• 한국축산식품학회:학술대회논문집
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• 한국축산식품학회 2003년도 제31차 춘계 학술대회
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• pp.75-93
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• 2003

• Journal of Chest Surgery
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• 제54권6호
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• pp.554-557
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• 2021

Surgeons are increasingly using the right mini-thoracotomy approach to perform aortic valve surgery. This approach has shown better results in terms of blood loss and length of hospital stay than the sternotomy approach. For selected patients requiring aortic root and ascending aorta surgery, a right mini-thoracotomy approach may prove beneficial. In our technique, we placed a 5-cm horizontal skin incision in the right second intercostal space. Femoro-femoral cardiopulmonary bypass was established. A valved aortic conduit was used for aortic root replacement. The patient's postoperative course was uneventful, with a short hospital stay. This technique offers a minimally invasive approach to aortic root and ascending aorta surgery with easy adaptability and reduced costs.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2006년도 춘계학술발표대회
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• pp.597-600
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• 2006

인터넷 기술의 발전으로 우편물류시스템은 우편집중국을 중심의 허브-스포크 구조를 기반으로 자동화 우편소통 시설과 우편물류정보시스템 구축 등의 많은 변화와 발전을 해왔다. 현행 우편물류정보시스템은 바코드를 기반으로 정보의 교환 및 처리를 수행하며, 물류정보의 수집, 처리 및 활용에 있어서 실시간성과 동적인 운용 측면에서 진일보하기 위해서는 차세대 정보기술인 RFID를 지원하기 위한 연구가 필요하다. 따라서 이 논문에서는 우편물류의 운송용기를 중심으로 업무 및 시스템을 분석하며, 업무 효율성과 생산성 개선을 위해 RFID 기술을 적용하기 위한 정보처리시스템 모형을 설명한다.

• IMMUNE NETWORK
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• 제11권6호
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• pp.348-357
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• 2011

Background: N-myc downstream-regulated gene 2 (NDRG2), a member of a newly described family of differentiation-related genes, has been characterized as a regulator of dendritic cells. However, the role of NDRG2 on the expression and activation of transcription factors in blood cells remains poorly understood. In this study, we investigated the effects of NDRG2 overexpression on GATA-1 expression in PMAstimulated U937 cells. Methods: We generated NDRG2-overexpressing U937 cell line (U937-NDRG2) and treated the cells with PMA to investigate the role of NDRG2 on GATA-1 expression. Results: NDRG2 overexpression in U937 cells significantly induced GATA-1 expression in response to PMA stimulation. Interestingly, JAK2/STAT and BMP-4/Smad pathways associated with the induction of GATA-1 were activated in PMA-stimulated U937-NDRG2 cells. We found that the inhibition of JAK2 activation, but not of BMP-4/Smad signaling, can elicit a decrease of PMA-induced GATA-1 expression in U937-NDRG2 cells. Conclusion: The results reveal that NDRG2 promotes the expression of GATA-1 through activation of the JAK2/STAT pathway, but not through the regulation of the BMP-4/Smad pathway in U937 cells. Our findings further suggest that NDRG2 may play a role as a regulator of erythrocyte and megakaryocyte differentiation during hematopoiesis.

• 전자공학회논문지CI
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• 제46권2호
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• pp.27-35
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• 2009

고령화 사회로의 진입과 삶의 질 향상에 따라 의료산업의 패러다임이 u-헬스케어(Healthcare)로 빠르게 변화하고 있다. u-헬스케어로의 변화는, 질병의 진단과 치료와 같은 의료서비스의 사후(事後)처리적인 관점에서 예방과 관리라는 사전(事前)예방적인 관점으로의 변화라는 점에서 의미가 있다. 그러나 u-헬스케어에 대한 관심은 새로운 서비스 도출과 측정기기(센서류)의 개발, 의료정보 표준화와 통합에만 그 관심이 집중되고 있다. 따라서 본고에서는 유비쿼터스 지능공간을 구성하고 사용자에게 u-헬스케어 기술을 제공함에 있어 "사용자 중심의 u-헬스케어 기술"이라는 개념을 적용함으로써, u-헬스케어 기술을 유비쿼터스 구성의 기본철학인 사라지는 컴퓨팅(Disappear Computing), 보이지 않는 컴퓨팅(Invisible Computing), 조용한 컴퓨팅(Calm Computing)과 사용자 중심(User Centered)의 기술 개발을 통해 실현 가능하도록 하는 방법에 대하여 소개하고자 한다.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2004년도 Sharing Experience of Human and Ecological Risk Assessment and Management in Asia/Pacific Region
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• pp.16-16
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• 2004

• International Journal of Contents
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• 제12권1호
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• pp.14-24
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• 2016

This study surveyed the variables associated with tailored user interfaces (UIs) to identify and apply to. healthcare web services. A total of 308 elderly people of age 50 and above), living in Incheon, South Korea, were surveyed through one-on-one interviews. The survey results of these 300 subjects were analyzed and used to demonstrate that younger subjects higher EQ-5D and TAM indices. The technology acceptance model showed the greatest effect on the perceived need for web services.

• 대한암한의학회지
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• 제17권1호
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• pp.45-53
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• 2012

Objective : We introduce a case of non-small cell lung cancer patient treated with allergen removed Rhus verniciflua Stokes. Methods : This patient started Allergen-removed Rhus Verniciflua Stokes from Feb 2010 right after his firstline chemotherapy, and maintained his Oriental medicine regimen until now. Results : It shows 12.0 months of progression-free-survival since starting point of maintenance chemotherapy, and 9.3 months of overall-survival since progression disease after 2nd chemotherapy, compared with 6.3 months of its known overall survival. Conclusion : Allergen removed Rhus verniciflua Stokes prolonged overall survival and slowed disease progression of a non-small cell lung cancer patient.

• Molecules and Cells
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• 제43권8호
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• pp.694-704
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• 2020

HslUV is a bacterial heat shock protein complex consisting of the AAA+ ATPase component HslU and the protease component HslV. HslV is a threonine (Thr) protease employing the N-terminal Thr residue in the mature protein as the catalytic residue. To date, HslUV from Gram-negative bacteria has been extensively studied. However, the mechanisms of action and activation of HslUV from Gram-positive bacteria, which have an additional N-terminal sequence before the catalytic Thr residue, remain to be revealed. In this study, we determined the crystal structures of HslV from the Gram-positive bacterium Staphylococcus aureus with and without HslU in the crystallization conditions. The structural comparison suggested that a structural transition to the symmetric form of HslV was triggered by ATP-bound HslU. More importantly, the additional N-terminal sequence was cleaved in the presence of HslU and ATP, exposing the Thr9 residue at the N-terminus and activating the ATP-dependent protease activity. Further biochemical studies demonstrated that the exposed N-terminal Thr residue is critical for catalysis with binding to the symmetric HslU hexamer. Since eukaryotic proteasomes have a similar additional N-terminal sequence, our results will improve our understanding of the common molecular mechanisms for the activation of proteasomes.

• Molecules and Cells
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• 제41권8호
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• pp.733-741
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• 2018

Mutations in spliceosome components have been implicated in carcinogenesis of various types of cancer. One of the most frequently found is U2AF1 S34F missense mutation. Functional analyses of this mutation have been largely limited to hematological malignancies although the mutation is also frequently seen in other cancer types including lung adenocarcinoma (LUAD). We examined the impact of knockdown (KD) of wild type (wt) U2AF1 and ectopic expression of two splice variant S34F mutant proteins in terms of alternative splicing (AS) pattern and cell cycle progression in A549 lung cancer cells. We demonstrate that induction of distinct AS events and disruption of mitosis at distinct sub-stages result from KD and ectopic expression of the mutant proteins. Importantly, when compared with the splicing pattern seen in LUAD patients with U2AF1 S34F mutation, ectopic expression of S34F mutants but not KD was shown to result in common AS events in several genes involved in cell cycle progression. Our study thus points to an active role of U2AF1 S34F mutant protein in inducing cell cycle dysregulation and mitotic stress. In addition, alternatively spliced genes which we describe here may represent novel potential markers of lung cancer development.