• Molecules and Cells
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• 제39권11호
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• pp.777-782
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• 2016

The innate immune system has evolved to detect and destroy invading pathogens before they can establish systemic infection. To successfully eradicate pathogens, including viruses, host innate immunity is activated through diverse pattern recognition receptors (PRRs) which detect conserved viral signatures and trigger the production of type I interferon (IFN) and pro-inflammatory cytokines to mediate viral clearance. Viral persistence requires that viruses co-opt cellular pathways and activities for their benefit. In particular, due to the potent antiviral activities of IFN and cytokines, viruses have developed various strategies to meticulously modulate intracellular innate immune sensing mechanisms to facilitate efficient viral replication and persistence. In this review, we highlight recent advances in the study of viral immune evasion strategies with a specific focus on how Kaposi's sarcoma-associated herpesvirus (KSHV) effectively targets host PRR signaling pathways.

• 한국보건간호학회지
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• 제7권1호
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• pp.17-29
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• 1993

Nursing centers are nurse-managed organizations that give the client direct access to professional nursing services. Academic nursing centers are faculty-created and -organized nursing centers integrated into nursing school or cooperated with community nursing center. Academic nursing centers are needed for providing services to the forgotten or underserved populations in the community, providing learning opportunities for nursing students and practice opportunities for faculties. The intent of this study is to identify the elements needed in developing process and operations of acedemic nursing center for elderlies and the disabled, and to present the desired model for academic nursing center. The processes of my study were : 1) The articles of the academic nursing centers in U. S. were reviewed and analysed. 2) The academic nursing center for elderlies and the disabled was developed and operated in my paper. 3) Desired model for academic nursing center was presented in my paper. The followings are the results of my study: 1. Elements needed in developing process of academic nursing center were philosophy and goals, the community support, assessment of the validity of the service and health needs, identification of the service contents, roles and responsibilities, communication lines, finances for facilities and operations, cooperation with resources, and developing record system. 2. Elements needed in operations of academic nursing center were the structural organizations, realization of the above philosophy and goals, development of policy and nursing standards, faculty participation, continuity of services, and financial solutions. 3. The desired model was presented according to the process and operations.

• 한국컴퓨터산업학회논문지
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• 제2권10호
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• pp.1309-1316
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• 2001

애니매이션과 컴퓨터 게임에서 오늘날 주요 관심사는 캐릭터의 행동을 미리 정의된 게임 로직이나 미리 설정된 동작에 의해 제어된다. 게임 개발자들은 더 풍부하고 더 상호 보완적인인 게임을 제작하고자 하기 때문에 자주 이러한 접근은 한계에 부딪힌다. 본 논문에서는 더욱 지능적이고 강제적인 컴퓨터 게임을 만들기 위해서 유전자 알고리즘을 사용한 게임 모델을 제안한다. 학습능력에 기반 한 유전자 알고리즘의 사용은 변화와 능동적인 게임 환경을 지원하도록 연속적인 진화를 하는 캐릭터를 활용할 것이다. 임의의 실시간 게임이 제안된 시스템의 수행과 제한성을 평가하기 위해 수행되었다.

• 한국기계가공학회지
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• 제20권2호
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• pp.14-22
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• 2021

A plan for the development of reliability-based ROK amphibious assault vehicles is proposed. By analyzing the development case of the U.S. EFV, considerations for the successful development of the next-generation Korea Forces amphibious assault vehicle are presented. If the vehicle reliability can be improved to the level of the fourth highest priority electric unit for power units, suspensions, decelerators, and body groups, which have the highest priority among fault frequency items, a system level MTBF of 36.4%↑ can be achieved, and the operational availability can be increased by 3.5%↑. The next-generation amphibious assault vehicles must fulfill certain operating and performance requirements, the underlying systems must be built, and sequencing of the hybrid engine and the modular concept should be considered. Along with big-data- and machine-learning-based failure prediction, machine maintenance based on augmented reality/virtual reality and remote maintenance should be used to improve the ability to maintain combat readiness and reduce lifecycle costs.

• 적정기술학회지
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• 제7권1호
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• pp.33-40
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• 2021

동아프리카에 속한 우간다도 농업 중심의 현 국가 상황에서 벗어나 중상위권 국가로 도약하기 위해 다양한 국가개발 계획을 세우고 진행하고 있다. 그러나 다양한 정부의 노력에도 도시-농촌간 균형적인 발전을 이루지 못하고 그 격차가 더욱 심화되고 있다. 특별히 도시-농촌간 교육 격차는 장기적으로 우간다 국가계발 계획에 부정적인 영향을 줄 수 있는 문제점으로 부각되고 있다. 본 논문에서는 우간다의 도시-농촌간 교육 불균형이 가속화되고 있는 원인들을 살펴 보고 전자도서관 시스템과 같은 ICT 적정 기술을 활용하여 교육 불균형을 감소 시킬 수 있는 방안을 소개하고자 한다.

• 교육시설
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• 제4권2호
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• pp.31-36
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• 1997

The Magnet Methodology is not the recording of knowledge, skills, techniques, and other information from the past, but creating a knowledge base using present issues of problems for students' and teachers' life-span development through the exploration of career choices and development. In short, it is the multi-cooperative information system for commensalism. It is the magnet program that connects various level of educational institutions under a certain theme and enables students to choose on their own. And this magnet program is being adminstered by the magnet school. And some regular schools provide magnet program as vocational educations and extra-curricular activities. Magnet program reflects the concept of desegregation which was proposed by the U.S. Federal Court decision against the racial conflict which had culminated in the 60s and 70s. Magnet program enables students to choose their own programs and schools, and gives teachers and students the opportunities to develop their teaching method and learning method. That's why magnet program is called continuous, future-oriented one. Teachers and students can also get fair judgement on their activities due to the voluntary magnet program. It mainly deals with practical issues, so it is very realistic to establish the multi cooperative information system including companies, homes, communities, or governments under these practical issues. The openness of magnet program is guaranteed not only by the characteristics of the program but also by the physical layout of the magnet schools. There are no doors and walls, and classrooms are facing one another and sharing all the opinions and information. This precisely corresponds to the concept of co-existence of eco-system and the interdisciplinary approach which is essential to solve our problems.

• 유통과학연구
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• 제13권1호
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• pp.7-18
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• 2015

Purpose - This study integrates a corporate competition system with a bird predation system to examine how organizational strategic adjustment capacity influences firm performance. By proving the prominent effects on performance, a financial vector is constructed to represent corporate strategic adjustment results, and an operation capacity vector is constructed, which can be categorized as a parameter for locating birds. All these works help us to propose a new method of investment, the portfolio decision model based on the strategic adjustment capacity. Research design, data, and methodology - Strategic adjustment capacity can be decomposed into three aspects: the organizational learning capacity from the top firms, the extent to which firms maintainor rely on the best operational capacity vector in history, and the ability to eliminate the disadvantages or retain the advantages of the operation capacity vector from the previous year. The method of solving cyclic equations is designed to evaluate strategic adjustment. Firms manufacturing specialized equipment are chosen to test the effects of the strategic adjustment capacity on three aspects of firm performance. Results - There is a positive correlation between the capacity to learn from the best firms and performance improvement. The relationship between the dependence or maintenance of a firm's advantages and performance improvement is a U-shape curve, and there is no significant effect of inertial control on performance improvement. Conclusions - A firm's competition system is a sophisticated adaptation, and competitive advantage and performance can be investigated based on the principles of competition in nature.

• 한국사회복지학
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• 제56권1호
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• pp.23-43
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• 2004

신노동당 정부에서 뉴딜이 도입된 이래 5년이라는 시차(time difference)는 뉴딜이 청년실직자, 장기실직자, 편부모, 장애인 등 사회적 배제집단을 노동시장에 편입시키고, 근로연령세대를 위한 소득관련 급여지출의 감소를 가져왔으며, 노동시장에서 근로연령세대의 고용률을 높이는 데 크게 기여하였다는 것을 보여준다. 뉴딜은 일자리우선모델보다는 인적자원개발모델에 보다 근접한 성격을 지니고 있다. 뉴딜은 근로능력이 있는 복지수급자를 일자리로 유인하기 위하여 근로연계복지를 지향하는 국가들에게 다음과 같은 정책학습의 기회를 제공한다. 첫째, 개인에게 책임과 의무를 부여함과 동시에 교육 및 직업훈련을 중심으로 한 적극적 노동시장사업을 통하여 개인의 자발적 참여를 유도할 수 있어야 한다. 둘째, 지역단위에서 복지와 고용을 연결하여 통합관리할 수 있는 분권적 전달체계를 갖추고, 다양한 고용사업을 진행하기 위하여 민간부문, 특히 기업가들과의 협력체계를 조성하기 위하여 노력하여야 한다. 셋째, 근로능력이 있는 복지수급자 개인에 대한 사례관리의 도입이 필요하다. 끝으로, 확고한 정치적 리더십에 의하여 주도되고 뒷받침되어야 한다.

• 대한원격탐사학회지
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• 제38권6_2호
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• pp.1691-1707
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• 2022

한반도와 중국 경계에 위치한 백두산의 칼데라호인 천지호는 계절에 따라 해빙과 결빙을 반복한다. 천지 아래에는 마그마 챔버가 존재하며 마그마 챔버의 변화에 의해 온천수의 온도 및 수압 변화와 같은 화산 전조현상이 발생한다. 이에 따라, 천지호 내에서 다른 부분보다 해빙이 빠르며 결빙기에도 늦게 얼며 물표면 온도가 높은 이상지역이 존재하게 된다. 해당 이상지역은 온천수 방출 지역으로, 이상지역의 얼음변화도 값을 통해 화산활동을 모니터링 할 수 있다. 그러나 지리적, 정치적 그리고 공간적 문제로 천지의 이상지역을 주기적으로 관측하기에는 한계가 존재한다. 따라서 본 연구에서는 Landsat -5/-7/-8 광학위성영상으로부터 Modified U-Net 회귀모델을 이용하여 이상지역내의 얼음변화도를 정량적으로 관측하였다. 1985년 1월 22일부터 2020년 12월 8일까지 이상지역을 갖는 83장의 Landsat 영상의 Visible and Near Infrared (VNIR)대역을 활용하였다. 얼음 변화도를 정량적으로 관측을 위해 VNIR대역에서 수체와 얼음과의 상대적인 분광반사도를 활용하여 새로운 데이터를 만들었다. 가시광선대역과 근적외선 대역이 가지고 있는 정보를 최대한 유지하기 위해 2개의 인코더를 가진 U-Net에 적용하여 얼음변화도를 관측하였으며 Root Mean Square Error (RMSE) 140, 상관계수 0.9968의 높은 예측 성능을 보여주었다. 따라서 Modified U-Net을 활용하면 추후 Landsat 영상으로부터 얼음변화도 값을 높은 정확도로 관측하므로 백두산 화산활동을 모니터링하는 방법 중 하나로 사용될 수 있으며, 다른 화산 모니터링 기법과 더불어 활용한다면 더욱 정밀한 화산감시체계 구축이 가능할 것이다.

• 한국치위생학회지
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• 제21권4호
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• pp.467-479
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• 2021

Objectives: The purpose of this study was to investigate the awareness of the performance and necessity of oral health promotion activities and seek ways to revitalize the professional role of dental hygienists in oral healthcare for the efficient oral care of the elderly. Methods: Eighty-five dental hygienists in charge of oral health promotion projects at public health centers and 38 dental hygienists in network dental clinical trials were investigated for their learning experience, performance experience, feasibility, and necessity of dental hygienists for general and oral health service items for the elderly. The collected data were analyzed using frequency analysis, chi-square test, and Mann-Whitney U test. Results: The degree of performance possibility according to the learning experience and performance experience of the dental hygienist for the whole body and oral health promotion activity items for the elderly showed that the degree of performance possibility was higher among those with experience compared to the non-experienced person, and it was statistically significantly higher (p<0.05). Conclusions: The dental hygienist's professional oral health service is a necessary system to improve practical knowledge and skills and to provide a wide range of professional oral health services for the elderly.