• The Journal of the Korea Contents Association
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• v.12 no.12
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• pp.111-118
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• 2012

Capstone design is silk engineering in the field of education, the program requires contractors, not the industrial ability to adapt with the creative overall design training programmes in design education in terms of the applicability of that remains to be seen. In this study, the University of art and industrial design major, konkuk University School of design of the Capstone design 2011 and take advantage of the performance, and the curriculum is mainly applied for the technology. Design and development should be followed for experimental studies and a wealth of knowledge for the creation of advanced technology and professional support for institutions and industries to improve practical skills and lessons based on the Convention. This course through the patent, utility model, design, intellectual property, such as money to improve the practical skills of students to gauge the capacity of enterprises through the design, companies will come up with a gauge, and enhancing the competitiveness of SMEs in the community support instrument.

• The Journal of the Korea Contents Association
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• v.10 no.2
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• pp.320-329
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• 2010

As software producers have tried to keep their profit against illegal piracy, contents producers also want to protect their contents from unlawful sharing among users. Some researchers uncovered that the regulation on the unlicensed contents is not the best policy to maximize their profit mainly due to network effect but this issue has been still controversial. In this paper, we develop a model to investigate the effect of regulation against unlicensed contents sharing on the profit of contents producers and present the optimal condition to maximize profit of contents producers under the regulation and non-regulation of unlicensed contents. As a result, we analyzed that the firm's payoff under the regulation on unlicensed contents is not always greater than the payoff under the non-regulation because of network externality. If the additional utility from off-line purchase of type P consumers (who enjoy the additional benefit of off-line purchase) is large enough, then the firm's payoff is maximized without regulation.

• The Korean Journal of Community Living Science
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• v.17 no.4
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• pp.113-125
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• 2006

The purpose of this study was to analyze the status of intellectual property rights and developmental direction for brands of special rural products in Korea. The data was derived from 166 special rural products in Korea. The major results of this study were as follows: Enterprises having intellectual property rights above one were Traditional soybean sauce 18(56.2%), Hangwa 15(42.9%), Kimchi 18(43.9%), Traditional tea 20(80%) and Crafted products 10(31.3%), respectively. Enterprises acquiring designation and certification due to national and local autonomous entities over one were Traditional soybean sauce 17(56.7%), Hangwa 23(63.9%), Kimchi 33(80.4%), Traditional tea. 13(52%), and Crafted products 20 (62.5%), respectively. The trademark registration of special rural products was invested with total 62 cases(37.3%) as Traditional soybean sauce 14(43.7%), Hangwa 15(41.7%), Kimchi 17(41.5%), Traditional tea. 12(48%) and Crafted products 4(12.5%). And Patent registration 39 cases(23.5%), design registration 32 cases(14.5%), and utility model registration 5 cases (3.01%) were invested respectively. It was shown that, where the origin of brand names was a proper non 107 were things(53%), 39 were materials(19.3%), 17 were the production method(8.41 %) and 55 were a composite trademark(33.1%).

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.2
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• pp.195-201
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• 2015

An electric excavator consumes battery energy to drive an electric motor attached to a hydraulic pump to generate hydraulic power. In a conventional hydraulic excavator, the hydraulic pump is controlled by regulators, which are used to optimize the diesel engine efficiency. Because of a lack of battery energy capacity, an electric excavator controller should consider not only the electric motor efficiency but also the hydraulic pump efficiency. Thus, electric motor and hydraulic pump efficiency maps were constructed. An optimal operating map (OOM) was created based on the most efficient operating points under each input condition. An integrated control algorithm controlled the speed of the electric motor and displacement of the hydraulic pump according to the OOM. To confirm the utility of this algorithm, a model-in-the-loop simulator for the algorithm with an electric excavator was established. The simulation results showed that the integrated control algorithm improved the energy efficiency of an electric excavator.

• Biomolecules & Therapeutics
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• v.21 no.6
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• pp.476-480
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• 2013

Obesity is one of the most serious health problems in developed countries. It negatively affects diverse aspects of human wellbeing. Of these, a relationship between obesity and depression is widely recognized but biomarkers for assessment of obesity-associated mood changes in animal obesity models are rarely known. Here we explored the link between obesity and the plasma levels of monoamine neurotransmitters involved in mood control using a sensitive UPLC/MSMS technique in high fat diet (HFD)-induced obesity model in male C57BL/6 mice to explore the potential utility of plasma tests for obesity-associated mood change. HFD (60% of total calories, 8 weeks) induced significantly higher weight gains in body (+37.8%) and fat tissue (+306%) in male C57BL/6 mice. Bioanalysis of serotonin, dopamine and norepinephrine in plasma at 8 weeks of HFD revealed that serotonin decreased significantly in the obese mice when compared to normal diet-fed mice ($2.7{\pm}0.6$ vs $4.3{\pm}2.0ng/ml$, N=8). Notably, a negative correlation was found between the levels of serotonin and body weight gains. Furthermore, principal component analysis (PCA) with the individual levels of neurotransmitters revealed that plasma levels of dopamine and serotonin could apparently differentiate the obese mice from lean ones. Our study demonstrated that blood plasma levels of neurotransmitters can be employed to evaluate the mood changes associated with obesity and more importantly, provided an important clue for understanding of the relationship between obesity and mood disorders.

• The Journal of Korean Association of Computer Education
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• v.14 no.2
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• pp.61-73
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• 2011

The analysis on learners made through the study focuses on the intention of the participants in the learning activities of the robot programming. Therefore, for the analysis of the learners' intention, which is tried in the study, TAM, the analysis tool used for understanding buying acts or buying intention of buyers in the business sector, is basically utilized, and the Flow theory is additionally applied, trying to know, through the quantum analysis methods, the factors to give influence on the intention for learners to take part in the robot programming lesson. For this, a quantum analysis was made by PLS analysis, a kind of structural equations. As the result of the analysis, it is confirmed that such factors as 'recognized utility' and 'recognized readiness' and 'Flow' give significant influence on the intention of learners' participation in the lesson. As the result of the synthetic analysis and in regard with the value of the programming lesson, it is found that the following factors give actual influence to the intention of learners: the group where learners belong or teaching-learning organizations together with creating social rapport, learning tasks given for learners, etc.

• Journal of Forest and Environmental Science
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• v.24 no.3
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• pp.127-135
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• 2008

The mission of the Forest Inventory and Analyis (FIA) program of the Forest Service, U.S. Department of Agriculture, is to conduct the national forest inventory of the United States of America for purposes of estimating the area of forest land; the volume, growth, and removal of forest resources; and the health of the forest. Users of FIA data, estimates, and related products include land managers, policy and decision-makers, forest industry, environmental organizations, and university researchers. To accomplish its mission, the FIA program has established a sampling design with an intensity of approximately one permanent plot per 2,400 ha across the entire country. Depending on the region of the country, each plot is remeasured at intervals of five or 10 years. The program releases data annually and reports estimates at the county level for each state every five years. Due to budgetary constraints and natural variability among plot observations, sufficient numbers of plots cannot be measured to satisfy precision guidelines for the estimates of many variables unless the estimation process is enhanced using ancillary data. Classified satellite imagery has been demonstrated to be a source of ancillary data that can be used with stratified estimation techniques to increase the precision of estimates with little corresponding increase in costs. A crucial factor restricting the utility of FIA data is that the exact locations of inventory plots cannot be released to the public. Thus, users are generally not able to obtain estimates for small areas or for their own areas of interest if exact plot locations are required. To compensate, satellite imagery, inventory plot data, and the k-Nearest Neighbors technique are being used to construct Internet-based maps of forest attributes from which estimates for arbitrary user-defined areas of interest may be obtained.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8861-8869
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• 2014

Background: The prognostic value of Bcl-2 protein expression in non-small cell lung cancer (NSCLC) is under debate. We therefore systematically reviewed the evidence for Bcl-2 protein effects on NSCLC survival to elucidate this issue. Materials and Methods: An electronic search in Pubmed and Embase complemented by manual searches in article references were conducted to identify eligible studies to evaluate the association between Bcl-2 protein expression and overall survival (OS) as well as disease free survival (DFS) of NSCLC patients. Combined hazard ratios (HRs) with corresponding 95% confidence intervals (95%CIs) were pooled using the random-effects model. Results: A total of 50 trials (including 52 cohorts) encompassing 7,765 patients were pooled in the meta-analysis regarding Bcl-2 expression and OS of NSCLC patients. High expression of Bcl-2 protein had a favorable impact (HR=0.76, 95%CI=0.67-0.86). In the group of Bcl-2 expression and DFS, 11 studies including 2,634 patients were included. The synthesized result indicated high expression of Bcl-2 protein might predict good DFS (HR=0.85, 95%CI=0.75-0.95). Conclusions: Our present meta-analysis demonstrated favorable prognostic values of Bcl-2 expression in patients with NSCLC. Further prospective trails are welcomed to validate the utility of assessing Bcl-2 in NSCLC patient management.

• Biomedical Science Letters
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• v.13 no.4
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• pp.273-278
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• 2007

Stem cells have been the subject of increasing scientific interest because of their utility in numerous biomedical applications. Stem cells are capable of renewing themselves; that is, they can be continuously cultured in an undifferentiated state, giving rise to more specialized cells of the human body. Therefore, stem cells are an important new tools for developing unique, in vitro model systems to test drugs and chemicals and a potential to predict or anticipate toxicity in humans. In the present study, in vitro cultured F3 immortalized human neural stem cell line and in vivo adult Sprague Dawley rats was used to evaluate the cytotoxicity of anticancer drug paclitaxel. In vitro apoptotic activity of paclitaxel was evaluated in F3 cell line by a MTT assay and DAPI test. The cell death was induced with the treatment of 20 nM paclitaxel and chromatin degradation was detected by DAPI staining, which was analyzed by fluorescent microscope. In vivo studies, we also observed nestin immunoreactivity on subventricular zone, which is stem cell rich region in the adult brain of the SD rat. Immunofluorescent staining result shows that pixel intensities of nestin were decreased in a dose dependent manner. These results suggest that paclitaxel is able to induce cytotoxic activity both in F3 neural stem cell line and neural stem cell in SD rat brain.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.411.1-411.1
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• 2014

This study evaluates the utility of an antibacterial microneedle composed of green tea extract (GT) and hyaluronic acid (HA), for the efficient delivery of GT. These microneedles have the potential to be a patient-friendly method for the conventional sustained release of drugs. In this study, a fabrication method using a mold-based technique to produce GT/HA microneedles with a maximum area of ${\sim}60mm^2$ with antibacterial properties was used to manufacture transdermal drug delivery systems. Fourier transform infrared (FTIR) spectrometry was carried out to observe the potential modifications in the microneedles, when incorporated with GT. The degradation rate of GT in GT/HA microneedles was controlled simply by adjusting the HA composition. The effects of different ratios of GT in the HA microneedles were determined by measuring the release properties. In HA microneedles loaded with 70% GT (GT70), a continuous higher release rate were sustained for 72 h. The in vitro cytotoxicity assays demonstrated that GT/HA microneedles are not generally cytotoxic to chinese hamster ovary cells (CHO-K1), human embryonic kidney cells (293T), and mouse muscle cells (C2C12), which were treated for 12 and 24 h. Antimicrobial activity of the GT/HA microneedles was demonstrated by ~95% growth reduction of gram negative [Escherichia coli (E. coli), Pseudomonas putida (P. putida) and Salmonella typhimurium (S. typhimurium)] and gram positive bacteria [Staphylococcus aureus (S. Aureus) and Bacillus subtilis (B. subtilis)], with GT70. Furthermore, GT/HA microneedles reduced bacterial growth in the infected skin wound sites and improved skin wound healing process in rat model.