• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3139-3145
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• 2016

Cancer is the leading cause of morbidity and mortality worldwide, characterized by irregular cell growth. Cytotoxicity or killing tumor cells that divide rapidly is the basic function of chemotherapeutic drugs. However, these agents can damage normal dividing cells, leading to adverse effects in the body. In view of great advances in cancer therapy, which are increasingly reported each year, we quantitatively and qualitatively evaluated the papers published between 1981 and December 2015, with a closer look at the highly cited papers (HCPs), for a better understanding of literature related to cytotoxicity in cancer therapy. Online documents in the Web of Science (WOS) database were analyzed based on the publication year, the number of times they were cited, research area, source, language, document type, countries, organization-enhanced and funding agencies. A total of 3,473 publications relevant to the target key words were found in the WOS database over 35 years and 86% of them (n=2,993) were published between 2000-2015. These papers had been cited 54,330 times without self-citation from 1981 to 2015. Of the 3,473 publications, 17 (3,557citations) were the most frequently cited ones between 2005 and 2015. The topmost HCP was about generating a comprehensive preclinical database (CCLE) with 825 (23.2%) citations. One third of the remaining HCPs had focused on drug discovery through improving conventional therapeutic agents such as metformin and ginseng. Another 33% of the HCPs concerned engineered nanoparticles (NPs) such as polyamidoamine (PAMAM) dendritic polymers, PTX/SPIO-loaded PLGAs and cell-derived NPs to increase drug effectiveness and decrease drug toxicity in cancer therapy. The remaining HCPs reported novel factors such as miR-205, Nrf2 and p27 suggesting their interference with development of cancer in targeted cancer therapy. In conclusion, analysis of 35-year publications and HCPs on cytotoxicity in cancer in the present report provides opportunities for a better understanding the extent of topics published and may help future research in this area.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.22 no.1
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• pp.18-30
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• 2017

The East Sea is almost entirely composed of sandy facies, and the facies type is the major factor influencing benthic polychaete communities. There have been few studies of the effects of environmental factors on benthic polychaetes in thermal discharge areas consisting of different sediment types. This study identified the spatial distribution patterns based on the species composition and distribution of benthic polychaete communities, and the environmental factors influencing benthic polychaetes near power plants were investigated. The polychaete communities in the Uljin, Hupo, and Gori coastal areas near the power plants in the East Sea were seasonally investigated from August 2006 to February 2013. As a result, 283 species were collected. The dominant species were Spiophanes bombyx, Magelona japonica, Lumbrineris longifolia, and Sternaspis scutata. Spiophanes bombyx was the dominant species at Uljin and Hupo, but M. japonica was the dominant species at Gori. Two dominant species from the coastal waters of the East Sea, Lumbrineris longifolia and M. japonica, were rare in the power plant water intake or drainage areas. Cluster analysis was performed to divide the study area into groups by the total organic carbon content, sediment grain size and facies patterns. This study suggests that the community structures of polychaetes are more affected by the total organic carbon, grain size of sediment and facies than by disturbance from thermal discharge, which only affected the polychaete community near power plant drainage areas.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.6
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• pp.1147-1159
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• 2018

This study focuses on the verification of a rapid protection automation system using an inflatable structure. The inflatable structure is an automatic rapid protection system against human and material damage when the subsea tunnel is flooded. Especially, it is essential for construction and operation of subsea tunnels. In this study, we have experimentally verified the rapid protection automation system using the inflatable structure designed for this problem. In order to verify this, a model tunnel with a 40: 1 reduction ratio was constructed, and air pressure of 0.1 bar and 0.15 bar was injected to divide the tunnel according to the expansion rate at 10 sec and 20 sec. According to the results of the study, the protection efficiency was better at 0.15 bar than 0.1 bar when the expansion structure was expanded, and the protection efficiency and influent control efficiency were different according to the pneumatic injection time of the inflating structure. As a result of this study, it was found that the higher the internal air pressure of the inflated structure and the faster the inflation of rate, the more effectively the inflated structure was inflated. As a result of this study, it is necessary to further study the wedge type structure which is useful for the storage method of expansion structure, shape and expansion derivative, inhibition of expansion structure during protection and control of inflow water.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.6
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• pp.440-447
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• 2020

Masonry structures are used as bearing walls in small buildings, but they are generally considered non-bearing walls. They are used as partition walls that divide the interior spaces of the frame structures of buildings. In addition, wetting techniques that use mortar as an adhesive between blocks or bricks in construction are vulnerable to climatic conditions, especially cracks in mortar, which can cause conduction collapse of the walls in seismic loading. The purpose of this research was to propose a dry concrete block construction method that complements the weak axial shear stiffness and improves the weakness of the wet construction method as well as to investigate its structural behavior. In this study, the material properties of concrete blocks were examined, and the seismic performance of the proposed dry assembly structure was verified by structural behavior tests on horizontal cyclic loads. First, in these study results, concrete blocks can be applied to the dry block construction method instead of wet construction methods because they secure more than C-type blocks in KS regulations. Second, the structural performance of the wall against a horizontal cyclic load indicates that the resisting force of the assembly block wall is increased by increasing the horizontal length of the wall, forming several diagonal cracks. Finally, the proposed dry block wall structure requires a seismic performance assessment considering that the ratio of the shape of the wall by height and length is considered a major influence variable on the structural behavior under a horizontal load.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.37 no.1
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• pp.55-63
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• 2000

This paper investigated the sub-region compression effect of the three dimensional DCT(3D-DCT) using the difference component(DC) of inter-frame in images. The proposed algorithm are the method that obtain compression effect to divide the information into subband after 3D-DCT, the data appear the type of cubic block(8${\times}$8${\times}$8) in eight difference components per unit. In the frequence domain that transform the eight differential component frames into eight DCT frames with components of both spatial and temporal frequencies of inter-frame, the image data are divided into frame component(8${\times}$8 block) of time-axis direction into 4${\times}$4 sub block in order to effectively obtain compression data because image components are concentrate in corner region with low-frequency of cubic block. Here, using the weight of sub block, we progressed compression ratio as consider to adaptive sub-region of low frequency part. In simulation, we estimated compression ratio, reconstructed image resolution(PSNR) with the simpler image and the complex image contained the higher frequency component. In the result, we could obtain the high compression effect of 30.36dB(average value in the complex-image) and 34.75dB(average value in the simple-image) in compression range of 0.04~0.05bpp.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.28 no.1
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• pp.59-65
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• 2010

The purpose of this study is to analyze the risk of the forest fire, considering the topography and the forest, for establishing disaster prevention measures of cultural heritage, Uireung, over in Cheonjang-mountain. To do that, we estimate the occurrence and spread of the forest fire over in Cheonjang-mountain through a forest fire probability model(logistic regression), using the space characteristic data($100m{\times}100m$). The factor, occurrence of the forest fire, are diameter class, southeast, southwest, south, coniferous, deciduous, and mixed forest. We assume the probability of the fire forest in each point as follow : [1+exp{-(-4.8081-(0.02453*diameter class)+(0.6608*southeast)+(0.507*southwest)+(0.7943*south)+(0.29498*coniferous forest)+(0.28897*deciduous forest)+(0.17788*mixed forest))}]$^{-1}$. To divide dangerous zone of the big forest fire, we make the basic materials for disaster prevention measures, through the map of coniferous forests, deciduous forests, and mixed forest. The damage of cultural heritage caused by a forest fire will be reduced through the effective preventive measures, by forecast a forest fire to using this study.

• Spatial Information Research
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• v.21 no.6
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• pp.91-98
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• 2013

Government introduces a Total Maximum Daily Loads(TMDL) which can be implemented for total pollutant amounts in 2004. Normally, the local governments have been calculated the amounts of pollutant discharge of each watershed using a water quality model. However, among the input data to use the water quality model, creating a schematic diagram of the stream or the modeling usually requires considerable amount of time and efforts due to the manual work. Therefore, this study tried to develop an algorithm which automates the creation of a schematic diagram for water quality modeling using the Korean Reach File capable of river network analysis. Further, this study creates a schematic diagram with the shape of a stream utilizing GIS capabilities. The diagram can be easily analyzed with overlapping various spatial information such as pollution sources and discharge points. This study mainly has automated element segmentation algorithm to divide streamflows into equal distance using line graphic data of Koran Reach File. Also, automated attribute input algorithm has also been developed to enable to insert element order and type into elements using point graphic data of Korean Reach File. For the verification of the developed algorithm, the algorithm was applied to kyungan stream basin to see the acceptable results. To conclude, it was possible to automate generating of schematic diagram of water quality model and it is expected to be able to save time and cost required for the water modeling. In future study, it is necessary to develop an automatic creation system of various types of input data for water quality modeling and this will lead to relatively easier and simple water quality modeling.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.3
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• pp.25-31
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• 2019

This study was conducted to evaluate the penetration performance of the Silane Surface Protection Material (SSPM) penetrating the micro pore of concrete surface. The results was indicated microstructure, porosity and penetration depth of applied SSPM. Silica sand and conventional sand were used as fine aggregate in mortar. And liquid and cream types SSPM were used. The amounts of SPM were applied the 127, 255, 382, 510 g/m2 on the surface of mortar. The penetration depth specimens were made with $100{\times}30mm$ in according with KS F 4930. Penetration depth was evaluated according to KS F 4930, divide specimen and then spraying with water in cross section of specimens, and measure the depth of the non-wetted area. The microstructure result of mortar applied SSPM, it was obtained liquid and cream SSPM in mortar. The porosity results of SSPM application specimens were improved with than that of plain specimens. Test results indicated that the penetration depth of SPM were improved with increasing in amounts of SSPM. As a result of test, application of SSPM to concrete surface, it will improve durability.

• Journal of Korean Society of Forest Science
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• v.75 no.1
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• pp.32-37
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• 1986

In order to get the fundamental information that could be useful to judge the potentiality of occurrence of rapid shallow landslide in the objective slope, factors selected on Jinhae regions in Korea, where many landslides were caused by heavy rainfall of daily 465 mm and hourly 52mm in August 1979, was carried out through the multiple statistics of quantification method (II) by the electronic computer. The net system with $2{\times}2cm$ unit mesh was overlayed with the contour map of scale 1:5000. 74 meshes of landslides and 119 meshes of non-landslide were sampled out to survey the state of vegetative cover and geomorphological conditions, those were divided into 6 items arid 27 categories. As a result, main factors that would lead to landslide were shown in order of vegetation, slope type, slope position, slope, aspect and numbers of stream. Particularly, coniferous forest of 10 years old, concave slope and foot of mountain were main factors making slope instability. On the contrary, coniferous forest of 20-30 years old, deciduous forest, convex slope and summit contributed to the stable against Landslide. The boundary value between two groups of existence and none of landslides was -0.123, and its prediction was 72%. It was well predicted to divide into two groups of them.

• Journal of Embryo Transfer
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• v.18 no.3
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• pp.243-248
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• 2003

Sperrnatogenesis, the process by which the male germ-line stem cells(GSCs; type A spermatogonia) divide and differentiate to produce the mature spermatozoa, occurs in the seminiferous tubules of the testis. The GSCs proliferate actively to produce two types of cells: other GSCs and differentiating spermatogonia. GSCs have unipotentcy, devoted solely to the generation of sperm. The function of GSCs has broad implications for development, disease, and evolution. Spermatogenesis is fundamental for propagation of species and the defects of this system can result in infertility or disease. The ability to identify, isolate, culture, and alter GSCs will allow powerful new approaches in animal transgenesis and human gene therapy relating to infertility. Until recently, research on stem cells in the testis has been limited because of technical difficulties in isolating and identifying these cell populations. Here, we were trying to find out optimal conditions for in vitro culture of GSCs for identifying and isolating GSCs. We collected mouse GSCs from 3-days old mouse by two-step enzyme digestion method. GSCs were plated and grown on mouse embryonic fibroblasts in Dulbecco's modified Eagle's medium (DMEM) containing 15％ fatal bovine serum, 10 mM 2-mercaptoethanol, 1％ non-essential amino acids, 1 ng/$m\ell$ bFGF, 10 $\mu$M forskolin, 1500 U/$m\ell$ human recombinant leukemia inhibitory factor (LIF). Over a period 3∼5 days, GSCs gave rise to large multicellular colonies resembling those of mouse pluripotent stem cells. After 5th passages, cells within the colonies continued to be alkaline phosphatase and Oct-4 positive and tested positive against a panel of two immunological markers(Integrin $\alpha$ 6 and Integrin $\beta$ 1) that have been recognized generally to characterize GSCs. SSEA-1, SSEA-3, and SSEA-4 also showed positive signals. Based on our data, these GSCs-derived cultures meet the criteria for GSCs itself and even other pluripotent stem cells. We reported here the establishment of in vitro cultures from mouse male GSCs.