• Molecules and Cells
• /
• v.38 no.2
• /
• pp.156-162
• /
• 2015

Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3' untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.

• KOREAN ASSOCIATION OF OCCUPATIONAL HEALTH NURSES
• /
• v.19 no.3
• /
• pp.50-54
• /
• 2012

• Journal of Acupuncture Research
• /
• v.27 no.6
• /
• pp.115-122
• /
• 2010

Objectives : The purpose of this study was to propose the utilization plan of Ryodoraku in the U-health care systems. Methods : Computerized literature searches were performed for Ryodoraku related articles using the following databases: KISS, RISS, DBPIA, NDSL from 1990 to Oct 2010. Search terms were '양도락' or 'Ryodoraku' or 'U-health'. Due to Ryodoraku coming from Japan, additional literature review(articles published by 2008) on Japanese journal of Ryodoraku medicine was done for compensation. Results : 1. Introduction of U-health : As rapid progress of population aging and strong interest in health, the demand for the traditional Korean medical service is increasing. Until now healthcare service has provided post treatment by face-to-face manner. But according to related researches, proactive treatment is resulted to be more effective for preventing diseases. Particularly, the existing healthcare services have limitations in preventing and managing chronic geriatric degenrative diseases such as metabolic syndrome, CVA, coronary heart diseases, parkinson's diseases, degenerative joint disease, spondylosis, etc., because the cause of the above is complex and even related to life habit. As the advent of ubiquitous technology, patients with the chronic geriatric degenrative diseases can improve life habit such as poor eating habits and physical inactivity without the constraints of time and space through u-healthcare service. Therefor, lots of researches for u-healthcare service focus on providing the personalized healthcare service for preventing and managing that. To cope with this situations, The concept of u-healthcare service should be adopted in the traditional korean medicine and diagnostic devices suitable for it should be also devised and developed based on traditonal korean medine. 2. Review of existing Ryodoraku related articles for applying to U-health : articles investigating feasibility applying Ryodoraku to meridian diagnosis and raising problems of it, articles providing recent research trends of Ryodoraku, Ryodoraku related articles considering usefulness for U-health, and articles confirming the repeatability and reproducity of Ryodoraku were included. Based on the review of the above Ryodoraku related articles, several application of Ryodoraku in the U-health care system. Conclusions : To make preparations for the increasing need of traditional Korean medicine due to rising morbidity rate of chronic geriatric degenerative diseases, it is necessary to appropriately apply Ryodoraku to the U-health care system. The application of Ryodoraku is as follows. 1. To use Ryodoraku additionally to the established diagnostic device of metabolic syndrome, CVA, coronary heart diseases, parkinson's diseases, degenerative joint disease, spondylosis. 2. To apply Ryodoraku to the symptoms or diseases having a tendency to be diagnosed by correlation between the affected meridian and the lesion such as headache, nuchal pain, shoulder pain, low back pain, sciatica, HNP, etc. 3. To secure the repeatability and reproducity of Ryodoraku. 4. To devise and develop Ryodoraku appliance in order to overcome the known drawbacks and to improve error of measurement.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.22 no.3
• /
• pp.273-280
• /
• 2012

As changed the clinical environment, the interest on u-Healthcare service and systems has been increased. The ubiquitous healthcare(u-Healthcare) systems are constructed at the integrated environment that consists of various devices and systems basically such as personal health devices(PHDs) measuring body signals, information aggregators gathering the data transmitted from PHDs through wireless technology, and health information systems storing and managing personal health information transmitted from the information aggregators. International standards such as IEEE 11073 and HL7 have been specified for the interoperability of PHDs and health information systems, but the research on u-Healthcare systems that were developed and applied in the real clinical environment by adopting the standards was rarely conducted. Therefore, we developed an u-Healthcare system which can manage personal health information, such as blood glucose, blood pressure, and body composition, based on health information exchange standards. Moreover, we verified the stability of the developed system through clinical trial in patients with endocrine disease at the Kyungpook National University Hospital, and listed problems occurred during clinical trial and found their solutions.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.33 no.4
• /
• pp.28-37
• /
• 2010

In this study, services for promoting health were provided to kindergarten children. As u-Health services for children, services centered of positioning of children are provided. However, since problems related with obesity and mental health are increasing day by day due to westernized eating habits, the necessity of physical and mental health care for children is on the rise. Considering this state, in this study, experiments of u-Health services under the concept of wellness were conducted on kindergarten children. For physical health, the children's obesity was controlled and for mental health, services of diagnosing hyperactivity disorder which is a sub symptom of ADHD were provided. Based on the results, it could be identified that parents' satisfaction and children's health conditions were improved.

• Korean Journal of Digital Imaging in Medicine
• /
• v.11 no.2
• /
• pp.79-84
• /
• 2009

Recently, there has been a rapid increase of interest in u-Health systems or instruments. The importance of testbeds has been discussed deeply also. However, beyond laboratory or ward environments, testbeds covering metropolitan area cannot be found easily. Moreover, there has been few papers which discuss the results of testbed operations for various instruments in different age groups. In this paper, the results of testbed which operated in Daegu metropolitan area are discussed and improvement directions to strengthen the competitiveness are proposed using user analysis. In particular, the results of trial services using the u-Life support instruments (medication reminder, falling safety phone, bio-patch and shirts, etc) for super aging societies in the near future are discussed.

• Journal of Society of Preventive Korean Medicine
• /
• v.23 no.1
• /
• pp.1-13
• /
• 2019

Backgrounds : The market of Complementary Alternative Medicine(CAM) in the United State(U.S.) accounts for a large proportion of the global CAM market and has a high growth rate. The recent introduction of Obama Care has brought the change in the health insurance system for CAM, and we need to analyze it for its implication to Korean system. Objectives : The purpose of this study is to investigate the current status of acupuncture and chiropractic health insurance in the U.S., and to draw implications for expanding the health insurance coverage for Korean traditional medicine through the comparison between the U.S. and Korean health insurance systems. Methods : We examined the data through the literature search and from the websites of both U.S. government departments and related organizations for the health insurance policy. Based on the collected data, we analyzed its CAM health insurance system in Korea. Results : The acupuncture covered by public health insurance in the U.S. has a limit in the number of treatments and a range of applied diseases compared with Korea. In addition, the practice of acupuncture is not subdivided. However, the chiropractic in the U.S. which also has a limited number of coverage and only three categories of practices are similar to that of Korea. Conclusions : Although the use of CAM by public health insurance is not active in the U.S., but the organizations such as Veterans Health Administration in Vermont is already discussing the use of acupuncture to solve the problem of opioid overuse. Thus Korea also needs to discuss to promote the expansion of the insurance system for CAM.

• Journal of the Korea Society of Computer and Information
• /
• v.16 no.3
• /
• pp.9-15
• /
• 2011

U-healthcare system has an aim to provide reliable and fast medical services for patient regardless of time and space by transmitting to doctors a large quantity of vital signs collected from sensor networks. Existing u-healthcare systems can merely monitoring patients' health status. In this paper, we describe the implementation and validation of a prototype of a u-health monitoring system based on a wireless sensor network. This system is easy to derive physiologically meaningful results by analyzing rapidly vital signs. The monitoring system sends only the abnormal data of examinee to the service provider. This technique can reduces the wireless data packet overload between a monitoring part and service provider. The real-time bio-signal monitoring system makes possible to implement u-health services and improving efficiency of medical services.

• Proceedings of the Safety Management and Science Conference
• /
• 2009.04a
• /
• pp.439-444
• /
• 2009

Recently ubiquitous sensor network(USN) technique has been applied into various industrial fields such as construction of u-city, civil and architectural engineering, medical areas. The main objective of this paper is to design a u-health system based on USN. Compared to the previous researches, the proposed system in this paper was designed to activate with collected information about health in outdoor environment.

• Proceedings of the KAIS Fall Conference
• /
• 2006.05a
• /
• pp.498-501
• /
• 2006

본 논문에서는 고령화 사회로 진입되고 있는 우리 사회에서 더 한층 관심이 고조되고 있는 의료 서비스를 목표로 하는 U-Health 케어 시스템의 선진국의 사례와 함께 적용 가능한 U-Health 케어 시스템 모델을 제시하였다.