• Proceedings of the Acoustical Society of Korea Conference
• /
• 1993.06a
• /
• pp.210-214
• /
• 1993

There are two general techniques to observe particle movements in fluid. One is the acoustic time domain correlation technique and another is the frequency domain Doppler-shift techniques. Both techniques were reviewed and mentioned their some merits and demerits in ocean wave and current observation. Some possible application of acoustic time domain correlation technique in ocean wind wave measurement was discussed.

• Journal of the Korean Mathematical Society
• /
• v.52 no.1
• /
• pp.1-21
• /
• 2015

C-domains are defined via class semigroups, and every C-domain is a Mori domain with nonzero conductor whose complete integral closure is a Krull domain with finite class group. In order to extend the concept of C-domains to rings with zero divisors, we study v-Marot rings as generalizations of ordinary Marot rings and investigate their theory of regular divisorial ideals. Based on this we establish a generalization of a result well-known for integral domains. Let R be a v-Marot Mori ring, $\hat{R}$ its complete integral closure, and suppose that the conductor f = (R : $\hat{R}$) is regular. If the residue class ring R/f and the class group C($\hat{R}$) are both finite, then R is a C-ring. Moreover, we study both v-Marot rings and C-rings under various ring extensions.

• Journal of Power Electronics
• /
• v.7 no.3
• /
• pp.213-221
• /
• 2007

A digital state feedback control method for the current mode control of DC-DC converters is proposed in this paper. This approach can precisely achieve interleaved current sharing among the converter modules. As the controller design and system analysis are performed in the time domain, the proposed method can easily satisfy the required converter specification by using the pole placement technique. The digital state feedback controller in the continuous and discrete time domain is derived for the robust tracking control. For the verification of the proposed control scheme, a parallel module bi-directional converter in a prototype 42V/14V hybrid automotive power system, which is a design example in the continuous time domain, and a parallel module buck converter, which is a design example in the discrete time domain, are implemented using a TMS320F2812 digital signal processor (DSP).

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.15 no.6
• /
• pp.695-702
• /
• 2015

A 1-V 1.6-GS/s 5.58-ENOB flash ADC with a high-speed time-domain comparator is proposed. The proposed time-domain comparator, which consumes low power, improves the comparison capability in high-speed operations and results in the removal of preamplifiers from the first-stage of the flash ADC. The time interpolation with two factors, implemented using the proposed time-domain comparator array and SR latch array, reduces the area and power consumption. The proposed flash ADC has been implemented using a 65-nm 1-poly 8-metal CMOS process with a 1-V supply voltage. The measured DNL and INL are 0.28 and 0.41 LSB, respectively. The SNDR is measured to be 35.37 dB at the Nyquist frequency. The FoM and chip area of the flash ADC are 0.38 pJ/c-s and $620{\times}340{\mu}m^2$, respectively.

• Journal of Microbiology and Biotechnology
• /
• v.29 no.5
• /
• pp.813-819
• /
• 2019

Middle East respiratory syndrome coronavirus (MERS-CoV) induces severe respiratory impairment with a reported mortality rate of ~36% in humans. The absence of clinically available MERS-CoV vaccines and treatments to date has resulted in uncontrolled incidence and propagation of the virus. In vaccine design, fusion with the IgG Fc domain is reported to increase the immunogenicity of various vaccine antigens. However, limited reports have documented the potential negative effects of Fc fusion on vaccine antigens. To determine whether Fc fusion affects the immunogenicity of MERS-CoV antigen, we constructed a Fcassociated MERS-CoV spike protein (eS770-Fc, 110 kDa), whereby human IgG4 Fc domain was fused to MERS-CoV spike protein (eS770) via a Gly/Pro linker using baculovirus as the expression system. For comparative analyses, two eS770 proteins lacking the IgG4 Fc domain were generated using the IdeS protease ($eS770-{\Delta}Fc$) or His tag attachment (eS770-His) and the immunogenicity of the above constructs were examined following intramuscular immunization in mice. Contrary to expectations, non-Fc spike proteins ($eS770-{\Delta}Fc$, eS770-His; 90 kDa) showed higher immunogenicity than the Fc fusion protein (eS770-Fc). Moreover, unlike non-Fc spike proteins, eS770-Fc immunization did not elicit neutralizing antibodies against MERS-CoV. The lower immunogenicity of Fc-fused eS770 was related to alterations in the structural conformation of the spike protein. Taken together, our results indicate that IgG Fc fusion reduces the immunogenicity of eS770 by interfering with the proper folding structure.

• Journal of the Korean Mathematical Society
• /
• v.44 no.4
• /
• pp.863-872
• /
• 2007

Let D be an integral domain with quotient field K, A a nonempty set of height-one maximal t-ideals of D, F$({\Lambda})={I{\subseteq}D|I$ is an ideal of D such that $I{\subseteq}P$ for all $P{\in}A}$, and $D_F({\Lambda})={x{\in}K|xA{\subseteq}D$ for some $A{\in}F({\Lambda})}$. In this paper, we prove that if each $P{\in}A$ is the radical of a finite type v-ideal (resp., a principal ideal), then $D_{F({\Lambda})}$ is a weakly Krull domain (resp., generalized weakly factorial domain) if and only if the intersection $D_{F({\Lambda})}={\cap}_{P{\in}A}D_P$ has finite character, if and only if $F({\Lambda})$ is a t-splitting set of ideals, if and only if $F({\Lambda})$ is v-finite.

• Journal of Microbiology and Biotechnology
• /
• v.18 no.6
• /
• pp.1186-1190
• /
• 2008

Single-chain Fv (scFv) antibody against c-Met is expected to be employed in clinical treatment or imaging of cancer cells owing to the important biological roles of c-Met in the proliferation of malignancies. Here, we show that the productivity of scFv against c-Met in Escherichia coli is significantly influenced by the orientation of its variable domains. We generated anti-c-Met scFv antibodies with two different domain orders (i.e., $V_L$-linker-$V_H$ and $V_H$-linker-$V_L$), expressed them in the cytoplasm of E. coli trx/gor deleted mutant, and compared their specific activities as well as their productivities. Productivity of total and functional anti-c-Met scFv with $V_H/V_L$ orientation was more than five times higher than that with $V_L/V_H$ format. Coexpression of DsbC enhanced the yield of soluble amounts of anti-c-Met scFv protein for both constructs. The purified scFv antibodies of the two different formats exhibited almost the same antigen-binding activities. We also compared the productivities and specific activities of anti-c-Met diabodies with $V_H/V_L$ or $V_L/V_H$ formats and obtained similar results to the case of scFv antibodies.

• IMMUNE NETWORK
• /
• v.21 no.5
• /
• pp.32.1-32.14
• /
• 2021

Over two hundred twenty-eight million cases of coronavirus disease 2019 (COVID-19) in the world have been reported until the 21^st of September 2021 after the first rise in December 2019. The virus caused the disease called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 4 million deaths blame COVID-19 during the last one year and 8 months in the world. Currently, four SARS-CoV-2 variants of concern are mainly focused by pandemic studies with limited experiments to translate the infectivity and pathogenicity of each variant. The SARS-CoV-2 α, β, γ, and δ variant of concern was originated from United Kingdom, South Africa, Brazil/Japan, and India, respectively. The classification of SARS-CoV-2 variant is based on the mutation in spike (S) gene on the envelop of SARS-CoV-2. This review describes four SARS-CoV-2 α, β, γ, and δ variants of concern including SARS-CoV-2 ε, ζ, η, ι, κ, and B.1.617.3 variants of interest and alert. Recently, SARS-CoV-2 δ variant prevails over different countries that have 3 unique mutation sites: E156del/R158G in the N-terminal domain and T478K in a crucial receptor binding domain. A particular mutation in the functional domain of the S gene is probably associated with the infectivity and pathogenesis of the SARS-CoV-2 variant.

• International Journal of Computer Science & Network Security
• /
• v.23 no.12
• /
• pp.199-203
• /
• 2023

In recent decades, the growth of communication technology has resulted in an explosion of data-related information. Ontology perception is being used as a growing requirement to integrate data and unique functionalities. Ontologies are not only critical for transforming the traditional web into the semantic web but also for the development of intelligent applications that use semantic enrichment and machine learning to transform data into smart data. To address these unclear facts, several researchers have been focused on expanding ontologies and semantic web technologies. Due to the lack of clear-cut limitations, ontologies would not suffice to deliver uncertain information among domain ideas, conceptual formalism supplied by traditional. To deal with this ambiguity, it is suggested that fuzzy ontologies should be used. It employs Ontology to introduce fuzzy logical policies for ambiguous area concepts such as darkness, heat, thickness, creaminess, and so on in a device-readable and compatible format. This survey efforts to provide a brief and conveniently understandable study of the research directions taken in the domain of ontology to deal with fuzzy information; reconcile various definitions observed in scientific literature, and identify some of the domain's future research-challenging scenarios. This work is hoping that this evaluation can be treasured by fuzzy ontology scholars. This paper concludes by the way of reviewing present research and stating research gaps for buddy researchers.

• Journal of Sensor Science and Technology
• /
• v.23 no.4
• /
• pp.229-233
• /
• 2014

In this study, a V-grooved single-mode fiber along with optical time domain reflectometry (OTDR) as a quasi-distributed temperature sensor was investigated. The external medium used to fill the V-groove affects the optical mode. The V-groove was filled with ethylene vinyl acetate (EVA) because its transmittance was sensitive to temperature. The experimental results showed that the optical loss of the sensor varies with temperature, and the sensitivity depends on the depth of the V-groove.