• IMMUNE NETWORK
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• 제2권2호
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• pp.79-85
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• 2002

Background: In contrast to evidences of Ig H chain receptor editing in transformed cell lines and transgenic mouse models, there has been no direct evidence that this phenomenon occurs in human developing B cells. Methods: $V_HDJ_H$ rearrangements were obtained from genomic DNA of individual $IgM^-$ B cells from liver and $IgM^+B$ cells from bone marrow of 18 wk of gestation human fetus by PCR amplification and direct sequencing. Results: We found three examples of H chain receptor editing from $IgM^+$ and $IgM^-human$ fetal B cells. Two types of $V_H$ replacements were identified. The first involved $V_H$ hybrid formation, in which part of a $V_H$ gene from the initial VDJ rearrangement is replaced by part of an upstream $V_H$ gene at the site of cryptic RSS. The second involved a gene conversion like replacement of CDR2, in which another $V_H$ gene donated a portion of its CDR2 sequence to the initial VDJ rearrangement. Conclusion: These data provide evidence of receptor editing at the H chain loci in developing human B cells, and also the first evidence of a gene conversion event in human Ig genes.

• 수산경영론집
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• 제48권1호
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• pp.51-71
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• 2017

We explore each of the three major domestic fishery product markets in South Korea- Frozen Squid, Frozen Hair tail and Dried Anchovy- to assess whether we can find evidence for Law of One Price (LOP) across the five major cities- Seoul, Dae-Jeon, Dae-Gu, Gwang-Ju and Busan. To achieve our aim, we utilize two different types of unit root tests: Augmented Dickey-Fuller (ADF) and Kwiatkowski-Phillips-Schmidt-Shin (KPSS) unit root test. In each of the three fishery product markets, we find evidence in support of LOP among several cities, which confirms that these markets are integrated to a certain extent. In particular, we find stronger evidence of LOP for Dried Anchovy market relative to the other two fishery product markets. Based on our findings, we argue that the Dried Anchovy market exhibits a greater degree of market integration across the five major cities in South Korea compared to the other two fishery product markets. The greater degree of market integration in the Dry Anchovy market is facilitated by its higher substitutability across cities; taken together these findings show that the market for Dried Anchovy in South Korea is more efficient than the markets for Frozen Squid and Frozen Hair tail.

• 한국언어정보학회지:언어와정보
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• 제12권2호
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• pp.1-20
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• 2008

This paper examines the effects of focus types on case ellipsis in Korean. A number of previous studies have suggested that accusative case markers in Korean and Japanese cannot be dropped when the object they mark is contrastively focused (Masunaga, 1988; Yatabe, 1999; Ko, 2000; Lee, 2002). Using experimental evidence, we argue against the view that case ellipsis in Korean is sensitive to the distinction between contrastive vs. non-contrastive focus. An alternative analysis is proposed which accounts for the phenomenon of variable case marking in terms of the interaction between the contrastive strength and the discourse accessibility of focused object NPs. By viewing patterns of case ellipsis as the result of balancing between these two forces, such an analysis can correctly predict the gradient pattern of case ellipsis shown by the three types of focused objects tested in the experiment (contrastive replacing focus, contrastive selecting focus and non-contrastive, informational focus), while at the same time offering an explanation for why subtypes of focus exert distinct influences on case ellipsis.

• 한국동물학회지
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• 제39권2호
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• pp.147-158
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• 1996

Since the floating goby, Choenogobius onnuloris, has intricate and diverse morphological variations, allozymic analysis at 25 loci was carried out for their populations in Korea to clarify its taxonomic status. A genetic assay carried out revealed that the floating gobies were clearly divided into three genetic groups (Tvpe-A, Tvpe-B and Tvpe-C) in Korea. Alternative alleles were fated at six loci (Aco, 6pgd, Ldh-1, Got-1, Gpf, Gp3l. Some loci had considerable heterogeneitv among three types and no evidence of gene exchange in slunpatric populations was found from statistical analyses. The genetic similarity (Rogers'S) among three types was lower than 0.80 and divergent time estimate indicates that they were speciated during 1.2-1.8 million year before present (WBP). ASso, these three types of C. unnuluris were distinguished morpholosicallv from each other by several characters such as band ornamentations. In conclusion, the evidences presented here support recognition of three types of Chuenogobius annularis as typical discrete species.

• 대한약리학회지
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• 제24권2호
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• pp.153-164
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• 1988

The potential role of endogenous opioid peptides (EOPS) in cardiovascular regulation has only recently been entertained. EOPS have been localized in brain, spinal cord, autonomic ganglia, particularly the adrenal gland, and many other peripheral tissues. There are at least five major types of opioid receptors; namely ${\mu},\;{\delta},\;k,\;{\sigma},\;and\;{\varepsilon}$ and Experimental evidence indicates that cardiovascular actions of the peptide are mediated primarily by ${\mu},\;{\delta}$ and k receptors, and that these receptor types may be allosterically coupled. In anesthetized rabbits met-enkephalin decreased blood pressure and heart rate, which closely paralleled a reduction in sympathetic discharge. Naloxone, but not naloxone methobromide, antagonized these effects, which suggests a central site of action of met-enkephalin. A number of autonomic agents, particularly adrenergic ${\alpha}$-and, ${\beta}-agonists$ and antagonists modify the cardiovascular actions of met-enkephalin. Experiments in reserpine-treated and adrenalectomized rats provide no evidence of sympathetic nervous system involvement in the pressor responses to intravenous injection of opioid peptides, but rather suggest a direct peripheral action. Finally, activation of a beta-endorphinergic pathway projecting from the arcuate nucleus to the nucleus tractos solitarii in rats can cause naloxone reversible hypotension and bradycardia. There is evidence to implicate this pathway in antihypertensive drug action and in the modulation of baroreflex activity.

• 한국조경학회지
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• 제44권4호
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• pp.75-85
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• 2016

최근 치유환경으로서 자연경관에 대한 연구는 의료환경과 산림분야에서 활발히 이루어지고 있다. 그러나 치유환경에 대한 연구들은 건물 내 자연요소 도입이나 자연경관 조망과 같은 단순한 설정을 통한 긍정적인 치유효과를 나타내는 데에 머무르고 있어, 치유환경설계의 근거로 활용하기에는 한계가 있다. 따라서 본 연구는 치유환경설계시 과학적 근거를 기반으로 하는 근거중심설계가 이루어질 수 있도록 치유환경과 치유효과 사이의 관련성을 찾고자 한다. 이를 위해 대표적 치유환경인 숲의 공간유형을 자연형 숲길, 조성형 숲길, 자연형 쉼터, 조성형 쉼터로 나누고, 각 공간의 주요이미지, 심리적 회복감과 만족도를 분석하였다. 수집된 자료는 통계프로그램 SPSS 18.0 for Windows의 요인분석, 분산분석, 다중회귀분석을 실시하였다. 연구결과, 1) 자연형 숲길은 5가지의 회복감 요인 중 벗어남, 적합성과 이해용이성을, 조성형 쉼터는 매혹감과 짜임새를을 통해 심리적 회복감을 주며, 2) 치유환경의 심리적 회복감은 흥미로운, 밝은, 생기있는, 아름다운 이미지가 높을수록, 분산된 이미지가 낮을수록 높아지고, 3) 심리적 회복감 요인은 벗어남, 짜임새 순으로 숲 공간 만족도에 영향을 미치는 것으로 나타났다. 위 결과는 숲 공간유형에 따른 치유환경 특성을 파악함으로써, 향후 치유공간 설계를 위한 기초자료와 지침 설정에 도움이 될 것으로 기대한다.

• 시큐리티연구
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• 제48호
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• pp.113-146
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• 2016

범죄 프로파일링(Criminal profiling)은 산업보안 활동의 효율성과 효과성을 증대시킬 수 있는 효과적인 도구이다. 카지노 이용자 중 위반행동(즉, 범죄행동)을 하는 사람들에 대한 프로파일을 작성한다면, 이를 보안활동 및 보안 활동 교육 및 훈련에 매우 유용하게 사용되어 질 수 있을 것이다. 안타깝게도, 국내외에서 이러한 연구가 수행된 바가 없어, 본 연구는 카지노 이용자들에 대한 범죄 프로파일링 작성을 통하여 카지노 산업보안 교육 및 훈련에 필요한 정책적 제언을 제시하고자 하였다. 구체적으로, 본 연구는 수사심리학(Investigative psychology), 연계분석(Linkage analysis), 그리고 행동증거분석(Behavioral evidence analysis) 등을 이론적 바탕으로 위반행동을 한 카지노 이용자의 행동증거 프로파일을 수립하였고, 카지노 보안 요원들이 중점 관찰하는 행동에 대한 프로파일을 수립하고 비교함으로써, 보안활동의 효율성 및 효과성을 증대할 정책방향을 모색하였다. 이를 위하여 본 연구는 90명의 카지노 보안 요원들로부터 설문데이터를 수집 분석하였다. 분석결과, 카지노 위반행위 유형별로 독특한 행동증거들이 나타났으며, 보안 요원들의 중점 관찰 행동이 행동증거 프로파일과 일치하지 않아 보안 관찰 활동의 효율성이 떨어지는 위험행동 유형이 존재하는 것으로 나타났다. 결과를 바탕으로 카지노 산업보안의 운영, 보안 교육 및 훈련, 카지노 관련 학술활동에 대한 정책제언을 제시하였다.

• 한국중재학회지:중재연구
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• 제21권2호
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• pp.47-64
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• 2011

The China International Economic and Trade Arbitration Commission(CIETAC) released online arbitration rules which apply the resolution of disputes over electronic commerce transactions, as well as other economic and trade disputes in which the parties agree to do. The evidence submitted by the parties may be electronic evidence created, sent, received or stored by electronic, optical or magnetic means. Electronic evidence with a reliable electronic signature shall carry the same effect and probative force as a document with a hand-written signature. Where a case is tried in a tribunal, the arbitration tribunal shall conduct an online trial hearing using internet video conference or other electronic or computer communication means. Unless the parties have another agreement, summary procedure shall apply to cases where the amount in dispute exceeds RMB 100,000 but no more than RMB 1 million, or where the amount in dispute exceeds RMB 1 million and a party submits a written application for summary procedure after obtaining the written consent of the other party. Unless the parties have agreed otherwise, fast-track procedure shall apply to cases where the amount in dispute does not exceed RMB 100,000 or where the amount in dispute exceeds RMB 100,000 and a party submits a written application for fast-track procedure after obtaining the written consent of the other party. Notable features of the Online Rules are as follows; first, there is not detailed consideration for online arbitration. Second, communications between the parties and the tribunal are allowed only through the Secretariat. Third, elaborate provisions regarding the electronic submission and transmission of documents is provided for. Forth, various factors must be considered by the tribunal in deciding the evidence's reliability. Fifth, reasonable endeavours is levied on CIETAC to keep data communications secure and encrypted. Sixth, the tribunal has the right to investigate and collect relevant evidence. And finally different procedures are provided for in consideration of the various types of E-commerce.

• 대한산업공학회지
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• 제22권3호
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• pp.399-412
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• 1996

With respect to the effects of types of knowledge on human diagnostic performance, the results of several experiments claimed that training with procedural knowledge is more effective than training with principle knowledge. However, more useful results would be attained by investigating when and how the principles of system dynamics is valuable for diagnosis. Accordingly, we conducted an experiment to reevaluate the value of principle knowledge in two problem situations. A simulator system, named DLD, to diagnose an electronic device was created. It is a context-free digital logic circuit which includes forty-one gates of three basic types. The experiment investigated the effects of principle knowledge over common procedural knowledge. The experimental results showed that the effects of principle knowledge is dependent on the complexity of diagnostic situations. This adds up on experimental evidence against the presumed ineffectiveness of principle knowledge and forward reasoning in fault diagnosis. The results also suggest the source of the usefulness of principle knowledge.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1995년도 춘계공동학술대회논문집; 전남대학교; 28-29 Apr. 1995
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• pp.387-394
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• 1995

With respect to the effectiveness of types of knowledge on human diagnostic performance, the results of several experiments claimed that training with diagnostic rules (procedural knowledge) is more effective than training that provides theoretical knowledge (principle knowledge). However, we usually have the idea that understanding the principles of system dynamics is necessary for diagnosis in some situations. In this study, we pointed out some problems in the previous experiments that force to reinterpret their experimental conclusions. Accordingly, we conducted an experiment to reinvestigate the value of theoretical knowledge in two problem situations. A simulator system, which is named DLD, that is to diagnose an electronic device was created for this purpose. It is a context-free digital logic circuit which includes forty-one gates of three basic types. Our experiment investigated the marginal effects of theoretical knowledge over common diagnostic rules. The experimental results showed that the effectiveness of the instruction in theoretical knowledge is dependent on the complexity of diagnostic situations. This adds up an experimental evidence against the presumed ineffectiveness of theoretical knowledge and forward reasoning in fault diagnosis. Furthermore, the result suggests the source of the use of theoretical knowledge.