• Biomedical Science Letters
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• v.12 no.3
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• pp.153-160
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• 2006

Human colon cancer is the second most fatal disease among a variety of cancers to cause cancer death in U.S.A. and its incidence rate is currently increased in Korea. Recently, many studies have been being progressed on the efficacy of diverse combination treatments. But results of these studies in vitro were not similar those in vivo. This study compared the anticancer reactions between each use of arsenic trioxide and taxol against human colon cancer HT-29 cell line and combined use of two drugs. And these results compared with the results of HT-29 spheroid cells having similar characteristics to the solid tumor in vivo. The spheroid of HT-29 cells was formed by using a multicellular spheroid system and the result was observed through electron microscopy. In vitro cytotoxicity of each use of arsenic trioxide and taxol was evaluated in HT-29 monolayer cells. The $IC_{50}$ value for arsenic trioxide was to be $33{\mu}M$ and taxol was to be 18nM. The result treated with the combination of taxol and arsenic trioxide decreased the cytotoxicity on the HT-29 monolayer cells. The spheroid cells represented higher resistance against drugs than the monolayer cells. I demonstrated DNA fragmentation after incubation with concentrations more than $10{\mu}M$ arsenic trioxide and 100nM taxol for 48h, on the monolayer cells. But the results of HT-29 cell line treated with the combination of taxol and arsenic trioxide was the same as the outcome of control samples that were not treated with any drug. And I don't demonstrated DNA fragmentation on the spheroid cells. These results suggest that apoptosis was not induced in the use of the combination can be thought as that arsenic trioxide might work as an antagonist to inhibit a taxol mechanism to induce apoptosis. And the spheroid cells represented higher resistance against drugs than the monolayer cells.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.6
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• pp.970-975
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• 2012

In Sasang constitutional medicine, doctors diagnose and treat patients according to their Sasang consitutition (SC) type. In this work, by a clinical test with a radial pulse tonometer, we investigated radial pulse properties which were significant in distinguishing unhealthy subjects from healthy subjects for each SC type. We measured radial pulse properties on left and right Gwan locations with a pulse tonometer for 299 elderly female subjects of age of 50 years old or above. We used a newly developed SCAT system to determine subjects' SC types. Subjects' health levels of either healthy or unhealthy were determined independently by two Korean medical doctors. To investigate the statistical differences, we used either of Student's t-test or Mann-Whitney U test depending on the normality of distribution of test statistic. For TE type, unhealthy subjects were characterized with significant increases in heart rate, systolic to diastolic period, pulse depth, while they showed significant decreases in width of pulse in normal direction, pulse area in diastolic period, and high harmonic components (6th, 7th) of power spectral density. For SE type, unhealthy subjects were characterized with significant increases in pulse pressure and pulse depth, while no significant differences were found for SY type. We investigated the characteristic differences in radial pulse properties due to change in health levels on each SC type for elderly females. Pulse variables which were significantly different between healthy subjects and unhealthy subjects were found to vary between SC types. For TE type subjects, many variables were found significant at the left Gwan location, which is in support of the theory of hyperactive liver functioning for TE type. Irrespective of the constitution, the related changes in the pulse properties due to worsened health level were in support of elevated blood flow amount in compensation with weakened blood circulatory function.

• Journal of Preventive Medicine and Public Health
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• v.27 no.3 s.47
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• pp.627-651
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• 1994

In this study, literature review was done to examine and compare the current status and problems of different evaluation approaches toward permanent impairment in Korea. Alternatives and improvements in the current approaches in Korea were suggested. Series of cases were also examined to compare different approaches applied to the real cases, using 105 cases from a hospital data and another 207 cases from a insurance company data. The main findings of the literature review are as follows; 1. The current evaluation methods of permanent impairment in Korea are grouped into two categories, grading and rating. Gradings of impairments are expressly specified in 17 various statutes. 2. In Grading methods, the rigid system of 74 different grades has been adopted uniformally for the convenience of administration, which may not be, appropriate or valid from medical and scientifical aspect. 3. The adventage of McBride method is assessment of occupational disability rate. However the classified compensable occupations are only 280 and limited to manufacturing industries in 1960s'of U.S.A., which is not appropriate to current Korean circumstances. Especially, the job list does not include managerial officers or mental workers. 4. AMA Guides is the scientific and reasonable method for the assessment of physical impairment rate. However compensation and reparation of impairment case is difficult because this method cannot assess the disability rate according to occupation, age, etc. The results of cases comparative study are as follows: 5. The physical Impairment could be compared in 167 out of total 312 cases, and for the cases of complex impairment, McBride method underestimate physical impairment rate compared with AM A method. 6. When disability late was assessed, occupation was considered the compensation of only 85 cases, and age was used in only 21 cases. This was because occupation and age compensation in McBride method are unreasonable. 7. The most Ideal alternative is to assess physical impairment according to AMA method and then to develop a compensation method appropriate for the circumstances of Korea society.

• International Journal of Advanced Culture Technology
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• v.6 no.3
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• pp.27-36
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• 2018

This is qualitative research using grounded theory to examine the experiences that mothers of children with epilepsy can have. Data were collected through in-depth interviews, observation, and memo-taking with a total of 13 participants in this study-10 mothers taking care of children with epilepsy and 3 principal informants-and the data were analyzed using the method developed by Strauss and Corbin (1998). As a result of data analysis, 163 concepts, 26 subcategories and 8 categories were formed through open coding. Such categories were analyzed by the paradigm of the grounded theory, and as a result the experiences of the mothers of epileptic children were based on a causal condition of 'confrontation' and the central phenomenon of 'Wandering around the forest under a yoke'. The contextual conditions, which exerted influence on phenomena, were 'stigma cognition', 'personality traits' and 'health of children.' The action/interaction strategy selected by participants was 'Quietly pulling through: Bracing myself, Getting to know my enemy and myself, Taking care while hiding, Putting out one step at a time, Establishing a foothold. The intervening condition affecting action/interaction was 'the support system', and its result was 'watching.'

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.8 no.5
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• pp.235-241
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• 2008

Please Interests in the medical service are increasing in internet environment as life quality of the people improves because of development in information and medical technology. The medical information in today's modern internet environment can violate privacy of the patients. Many medical institutions in Korea are very passive in the privacy protection of patients in the internet environment. The law, standard scheme and systematic guidance to prevent drain of medical information are not developed. This study examines cases of infringement pattern on information of each patient in the internet environment. This study will also try to find a solution to protect the personal information of patients in the internet environment in the measures of law system, technique and management.

• Journal of environmental and Sanitary engineering
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• v.9 no.2
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• pp.50-57
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• 1994

Densities of total and injured coliforms in treated water( TW ) and three tap water salt pies( Taps Kl, K2 and K3) of Ku- eui water treatment plant and one tap water sample( Tap T) of Tuk- do water treatment plant were measured 23 times from 1991 to 1992. Coliform regrowth in the water distribution system occurred three times during the study period. When the regrowth episode occurred, injured coliforms were always but total coliforms were not always detected in treated water. Mean densities of total coliforms in TW, and Taps Kl, K2, K3 and T were 0.8, 2.3, 1.9, 1.4 and 2.1 cfu/100mℓ by membrane filtration method using m- TF agar and those of injured coliforms were 3.4, 2.8, 2.5, 2.7 and 2.9 c1u/100mℓ using mondo- LES agar. The injury rates of TW and Taps Kl, K2, K3 and T were 89.5,77.4,67.9, 82.8 and 75.9%, respectively. The high injury rate of coliform bacteria in Seoul water supply can cause regrowth problems in distribution systems due to the repair of injured cells under an appropriate condition. It is recommended the injured coliforms should be measured in drinking water since they can lead to a significant underestimation of total coliforms and result in an inaccurate evaluation of the potential health risks.

• Molecules and Cells
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• v.28 no.4
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• pp.397-401
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• 2009

Flavonoids are a group of polyphenolic compounds that have been recognized as important due to their physiological and pharmacological roles and their health benefits. Glycosylation of flavonoids has a wide range of effects on flavonoid solubility, stability, and bioavailability. We previously generated the E. coli BL21 (DE3) ${\Delta}pgi$ host by deleting the glucose-phosphate isomerase (Pgi) gene in E. coli BL21 (DE3). This host was further engineered for whole-cell biotransformation by integration of galU from E. coli K12, and expression of calS8 (UDP-glucose dehydrogenase) and calS9 (UDP-glucuronic acid decarboxylase) from Micromonospora echinospora spp. calichensis and arGt-4 (7-O-glycosyltransferase) from Arabidopsis thaliana to form E. coli (US89Gt-4), which is expected to produce glycosylated flavonoids. To test the designed system, the engineered host was fed with naringenin as a substrate, and naringenin 7-O-xyloside, a glycosylated naringenin product, was detected. Product was verified by HPLC-LC/MS and ESI-MS/MS analyses. The reconstructed host can be applied for the production of various classes of glycosylated flavonoids.

• Journal of Ocean Engineering and Technology
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• v.18 no.4 s.59
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• pp.65-70
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• 2004

Many port states, such as New Zealand, U.S.A., Australia, and Canada, have strict regulations to prevent arriving ships from discharging polluted ballast water that contains harmful aquatic organisms and pathogens. They are notified that transfer of polluted ballast water can cause serious injury to public health and damage to property and environment. For this reason, ballast exchange in deep sea is perceived as the most effective method of emptying ballast water. The ballast management plan contains the effective exchange method, ballast system, and safety considerations. In this study, we pursued both nautical engineering analysis and optimization of the algorithm, in order to generate the sequence of stability and rapidity. A heuristic algorithm was chosen on the basis of optimality and applicability to a sequential exchange problem. We have built an optimized algorithm for the automatic exchange of ballast water, by redefining core elements of the A$\ast$ algorithm, such as node, operator, and evaluation function. The final version of the optimized algorithm has been applied to existing bulk carrier, and the performance of the algorithm has been successfully verified.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.08a
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• pp.151-154
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• 2008

사람들의 건강에 대한 관심이 증가하면서 이러한 사람들의 요구사항을 만족시킬 수 있는 다양한 서비스가 개발되어지고 있다. 헬스-관광 서비스는 관광 서비스와 헬스 서비스를 접목하여 관광객의 건강관리를 도와주는 서비스이다. 헬스-관광 서비스는 PDA의 지리정보 및 관광정보를 활용하여 방문할 관광지역과 이동방법을 선정한다. 시스템은 사용자의 기본 정보와 이동반경을 계산하여 사용자의 예상 운동량을 산출하여 보여주고, 사용자는 해당 정보를 바탕으로 전체 관광코스를 선정한다. 실 운동량 측정은 관광객의 이동거리, 이동속도, 고도, 맥박, 체온 등의 정보를 이용하여 측정하고, 측정된 운동량을 사용자에게 알려준다. 또한 실 운동량이 예상 운동량과 비교하여 과도하거나 부족한 경우 관광코스의 수정을 유도하여 적정량의 운동을 할 수 있도록 코치할 수 있다. 본 논문에서는 헬스-관광 서비스 시스템의 서비스 방법을 제안하고, 헬스-관광 서비스 시스템을 설계하였다.

• Journal of Korea Society of Digital Industry and Information Management
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• v.13 no.4
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• pp.13-23
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• 2017

In order to protect personal information and important information (confidential information, sales information, user information, etc.) in the internal network, companies and organizations apply encryption to the Server-To-Server or Server-To-Client communication section, And are experiencing difficulties due to the increasing number of known attacks and intelligent security attacks. In order to apply the existing S / W encryption technology, it is necessary to modify the application. In the financial sector, "Comprehensive Measures to Prevent the Recurrence of Personal Information Leakage in the Domestic Financial Sector" has been issued, and standard guidelines for financial computing security have been laid out, and it is required to expand the whole area of encryption to the internal network. In addition, even in environments such as U-Health and Smart Grid, which are based on the Internet of Things (IoT) environment, which is increasingly used, security requirements for each collection gateway and secure transmission of the transmitted and received data The requirements of the secure channel for the use of the standard are specified in the standard. Therefore, in this paper, we propose a secure encryption algorithm through mutual authentication and grouping for each node through H / W based Network Control Server (NCS) applicable to internal system and IoT environment provided by enterprises and organizations. We propose a protocol design that can set the channel.