• The Korean Journal of Physiology and Pharmacology
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• v.20 no.1
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• pp.63-67
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• 2016

Severe graft-versus-host disease (GVHD) is an often lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT). The safety of clinical-grade mesenchymal stem cells (MSCs) has been validated, but mixed results have been obtained due to heterogeneity of the MSCs. In this phase I study, the safety of bone marrow-derived homogeneous clonal MSCs (cMSCs) isolated by a new subfractionation culturing method was evaluated. cMSCs were produced in a GMP facility and intravenously administered to patients who had refractory GVHD to standard treatment resulting after allogeneic HSCT for hematologic malignancies. After administration of a single dose ($1{\times}10^6cells/kg$), 11 patients were evaluated for cMSC treatment safety and efficacy. During the trial, nine patients had 85 total adverse events and the rate of serious adverse events was 27.3% (3/11 patients). The only one adverse drug reaction related to cMSC administration was grade 2 myalgia in one patient. Treatment response was observed in four patients: one with acute GVHD (partial response) and three with chronic GVHD. The other chronic patients maintained stable disease during the observation period. This study demonstrates single cMSC infusion to have an acceptable safety profile and promising efficacy, suggesting that we can proceed with the next stage of the clinical trial.

• Journal of the Korean Society for Nondestructive Testing
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• v.11 no.1
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• pp.38-43
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• 1991

The relationship between eddy current response and case hardening depth has been studied on SM40C(KS D-3752) and SCM440(KS D-3711) steels which were surface hardened by high frequency induction hardening. The results obtained in this study were as follows ; 1) Case hardening depth was successfully measured by observing the eddy current impedance changes of each steel. The impedance decreased linearly with increasing case hardening depth. 2) For large impedance gradient between the hardened surface and core metal, the eddy current response was more sensitive to case hardening depth than for low impedance gradient.

• Proceedings of the Safety Management and Science Conference
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• 2006.04a
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• pp.115-121
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• 2006

SCM 경쟁력 재고는 기업 내의 부문별 또는 개별기업 내부의 한정된 개선 노력이 외부의 부문 또는 기업에서의 활동과 연계되어 전체의 최적화가 되지 않으면 그 성과가 극히 제한적일 수 밖에 없다. 따라서 히든 코스트(hidden cost)의 발견 및 유통물류의 최적화에 박차를 가하는 것이 현실이다. 본 연구는 순 물류로 진행한 유통 경로 상에서 만약 역 물류가 발생할 경우 순물류 비용이외 공차(empty driving)로 인한 역물류의 히든 코스트를 최소화하는 모형을 통해 물류이익을 최대화 할 수 있는 방안을 찾기 위해 노력하며 결국 순물류와 역물류상의 유통상의 비용과 이익의 쌍대성에 기초하여 Pull, Push 시스템을 이용한 최적 시스템 모델화를 수행하여 효율적인 물류비용 산정의 방법을 모색한다.

• IE interfaces
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• v.13 no.3
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• pp.306-319
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• 2000

The purpose of this research is to study customer-supplier relationships, particularly their partnerships, to help managers and practitioners successfully design, develop, implement and deploy tools and joint practices as a means for an effective supply chain management (SCM). To achieve this purpose, a total of 1,811 potential survey questionnaire respondents responsible for purchasing, sales/marketing, quality-, and production- or operations-related functions of U.S. private manufacturing companies in SIC 35, 36, and 37 were used to collect quantitative data. Using 172 usable survey questionnaire responses, eight hypothesized relationships were tested using two independent (joint use of specific tools and joint practices) and four dependent variables (informed partners, role integrity, conflict resolution, and mutuality). From the overall perspective (customer+supplier), organizations with higher levels of joint action have higher degrees of informed partners whereas organizations with higher levels of joint action resolve conflicts formally and do not have higher degrees of mutuality.

• Proceedings of the Korean Information Science Society Conference
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• 2007.10d
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• pp.184-189
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• 2007

물류유통분야에서는 SCM(Supply Chain Management)의 효율을 위하여 RFID 기술의 적용을 날로 확대하고 있다. 시대흐름에 편승하여 국방에서는 군수분야에 이 기술을 적용하고 있다. 군수물자 관리에서 필요성을 인식하고 국방탄약관리 시스템 구축사업, 신무기체계 자산관리 시스템 구축사업 등에 RFID 기술을 적용하였다. u-군수정보체계를 구축하기 위해서는 탄약뿐만 아니라 물자, 장비정비 RFID 시스템이 국방차원의 ONS(Object Naming Service) 및 DS(Discovery Service)와 연계되어야 비로소 군수물자 전체에 대하여 실시간으로 흐름을 파악할 수 있게 된다. 그러나 시범사업을 통하여 구축된 탄약 RFID 시스템이나 신무기체계 자산관리 시스템은 기관간 정보를 공유할 수 있도록 하는 국방차원의 ONS가 구비되어 있지 않고, 향후 구축할 계획을 가지고 있다. 따라서 본 논문에서는 EPCglobal 네트워크의 시사점 및 향후 추진 방향을 정리해 보고, 국방분야에서 RFID 시스템 도입사례와 향후 국방 RFID 추진방향, 국방 군수지원 개념을 고찰하였다. 그리고 군에 적합하고 인트라넷 환경에서 운영이 가능한 MND-ONS(Military and Defense) 시스템 구축방안을 제시하였다.

• IE interfaces
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• v.19 no.4
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• pp.333-341
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• 2006

RFID (Radio Frequency Identification) is a technology that can input identification information to microchip and make goods, animals, persons recognized, chased, and managed using radio frequency, and is founded on the core technology of ubiquitous environment of the future. In this paper, we propose a RFID integrated system designed to manage the lifecycle of an individual product efficiently. The proposed system can enable traceability and visibility of items through their entire life by integrating distribution and banking information on the basis of EPCglobal Network. It may provide the infra of Digital Manufacturing and RTE (Real Time Enterprise) and effective information sharing structure with existing legacy system (ERP, CRM, SCM) by real time.

• IE interfaces
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• v.25 no.1
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• pp.40-51
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• 2012

Today, many manufacturing companies realize that collaboration is crucial for their survival. Especially, in the perspective of quality, the importance of collaboration is emphasized because economic loss increases exponentially while defective parts go through the process in supply chain. However, the manufacturing companies are facing two main difficulties in implementing collaborative relationships with their suppliers. First, it is difficult for the suppliers to produce reliable products due to their obsolete facilities. The problem gets worse for second- or third-tire vendors. Second, the companies experience the lack of universally understandable set of terminology and effective methodologies for knowledge representation. Ontology is one of the best approaches to expressing and processing a domain knowledge. In this paper, we propose the manufacturing ontology-based quality prediction framework to represent and share the knowledge of industrial environment and to predict product quality in manufacturing processes. In addition, we develop the ontology-based quality prediction system based on the proposed framework. We carried out a series of experiments for an injection molding process at an automotive part supplier. The experimental results demonstrated that the proposed framework and system can be successfully applicable in manufacturing industry.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2000.10a
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• pp.33-36
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• 2000

The dynamic recrystallization (DRX) of medium carbon steels (SCM 440 and POSMA45) was studied with torsion test in the temperature range of $900-1100^{\circ}C$ and the strain rate range of $5.0x10^{-2}\;-\;5.0x10^0/sec$. To establish the quantitative equations for DRX, the evolution of flow stress curve with strain was analyzed. The critical strain (${\varepsilon}_c$) and strain for maximum softening rate ( ${\varepsilon}^{*}$) could be confirmed by the analysis of work hardening rate ($d{\sigma}/d{\varepsilon}\;=\; \theta$). The volume fraction of dynamic recrystallization ($X_{DRX}$) as a function of processing variables, such as strain rate ( $\dot{\varepsilon}$ ), temperature (T), and strain ( $\varepsilon$ ) were established using the ${\varepsilon}_c$ and ${\varepsilon}^{*}$. For the exact prediction, the ${\varepsilon}_c$, ${\varepsilon}^{*}$ and Avrami' exponent (m') were quantitatively expressed by dimensionless parameter, Z/A respectively. The transformation-effective strain-temperature curve for DRX could be composed. It was found that the calculated results were agreed with the experimental data for the steels at any deformation conditions.

• Geotechnical Engineering
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• v.12 no.1
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• pp.47-62
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• 1996

The bedding zone which influence directly to the safety of dam is supporting the face slab under hydraulic load in concrete faced rockfill dam. In case that leakage is developed due to various ruptured joint or cracks of face slab and etc., the bedding zone should limit the leakage by low permeability and keep the internal stability. In this study for the proper coefficient of permeability various properties, such as gradation, dry density, performance of embankment work and etc. were analysed. The results from the large scale test of permeability and density are summerized as follows : 1. Coefficient of permeability is decreased clearly by increase of dry density. 2. The particles smaller than the No.4 strive( p,) greatly influences the permeability under dry density of 2.24t 1 m3. 3. In case of C.40 and p,40%, even if dry density decreased to 2.0t/m3, the permeability coefficient is assumed to u x1-scm/s and internal stability is abtained. 4. Generally in dam construction since dry density and uniformity coefficient of bedding zone were higher than 2.2t/m3 and 50 respectively p, of 30~40% is assumed to be suitable and permeability coefficient of below 1$\times$10-3cm l s is expectable.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.30 no.4
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• pp.155-163
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• 2007

Future war needs a lot of changes for military organization. Specially, concept of the "Speed" is raised importantly after Iraq war of U.S. Armed Forces. So, He is a lot of studying supply chain for logistical support speed improvement. Korea Marine Corps has made an efforts to improve supply chain. However it is real that is putting various techniques by prescription rather than fundamental change. These simplicity prescriptions are not only systematic but also insufficient for Marine Corps' survival. In addition, Korea marine corps in actuality is depending on many members in marine and navy in feed chain. Thus it is not establishing even tactical, decision-making plan of operation for support ability cultivation. Therefore, in this study, with Sense and Response concept that is United States Marine Corps' support strategy, presented theoretical background and basis frame that serve that Korea Marine Corps's supply chain changes to perception reaction formation.