• Journal of Information Management
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• v.37 no.3
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• pp.61-84
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• 2006

In this paper, we proposed one of the methods for building thesaurus in Science & Technology domain and investigated its applicability as an inference service based on ontology. There exist as many building methods for thesaurus as its role and function, and actually many thesauri capable of ensuring the accuracy and efficiency in information search are being built by many experts. After examining the previous studies related to the principles of building thesaurus and relevant concept "facet", we focused on its characteristics and applied it to building thesaurus. The facet is classified into 2 categories, conceptual facet and relational facet. The latter contains 3 subcategories: category relational facet, attribute relational facet and thematic relational facet. The thesaurus for Science & Technology domain using facets can be applied as a web-based inference service. As a result, the three types of inference service, COP(Communities of Practice), Researcher Tracing and Research Map are provided by means of ontology, and can be applied for the Query Expansion.

• Molecular & Cellular Toxicology
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• v.4 no.4
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• pp.323-330
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• 2008

Surrogate tissue analysis incorporating -omics technologies has emerged as a potential alternative method for evaluating toxic effect of the tissues which are not accessible for sampling. Among the recent applications, blood including whole blood, peripheral blood lymphocytes and peripheral blood mononuclear cells (PBMCs) was suggested as a suitable surrogate tissue in determining toxicant exposure and effect at the pre- or early clinical stage. In this application, we investigated transcriptomic profiles in astemizole treated Cynomolgus monkey's PBMCs. PBMCs were isolated from 4-6 years old male monkeys at 24 hr after administration45 Helvetica Light (10 mg/kg, 30 mg/kg). Gene expression profiles of astemizole treated monkey's PBMCs were determined using Affymetrix $GeneChip^{(R)}$ Human Genome U133 plus 2.0 arrays. The expression levels of 724 probe sets were significantly altered in PBMCs at 10 or 30 mg/kg after astemizole administration following determination of paired t-test using statistical criteria of ${\geq}$$1.5-fold changes at P<0.05. Gene expression patterns in PBMCs showed a considerable difference between astemizole 10 and 30 mg/kg administration groups in spite of an administration of the same chemical. However, close examination using Ingenuity Pathway Analysis (IPA) software revealed that several gene sets related to cardiotoxicity were deregulated at astemizole 10 and 30 mg/kg administration groups. The deregulation of cardiac hypertrophy related genes such as TXN, GNAQ, and MAP3K5 was observed at 10 mg/kg group. In astemizole 30 mg/kg group, genes involved in cardiotoxicity including cardiac necrosis/cell death, dilation, fibrosis, and hypertrophy were also identified. These results suggest that toxicogenomic approach using PBMCs as surrogate tissues will contribute to assess toxicant exposures and identify biomarkers at the pre-clinical stage.

• Journal of KIISE
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• v.43 no.8
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• pp.910-918
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• 2016

A tensor is a multi-dimensional array that represents many data such as (user, user, time) in the social network system. A tensor generator is an important tool for multi-dimensional data mining research with various applications including simulation, multi-dimensional data modeling/understanding, and sampling/extrapolation. However, existing tensor generators cannot generate sparse tensors like real-world tensors that obey power law. In addition, they have limitations such as tensor sizes that can be processed and additional time required to upload generated tensor to distributed systems for further analysis. In this study, we propose TeT, a distributed tera-scale tensor generator to solve these problems. TeT generates sparse random tensor as well as sparse R-MAT and Kronecker tensor without any limitation on tensor sizes. In addition, a TeT-generated tensor is immediately ready for further tensor analysis on the same distributed system. The careful design of TeT facilitates nearly linear scalability on the number of machines.

• Korean Journal of Agricultural and Forest Meteorology
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• v.6 no.3
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• pp.177-182
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• 2004

A chill unit has been used to estimate chilling requirement for dormancy release and risk of freezing damage. A system that calculates chill units was developed to obtain site-specific estimates of dormancy release date for grapes and evaluated in Baekgu myun near Kimje City, Chunbuk, Korea from September 2002 to March 2003. The system utilized daily minimum and maximum temperature maps generated from spatial interpolation with temperature correction for topography. Hourly temperature was temporally interpolated from the daily data using a sine-exponential equation (Patron and Logan, 1981). Hourly chill units were determined from sigmoid, reverse sigmoid, and negatively increasing sigmoid functions based on temperature ranges and summed for 24 h. Cumulative daily chill units obtained from measurements did not increase until 20 October 2002, which was used as a start date for accumulation to estimate the dormancy release date. As a result, a map of dormancy release date in the study area was generated, assuming 800 chill units as a threshold for the chilling requirement. The chill unit accumulation system, implemented using Microsoft Visual Basic and C++ (Microsoft, Redmond, WA, USA), runs in the Windows environment with ArcView (ESRl Inc., Redlands, CA, USA).

• The Transactions of the Korea Information Processing Society
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• v.3 no.6
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• pp.1483-1492
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• 1996

In this paper, related on the postal business with the GIS(Geographics Information System), it discusses design and implementation of the PROS(Postal Route Optimization System) model and its main module, the shortest path generation algorithm, for supporting to postal route managements. It explains examples requirements of postal route system, and suggests the efficient PROS model using our developed shortest path generation algorithm. Because the shortest path algorithm adopts not only consider the Dijkstra algorithm of graph theory, but also the method with the direction property, PROS can be implemented with fast and efficient route search. PROS is mainly constituted of the Shortest Generator, the Isochronal Area Generator, and the Path Rearrangement Generator. It also exploits the GIS engine and the spatial DBMS (Data Base Management System) for processing coordinates in the map and geographical features. PROS can be used in the management of postal delivery business and delivery area and route, and in the rearrangement of route. In the near future, it can be also applied to commercial delivery businesses, guides of routs and traffic informations, and auto navigation system with GPS(Global Positioning System).

• The Transactions of the Korea Information Processing Society
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• v.4 no.2
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• pp.491-498
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• 1997

Geographic Infprmation System(GIS)is being apply to extended from specified ppkication to general purpose deu to the omprovement of computing power.As one part of postal Integarated Information Servies, Postalroute Optimication system(PROS) is comprsed of the composed of the shortest pathe genrator for providing fast and shortest route of postal delivery, the ischronal area generator, the boudary relacation generator, GIS engine, road map, and rdelational database , etc.This paper is related to creation algorithm of the shortest path generation (SPAWD;Shortest Path Algorithm With Direction)from PEOS model.To differ from the exsting shortest path generating methods, this paper suggests SPAWD alforithm for searching destinations of fast time between start and destination points with dirdstion.It comapares and analyzes the new algorithm with existion algorithms, and suggests directions of future studies.

• Journal of Environmental Health Sciences
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• v.35 no.1
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• pp.1-10
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• 2009

This study assessed the relationships between levels of $PM_{10}$ and hospitalization rates for asthma among children from 2003 to 2005 at four major cities in Korea. In addition, we estimated the reduced number of asthma hospitalization associated with an ambient $PM_{10}$ improvement to the acceptable levels as recommended by the World Health Organization (WHO). The Generalized Additive Model (GAM) was used to estimate the relative risks (RR) of asthma hospitalization associated with changes in $PM_{10}$ The RRs of children's asthma hospitalization for every $10{\mu}g/m^3$ increment in $PM_{10}$ were 1.009(95% CI = 1.004-1.014) in Seoul, 1.013(95% CI = 1.006-1.021) in Incheon, 1.009(95% CI = 1.002-1.016) in Busan, and 1.021(95% CI = 1.005-1.037) in Ulsan. We assessed $PM_{10}$ related health benefits from implementing the WHO's guidelines (24-hour average $50{\mu}g/m^3$) using the U.S. Environmental Protection Agency's Environmental Benefits Mapping and Analysis Program. The estimated benefits were 439(95% CI = 216-666) reduced asthma hospitalization in Seoul, 720(95% CI = 304-1,151) in Incheon, 260(95% CI = 66-459) in Busan, and 126(95% CI = 30-228) in Ulsan. It was concluded that improving $PM_{10}$ condition to the WHO guideline would make a significant contribution to the reduction in asthma hospitalization among children. Therefore, public health measures are still needed to improve air quality in Korea.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.39 no.2
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• pp.69-78
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• 2002

This paper addresses a method to automatically detect out a person's face from a given image that consists of a hair and face view of the person and a complex background scene. Out method involves an effective detection algorithm that exploits the spatial distribution characteristics of human skin color via an adaptive fuzzy color classifier (AFCC), The universal skin-color map is derived on the chrominance component of human skin color in Cb, Cr and their corresponding luminance. The desired fuzzy system is applied to decide the skin color regions and those that are not. We use RGB model for extracting the hair color regions because the hair regions often show low brightness and chromaticity estimation of low brightness color is not stable. After some preprocessing, we apply convex-hull to each region. Consequent face detection is made from the relationship between a face's convex-hull and a head's convex-hull. The algorithm using the convex-hull shows better performance than the algorithm using pattern method. The performance of the proposed algorithm is shown by experiment. Experimental results show that the proposed algorithm successfully and efficiently detects the faces without constrained input conditions in color images.

• Journal of the Korean Geophysical Society
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• v.2 no.1
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• pp.65-74
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• 1999

From refraction data along four seismic profiles near Eonyang which the Yangsan fault passes through, the Slope Variation Indicators (SVI) are computed and interpreted in terms of fault distribution. The average velocities of 2,250-2,870 m/s are estimated using velocity-analysis functions for the target boundary along those profiles. The average velocity for Line 1 is approximately 600 m/s lower than ones for the other lines. The SVI's with amplitude greater than or equal to 0.5 ms/m are turned out to be located near faults shown on the high-resolution reflection section, as closely as one station spacing (3 m). Large amplitude SVI's are densely distributed near National Road 35, and the fault having the largest vertical slip is indicated to be located approximately 930 m west of the inferred fault on the published geologic map.

• Molecules and Cells
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• v.40 no.1
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• pp.17-23
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• 2017

Mitogen-activated protein kinase (MAPK) signaling cascades play critical roles in various cellular events in plants, including stress responses, innate immunity, hormone signaling, and cell specificity. MAPK-mediated stress signaling is also known to negatively regulate nitrogen-fixing symbiotic interactions, but the molecular mechanism of the MAPK signaling cascades underlying the symbiotic nodule development remains largely unknown. We show that the MtMKK5-MtMPK3/6 signaling module negatively regulates the early symbiotic nodule formation, probably upstream of ERN1 (ERF Required for Nodulation 1) and NSP1 (Nod factor Signaling Pathway 1) in Medicago truncatula. The overexpression of MtMKK5 stimulated stress and defense signaling pathways but also reduced nodule formation in M. truncatula roots. Conversely, a MAPK specific inhibitor, U0126, enhanced nodule formation and the expression of an early nodulation marker gene, MtNIN. We found that MtMKK5 directly activates MtMPK3/6 by phosphorylating the TEY motif within the activation loop and that the MtMPK3/6 proteins physically interact with the early nodulation-related transcription factors ERN1 and NSP1. These data suggest that the stress signaling-mediated MtMKK5/MtMPK3/6 module suppresses symbiotic nodule development via the action of early nodulation transcription factors.