• Journal of Pharmaceutical Investigation
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• v.37 no.1
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• pp.27-37
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• 2007

Proficiency test is an essential tool far ensuring analytical ability of analytical chemists and analytical institutes. Usually, the standard protocol for proficiency test is focused on acceptability of reported analytical results of participants by calculating z-scores and related diagnostic parameters. The ultimate goal of this process is to reveal the sources of variability of analytical results and to find the way to reduce their influence. In this study, the method of analysis of variance (ANOVA) was applied to the analytical data collected from qualify control departments of pharmaceutical companies in KyungIn province in Korea in the year of 2000. As influencing factors of variability of analytical results, the use of internal standards for liquid and gas chromatograpy, the educational and professional background of participants, geological locations and yearly production sizes of participating companies were evaluated. To evaluate the variability in accuracy of analytical results, absolute differences from sample mean and sample median were used and to evaluate variability in precision of individual participants, the reported standard deviation of each participant was used. As a result, the use of internal standards in gas chromatographic analysis, participants' academic background and the yearly production sizes of pharmaceutical companies showed statistically significant influence to the accuracy and the precision of the reported analytical results used in this study.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.5
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• pp.1050-1056
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• 2009

Heart Rate Variability(HRV) is a parameter that represents monitoring variability of time intervals between R-peak in electrocardiography. HRV serves to various applications, such as indices of autonomic functions, prediction of cardiac sudden death, assessment of stress and emotional, etc. However, as measuring R-peak in ECG needs at least 3-electrodes, and it is inconvenient for end users. In this paper, we suggested the modified laplacian electrodes for measuring HRV at one-point, which are producted by MEMS fabrication and have the two circular electrodes on the pad. For optimal position and direction, we performed an experiment that compared with pearson correlation coefficient and the amplitude of signals, between standard lead II and proposed electrodes. We analyzed the HRV parameters, such as standard deviation of the NN interval(SDNN), high frequency(HF), low frequency(LF), LF/HF ratio. The result showed that the average correlation coefficient and amplitude are 0.967 and 0.685 mVpp at the position 2. The coeffiecient correlation between the standard HRV and proposed electrode-HRV is 0.999

• Journal of Mechanical Science and Technology
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• v.20 no.10
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• pp.1662-1669
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• 2006

Since randomness and uncertainties of design parameters are inherent, the robust design has gained an ever increasing importance in mechanical engineering. The robustness is assessed by the measure of performance variability around mean value, which is called as standard deviation. Hence, constraints in robust optimization problem can be approached as probability constraints in reliability based optimization. Then, the FOSM (first order second moment) method or the AFOSM (advanced first order second moment) method can be used to calculate the mean values and the standard deviations of functions describing constraints and object. Among two methods, AFOSM method has some advantage over FOSM method in evaluation of probability. Nevertheless, it is difficult to obtain the mean value and the standard deviation of objective function using AFOSM method, because it requires that the mean value of function is always positive. This paper presented a special technique to overcome this weakness of AFOSM method. The mean value and the standard deviation of objective function by the proposed method are reliable as shown in examples compared with results by FOSM method.

• Journal of Korea Association of Health Promotion
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• v.4 no.1
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• pp.28-38
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• 2006

Background : Phentermine classified by "sympathomimmetic amie", is a stimulant of sympatheic tone But there has been no concrete study which presents the influence of phentermine on autonomic nervous system. Analysis of Heart rate variability is reliable, non-invasive and very useful for evaluating function of autonomic nervous system. We tried to elucidate the influence of phentermine on autonomic nervovs system by heart rate variability. MethodsAmong the 70 candidates who participated in the double-blind case control study whichwas designed in purpose of approving whether- Adipekⓓ is effective for treatment of obesity, 45persons were folled up. From April, 2005 to May 2005, HRV of the candidates who takes phentermine or placebo for 1month, was recorded using BFM-5000ⓓ(medi-core) for 5 minutes in resting state. HRV measures were assessed by time-domain and by frequency- domain analysis. Time domain parameters contain SDNN(Standard Deviation of NN intervals) and RMSSD(Root-Mean-Square of Successive Differences), etc and frequency domain Parameters contain Total Power(TP), Low frequency(LF'0.04-0.15Hz) power. High Frequency(HF:0.15-0.4Hz) power and LF/HF ratio etc. Results: Intakes of phentermine reduce HRV significant1y. SDNN & RMSSD, the main tine domain parameters of HRV, were decreased significantly(P=0.007. 0.016). PSI(Physical Stress Index of Pressure Index) was increase significantly(P=0.002)The main frequency domain parameters(TP, LF & VLF), also decreased significantly. (P=0.024,0.033, 0.015)Conclusion: The result showed that intakes of phentermine reduce heart rate variability and influence on most parameters of HRV. So phentermine not only accelerates sympathetic tone, but also inhibit the balance and function of autonomic nervous system.

• The Journal of Korean Physical Therapy
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• v.27 no.1
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• pp.38-42
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• 2015

Purpose: Accuracy and variability of movement in daily life require synchronization of muscular activities through a specific chronological order of motor performance, which is controlled by higher neural substrates and/or lower motor centers. We attempted to investigate whether transcranial direct current stimulation (tDCS) over primary sensorimotor areas (SM1) could influence movement variability in healthy subjects, using a tapping task. Methods: Twenty six right-handed healthy subjects with no neurological or psychiatric disorders participated in this study. They were randomly and equally assigned to the real tDCS group or sham control group. Direct current with intensity of 1 mA was delivered over their right SM1 for 15 minutes. For estimation of movement variability before and after tDCS, tapping task was measured, and variability was calculated as standard deviation of the inter-tap interval (SD-ITI). Results: At the baseline test, there was no significant difference in SD-ITI between the two groups. In two-way ANOVA with repeated measurement no significant differences were found in a large main effect of group and interaction effect between two main factors (i.e., group factor and time factor (pre-post test)). However, significant findings were observed in a large main effect of the pre-post test. Conclusion: Our findings showed that the anodal tDCS over SM1 for 15 minutes with intensity of 1 mA could enhance consistency of motor execution in a repetitive-simple tapping task. We suggest that tDCS has potential as an adjuvant brain facilitator for improving rhythm and consistency of movement in healthy individuals.

• Child Health Nursing Research
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• v.21 no.3
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• pp.195-203
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• 2015

Purpose: This study was done to investigate quality of sleep and heart rate variability by the physical activity in high school students. Methods: A survey that measures physical activity and quality of sleep was distributed to 118 students at Y High School. Heart rate variability was obtained using the LXC3203 heart rate monitor. The data of 105 students were analyzed using descriptive statistics, t-test, x2-test, and ANOVA with $Scheff{\acute{e}}$ test. Results: Boys and students with part-time jobs had significantly higher physical activity. The quality of sleep was significantly high when the students were non-smokers, felt healthy, happy, less stressed, and satisfied with their school lives. Mean heart rate was significantly higher among girls, and standard deviation from normal to normal R-R intervals were high in boys. Physical activity had no significant relationships with quality of sleep and heart rate variability. Conclusions: Physical activity should be encouraged for high school students, especially for girls. An experimental study with different intensity and time of physical activity is recommended to examine the relationships with quality of sleep and heart rate variability in the future.

• Journal of the Korean earth science society
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• v.44 no.1
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• pp.1-12
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• 2023

Oceanic wind waves have been recognized as one of the important indicators of global warming and climate change. It is necessary to study the spatial and temporal variability of significant wave height (SWH) and wave direction in the Yellow Sea and a part of the East China Sea, which is directly affected by the East Asian monsoon and climate change. In this study, the spatial and temporal variability including seasonal and interannual variability of SWH and wave direction in the Yellow Sea and East China Sea were analyzed using European Center for Medium-Range Weather Forecasts (ECMWF) Reanalysis 5 (ERA5) data. Prior to analyzing the variability of SWH and wave direction using the model reanalysis, the accuracy was verified through comparison with SWH and wave direction measurements from Ieodo Ocean Science Station (I-ORS). The mean SWH ranged from 0.3 to 1.6 m, and was higher in the south than in the north and higher in the center of the Yellow Sea than in the coast. The standard deviation of the SWH also showed a pattern similar to the mean. In the Yellow Sea, SWH and wave direction showed clear seasonal variability. SWH was generally highest in winter and lowest in late spring or early summer. Due to the influence of the monsoon, the wave direction propagated mainly to the south in winter and to the north in summer. The seasonal variability of SWH showed predominant interannual variability with strong variability of annual amplitudes due to the influence of typhoons in summer.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.8
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• pp.2042-2051
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• 1998

VBR compressed, pre-recorded video is known to exhibit significant, multiple time-scale bit rate variability. To reduce the variability and burstiness of the aggregated transmission rate as low as possible, in this paper, we present an adaptive bandwidth smoothing algorithm, that can be effectively applicalble for VoD services over a shared-medium channel. For these environments where many clients are connected to a single server, by introducing the conventional MVBA(minimum variability bandwidth allocation) algorithm and controlling adaptively the conventional MVBA(minimum variability bandwidth asllocation) algorithm and controlling adaptively the aggregated transmission rate whenever a new clients request is arrived at the server side, the proposed algorithm effectively reduces the burstiness and variability of the aggregated transmission rate. Through computer experiments, it is shown that the proposed method perporms better than the convertional non-aggregated bandwidth smoothing schemes in terms of the peak rate, standard deviation, number of rate changes for the aggregated traffic.

• Journal of Environmental Health Sciences
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• v.41 no.4
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• pp.223-230
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• 2015

Objectives: There is considerable evidence that polluted ambient air contributes to the risk of cardiovascular morbidity and mortality. Heart rate variability (HRV) is defined as the variation in heartbeat intervals and has been reported as a biological marker of cardiovascular disease. This article reviews the existing literature in order to examine the association between air pollution and HRV. Methods: Literature was searched using Web of Science with the key words of "air pollution", "heart rate variability" and other related terms. A total of 156 articles were listed. For review, 21 of those listed publications were chosen after excluding studies regarding chamber studies, occupational environment, secondhand smoke and automobile exhaust. Results: Research methods employed in the publications were classified by type of participants (elderly/adult), air pollution monitoring (ambient/personal) and HRV monitoring (continuous/spot). Among HRV parameters, power in the low frequency range (LF), power in the high frequency range (HF) and standard deviation of all NN intervals (SDNN) were all associated with air pollutants. The chosen studies were mostly based on elderly populations. In studies based on continuous HRV monitoring, LF and SDNN significantly decreased when $PM_{2.5}$ exposure increased. Conclusion: Continuous HRV monitoring combined with personal exposure monitoring has been one of the most common study methods in recent publications. We expect that this review will be useful for the study of the association between air pollution and cardiovascular effects using HRV.

• Structural Engineering and Mechanics
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• v.81 no.2
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• pp.205-217
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• 2022

The thermodynamic properties of shaft lining concrete (SLC) are important evidence for the design and construction, and the spatial variability of concrete materials can directly affect the stochastic thermal analysis of the concrete structures. In this work, an array of field experiments of the concrete materials are carried out, and the statistical characteristics of thermophysical parameters of SLC are obtained. The coefficient of variation (COV) and scale of fluctuation (SOF) of uncertain thermophysical parameters are estimated. A three-dimensional (3-D) stochastic thermal model of concrete materials with heat conduction and hydration heat is proposed, and the uncertain thermodynamic properties of SLC are computed by the self-compiled program. Model validation with the experimental and numerical temperatures is also presented. According to the relationship between autocorrelation functions distance (ACD) and SOF for the five theoretical autocorrelation functions (ACFs), the effects of the ACF, COV and ACD of concrete materials on the uncertain thermodynamic properties of SLC are analyzed. The results show that the spatial variability of concrete materials is subsistent. The average temperatures and standard deviation (SD) of inner SLC are the lowest while the outer SLC is the highest. The effects of five 3-D ACFs of concrete materials on uncertain thermodynamic properties of SLC are insignificant. The larger the COV of concrete materials is, the larger the SD of SLC will be. On the contrary, the longer the ACD of concrete materials is, the smaller the SD of SLC will be. The SD of temperature of SLC increases first and then decreases. This study can provide a reliable reference for the thermodynamic properties of SLC considering spatial variability of concrete materials.