of cepstral analysis, we set the frame size to 3 periods of input signal and more cepstral coefficients are used to extract formants. The performance is enhanced by flexibly controlling the cutoff frequency of bandpass filter depending on the resonances in the synthesis process of sinusoidal components and the deleting peaks remained in the residual signal. To detect the change of pitch, we divide the input frames into silence, attack, and sustain region and determine which region the current frame is involved in. Then, the proposed method readjusts the frame size according to the fundamental frequency in the case of the current frame is in attack region and corrects the extraction errors of the fundamental frequency for the frames in sustain region. With these processes, the synthesized sounds are much more similar to the originals. The evaluation result through the listening test by a Haegeum player says that the synthesized sounds are almost similar to originals (96~100 % similar to the original sounds).

• Geomechanics and Engineering
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• v.36 no.6
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• pp.601-618
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• 2024

The joint probability distribution of uncertain geomechanical parameters of geotechnical strata is a crucial aspect in constructing the reliability functional function for roof structures. However, due to the limited number of on-site exploration and test data samples, it is challenging to conduct a scientifically reliable analysis of roof geotechnical strata. This study proposes a Copula method based on small sample exploration and test data to construct the intensity characteristics of roof geotechnical strata. Firstly, the theory of multidimensional copula is systematically introduced, especially the construction of four-dimensional Gaussian copula. Secondly, data from measurements of 176 groups of geomechanical parameters of roof geotechnical strata in 31 coal mines in China are collected. The goodness of fit and simulation error of the four-dimensional Gaussian Copula constructed using the Pearson method, Kendall method, and Spearman methods are analyzed. Finally, the fitting effects of positive and negative correlation coefficients under different copula functions are discussed respectively. The results demonstrate that the established multidimensional Gaussian Copula joint distribution model can scientifically represent the uncertainty of geomechanical parameters in roof geotechnical strata. It provides an important theoretical basis for the study of reliability functional functions for roof structures. Different construction methods for multidimensional Gaussian Copula yield varying simulation effects. The Kendall method exhibits the best fit in constructing correlations of geotechnical parameters. For the bivariate Copula fitting ability of uncertain parameters in roof geotechnical strata, when the correlation is strong, Gaussian Copula demonstrates the best fit, and other Copula functions also show remarkable fitting ability in the region of fixed correlation parameters. The research results can offer valuable reference for the stability analysis of roof geotechnical engineering.

• Ocean Systems Engineering
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• v.13 no.4
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• pp.349-365
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• 2023

Targeting a floating wave and offshore wind hybrid power generation system (FWWHybrid) designed in the Republic of Korea, this study examines the impact of the interaction, with multiple wave energy converters (WECs) placed on the platform, on platform motion. To investigate how the motion of WECs affects the behavior of the FWWHybrid platform, it was numerically compared with a scenario involving a 'single-body' system, where multiple WECs are constrained to the platform. In the case of FWWHybrid, because the platform and multiple WECs move in response to waves simultaneously as a 'multi-body' system, hydrodynamic interactions between these entities come into play. Additionally, the power take-off (PTO) mechanism between the platform and individual WECs is introduced for power production. First, the hydrostatic/dynamic coefficients required for numerical analysis were calculated in the frequency domain and then used in the time domain analysis. These simulations are performed using the extended HARP/CHARM3D code developed from previous studies. By conducting regular wave simulations, the response amplitude operator (RAO) for the platform of both single-body and multi-body scenarios was derived and subsequently compared. Next, to ascertain the difference in response in the real sea environment, this study also includes an analysis of irregular waves. As the floating body maintains its position through connection to a catenary mooring line, the impact of the slowly varying wave drift load cannot be disregarded. To assess the influence of the 2^nd-order wave exciting load, irregular wave simulations were conducted, dividing them into cases where it was not considered and cases where it was included. The analysis of multi-degree-of-freedom behavior confirmed that the action of multiple WECs had a substantial impact on the platform's response.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.20 no.2
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• pp.232-237
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• 2008

A method to generate electric power from small scale water tank. For this purpose, manufacturing tank is investigated, measuring water level change at any time, and finally comparing experimental and theoretical value, are performed. Inner and outer tank are made to simulate flood and ebb generation. Two sets of pipe are connected between tanks, and experiments are performed under varying flowrate. Coefficients of flowrate are calculated comparing water level change data and theoretical value. Measured and theoretical water levels are highly correlated, and this ascertains that analytical equation simulates real water level changes well. Flowrate change depending on the existence of propeller and valve, on flood and ebb generation, shows the necessity of experiments in the process of manufacturing electric power system. Moreover, total energy calculated from experimental data agrees well with that of theoretical equation. In spite of small tidal power output, this generating system with optimum water tank can be applied to any place where high water level change occurs, and can make a contribution to producing new and renewable energy consequently.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.5 no.4
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• pp.45-56
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• 1985

This study was made to evaluate temperature effects on biological wastewater treatment particularly at the lower temperatures. Cell yield coefficients and other kinetic factors were compared by varying temperature for industrial wastes. Bench scale aeration-only complete mixing activated sludge(CMAS) units were operated at temperatures of $1^{\circ}$, $4^{\circ}$, $7^{\circ}$ and $10^{\circ}C$ with substrate concentrations of 5,000 and 200 mg/l COD. The study results indicate that the cell yields were computed to be 0.5 to 0.6 grams VSS per grams BOD removed, and were not influenced by temperature variations. The synthesis/total energy ratios were computed to be 0.45 to 0.58 and had a tendency to become larger at lower temperatures. The endogenous respiration rates were computed to be 0.07 to 0.08/day, and seemed to be independent of temperature. In addition, very little temperature effects were observed when F/M ratio and substrate concentrations were reduced.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.11
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• pp.1738-1745
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• 2007

A growth trial and a digestibility trial were conducted to examine the effect of feed particle size on the performance, nutrient digestibility, gastric ulceration and intestinal morphology in pigs fed barley-based diets. Barley was processed through a hammer mill to achieve four diets varying in particle size (average particle $size{\pm}standard $deviation): coarse ($1,100{\pm}2.19\;{\mu}m$), medium ($785{\pm}2.23\;{\mu}m$), fine ($434{\pm}1.70\;{\mu}m$) and mixed (1/3 of coarse, medium and fine) ($789{\pm}2.45\;{\mu}m$). Sixty-four entire male pigs were used in the growth trial and the diets were fed ad libitum between 31 kg and 87 kg live weight. Following slaughter, stomach and ileal tissues were scored for integrity (ulceration or damage) and histological measurements taken. Twenty-four entire male pigs were used in the digestibility trial, which involved total faecal collection. Over the entire growth phase, there were no differences (p>0.05) in average daily gain and feed conversion ratio between pigs fed diets of different particle size. Pigs fed the coarse and medium diets had lower (p<0.05) stomach ulceration scores (0.20 and 0.25, respectively, on a scale from 0 to 3) than those fed the mixed (0.69) or the fine diets (1.87). The stomachs of all animals fed the fine diet had lesions and stomach ulcerations were present only in this group. Pigs fed the fine diet had thicker (p<0.001) ileal epithelial cell layer with no differences (p>0.05) being observed for villous height or crypt depth. Faecal digestibility coefficients of neutral and acid detergent fibre were the highest (p<0.05) for the mixed diet, intermediate for the fine and coarse diets and the lowest for the medium diet. A similar numerical trend (p = 0.103) was observed for the apparent faecal energy digestibility coefficient. It is concluded that, with barley based diets, a variation in average particle size between $400{\mu}m$ and $1,100{\mu}m$ had no effect on pig performance but the fine dietary particle size affected the integrity of the stomach, as well as the structure of the small intestine, thus compromising overall gut health. Our data also demonstrate that changes in particle size distribution during the digestion process, rather than average particle size or particle size variation, are related to apparent faecal digestibility.