• Nutrition Research and Practice
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• 제16권6호
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• pp.729-744
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• 2022

BACKGROUND/OBJECTIVES: 4-Hydroxy-2-nonenal (HNE) is a biomarker for oxidative stress to induce inflammation. Methionine is an essential sulfur-containing amino acid with antioxidative activity. On the other hand, the evidence on whether and how methionine can depress HNE-derived inflammation is lacking. In particular, the link between the regulation of the nuclear factor-κB (NF-κB) signaling pathway and methionine intake is unclear. This study examined the link between depression from HNE accumulation and the anti-inflammatory function of ⳑ-methionine in rats. MATERIALS/METHODS: Male Wistar rats (3-week-old, weighing 70-80 g) were administered different levels of ⳑ-methionine orally at 215.0, 268.8, 322.5, and 430.0 mg/kg body weight for two weeks. The control group was fed commercial pellets. The hepatic HNE contents and the protein expression and mRNA levels of the inflammatory mediators were measured. The interleukin-10 (IL-10) and glutathione S-transferase (GST) levels were also estimated. RESULTS: Compared to the control group, hepatic HNE levels were reduced significantly in all groups fed ⳑ-methionine, which were attributed to the stimulation of GST by ⳑ-methionine. With decreasing HNE levels, ⳑ-methionine inhibited the activation of NF-κB by up-regulating inhibitory κBα and depressing phosphoinositide 3 kinase/protein kinase B. The mRNA levels of the inflammatory mediators (cyclooxygenase-2, interleukin-1β, interleukin-6, inducible nitric oxide synthase, tumor necrotic factor alpha) were decreased significantly by ⳑ-methionine. In contrast, the protein expression of these inflammatory mediators was effectively down regulated by ⳑ-methionine. The anti-inflammatory action of ⳑ-methionine was also reflected by the up-regulation of IL-10. CONCLUSIONS: This study revealed a link between the inhibition of HNE accumulation and the depression of inflammation in growing rats, which was attributed to ⳑ-methionine availability. The anti-inflammatory mechanism exerted by ⳑ-methionine was to inhibit NF-κB activation and to up-regulate GST.

• 한국통신학회논문지
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• 제22권10호
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• pp.2171-2180
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• 1997

본 논문에서는 WATM에서 멀티미디어트래픽을 지원하기 위해 동적채널할당기법을 이용한 MAC 프로토콜 P/S-DCA를 제안하고, 하향트래픽의 변화에 따른 상/하향링크의 throughput과 지연을 해석적으로 분석한다. 동적채널할당기법을 평가하기위해 시뮬레이션을 수행하였다. 그 결과 시스템용량이 PRMA와 C-PRMA보다 향상되는 것을 알 수 있었다. $M_{0.01}$로 표시되는 시스템용량은 패킷폐기율이 1%를 넘지 않는 범위에서 지원가능한 음성단말의 수로 정의된다. 시뮬레이션 결과 $M_{0.01}$의 값이 ${\lambda}_{d}=0.5,\;{\lambda}_{d}=0.2\;{\lambda}_{d}=0.1\;{\lambda}_{d}=0.001$에 대해 각각 43, 69, 77, 83으로 증가하는 것을 알 수 있었다. 이 결과는 P/S-DCA 프로토콜이 PRMA나 C-PRMA에 비해 시스템용량을 증가시키는 것을 보여준다.

• Molecules and Cells
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• 제44권3호
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• pp.146-159
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• 2021

DNA methylation, and consequent down-regulation, of tumour suppressor genes occurs in response to epigenetic stimuli during cancer development. Similarly, human oncoviruses, including human papillomavirus (HPV), up-regulate and augment DNA methyltransferase (DNMT) and histone deacetylase (HDAC) activities, thereby decreasing tumour suppressor genes (TSGs) expression. Ubiquitin-like containing PHD and RING finger domain 1 (UHRF1), an epigenetic regulator of DNA methylation, is overexpressed in HPV-induced cervical cancers. Here, we investigated the role of UHRF1 in cervical cancer by knocking down its expression in HeLa cells using lentiviral-encoded short hairpin (sh)RNA and performing cDNA microarrays. We detected significantly elevated expression of thioredoxin-interacting protein (TXNIP), a known TSG, in UHRF1-knockdown cells, and this gene is hypermethylated in cervical cancer tissue and cell lines, as indicated by whole-genome methylation analysis. Up-regulation of UHRF1 and decreased TXNIP were further detected in cervical cancer by western blot and immunohistochemistry and confirmed by Oncomine database analysis. Using chromatin immunoprecipitation, we identified the inverted CCAAT domain-containing UHRF1-binding site in the TXNIP promoter and demonstrated UHRF1 knockdown decreases UHRF1 promoter binding and enhances TXNIP expression through demethylation of this region. TXNIP promoter CpG methylation was further confirmed in cervical cancer tissue by pyrosequencing and methylation-specific polymerase chain reaction. Critically, down-regulation of UHRF1 by siRNA or UHRF1 antagonist (thymoquinone) induces cell cycle arrest and apoptosis, and ubiquitin-specific protease 7 (USP7), which stabilises and promotes UHRF1 function, is increased by HPV viral protein E6/E7 overexpression. These results indicate HPV might induce carcinogenesis through UHRF1-mediated TXNIP promoter methylation, thus suggesting a possible link between CpG methylation and cervical cancer.

• Tribology and Lubricants
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• 제36권1호
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• pp.27-33
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• 2020

Self-equalizing tilting pad thrust bearings are usually employed in turbomachines to achieve high stability and reliability. A tilting pad bearing can incorporate self-equalizing links to handle the misalignment between the bearing and the thrust collar. In this popular design method, the pads sit on the upper-level plates and the lower-level plates stay on the retainer base. With misalignment, the pads that are heavily loaded are pushed down. Consequently, the link pushes up the pads on the opposite side, keeping the bearing surface parallel to the thrust collar surface. The self-equalizing link is used to handle the misalignment from the thermal and mechanical effects. In this study, the experimental investigation deals with the performance of self-equalizing tilting pad thrust bearings. The test rig for evaluating the performance of bearing is developed which can control the misalignment angle. Simultaneous measurements are taken for the force acting on each pad. Pad metal temperature and oil film thickness are functions of the shaft speed, bearing load, misalignment angle, and design of leveling plates. The effect of misalignment on bearing performance is discussed. The results demonstrate that the load on each pad depends on the test conditions(especially misalignment angle), and the load influences the performance of bearings.

• 대한전자공학회논문지TC
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• 제37권2호
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• pp.83-90
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• 2000

본 논문에서는 이중공진 및 광대역, 고이득의 특성을 갖는 적층된 원형-디스크 마이크로스트립 1×4 배열 안테나를 차세대 이동통신인 IMT-2000시스템(상향링크: 1.885 GHz∼2.025 GHz, 하향링크: 2.11 GHz∼2.2 GHz)기지국에서 응용할 수 있도록 설계 제작 및 실험하였다. 실험결과 상향:l.885 GHz, 하향:2.178 GHz로 원하는 주파수대에서 정확히 이중 공진하고, 궤환 손실은 -30.19dB, -24.99dB로 나타났으며 VSWR은 각각 1.06, 1.43, 그리고 VSWR<2 에서의 대역폭 402 MHz, -3dB 빔 폭은 1.88 GHz에서( αE :16.8。, αH : 69。), 2.178 GHz에서(αE:15.2。, αH:51.5。)를 갖고, 이득은 사용 하고자 하는 주파수 전반에 거쳐 약 13.7 dBi∼15.21 dBi의 이득을 얻었다.

• 전자공학회논문지D
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• 제36D권6호
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• pp.1-12
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• 1999

본 논문에서는 초고속 정보통신망의 무선인프라(INFRA)로 주목 받고 있는 LMDS(Local Multipoint Distribution Service) 시스템을 국내 환경에 적절한 망구조 및 서비스 구조로 설계하였을 때의 시스템구조와 국내 환경에 맞는 링크버짓을 분석하였으며, HUB 에 실장되는 Power Amplifier의 LPA급 또는 HPA급의 선택에 따른 셀반경 변화 분석, 그리고 채널 확장시의 시스템 설계구조와 특징을 분석하였다. 한편, 본 논문에서 분석을 위해 사용된 각종 피라메타들은 국내 정보통신부에서 고시한 허가주파수대역(상향: 24.25GHz-24.75GHz, 하향 25.5GHz-27.5GHz)를 적용하였고, 변복조방식 및 채널코딩에 관한 규정은 DAVIC에서 권고한 규격을 적용하였으며, 기상관련 자료는 ITU-R에서 보고한 자료를 참조하였다. 본 논문은 향후 통신망사업자가 국내 LMDS 서비스를 위한 최적의 망설계시 참고자료로 활용될 수 있도록 하였다.

• 디지털콘텐츠학회 논문지
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• 제16권4호
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• pp.615-622
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• 2015

최근 가상광고는 비용의 절감 및 적용의 편의성으로 인하여 TV시장에서 중요한 관심 영역으로 자리 잡고 있다. 방송에 가상광고를 삽입하는 방법으로는 촬영현장에 장비와 기술진을 파견해 방송사의 제작 장비와 연동하여 이미지를 삽입하는 업링크(Uplink)기법과 영상처리 기법을 활용하여 중계 영상에 자동적으로 가상이미지를 삽입하는 다운스트리밍(Down streaming)기법이 있다. 최근에는 자동적인 가상광고 삽입을 위한 영상 처리 기술이 가상광고 영역에서 중요한 연구 분야로 자리 잡고 있다. 따라서 본 논문에서는 스포츠 영상 내에서 자동적으로 가상광고를 삽입하기 위해 영상처리 기법을 활용하여 저정보영역을 추출하는 방법을 제안한다. 제안 방법은 허프(Hough)변환을 이용한 사각형 검출과 검출된 사각형영역에 대한 색 히스토그램 분포의 분석을 통해 저정보영역을 추출한다.

• 기록학연구
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• 제11호
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• pp.123-143
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• 2005

1. Introduction : From the Memorial to the Records, From the Records to the Archives 2. Archivists and Historians : the Records Keeping, Appraisal and Selection 3. Records and Historical Materials in the Historical Narrative 4. the Relation of the Facts and Theory in the History 5. Conclusion In this essay I considered the relations of records and history, namely the process on the selection and choice from the records to the archives and the historical materials and in the process the role on the archivists and historians and difference and the relation of the facts and theory in the history. Archival science posits that an archives is the whole of the documents made or received in the course of purposeful activity, and of the relationships among those documents. Archival theory posits that it is the primary function of the archivists to maintain unbroken, continuing custody of societal archives, and to protect their integrity by keeping them physically and intellectually uncorrupted. The ultimate purpose of archival endeavors is to hand down to the next generations a reliable, trustworthy, and complete testimony of societal actions so that they can constitute sources of, and foundations for, future decision making. However, historical science searches for the truth in the historical facts, explains the cause and origin of the matters and reflects on th knowledge about the why and how the events happened. And history is firmly rooted on the philosophy. The goal of historian is analysing the nature of meaning of past in the society and tracing up the change and process of the transition. Archival science means historical source studies and other related disciplines. On the other hand archival management is the principle of respect for original order and the importance of original forms and conditions. Thus the relations between archival science and archives management are not one-sided but mutual. Archival science and historical studies, archivists and historians need to link more closely in order to hand down the contemporary memorial, the common memorial of mankind to the future.

• 한국CDE학회논문집
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• 제20권3호
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• pp.312-319
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• 2015

The grinding and furbishing process as the finishing process for molds include the works such as the grinding, buffing, lapping and polishing among others. A finishing tool unit is applied to this finishing process for the burr, lapping, polishing and others of molds. A finishing tool unit can carry out the flexible machining, depending on the machining allowance for objects to be cut on the basis of the instrumental driving mechanism which enables the up, down, left and right floating, which is applied in link with the dedicated cutters and robot machining systems. This study selected the shape to increase the rotatory force of an impeller when air is discharged during the driving of a finishing tool unit, and reflected it to the impeller designing. In addition, the study analyzed each flow velocity and pressure distribution per air pressurization value and finally analyzed the rotating torque to suggest the optimal conditions in designing impellers.

• 한국생산제조학회지
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• 제21권2호
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• pp.305-310
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• 2012

Planetary gear box is a power transmitter having very high gear ratio in compact volume. The planetary step-down gear box converts high speed and low torque into low speed and high torque, which is widely used in constructional and industrial machinery field. And, the planetary step-up gear box does vice versa working, which is used as main gear box of large sized wind mill system. The large sized planetary gear box must be performed the normal-opposite rotation test as a its durability test for achieving the reliability. The large sized planetary gear box is composed by triple gear trains of sun gear, carrier, and ring gear. If input power is supplied into one of them and the other is fixed, and then another becomes the output part. In this paper, we designed a new test equipment which can do rapid normal and opposite rotational change with only small displacement by supplying test power using the above rotation (driving) characteristics and hydraulic cylinder and link, and also compared and analyzed with existing method through various experiments.