• 한국지반공학회지:지반
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• 제13권3호
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• pp.21-32
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• 1997

본 연구에서는 암반의 국부파괴 현상을 현실적으로 모형 화하기 위하여 혼합체기법을 적용한 새로운 유한요소를 제안하였다. 이를 위하여 각 유한요소의 적분점에서 재료의 안정성을 검토하고 필요시 국부파괴 요소와 인접한 암반 물성을 이용한 혼합체 물성을 도출하였으며 국부파괴 후의 재료 거동을 추적하였다. 제시한 모형을 사용하면 변형율 연화 모형을 사용하더라도 유한요소망의 객관성을 유지할 수 있으며 국부파괴 이후 재료의 거동을 현실적으로 모형화 할 수 있다. 또한 유한요소 갯수가 비교적 작더라도 수치해석 결과와 실험 결과가 잘 일치하고 있음을 알 수 있다.

• 한국정보교육학회:학술대회논문집
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• 한국정보교육학회 2010년도 하계학술대회
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• pp.119-123
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• 2010

다양한 지식이 넘쳐나는 요즘, 많은 양의 지식을 바르게 선별하고, 본인에게 맞게 지식을 구성하는 능력이 요구되고 있다. 이는 단순한 암기 위주의 교육으로는 시대가 요구하는 인간을 육성할 수가 없다. 개정된 초 중등학교 정보통신 기술 지침에 근거하면 초등학교에서부터 프로그래밍 교육이 이루어지게 되어있다. 하지만 초등학교 아동들은 기존 프로그램을 통한 학습에서는 지루해하거나 어려워하는 것이 현실이다. 본 연구에서는 이러한 문제해결을 위하여 새로운 멀티미디어교육용 언어인 스크래치를 이용한 현장연구를 하고자 한다. 스크래치를 이용한 교수 학습과정을 설계한 후 학습자들과 직접 수업을 진행하여 전통적 교육용 프로그래밍언어에 비교하여 그 효과를 알아보고자 한다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제16권4호
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• pp.395-404
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• 2016

A 6-bit 3.4 GS/s flash ADC in a 65 nm CMOS process is reported along with the proposed 4x time-domain interpolation technique which allows the reduction of the number of comparators from the conventional $2^N-1$ to $2^{N-2}$ in a N-bit flash ADC. The proposed scheme effectively achieves a 4x interpolation factor with simple SR-latches without extra clocking and calibration hardware overhead in the interpolated stage where only offset between the $2^{N-2}$ comparators needs to be calibrated. The offset in SR-latches is within ${\pm}0.5$ LSB in the reported ADC under a wide range of process, voltage supply, and temperature (PVT). The design considerations of the proposed technique are detailed in this paper. The prototype achieves 3.4 GS/s with 5.4-bit ENOB at Nyquist and consumes 12.6 mW power at 1 V supply, yielding a Walden FoM of 89 fJ/conversion-step.

• 한방재활의학과학회지
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• 제21권3호
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• pp.21-32
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• 2011

Objectives : The purpose of this is to prove that using burning acupuncture therapy with chuna therapy can be more effective therapy for low bock pain patient. Methods : 43 patients with low back pan were divided into 2 groups; using burning acupuncture therapy with chuna therapy group and using chuna therapy only group. The patients were evaluated by visual analogue scale(VAS) and pain rating score(PRS). Results : Each group showed significant in decreasing VAS score and PRS score. After 2nd treatment, the sample group was significant mere effective in decreasing VAS. And after 3rd treatment, the sample group was significantly more effective in decreasing PRS(p<0.05). Constructive disease didn't affect the change of pain significantly. Conclusions : In this clinical study, using burning acupuncture therapy with chuna therapy group was more effective in relieving low back pain than using chuna therapy only group.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제50권2호
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• pp.65-72
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• 2001

This paper presents the design and test results of a 10kVA single phase HTS transformer which is operating at 77K. Double pancake windings with BSCCO -2223 HTS tape and GFRP cryostat with room temperature bore are used in the transformer. Four double pan cake windings were used in pancake windings are connected in parallel to conduct the secondary current of 45.4A. the rated voltages of each winding are 440/220V. Numerical calculation using Finite Element Method was used to evaluated the performance of each arrangement. Considering the magnetizing reactance, leakage reactance, electrical insulation and the circulating current in low voltage winding which had two windings in parallel, HLLH arrangement was finally chosen. Estimation of the AC loss, magnetizing loss and self field loss, in the design stage, where effects of perpendicular field and parallel field are considered. Room temperature bore type cryostat has been constructed and its heat loss was measured.

• The Korean Journal of Physiology and Pharmacology
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• 제23권3호
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• pp.181-189
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• 2019

Curcumin, an active ingredient of Curcuma longa L., can reduce the concentration of low-density lipoproteins in plasma, in different ways. We had first reported that curcumin exhibits hypocholesterolemic properties by improving the apolipoprotein B (apoB) mRNA editing in primary rat hepatocytes. However, the role of curcumin in the regulation of apoB mRNA editing is not clear. Thus, we investigated the effect of curcumin on the expression of multiple editing components of apoB mRNA cytidine deamination to uridine (C-to-U) editosome. Our results demonstrated that treatment with $50{\mu}M$ curcumin markedly increased the amount of edited apoB mRNA in primary mouse hepatocytes from 5.13%-8.05% to 27.63%-35.61%, and significantly elevated the levels of the core components apoB editing catalytic polypeptide-1 (APOBEC-1), apobec-1 complementation factor (ACF), and RNA-binding-motif-protein-47 (RBM47), as well as suppressed the level of the inhibitory component glycine-arginine-tyrosine-rich RNA binding protein. Moreover, the increased apoB RNA editing by $50{\mu}M$ curcumin was significantly reduced by siRNA-mediated APOBEC-1, ACF, and RBM47 knockdown. These findings suggest that curcumin modulates apoB mRNA editing by coordinating the multiple editing components of the edito-some in primary hepatocytes. Our data provided evidence for curcumin to be used therapeutically to prevent atherosclerosis.

• Journal of Korean Society for Atmospheric Environment
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• 제10권E호
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• pp.311-324
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• 1994

The quantitative knowledge of N $O_{\gamma}$ (＝N $O_{x}$ ＋HN $O_3$＋/PAN＋N $O_3$ ＋$N_2$ $O_{5}$ ＋HN $O_2$＋N $O_3$$^{-10}$ ＋organic nitrates＋......)distribution is essential in tropospheric chemistry, especially, especially that related to understanding the processes leading to ozone production. Ambient concentrations of NO, N $O_2$, HN $O_3$ and PAN as well as total N $O_{\gamma}$ were measured during June and early July 1992 at a rural site(Candor, NC), in the central Piedmont region of NC. The measurements of N $O_{\gamma}$ species were made in an effort to provide a comprehensive understanding of nitrogen chemistry and to investigate the total nitrogen budget at the site. N $O_{\gamma}$, N $O_2$, and NO showed diurnal variations with maxima in the morning. The maximum N $O_{\gamma}$ concentration reached was 14.5 ppbv, and the maximum concentrations of NO and N $O_2$ were 5.4 and 7.8 PPbv, respectively. The mean N $O_{\gamma}$ concentration as found to be 2.88$\pm$1.58 ppbv(n=743). The mean concentrations of NO and N $O_2$, were found to be 0.15 $\pm$ 0.29 ppbv(n＝785) and 1.31 $\pm$ 0.99 ppbv(n＝769). Products of photochemical oxidants, (N <$O_{\gamma}$-N $O_{x}$ ), such as HN $O_3$ and PAN, as well as ozone showed diurnal variation with maxima in the afternoon and minima at night The fractions of individual reactive nitrogen species to total N $O_{\gamma}$ were investigated and contrasted to the results from remote marine site and rural continental sites. N $O_{x}$ was the major species to total N $O_{\gamma}$(45%). NO concentrations appeared to be nearly constant whether the Prevailing winds were from continental areas or from oceanic areas. Linear regression of $O_3$ with (N $O_{\gamma}$- N $O_{x}$ )/N $O_{\gamma}$ (i.e. percent N $O_{x}$ converted to the photochemical products of N $O_{\gamma}$) yielded ( $O_3$) ＝25.8 〔 N $O_{\gamma}$-N $O_{x}$ 〕/(N $O_{\gamma}$) ＋27, ( $r^{2}$＝0.58). The regression intercept is interpreted as the ozone back ground (intercept=27ppbv) and the slope suggests that 8.6 molecules of ozone are formed per molecule of N $O_{x}$ oxidized products (when the average N $O_{\gamma}$ concentration, about 3 ppbv at the site, is used). The N $O_{x}$ N $O_{\gamma}$ ratio was used as an indicator of the chemical age of airmasses and the ratio showed strong positive correlations with HN $O_3$( $r^{2}$=0.58), PAN ( $r^{2}$=0.46) and $O_3$( $r^{2}$=0.62). Larger N $O_{\gamma}$ and N $O_{x}$ N $O_{\gamma}$ ratio were found when winds came from continental sides. It may suggest that synoptic meteorological conditions and transport of N $O_{x}$ are important in the distribution of N $O_{\gamma}$ and its relationship with photochemical oxidants at the site.

• 정보교육학회논문지
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• 제11권1호
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• pp.11-19
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• 2007

7차 교육 과정은 학교 운영에 학생, 교사, 학부모와 지역 사회의 요구를 적극 수렴하고 이를 반영할 것을 요구하고 있다. 이에 본 연구는 학교 운영을 효율적으로 하기 위한 웹 설문 시스템을 설계하고 구현하고자 한다. 본 연구에서 제시한 웹기반 설문 시스템은 관리자(조사자)와 응답자로 구분하여 설계하고 관리자는 인터넷만 연결되면 설문을 관리하고 결과를 확인할 수 있도록 하였다. 또한 문항별로 관련된 자료 데이터베이스를 제공하여 별도의 프로그램없이 본 시스템 내에서 실시간으로 설문 작성과 통계처리가 되도록 설계하였다. 본 시스템은 학교의 홈페이지에 한 메뉴로 활용하거나 단독 시스템으로 운영이 가능하여 학교 단위의 설문 조사를 쉽고 빠르게 할 수 있도록 해 준다.

• Journal of Microbiology and Biotechnology
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• 제19권3호
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• pp.257-264
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• 2009

A $\beta$-agarase gene, agaB34, was functionally cloned from the genomic DNA of a marine bacterium, Agarivorans albus YKW-34. The open reading frame of agaB34 consisted of 1,362 bp encoding 453 amino acids. The deduced amino acid sequence, consisting of a typical N-terminal signal peptide followed by a catalytic domain of glycoside hydrolase family 16 (GH-16) and a carbohydrate-binding module (CBM), showed 37-86% identity to those of agarases belonging to family GH-16. The recombinant enzyme (rAgaB34) with a molecular mass of 49 kDa was produced extracellularly using Escherichia coli $DH5{\alpha}$ as a host. The purified rAgaB34 was a $\beta$-agarase yielding neoagarotetraose (NA4) as the main product. It acted on neoagarohexaose to produce NA4 and neoagarobiose, but it could not further degrade NA4. The maximal activity of rAgaB34 was observed at $30^{\circ}C$ and pH 7.0. It was stable over pH 5.0-9.0 and at temperatures up to $50^{\circ}C$. Its specific activity and $k_{cat}/K_m$ value for agarose were 242 U/mg and $1.7{\times}10^6/sM$, respectively. The activity of rAgaB34 was not affected by metal ions commonly existing in seawater. It was resistant to chelating reagents (EDTA, EGTA), reducing reagents (DTT, $\beta$-mercaptoethanol), and denaturing reagents (SDS and urea). The E. coli cell harboring the pUC18-derived agarase expression vector was able to efficiently excrete agarase into the culture medium. Hence, this expression system might be used to express secretory proteins.

• Journal of Microbiology and Biotechnology
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• 제17권7호
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• pp.1106-1112
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• 2007

This report provides the complete nucleotide sequences of the full-length cDNA encoding squalene synthase (SQS) and its genomic DNA sequence from a triterpene-producing fungus, Ganoderma lucidum. The cDNA of the squalene synthase (SQS) (GenBank Accession Number: DQ494674) was found to contain an open reading frame (ORF) of 1,404 bp encoding a 468-amino-acid polypeptide, whereas the SQS genomic DNA sequence (GenBank Accession Number: DQ494675) consisted of 1,984 bp and contained four exons and three introns. Only one gene copy was present in the G. lucidum genome. The deduced amino acid sequence of Ganoderma lucidum squalene synthase (GI-SQS) exhibited a high homology with other fungal squalene synthase genes and contained six conserved domains. A phylogenetic analysis revealed that G. lucidum SQS belonged to the fungi SQS group, and was more closely related to the SQS of U. maydis than to those of other fungi. A gene expression analysis showed that the expression level was relatively low in mycelia incubated for 12 days, increased after 14 to 20 days of incubation, and reached a relatively high level in the mushroom primordia. Functional complementation of GI-SQS in a SQS-deficient strain of Saccharomyces cerevisiae confirmed that the cloned cDNA encoded a squalene synthase.