• Korean Journal of Radiology
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• 제24권8호
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• pp.795-806
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• 2023

Occupational lung diseases (OLD) are a group of preventable conditions caused by noxious inhalation exposure in the workplace. Workers in various industries are at a higher risk of developing OLD. Despite regulations contributing to a decreased incidence, OLD remain among the most frequently diagnosed work-related conditions, contributing to significant morbidity and mortality. A multidisciplinary discussion (MDD) is necessary for a timely diagnosis. Imaging, particularly computed tomography, plays a central role in diagnosing OLD and excluding other inhalational lung diseases. OLD can be broadly classified into fibrotic and non-fibrotic forms. Imaging reflects variable degrees of inflammation and fibrosis involving the airways, parenchyma, and pleura. Common manifestations include classical pneumoconioses, chronic granulomatous diseases (CGD), and small and large airway diseases. Imaging is influenced by the type of inciting exposure. The findings of airway disease may be subtle or solely uncovered upon expiration. High-resolution chest CT, including expiratory-phase imaging, should be performed in all patients with suspected OLD. Radiologists should familiarize themselves with these imaging features to improve diagnostic accuracy.

• BMB Reports
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• 제48권1호
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• pp.19-24
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• 2015

A mouse homozygous for the spontaneous mutation uncovered (Uncv) has a hairless phenotype. A 309-bp non-frameshift deletion mutation in the N-terminal cytoplasmic domain of iRhom2 was identified in Uncv mice ($iRhom2^{Uncv}$) using target region sequencing. The detailed molecular basis for how the iRhom2 mutation causes the hairless phenotype observed in the homozygous $iRhom2^{Uncv}$ mouse remains unknown. To identify differentially expressed proteins in the skin of wild-type and homozygous $iRhom2^{Uncv}$ littermates at postnatal day 5, proteomic approaches, including two-dimensional gel electrophoresis and mass spectrometry were used. Twelve proteins were differentially expressed in the skin in a comparison between wild-type and homozygous $iRhom2^{Uncv}$ mice. A selection of the proteomic results were tested and verified using qRT-PCR, western blot and immunohistochemistry. These data indicate that differentially expressed proteins, especially KRT73, MEMO1 and Coro-1, might participate in the mechanism by which iRhom2 regulates the development of murine skin.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2008년도 추계학술발표대회 논문집
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• pp.184-189
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• 2008

The excess heat that is generated from PV modules can be removed and converted into useful thermal energy. A photovoltaic/thermal(PVT) module is a combination of photovoltaic module with a solar thermal collector, forming one device that converts solar radiation into electricity and heat simultaneously In general, two types of PVT can be distinguished: glass-covered PVT module, which produces high-temperature heat but has a slightly lower electrical yield, and uncovered PVT module, which produces relatively low-temperature heat but has a somewhat higher electrical performance. In this paper, the experimental performance of water type unglazed PVT combined module, analyzed. The electrical and thermal performance of the module were measured in outdoor conditions, and the results are analyzed. The results showed that the thermal efficiency of the PVT module was 27.05% average and its PV efficiency was about 11.85% average, both depending on solar radiation, inlet water temperature and ambient temperature.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2009년도 하계학술발표대회 논문집
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• pp.792-797
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• 2009

The excess heat that is generated from PV modules can be removed and converted into useful thermal energy. A photovoltaic-thermal(PVT) module is a combination of photovoltaic module with a solar thermal collector, forming one device that receives solar radiation and produces electricity and heat simultaneously. In general, two types of PVT can be classified: glass-covered PVT module, which produces high-temperature heat but has a slightly lower electrical yield, and uncovered PVT module, which produces relatively lower temperature heat but has a somewhat higher electrical performance. In this paper, the experimental performance of two types of the PVT combined module(water type), glazed(glass-covered) and unglazed, was analyzed. The electrical and thermal performance of the PVT combined modules were measured in outdoor conditions, and the results were compared.

• 설비공학논문집
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• 제20권4호
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• pp.260-265
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• 2008

The excess heat that is generated from PV modules can be removed and converted into useful thermal energy. A photovoltaic/thermal (PVT) module is a combination of photovoltaic module with a solar thermal collector, forming one device that converts solar radiation into electricity and heat simultaneously. In general, two types of PVT can be distinguished : glass-covered PVT module, which produces high-temperature heat but has a slightly lower electrical yield, and uncovered PVT module, which produces relatively low-temperature heat but has a somewhat higher electrical performance. In this paper, the experimental performance of water type PVT combined module, glass-covered, analyzed. The electrical and thermal performance of the module were measured in outdoor conditions, and the results are analyzed. The results showed that the thermal efficiency of the PVT module was 27.6% average and its PV efficiency was about 10.0% average, both depending on solar radiation, inlet water temperature and ambient temperature.

• Weed & Turfgrass Science
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• 제2권3호
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• pp.292-297
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• 2013

Winter turfgrass injury is one of the critical problems of many golf courses in Korea. Turfgrass loss from freezing injury due to low temperature leads to many types of damages including weed invasion, increased herbicide cost, increased soil erosion, and expensive re-establishment. Although Kentucky bluegrass (Poa pratensis L.) which is the most widely used among cool-season grasses in Korea is well known as cold tolerance species, freezing injuries to Kentucky bluegrass during winter are often found. Protecting the turfgrass crown is necessary to recover from low temperature stress in winter because shoots and roots can be recovered from the crown. Turf covers may protect the crowns from direct low temperatures and desiccation. Six different turf covers were installed to cover Kentucky bluegrass during a period of low temperatures. Turf covers had positive effects for spring green-up of Kentucky bluegrass based on the study. Applying any type of turf covers on Kentucky bluegrass resulted in an increase average and minimum temperature compared to the uncovered plot. Among turf covers, clear PVC film without holes produced the longest root length and the highest turfgrass quality.

• Molecules and Cells
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• 제39권6호
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• pp.484-494
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• 2016

Plant cells have a remarkable ability to induce pluripotent cell masses and regenerate whole plant organs under the appropriate culture conditions. Although the in vitro regeneration system is widely applied to manipulate agronomic traits, an understanding of the molecular mechanisms underlying callus formation is starting to emerge. Here, we performed genome-wide transcriptome profiling of wild-type leaves and leaf explant-derived calli for comparison and identified 10,405 differentially expressed genes (> two-fold change). In addition to the well-defined signaling pathways involved in callus formation, we uncovered additional biological processes that may contribute to robust cellular dedifferentiation. Particular emphasis is placed on molecular components involved in leaf development, circadian clock, stress and hormone signaling, carbohydrate metabolism, and chromatin organization. Genetic and pharmacological analyses further supported that homeostasis of clock activity and stress signaling is crucial for proper callus induction. In addition, gibberellic acid (GA) and brassinosteroid (BR) signaling also participates in intricate cellular reprogramming. Collectively, our findings indicate that multiple signaling pathways are intertwined to allow reversible transition of cellular differentiation and dedifferentiation.

• 동의신경정신과학회지
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• 제29권2호
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• pp.111-119
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• 2018

Objectives: To investigate the characteristics of patients diagnosed with dementia or mild cognitive impairment who are treated by means of a blend between Western and Korean medicine. Methods: We searched for outpatients with dementia or mild cognitive impairment by means of a collaboration between Western and Korean medicine from August 1, 2015, to July 31, 2017, through electronic medical records in Wonkwang Hospital. The records were retrospectively analyzed according to the patients' demographic and clinical characteristics, pathway of medical care, diagnostic tests, treatment, and medical expenses. Results: Thirteen patients were included in the analysis. Among them, six patients were diagnosed with mild cognitive impairment, five with dementia, Alzheimer's type, one patient with frontotemporal dementia, and one patient with unspecified dementia. Twelve of the thirteen patients were over 60 years of age. The number of pathways from the Dept. of Neurology to the Dept. of Neuropsychiatry of Korean Medicine was almost the same as the opposite pathway. The most used diagnostic test in Korean medicine was a neuropsychological test such as SNSB, MMSE and GDS. In Western medicine, hematology and neuroimaging were frequently used for patients. Acupuncture in Korean medicine and medication in Western medicine were the most frequently used. In Korean medicine, uncovered service costs were much higher than covered service costs,. whereas, in Western medicine, covered service costs were higher than uncovered service costs. Conclusions: This study describes the basic characteristics of dementia and mild cognitive impairment patients treated by a collaboration between Western and Korean medicine. Based on these results, a clinical pathway of the collaborative practice system between Western and Korean medicine for dementia patients needs to be developed.

• Journal of Microbiology and Biotechnology
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• 제28권9호
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• pp.1482-1492
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• 2018

Fusarium oxysporum trypsin (FOT) is a fungal serine protease similar to mammal trypsin. The FOT could be successfully expressed in Pichiapastoris by engineering the natural propeptide APQEIPN. In this study, we constructed two recombinant enzymes with engineered amino acid sequences added to the N-terminus of FOT and expressed in P. pastoris. The N-terminal residues had various effects on the structural and functional properties of trypsin. The FOT, and the recombinants TE (with peptide YVEF) and TS (with peptide YV) displayed the same optimum temperature ($40^{\circ}C$) and pH (8.0). However, the combinants TE and TS showed significantly increased thermal stability at $40^{\circ}C$ and $50^{\circ}C$. Moreover, the combinants TE and TS also showed enhanced tolerance of alkaline pH conditions. Compared with those of wild-type FOT, the intramolecular hydrogen bonds and the cation ${\pi}$-interactions of the recombinants TE and TS were significantly increased. The recombinants TE and TS also had significantly increased catalytic efficiencies (referring to the specificity constant, $k_{cat}/K_m$), 1.75-fold and 1.23-fold than wild-type FOT. In silico modeling analysis uncovered that the introduction of the peptides YVEF and YV resulted in shorter distances between the substrate binding pocket (D174, G198, and G208) and catalytic triad (His42, Asp102, and Ser180), which would improve the electron transfer rate and catalytic efficiency. In addition, N-terminal residues modification described here may be a useful approach for improving the catalytic efficiencies and characteristics of other target enzymes.

• Applied Science and Convergence Technology
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• 제24권3호
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• pp.53-59
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• 2015

The field-effect transistors (FETs) with a graphene-based p-n junction channel were fabricated using the patterned self-assembled monolayers (SAMs). The self-assembled 3-aminopropyltriethoxysilane (APTES) monolayer deposited on $SiO_2$/Si substrate was patterned by hydrogen plasma using selective coating poly-methylmethacrylate (PMMA) as mask. The APTES-SAMS on the $SiO_2$ surface were patterned using selective coating of PMMA. The APTES-SAMs of the region uncovered with PMMA was removed by hydrogen plasma. The graphene synthesized by thermal chemical vapor deposition was transferred onto the patterned APTES-SAM/$SiO_2$ substrate. Both p-type and n-type graphene on the patterned SAM/$SiO_2$ substrate were fabricated. The graphene-based p-n junction was studied using Raman spectroscopy and X-ray photoelectron spectroscopy. To implement low voltage operation device, via ionic liquid ($BmimPF_6$) gate dielectric material, graphene-based p-n junction field effect transistors was fabricated, showing two significant separated Dirac points as a signature for formation of a p-n junction in the graphene channel.